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研究開発

研究開発

Assessing the Therapeutic Potential of Lab-Made Hepatocytes

Rezvani, M. Grimm, A. Willenbring, H.

Hepatology. 2016 Mar 25. doi: 10.1002/hep.28569

Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound

    Kamimura, H. Ito, S.

    Xenobiotica. 2015 Oct 7:1-13.

    動物モデルを用いた発癌研究

    森屋恭爾、三好秀征、小池和彦

    新ウイルス性肝炎学 2015 page74-78

    肝炎ウイルスの動物モデルと治療開発

    茶山一彰、今村道雄

    新ウイルス性肝炎学 2015 page69-73

    ヒト肝細胞キメラマウスを用いたin vivoおよびin vitro HBV感染モデル

    石田雄二、横道博、加国雅和、立野知世

    新ウイルス性肝炎学 2015 page386-391

    In Vitro and in Vivo Assessments of Drug-induced Hepatotoxicity and Drug Metabolism in Humans (In Japanese)(ヒトにおける医薬品の肝毒性及び代謝物のin vtro, in vivo予測評価系の構築に関する研究)

      Sanoh, S.

      Yakugaku Zasshi. 2015;135(11):1273-9. doi: 10.1248/yakushi.15-00200.

      Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound

        Kamimura, H. Ito, S.

        Xenobiotica. 2015 Oct 7:1-13.

        Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics

          Sanoh, S. Ohta, S.
          Biopharm Drug Dispos. 2014 Mar;35(2):71-86.

          Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver

            Kitamura, S. Sugihara, K.
            Xenobiotica. 2014 Jan; 44(2): 123-34.

            A mouse with humanized liver as an animal model for predicting drug effects and for studying hepatic viral infection: where to next?

              Yoshizato, K. Tateno, C.

              Expert Opin Drug Metab Toxicol. 2013 Nov;9(11):1419-35.

              Mice with liver composed of human hepatocytes as an animal model for drug testing.

                Yoshizato K, Tateno C, Utoh R.

                Curr Drug Discov Technol. 2012 Mar;9(1):63-76. Review.

                Chimeric mice with humanized liver: mechanism of hepatic hyperplasia induction.

                Tateno C.

                生化学 2012 Aug;84(8):699-706.

                Impact of interleukin-28B genotype on in vitro and in vivo systems of hepatitis C virus replication.

                  Chayama K, Hayes CN, Imamura M.
                  Hepatol Res. 2012 Sep;42(9):841-53.

                  ヒト肝細胞キメラマウスを用いた抗肝炎ウイルス薬効評価系

                  加国雅和、立野知世

                  ファルマシア 2012; 48(10): 956-958

                  An experimental mouse model for hepatitis C virus.

                    Kimura K, Kohara M.

                    Exp Anim. 2011;60(2):93-100. Review.

                    PBXマウス由来新鮮肝細胞を用いたインビトロ代謝試験

                    安達弥長

                    HAB Newsleter 2011; 18(1): 21-23

                    Animal model for study of human hepatitis viruses.

                      Chayama K, Hayes CN, Hiraga N, Abe H, Tsuge M, Imamura M.
                      J Gastroenterol Hepatol. 2011 Jan;26(1):13-8

                      C型肝炎感染を起こすタンパク質

                      中国新聞

                      Assessment of chimeric mice with humanized liver as a tool for predicting circulating human metabolites.

                        Kamimura H, Nakada N, Suzuki K, Mera A, Souda K, Murakami Y, Tanaka K, Iwatsubo T, Kawamura A, Usui T.

                        Drug Metab Pharmacokinet. 2010;25(3):223-35.

                        ヒト型肝臓を持つキメラマウスから分離したヒト肝細胞のCYPおよびUGT活性の評価

                        Yamasaki, C., et al

                        DMPK. 2010; 6:45