Phoenix Bio

研究開発

研究開発

新規ready-to-use ヒト肝細胞三次元培養システム「PXB-able」の有用性の検討

    赤平有希、山崎ちひろ、石田雄二、立野知世、城村友子

    BIO-INDUSTRY 2018;35(3):27-37

    Use of hepatocytes isolated from a liver-humanized mouse for studies on the metabolism of drugs: application to the metabolism of fentanyl and acetylfentanyl

      Kanamori, T. Togawa-Iwata, Y. Segawa, H. Yamamuro, T. Kuwayama, K. Tsujikawa, K. Inoue, H.

      Forensic Toxicol. 2018;36(2):467-475.

      Generation of the Adenovirus Vector-Mediated CRISPR/Cpf1 System and the Application for Primary Human Hepatocytes Prepared from Humanized Mice with Chimeric Liver

        Tsukamoto, T. Sakai, E. Iizuka, S. Taracena-Gandara, M. Sakurai, F. Mizuguchi, H.

        Biol Pharm Bull. 2018;41(7):1089-1095. doi: 10.1248/bpb.b18-00222.

        Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction

          Tsukamoto, Y. Ikeda, S. Uwai, K. Taguchi, R. Chayama, K. Sakaguchi, T. Narita, R. Yao, W. L. Takeuchi, F. Otakaki, Y. Watashi, K. Wakita, T. Kato, H. Fujita, T.

          PLoS One. 2018 May 21;13(5):e0197664.

          Investigating the hepatitis B virus life cycle using engineered reporter hepatitis B viruses

            Nishitsuji, H. Harada, K. Ujino, S. Zhang, J. Kohara, M. Sugiyama, M. Mizokami, M. Shimotohno, K.

            Cancer Sci. 2018 Jan;109(1):241-249.

            Candidate genes responsible for early key events of phenobarbital-promoted mouse hepatocellular tumorigenesis based on differentiation of regulating genes between wild type mice and humanized chimeric mice

              Ohara A , Takahashi Y,  Kondo  M,  Okuda Y, Takeda  S,  Kushida M, Kobayashi  K,  Sumida K, Yamada T

              Toxicol Res. 2017; 6(6): 795-813

              Evaluation of the human relevance of the constitutive androstane receptor-mediated mode of action for rat hepatocellular tumor formation by the synthetic pyrethroid momfluorothrin

                Okuda, Y. Kushida, M. Kikumoto, H. Nakamura, Y. Higuchi, H. Kawamura, S. Cohen, S. M. Lake, B. G.Yamada, T.

                J Toxicol Sci. 2017;42(6):773-788. doi: 10.2131/jts.42.773.

                Organic anion transporting polypeptides (OATPs)-mediated drug-drug interaction study between rosuvastatin and cyclosporine A in chimeric mice with humanized liver

                  Uchida, M. Tajima, Y. Kakuni, M. Kageyama, Y. Okada, T. Sakudara, E. Tateno, C. Hayashi, R.

                  Drug Metab Dispos. 2017 Oct 19. pii: dmd.117.075994. doi: 10.1124/dmd.117.075994.

                  Transmission of HBV DNA Mediated by Ceramide-Triggered Extracellular Vesicles

                    Sanada,Takahiro1,*  Hirata, Yuichi1,* Naito, Yutaka 2,  Yamamoto,Naoki1,  Kikkawa, Yoshiaki3, Ishida, Yuji 4,  Yamasaki,Chihiro 4,  Tateno, Chise 4,  Ochiya, Takahiro 2 and  Kohara, Michinori 1

                    Cell Mol Gastroenterol Hepatol. 2016 Oct 24;3(2):272-283.

                    Cyclosporin derivatives inhibit hepatitis B virus entry without interfering with NTCP transporter activity

                      Shimura, S. Watashi, K. Fukano, K. Peel, M. Sluder, A. Kawai, F. Iwamoto, M. Tsukuda, S. Takeuchi, J. S. Miyake, T. Sugiyama, M. Ogasawara, Y. Park, S. Y. Tanaka, Y. Kusuhara, H. Mizokami, M. Sureau, C. Wakita, T.

                      J Hepatol. 2016 Nov 24. pii: S0168-8278(16)30683-3. doi: 10.1016/j.jhep.2016.11.009.

                      A new class of hepatitis B and D virus entry inhibitors, proanthocyanidin and its analogs, that directly act on the viral large surface proteins

                        Tsukuda, S. Watashi, K. Hojima, T. Isogawa, M. Iwamoto, M. Omagari, K. Suzuki, R. Aizaki, H. Kojima, S. Sugiyama, M. Saito, A. Tanaka, Y. Mizokami, M. Sureau, C. Wakita, T.

                        Hepatology. 2016 Nov 18. doi: 10.1002/hep.28952.

                        Possible Involvement of Hepatitis B Virus Infection of Hepatocytes in the Attenuation of Apoptosis in Hepatic Stellate Cells

                          Sasaki, R. Kanda, T. Nakamura, M. Nakamoto, S. Haga, Y. Wu, S. Shirasawa, H. Yokosuka, O.

                          PLoS One. 2016 Jan 5;11(1):e0146314. doi: 10.1371/journal.pone.0146314. eCollection 2016.

                          A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide

                            Kaneko, M. Watashi, K. Kamisuki, S. Matsunaga, H. Iwamoto, M. Kawai, F. Ohashi, H. Tsukuda, S. Shimura, S. Suzuki, R. Aizaki, H. Sugiyama, M. Park, S. Y. Ito, T. Ohtani, N. Sugawara, F. Tanaka, Y. Mizokami, M. Sureau, C. Wakita, T.

                            J Virol. 2015 Dec;89(23):11945-53. doi: 10.1128/JVI.01855-15.

                            ヒト肝細胞キメラマウスを用いたin vivoおよびin vitro HBV感染モデル

                            石田雄二、横道博、加国雅和、立野知世

                            新ウイルス性肝炎学 2015 page386-391

                            Novel pH-sensitive multifunctional envelope-type nanodevice for siRNA-based treatments for chronic HBV infection

                              Yamamoto, N. Sato, Y. Munakata, T. Kakuni, M. Tateno, C. Sanada, T. Hirata, Y. Murakami, S.  Tanaka, Y. Chayama, K. Hatakeyama, H. Hyodo, M. Harashima, H. Kohara, M.

                              J Hepatol. 2015 Oct 23. pii: S0168-8278(15)00713-8. doi: 10.1016/j.jhep.2015.10.014.

                              A novel reporter system to monitor early stages of the HBV life cycle

                                Nishitsuji, H. Ujino, S. Shimizu, Y. Harada, K. Zhang, J. Sugiyama, M. Mizokami, M. Shimotohno, K.

                                Cancer Sci. 2015 Aug 27. doi: 10.1111/cas.12799.

                                第63回日本ウイルス学会学術集会でのPXBマウス・PXB-cells関連研究発表のご案内

                                2015年 11月22日(日)~24日(火)に福岡国際会議場(福岡市博多区)にて開催の第63回日本ウイルス学会学術集会にてPXBマウス・PXB-cells関連研究発表がありましたので、ご案内申し上げます。

                                Association between hepatitis B virus and MHC class I polypeptide-related chain A in human hepatocytes derived from human-mouse chimeric mouse liver

                                  Sasaki, R. Kanda, T. Wu, S. Nakamoto, S. Haga, Y. Jiang, X. Nakamura, M.

                                  Shirasawa, H. Yokosuka, O.

                                  Journal: Biochem Biophys Res Commun. 2015 Jul 23. pii: S0006-291X(15)30332-6.

                                  doi: 10.1016/j.bbrc.2015.07.102.

                                  Postexposure Prophylactic Effect of Hepatitis B Virus (HBV)-Active Antiretroviral Therapy against HBV Infection

                                    Watanabe, T. Hamada-Tsutsumi, S. Yokomaku, Y. Imamura, J. Sugiura, W. Tanaka, Y.

                                    Antimicrob Agents Chemother. 2015 Feb;59(2):1292-8.

                                    Discovering novel direct acting antiviral agents for HBV using in silico screening

                                      Murakami, Y. Hayakawa, M. Yano, Y. Tanahashi, T. Enomoto, M. Tamori, A. Kawada, N. Iwadate, M. Umeyama, H.

                                      Biochem Biophys Res Commun. 2015 Jan 2;456(1):20-8.