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研究開発

研究開発

In Vivo Drug Metabolism Model for Human Cytochrome P450 Enzyme Using Chimeric Mice with Humanized Liver

    Katoh M, Sawada T, Soeno Y, Nakajima M, Tateno C, Yoshizato K, Yokoi T.

    J Pharm Sci. 2007 Feb;96(2):428-437.

    Evaluation of human hepatocyte chimeric mice as a model for toxicological investigation using panomic approaches–effect of acetaminophen on the expression profiles of proteins and endogenous metabolites in liver, plasma and urine

      Yamamoto T, Tomizawa K, Fujikawa M, Sato Y, Yamada H, Horii I.
      J Toxicol Sci. 2007 Aug;32(3):205-15.

      Bezafibrate induces multidrug-resistance P-Glycoprotein 3 expression in cultured human hepatocytes and humanized livers of chimeric mice.

        Shoda J, Okada K, Inada Y, Kusama H, Utsunomiya H, Oda K, Yokoi T, Yoshizato K, Suzuki H.
        Hepatol Res. 2007 Jul;37(7):548-56.

        Humanization of Excretory Pathway in Chimeric Mice with Humanized Liver

          Okumura H, Katoh M, Sawada T, Nakajima M, Soeno Y, Yabuuchi H, Ikeda T, Tateno C, Yoshizato K, Yokoi T.
          Toxicol Sci. 2007 Jun;97(2):533-8. Epub 2007 Mar 6.

          In Vivo Induction of Human Cytochrome P450 Enzymes Expressed in Chimeric Mice with Humanized Liver

            Katoh M, Matsui T, Nakajima M, Tateno C, Soeno Y, Horie T, Iwasaki K, Yoshizato K, Yokoi T.

            Drug Metab Dispos. 2005 Jun;33(6):754-763.

            Evaluation of Human CYP1A2 and CYP3A4 mRNA Expression in Hepatocytes from Chimeric Mice with Humanized Liver

              Yoshitsugu H, Nishimura M, Tateno C, Kataoka M, Takahashi E, Soeno Y, Yoshizato K, Yokoi T, Naito S.

              Drug Metab Pharmacokinet. 2006;21(6):465-474.

              Characterization of Humanized Liver from Chimeric Mice Using Coumarin as a Human CYP2A6 and Mouse CYP2A5 Probe

                Aoki K, Kashiwagura Y, Horie T, Sato H, Tateno C, Ozawa N, Yoshizato K.

                Drug Metab Pharmacokinet. 2006 ;21(4):277-285.

                Induction of Human CYP1A2 and CYP3A4 in Primary Culture of Hepatocytes from Chimeric Mice with Humanized Liver

                  Nishimura M, Yokoi T, Tateno C, Kataoka M, Takahashi E, Horie T, Yoshizato K, Naito S.

                  Drug Metab Pharmacokinet. 2005;20(2):121-126.

                  Evaluation of mRNA expression of human drug-metabolizing enzymes and transporters in chimeric mouse with humanized liver

                    Nishimura M, Yoshitsugu H, Yokoi T, Tateno C, Kataoka M, Horie T, Yoshizato K, Naito S.

                    Xenobiotica. 2005 Sep;35(9):877-890.

                    In vivo induction of human cytochrome P450 3A4 by rifabutin in chimeric mice with humanized liver

                      Katoh M, Watanabe M, Tabata T, Sato Y, Nakajima M, Nishimura M, Naito S, Tateno C, Iwasaki K, Yoshizato K, Yokoi T.

                      Xenobiotica. 2005 Sep;35(9):863-875.

                      Expression of Human Phase Ⅱ Enzymes in Chimeric Mice with Humanized Liver

                        Katoh M, Matsui T, Okumura H, Nakajima M, Nishimura M, Naito S, Tateno C, Yoshizato K, Yokoi T.

                        Drug Metab Dispos. 2005 Sep;33(9):1333-1340.

                        Near Completely Humanized Liver in Mice Shows Human-Type Metabolic Responses to Drugs

                          Tateno C, Yoshizane Y, Saito N, Kataoka M, Utoh R, Yamasaki C, Tachibana A, Soeno Y, Asahina K, Hino H, Asahara T, Yokoi T, Furukawa T, Yoshizato K.

                          Am J Pathol. 2004 Sep;165(3):901-912.

                          Expression of Human Cytochromes P450 in Chimeric Mice with Humanized Liver

                            Katoh M, Matsui T, Nakajima M, Tateno C, Kataoka M, Soeno Y, Horie T, Iwasaki K, Yoshizato K, Yokoi T.

                            Drug Metab Dispos. 2004 Dec;32(12):1402-1410.