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研究開発

研究開発

Hepatitis Virus Infection Affects DNA Methylation in Mice with Humanized Livers

    Okamoto, Y. Shinjo, K., Shimizu, Y. Sano, T. Yamao, K. Gao, W. Fujii, M. Osada, H. Sekido, Y. Murakami, S. Tanaka, Y. Joh, T. Sato, S. Takahashi, S. Wakita, T. Zhu, J.Issa, J. P. Kondo, Y.
    Gastroenterology. 2014 Feb;146(2):562-72.

    Long-Term Elimination of Hepatitis C Virus from Human Hepatocyte Chimeric Mice After Interferon-gamma Gene Transfer

      Takahashi, Y. Ando, M. Nishikawa, M. Hiraga, N. Imamura, M. Chayama, K. Takakura, Y.

      Hum Gene Ther Clin Dev. 2014 Mar;25(1):28-39.

      Formulated Minimal-Length Synthetic Small Hairpin RNAs are Potent Inhibitors of Hepatitis C Virus in Mice with Humanized Livers

        Ma, H. Dallas, A. Ilves, H. Shorenstein, J. Maclachlan, I. Klumpp, K. Johnston, B. H.
        Gastroenterology. 2014 Jan;146(1):63-6.

        Isolation and characterization of highly replicable hepatitis C virus genotype 1a strain

          Arai M, Tokunaga Y, Takagi A, Tobita Y, Hirata Y, Ishida Y, TatenoC, Kohara M
          PLoS One. 2013 Dec 16;8(12):e82527.

          HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-beta type I receptor

            Sakata, K. Hara, M. Terada, T. Watanabe, N. Takaya, D. Yaguchi, S. Matsumoto, T. Matsuura, T. Shirouzu, M. Yokoyama, S. Yamaguchi, T. Miyazawa, K. Aizaki, H. Suzuki, T. Wakita, T. Imoto, M. Kojima, S.
            Sci Rep. 2013 Nov 22;3:3243. doi: 10.1038/srep03243.

            Hepatitis C virus kinetics by administration of pegylated interferon-α in human and chimeric mice carrying human hepatocytes with variants of the IL28B gene.

              Watanabe T, Sugauchi F, Tanaka Y, Matsuura K, Yatsuhashi H, Murakami S, Iijima S, Iio E, Sugiyama M, Shimada T, Kakuni M, Kohara M, Mizokami M.
              Gut. 2013 Sep;62(9):1340-6

              Targeted induction of interferon-λ in humanized chimeric mouse liver abrogates hepatotropic virus infection.

                Nakagawa S, Hirata Y, Kameyama T, Tokunaga Y, Nishito Y, Hirabayashi K, Yano J, Ochiya T, Tateno C, Tanaka Y, Mizokami M, Tsukiyama-Kohara K, Inoue K, Yoshiba M, Takaoka A, Kohara M.
                PLoS One. 2013;8(3):e59611.

                Thromboxane A2 Synthase Inhibitors Prevent Production of Infectious Hepatitis C Virus in Mice with Humanized Livers.

                  Abe Y, Aly HH, Hiraga N, Imamura M, Wakita T, Shimotohno K, Chayama K, Hijikata M
                  Gastroenterology. 2013 Sep;145(3):658-67.e11.

                  A Serine Palmitoyltransferase Inhibitor Inhibits Hepatitis C Virus Replication in Human Hepatocytes.

                    Katsume A, Tokunaga Y, Hirata Y, Munakata T, Saito M, Hayashi H, Okamoto K, Ohmori Y, Kusanagi I, Fujiwara S, Tsukuda T, Aoki Y, Klumpp K, Tsukiyama-Kohara K, El-Gohary A, Sudoh M, Kohara M.
                    Gastroenterology. 2013 Oct;145(4):865-73.

                    Demonstration of hepatitis C virus RNA with in situ hybridization employing a locked nucleic Acid probe in humanized liver of infected chimeric mice and in needle-biopsied human liver.

                      Shiogama K, Inada K, Kohara M, Teramoto H, Mizutani Y, Onouchi T, Tsutsumi Y.
                      Int J Hepatol. 2013;2013:249535. doi: 10.1155/2013/249535. Epub 2013 Jun 18.

                      Combination therapies with NS5A, NS3 and NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice.

                        Shi N, Hiraga N, Imamura M, Hayes CN, Zhang Y, Kosaka K, Okazaki A, Murakami E, Tsuge M, Abe H, Aikata H, Takahashi S, Ochi H, Tateno-Mukaidani C, Yoshizato K, Matsui H, Kanai A, Inaba T, McPhee F, Gao M, Chayama K.
                        Gut. 2013 Jul;62(7):1055-61

                        Neutralizing antibodies induced by cell culture-derived hepatitis C virus protect against infection in mice

                          Akazawa D, Moriyama M, Yokokawa H, Omi N, Watanabe N, Date T, Morikawa K, Aizaki H, Ishii K, Kato T, Mochizuki H, Nakamura N, Wakita T
                          Gastroenterology. 2013 Aug;145(2): 447-455.

                          Synthetic lipophilic antioxidant BO-653 suppresses HCV replication.

                            Yasui F, Sudoh M, Arai M, Kohara M.
                            J Med Virol. 2013 Feb;85(2):241-9.

                            Novel cell culture-adapted genotype 2a hepatitis C virus infectious clone.

                              Date T, Kato T, Kato J, Takahashi H, Morikawa K, Akazawa D, Murayama A, Tanaka-Kaneko K, Sata T, Tanaka Y, Mizokami M, Wakita T.
                              J Virol. 2012 Oct;86(19):10805-20.

                              An orally available, small-molecule interferon inhibits viral replication

                                Hideyuki Konishi, Koichi Okamoto, Yusuke Ohmori, Hitoshi Yoshino, Hiroshi Ohmori, Motooki Ashihara, Yuichi Hirata, Atsunori Ohta, Hiroshi Sakamoto, Natsuko Hada, Asao Katsume, Michinori Kohara, Kazumi Morikawa, Takuo Tsukuda, Nobuo Shimma, Graham R. Foster, William Alazawi, Yuko Aoki, Mikio Arisawa & Masayuki Sudoh
                                Scientific Reports Volume: 2,Article number:259

                                Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor.

                                  Sainz B Jr, Barretto N, Martin DN, Hiraga N, Imamura M, Hussain S, Marsh KA, Yu X, Chayama K, Alrefai WA, Uprichard SL.
                                  Nat Med. 2012 Jan 8;18(2):281-5

                                  Evaluation of combination therapy against hepatitis C virus infection in human liver chimeric mice

                                    Ype P. de Jong1,2, Charles M. Rice1, Alexander Ploss1,

                                    J Hepatol.2011; 54:848–850

                                     

                                    Impact of viral amino acid substitutions and host interleukin-28b polymorphism on replication and susceptibility to interferon of hepatitis C virus.

                                      Hiraga N, Abe H, Imamura M, Tsuge M, Takahashi S, Hayes CN, Ochi H, Tateno C, Yoshizato K, Nakamura Y, Kamatani N, Chayama K.
                                      Hepatology. 2011 Sep 2;54(3):764-71.

                                      Rapid emergence of telaprevir resistant hepatitis C virus strain from wildtype clone in vivo.

                                        Hiraga N, Imamura M, Abe H, Hayes CN, Kono T, Onishi M, Tsuge M, Takahashi S, Ochi H, Iwao E, Kamiya N, Yamada I, Tateno C, Yoshizato K, Matsui H, Kanai A, Inaba T, Tanaka S, Chayama K.
                                        Hepatology. 2011 Sep 2;54(3):781-8.

                                        Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes.

                                          Takano T, Tsukiyama-Kohara K, Hayashi M, Hirata Y, Satoh M, Tokunaga Y, Tateno C, Hayashi Y, Hishima T, Funata N, Sudo M, Kohara M.

                                          J Hepatol. 2011 Sep;55(3):512-21