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研究開発

研究開発

Critical role of CREBH-mediated induction of TGF-beta2 by HCV infection in fibrogenic responses in hepatic stellate cells

    Chida, T. Ito, M. Nakashima, K. Kanegae, Y. Aoshima, T. Takabayashi, S. Kawata, K. Nakagawa, Y. Yamamoto, M. Shimano, H. Matsuura, T. Kobayashi, Y. Suda, T. Suzuki, T.

    Hepatology. 2017 Jun 16. doi: 10.1002/hep.29319.

    Interferon alpha treatment stimulates interferon gamma expression in type I NKT cells and enhances their antiviral effect against hepatitis C virus

      Miyaki, E. Hiraga, N. Imamura, M. Uchida, T.  Kan, H.  Tsuge, M. Abe-Chayama, H. Hayes, C. N. Makokha, G. N. Serikawa, M. Aikata, H. Ochi, H. Ishida, Y. Tateno, C. Ohdan, H. Chayama, K.

      PLoS One. 2017 Mar 2;12(3):e0172412.

      Usefulness of humanized cDNA-uPA/SCID mice for the study of hepatitis B virus and hepatitis C virus virology

        Uchida, T. Imamura, M. Kan, H. Hiraga, N. Hayes, C. N. Tsuge, M. Abe-Chayama, H. Aikata, H. Makokha, G. N. Miki, D. Ochi, H. Ishida, Y. Tateno, C. Chayama, K.

        J Gen Virol. 2017 Jan 28. doi: 10.1099/jgv.0.000726.

        Protease inhibitor resistance remains even after mutant strains become undetectable using deep sequencing

          Kan, H. Imamura, M. Uchida, T. Hiraga, N. Hayes, C. N. Tsuge, M. Abe, H. Aikata, H. Makokha, G. N. Chowdhury, S. Miki, D. Ochi, H. Ishida, Y. Tateno, C. Chayama, K.

          J Infect Dis. 2016 Sep 20. pii: jiw437.

          Hepatitis C virus dynamics and cellular gene expression in uPA-SCID chimeric mice with humanized livers during intravenous silibinin monotherapy

            DebRoy, S.  Hiraga, N. Imamura, M. Hayes, C. N. Akamatsu, S. Canini, L. Perelson, A. S. Pohl, R. T. Persiani, S. Uprichard, S. L. Tateno, C. Dahari, H. Chayama, K.

            J Viral Hepat. 2016 Jun 8. doi: 10.1111/jvh.12551.

            Elimination of HCV via a non-ISG-mediated mechanism by vaniprevir andBMS-788329 combination therapy in human hepatocyte chimeric mice

              Uchida, T. Hiraga, N. mamura, M. Yoshimi, S. Kan, H. Miyaki, E. Tsuge, M. Abe, H. Hayes, C. N. Aikata, H. Ishida, Y. Tateno, C. Ellis, J. D. Chayama, K.

              Virus Res. 2015 Nov 10. pii: S0168-1702(15)30117-9. doi: 10.1016/j.virusres.2015.11.010.

              Combination therapies with daclatasvir and asunaprevir on NS3-D168 mutated HCV in human hepatocyte chimeric mice

                Kan, H. Hiraga, N. Imamura, M. Hayes, C. N. Uchida, T. Miyaki, E. Tsuge, M. Abe, H. Aikata, H. Miki, D. Ochi, H. Ishida, Y. Tateno, C. Chayama, K.

                Antivir Ther. 2015 Nov 12. doi: 10.3851/IMP3009.

                第63回日本ウイルス学会学術集会でのPXBマウス・PXB-cells関連研究発表のご案内

                2015年 11月22日(日)~24日(火)に福岡国際会議場(福岡市博多区)にて開催の第63回日本ウイルス学会学術集会にてPXBマウス・PXB-cells関連研究発表がありましたので、ご案内申し上げます。

                Preclinical characterization andin vivoefficacy of GSK8853, a small molecule inhibitor of the Hepatitis C virus NS4B protein

                  Pouliot, Jeffrey J. Thomson, Michael Xie, Mi Horton, Joseph Johnson, John Krull, David Mathis, Amanda Morikawa, Yoshio Parks, Derek Peterson, Richard, Shimada, Takashi Thomas, Elizabeth Vamathevan, Jessica Van Horn, Stephanie Xiong, Zhiping Hamatake, Robert  Peat, Andrew J.

                  Antimicrob. Agents Chemother. doi:10.1128/AAC.00813-15

                  Prevention of hepatitis C virus infection and spread in human liver chimeric mice by an anti-CD81 monoclonal antibody

                    Ji, C. Liu, Y. Pamulapati, C. Bohini, S. Fertig, G. Schraeml, M. Rubas, W. Brandt, M. Ries, S. Ma, H. Klumpp, K.

                    Hepatology. 2015 Apr;61(4):1136-44.

                    Monoclonal Antibodies against Extracellular Domains of Claudin-1 Block Hepatitis C Virus Infection in a Mouse Model

                      Fukasawa, M. Nagase, S. Shirasago, Y. Iida, M. Yamashita, M. Endo, K. Yagi, K. Suzuki, T. Wakita, T. Hanada, K. Kuniyasu, H. Kondoh, M.

                      J Virol. 2015 May 1;89(9):4866-79.

                      Hepatitis C Virus Core Protein Suppresses Mitophagy by Interacting with Parkin in the Context of Mitochondrial Depolarization

                        Hara, Y. Yanatori, I. Ikeda, M. Kiyokage, E. Nishina, S. Tomiyama, Y. Toida, K. Kishi, F. Kato, N. Imamura, M. Chayama, K. Hino, K.

                        Am J Pathol. 2014 Sep 19. pii: S0002-9440(14)00483-0. doi: 10.1016/j.ajpath.2014.07.024.

                        In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus

                          Watanabe, T. Hatakeyama, H. Matsuda-Yasui, C. Sato, Y. Sudoh, M. Takagi, A. Hirata, Y. Ohtsuki, T. Arai, M. Inoue, K. Harashima, H. Kohara, M.

                          Sci Rep. 2014 Apr 23;4:4750. doi: 10.1038/srep04750.

                           

                           

                          Inhibition of hepatitis C virus in chimeric mice by short synthetic hairpin RNAs: sequence analysis of surviving virus shows added selective pressure of combination therapy

                            Dallas, A. Ilves, H. Ma, H. Chin, D. J. Maclachlan, I. Klumpp, K. Johnston, B. H.
                            J Virol. 2014 May;88(9):4647-4656.

                            Hepatitis Virus Infection Affects DNA Methylation in Mice with Humanized Livers

                              Okamoto, Y. Shinjo, K., Shimizu, Y. Sano, T. Yamao, K. Gao, W. Fujii, M. Osada, H. Sekido, Y. Murakami, S. Tanaka, Y. Joh, T. Sato, S. Takahashi, S. Wakita, T. Zhu, J.Issa, J. P. Kondo, Y.
                              Gastroenterology. 2014 Feb;146(2):562-72.

                              Long-Term Elimination of Hepatitis C Virus from Human Hepatocyte Chimeric Mice After Interferon-gamma Gene Transfer

                                Takahashi, Y. Ando, M. Nishikawa, M. Hiraga, N. Imamura, M. Chayama, K. Takakura, Y.

                                Hum Gene Ther Clin Dev. 2014 Mar;25(1):28-39.

                                Formulated Minimal-Length Synthetic Small Hairpin RNAs are Potent Inhibitors of Hepatitis C Virus in Mice with Humanized Livers

                                  Ma, H. Dallas, A. Ilves, H. Shorenstein, J. Maclachlan, I. Klumpp, K. Johnston, B. H.
                                  Gastroenterology. 2014 Jan;146(1):63-6.

                                  Isolation and characterization of highly replicable hepatitis C virus genotype 1a strain

                                    Arai M, Tokunaga Y, Takagi A, Tobita Y, Hirata Y, Ishida Y, TatenoC, Kohara M
                                    PLoS One. 2013 Dec 16;8(12):e82527.

                                    HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-beta type I receptor

                                      Sakata, K. Hara, M. Terada, T. Watanabe, N. Takaya, D. Yaguchi, S. Matsumoto, T. Matsuura, T. Shirouzu, M. Yokoyama, S. Yamaguchi, T. Miyazawa, K. Aizaki, H. Suzuki, T. Wakita, T. Imoto, M. Kojima, S.
                                      Sci Rep. 2013 Nov 22;3:3243. doi: 10.1038/srep03243.

                                      Hepatitis C virus kinetics by administration of pegylated interferon-α in human and chimeric mice carrying human hepatocytes with variants of the IL28B gene.

                                        Watanabe T, Sugauchi F, Tanaka Y, Matsuura K, Yatsuhashi H, Murakami S, Iijima S, Iio E, Sugiyama M, Shimada T, Kakuni M, Kohara M, Mizokami M.
                                        Gut. 2013 Sep;62(9):1340-6