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研究開発

研究開発

Transmission of HBV DNA Mediated by Ceramide-Triggered Extracellular Vesicles

    Sanada,Takahiro1,*  Hirata, Yuichi1,* Naito, Yutaka 2,  Yamamoto,Naoki1,  Kikkawa, Yoshiaki3, Ishida, Yuji 4,  Yamasaki,Chihiro 4,  Tateno, Chise 4,  Ochiya, Takahiro 2 and  Kohara, Michinori 1

    Cell Mol Gastroenterol Hepatol. 2016 Oct 24;3(2):272-283.

    Cyclosporin derivatives inhibit hepatitis B virus entry without interfering with NTCP transporter activity

      Shimura, S. Watashi, K. Fukano, K. Peel, M. Sluder, A. Kawai, F. Iwamoto, M. Tsukuda, S. Takeuchi, J. S. Miyake, T. Sugiyama, M. Ogasawara, Y. Park, S. Y. Tanaka, Y. Kusuhara, H. Mizokami, M. Sureau, C. Wakita, T.

      J Hepatol. 2016 Nov 24. pii: S0168-8278(16)30683-3. doi: 10.1016/j.jhep.2016.11.009.

      A new class of hepatitis B and D virus entry inhibitors, proanthocyanidin and its analogs, that directly act on the viral large surface proteins

        Tsukuda, S. Watashi, K. Hojima, T. Isogawa, M. Iwamoto, M. Omagari, K. Suzuki, R. Aizaki, H. Kojima, S. Sugiyama, M. Saito, A. Tanaka, Y. Mizokami, M. Sureau, C. Wakita, T.

        Hepatology. 2016 Nov 18. doi: 10.1002/hep.28952.

        Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation

          Tanaka, T. Okuyama-Dobashi, K. Murakami, S. Chen, W. Okamoto, T. Ueda, K. Hosoya, T. Matsuura, Y. Ryo, A. Tanaka, Y. Hagiwara, M. Moriishi, K.

          Antiviral Res. 2016 Aug 8. pii: S0166-3542(16)30357-6.

          新規核酸アナログ4′-C-cyano-2′-deoxyadenosine, 4′-C-cyano-2′-deoxyguanosineは薬剤耐性B型肝炎ウイルス変異種に対して有効である(短報)

          林 佐奈衣、高松悠樹、前田賢次、村上周子,尾曲克已、松居剛志、五十川正記、渡邊網正、狩野吉康、向後悟、濱屋裕明、田中靖人

          肝臓 2016; 57(6):299-301

          Antiviral effects of anti-HBs immunoglobulin and vaccine on HBs antigen seroclearance for chronic hepatitis B infection

            Tsuge, M. Hiraga, N. Uchida, T. Kan, H. Miyaki, E. Masaki, K. Ono, A. Nakahara, T. Abe-Chayama, H. Zhang, Y. Naswa, M. G. Kawaoka, T. Miki, D. Imamura, M. Kawakami, Y. Aikata, H. Ochi, H. Hayes, C. N. Chayama, K.

            J Gastroenterol. 2016 Mar 4.

            Possible Involvement of Hepatitis B Virus Infection of Hepatocytes in the Attenuation of Apoptosis in Hepatic Stellate Cells

              Sasaki, R. Kanda, T. Nakamura, M. Nakamoto, S. Haga, Y. Wu, S. Shirasawa, H. Yokosuka, O.

              PLoS One. 2016 Jan 5;11(1):e0146314. doi: 10.1371/journal.pone.0146314. eCollection 2016.

              A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide

                Kaneko, M. Watashi, K. Kamisuki, S. Matsunaga, H. Iwamoto, M. Kawai, F. Ohashi, H. Tsukuda, S. Shimura, S. Suzuki, R. Aizaki, H. Sugiyama, M. Park, S. Y. Ito, T. Ohtani, N. Sugawara, F. Tanaka, Y. Mizokami, M. Sureau, C. Wakita, T.

                J Virol. 2015 Dec;89(23):11945-53. doi: 10.1128/JVI.01855-15.

                ヒト肝細胞キメラマウスを用いたin vivoおよびin vitro HBV感染モデル

                石田雄二、横道博、加国雅和、立野知世

                新ウイルス性肝炎学 2015 page386-391

                Human Cytotoxic T Lymphocyte-Mediated Acute Liver Failure and Rescue by Immunoglobulin in Human Hepatocyte Transplant TK-NOG Mice

                  Uchida, T. Hiraga, N. Imamura, M. Tsuge, M. Abe, H. Hayes, C. N. Aikata, H. Ishida, Y. Tateno, C. Yoshizato, K. Ohdan, H. Murakami, K. Chayama, K.

                  J Virol. 2015 Oct;89(19):10087-96. doi: 10.1128/JVI.01126-15. Epub 2015 Aug 5.

                  Novel pH-sensitive multifunctional envelope-type nanodevice for siRNA-based treatments for chronic HBV infection

                    Yamamoto, N. Sato, Y. Munakata, T. Kakuni, M. Tateno, C. Sanada, T. Hirata, Y. Murakami, S.  Tanaka, Y. Chayama, K. Hatakeyama, H. Hyodo, M. Harashima, H. Kohara, M.

                    J Hepatol. 2015 Oct 23. pii: S0168-8278(15)00713-8. doi: 10.1016/j.jhep.2015.10.014.

                    Effect of tenofovir disoproxil fumarate on drug-resistant HBV clones

                      Murakami, E. Tsuge, M. Hiraga,  N.Kan, H. Uchida, T. Masaki, K. Nakahara, T. Ono, A. Miki, D. Kawaoka, T. Abe, H.Imamura, M. Aikata, H. Ochi, H. Hayes, C. N. Akita, T. Tanaka, J. Chayama, K.

                      J Infect. 2015 Oct 26. pii: S0163-4453(15)00339-4. doi: 10.1016/j.jinf.2015.09.038.

                      A novel reporter system to monitor early stages of the HBV life cycle

                        Nishitsuji, H. Ujino, S. Shimizu, Y. Harada, K. Zhang, J. Sugiyama, M. Mizokami, M. Shimotohno, K.

                        Cancer Sci. 2015 Aug 27. doi: 10.1111/cas.12799.

                        第63回日本ウイルス学会学術集会でのPXBマウス・PXB-cells関連研究発表のご案内

                        2015年 11月22日(日)~24日(火)に福岡国際会議場(福岡市博多区)にて開催の第63回日本ウイルス学会学術集会にてPXBマウス・PXB-cells関連研究発表がありましたので、ご案内申し上げます。

                        Lack of infectivity of HBV in feces from patients with chronic hepatitis B virus infection, and infection using chimeric mice

                          Komatsu, H. Inui, A. Murano, T. Tsunoda, T. Sogo, T. Fujisawa, T.

                          BMC Res Notes. 2015 Aug 20;8:366. doi: 10.1186/s13104-015-1337-z.

                          Characterization of novel entecavir resistance mutations

                            Hayashi, S. Murakami, S. Omagari, K. Matsui, T. Iio, E. Isogawa, M. Watanabe, T. Karino, Y. Tanaka, Y.

                            J Hepatol. 2015 Sep;63(3):546-53. doi: 10.1016/j.jhep.2015.03.020. Epub 2015 Mar 25.

                            Association between hepatitis B virus and MHC class I polypeptide-related chain A in human hepatocytes derived from human-mouse chimeric mouse liver

                              Sasaki, R. Kanda, T. Wu, S. Nakamoto, S. Haga, Y. Jiang, X. Nakamura, M.

                              Shirasawa, H. Yokosuka, O.

                              Journal: Biochem Biophys Res Commun. 2015 Jul 23. pii: S0006-291X(15)30332-6.

                              doi: 10.1016/j.bbrc.2015.07.102.

                              4′-modified nucleoside analogs: Potent inhibitors active against entecavir-resistant hepatitis B virus

                                Takamatsu, Y. Tanaka, Y. Kohgo, S. Murakami, S. Singh, K. Das, D. Venzon, D.  J. Amano, M. Kuwata,N. Aoki, M. Delino, N. S. Hayashi, S. Takahashi, S. Sukenaga, Y. Haraguchi, K. Sarafianos, S. G. Maeda, K. Mitsuya, H.

                                Journal: Hepatology. 2015 Jun 29. doi: 10.1002/hep.27962.

                                Postexposure Prophylactic Effect of Hepatitis B Virus (HBV)-Active Antiretroviral Therapy against HBV Infection

                                  Watanabe, T. Hamada-Tsutsumi, S. Yokomaku, Y. Imamura, J. Sugiura, W. Tanaka, Y.

                                  Antimicrob Agents Chemother. 2015 Feb;59(2):1292-8.

                                  Discovering novel direct acting antiviral agents for HBV using in silico screening

                                    Murakami, Y. Hayakawa, M. Yano, Y. Tanahashi, T. Enomoto, M. Tamori, A. Kawada, N. Iwadate, M. Umeyama, H.

                                    Biochem Biophys Res Commun. 2015 Jan 2;456(1):20-8.