Phoenix Bio

研究開発

研究開発

Protease inhibitor resistance remains even after mutant strains become undetectable using deep sequencing

    Kan, H. Imamura, M. Uchida, T. Hiraga, N. Hayes, C. N. Tsuge, M. Abe, H. Aikata, H. Makokha, G. N. Chowdhury, S. Miki, D. Ochi, H. Ishida, Y. Tateno, C. Chayama, K.

    J Infect Dis. 2016 Sep 20. pii: jiw437.

    Hepatitis C virus dynamics and cellular gene expression in uPA-SCID chimeric mice with humanized livers during intravenous silibinin monotherapy

      DebRoy, S.  Hiraga, N. Imamura, M. Hayes, C. N. Akamatsu, S. Canini, L. Perelson, A. S. Pohl, R. T. Persiani, S. Uprichard, S. L. Tateno, C. Dahari, H. Chayama, K.

      J Viral Hepat. 2016 Jun 8. doi: 10.1111/jvh.12551.

      Elimination of HCV via a non-ISG-mediated mechanism by vaniprevir andBMS-788329 combination therapy in human hepatocyte chimeric mice

        Uchida, T. Hiraga, N. mamura, M. Yoshimi, S. Kan, H. Miyaki, E. Tsuge, M. Abe, H. Hayes, C. N. Aikata, H. Ishida, Y. Tateno, C. Ellis, J. D. Chayama, K.

        Virus Res. 2015 Nov 10. pii: S0168-1702(15)30117-9. doi: 10.1016/j.virusres.2015.11.010.

        Combination therapies with daclatasvir and asunaprevir on NS3-D168 mutated HCV in human hepatocyte chimeric mice

          Kan, H. Hiraga, N. Imamura, M. Hayes, C. N. Uchida, T. Miyaki, E. Tsuge, M. Abe, H. Aikata, H. Miki, D. Ochi, H. Ishida, Y. Tateno, C. Chayama, K.

          Antivir Ther. 2015 Nov 12. doi: 10.3851/IMP3009.

          第63回日本ウイルス学会学術集会でのPXBマウス・PXB-cells関連研究発表のご案内

          2015年 11月22日(日)~24日(火)に福岡国際会議場(福岡市博多区)にて開催の第63回日本ウイルス学会学術集会にてPXBマウス・PXB-cells関連研究発表がありましたので、ご案内申し上げます。

          Preclinical characterization andin vivoefficacy of GSK8853, a small molecule inhibitor of the Hepatitis C virus NS4B protein

            Pouliot, Jeffrey J. Thomson, Michael Xie, Mi Horton, Joseph Johnson, John Krull, David Mathis, Amanda Morikawa, Yoshio Parks, Derek Peterson, Richard, Shimada, Takashi Thomas, Elizabeth Vamathevan, Jessica Van Horn, Stephanie Xiong, Zhiping Hamatake, Robert  Peat, Andrew J.

            Antimicrob. Agents Chemother. doi:10.1128/AAC.00813-15

            Prevention of hepatitis C virus infection and spread in human liver chimeric mice by an anti-CD81 monoclonal antibody

              Ji, C. Liu, Y. Pamulapati, C. Bohini, S. Fertig, G. Schraeml, M. Rubas, W. Brandt, M. Ries, S. Ma, H. Klumpp, K.

              Hepatology. 2015 Apr;61(4):1136-44.

              Monoclonal Antibodies against Extracellular Domains of Claudin-1 Block Hepatitis C Virus Infection in a Mouse Model

                Fukasawa, M. Nagase, S. Shirasago, Y. Iida, M. Yamashita, M. Endo, K. Yagi, K. Suzuki, T. Wakita, T. Hanada, K. Kuniyasu, H. Kondoh, M.

                J Virol. 2015 May 1;89(9):4866-79.

                Hepatitis C Virus Core Protein Suppresses Mitophagy by Interacting with Parkin in the Context of Mitochondrial Depolarization

                  Hara, Y. Yanatori, I. Ikeda, M. Kiyokage, E. Nishina, S. Tomiyama, Y. Toida, K. Kishi, F. Kato, N. Imamura, M. Chayama, K. Hino, K.

                  Am J Pathol. 2014 Sep 19. pii: S0002-9440(14)00483-0. doi: 10.1016/j.ajpath.2014.07.024.

                  In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus

                    Watanabe, T. Hatakeyama, H. Matsuda-Yasui, C. Sato, Y. Sudoh, M. Takagi, A. Hirata, Y. Ohtsuki, T. Arai, M. Inoue, K. Harashima, H. Kohara, M.

                    Sci Rep. 2014 Apr 23;4:4750. doi: 10.1038/srep04750.

                     

                     

                    Inhibition of hepatitis C virus in chimeric mice by short synthetic hairpin RNAs: sequence analysis of surviving virus shows added selective pressure of combination therapy

                      Dallas, A. Ilves, H. Ma, H. Chin, D. J. Maclachlan, I. Klumpp, K. Johnston, B. H.
                      J Virol. 2014 May;88(9):4647-4656.

                      Hepatitis Virus Infection Affects DNA Methylation in Mice with Humanized Livers

                        Okamoto, Y. Shinjo, K., Shimizu, Y. Sano, T. Yamao, K. Gao, W. Fujii, M. Osada, H. Sekido, Y. Murakami, S. Tanaka, Y. Joh, T. Sato, S. Takahashi, S. Wakita, T. Zhu, J.Issa, J. P. Kondo, Y.
                        Gastroenterology. 2014 Feb;146(2):562-72.

                        Long-Term Elimination of Hepatitis C Virus from Human Hepatocyte Chimeric Mice After Interferon-gamma Gene Transfer

                          Takahashi, Y. Ando, M. Nishikawa, M. Hiraga, N. Imamura, M. Chayama, K. Takakura, Y.

                          Hum Gene Ther Clin Dev. 2014 Mar;25(1):28-39.

                          Formulated Minimal-Length Synthetic Small Hairpin RNAs are Potent Inhibitors of Hepatitis C Virus in Mice with Humanized Livers

                            Ma, H. Dallas, A. Ilves, H. Shorenstein, J. Maclachlan, I. Klumpp, K. Johnston, B. H.
                            Gastroenterology. 2014 Jan;146(1):63-6.

                            Isolation and characterization of highly replicable hepatitis C virus genotype 1a strain

                              Arai M, Tokunaga Y, Takagi A, Tobita Y, Hirata Y, Ishida Y, TatenoC, Kohara M
                              PLoS One. 2013 Dec 16;8(12):e82527.

                              HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-beta type I receptor

                                Sakata, K. Hara, M. Terada, T. Watanabe, N. Takaya, D. Yaguchi, S. Matsumoto, T. Matsuura, T. Shirouzu, M. Yokoyama, S. Yamaguchi, T. Miyazawa, K. Aizaki, H. Suzuki, T. Wakita, T. Imoto, M. Kojima, S.
                                Sci Rep. 2013 Nov 22;3:3243. doi: 10.1038/srep03243.

                                Hepatitis C virus kinetics by administration of pegylated interferon-α in human and chimeric mice carrying human hepatocytes with variants of the IL28B gene.

                                  Watanabe T, Sugauchi F, Tanaka Y, Matsuura K, Yatsuhashi H, Murakami S, Iijima S, Iio E, Sugiyama M, Shimada T, Kakuni M, Kohara M, Mizokami M.
                                  Gut. 2013 Sep;62(9):1340-6

                                  Targeted induction of interferon-λ in humanized chimeric mouse liver abrogates hepatotropic virus infection.

                                    Nakagawa S, Hirata Y, Kameyama T, Tokunaga Y, Nishito Y, Hirabayashi K, Yano J, Ochiya T, Tateno C, Tanaka Y, Mizokami M, Tsukiyama-Kohara K, Inoue K, Yoshiba M, Takaoka A, Kohara M.
                                    PLoS One. 2013;8(3):e59611.

                                    Thromboxane A2 Synthase Inhibitors Prevent Production of Infectious Hepatitis C Virus in Mice with Humanized Livers.

                                      Abe Y, Aly HH, Hiraga N, Imamura M, Wakita T, Shimotohno K, Chayama K, Hijikata M
                                      Gastroenterology. 2013 Sep;145(3):658-67.e11.

                                      A Serine Palmitoyltransferase Inhibitor Inhibits Hepatitis C Virus Replication in Human Hepatocytes.

                                        Katsume A, Tokunaga Y, Hirata Y, Munakata T, Saito M, Hayashi H, Okamoto K, Ohmori Y, Kusanagi I, Fujiwara S, Tsukuda T, Aoki Y, Klumpp K, Tsukiyama-Kohara K, El-Gohary A, Sudoh M, Kohara M.
                                        Gastroenterology. 2013 Oct;145(4):865-73.