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研究開発

研究開発

Significance of aldehyde oxidase during drug development: Effects on drug metabolism, pharmacokinetics, toxicity, and efficacy

    Sanoh, S. Tayama, Y. Sugihara, K. Kitamura, S. Ohta, S.

    Drug Metab Pharmacokinet. 2015 Feb;30(1):52-63.

    Assessing the Therapeutic Potential of Lab-Made Hepatocytes

    Rezvani, M. Grimm, A. Willenbring, H.

    Hepatology. 2016 Mar 25. doi: 10.1002/hep.28569

    Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound

      Kamimura, H. Ito, S.

      Xenobiotica. 2015 Oct 7:1-13.

      動物モデルを用いた発癌研究

      森屋恭爾、三好秀征、小池和彦

      新ウイルス性肝炎学 2015 page74-78

      肝炎ウイルスの動物モデルと治療開発

      茶山一彰、今村道雄

      新ウイルス性肝炎学 2015 page69-73

      ヒト肝細胞キメラマウスを用いたin vivoおよびin vitro HBV感染モデル

      石田雄二、横道博、加国雅和、立野知世

      新ウイルス性肝炎学 2015 page386-391

      In Vitro and in Vivo Assessments of Drug-induced Hepatotoxicity and Drug Metabolism in Humans (In Japanese)(ヒトにおける医薬品の肝毒性及び代謝物のin vtro, in vivo予測評価系の構築に関する研究)

        Sanoh, S.

        Yakugaku Zasshi. 2015;135(11):1273-9. doi: 10.1248/yakushi.15-00200.

        Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound

          Kamimura, H. Ito, S.

          Xenobiotica. 2015 Oct 7:1-13.

          Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics

            Sanoh, S. Ohta, S.
            Biopharm Drug Dispos. 2014 Mar;35(2):71-86.

            Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver

              Kitamura, S. Sugihara, K.
              Xenobiotica. 2014 Jan; 44(2): 123-34.

              A mouse with humanized liver as an animal model for predicting drug effects and for studying hepatic viral infection: where to next?

                Yoshizato, K. Tateno, C.

                Expert Opin Drug Metab Toxicol. 2013 Nov;9(11):1419-35.

                Mice with liver composed of human hepatocytes as an animal model for drug testing.

                  Yoshizato K, Tateno C, Utoh R.

                  Curr Drug Discov Technol. 2012 Mar;9(1):63-76. Review.

                  Chimeric mice with humanized liver: mechanism of hepatic hyperplasia induction.

                  Tateno C.

                  生化学 2012 Aug;84(8):699-706.

                  Impact of interleukin-28B genotype on in vitro and in vivo systems of hepatitis C virus replication.

                    Chayama K, Hayes CN, Imamura M.
                    Hepatol Res. 2012 Sep;42(9):841-53.

                    ヒト肝細胞キメラマウスを用いた抗肝炎ウイルス薬効評価系

                    加国雅和、立野知世

                    ファルマシア 2012; 48(10): 956-958

                    An experimental mouse model for hepatitis C virus.

                      Kimura K, Kohara M.

                      Exp Anim. 2011;60(2):93-100. Review.

                      PBXマウス由来新鮮肝細胞を用いたインビトロ代謝試験

                      安達弥長

                      HAB Newsleter 2011; 18(1): 21-23

                      Animal model for study of human hepatitis viruses.

                        Chayama K, Hayes CN, Hiraga N, Abe H, Tsuge M, Imamura M.
                        J Gastroenterol Hepatol. 2011 Jan;26(1):13-8

                        C型肝炎感染を起こすタンパク質

                        中国新聞

                        Assessment of chimeric mice with humanized liver as a tool for predicting circulating human metabolites.

                          Kamimura H, Nakada N, Suzuki K, Mera A, Souda K, Murakami Y, Tanaka K, Iwatsubo T, Kawamura A, Usui T.

                          Drug Metab Pharmacokinet. 2010;25(3):223-35.