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研究開発

研究開発

Chimeric Mice with Hepatocyte-humanized Liver as an Appropriate Model to Study Human Peroxisome Proliferator-activated Receptor-alpha

    Tateno, C. Yamamoto, T. Utoh, R. Yamasaki, C. Ishida, Y. Myoken, Y. Oofusa, K. Okada, M. Tsutsui, N. Yoshizato, K.
    Toxicol Pathol. 2014 Aug 8. pii: 0192623314544378.

    Inhibition of hepatitis C virus in chimeric mice by short synthetic hairpin RNAs: sequence analysis of surviving virus shows added selective pressure of combination therapy

      Dallas, A. Ilves, H. Ma, H. Chin, D. J. Maclachlan, I. Klumpp, K. Johnston, B. H.
      J Virol. 2014 May;88(9):4647-4656.

      Application of Chimeric Mice with Humanized Liver for Study of Human-Specific Drug Metabolism

        Bateman, T. Reddy, V. B. Kakuni, M. Morikawa, Y. Kumar, S.
        Drug Metab Dispos. 2014 Jun;42(6):1055-65.

        Validation of uPA/SCID mouse with humanized liver as a human liver model: protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases by LC-MS/MS

          Ohtsuki, S. Kawakami, H. Inoue, T. Nakamura, K. Tateno, C. Katsukura, Y. Obuchi, W. Uchida, Y. Kamiie, J. Horie, T. Terasaki, T.
          Drug Metab Dispos. 2014 Jun;42(6):1039-43.

          Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics

            Sanoh, S. Ohta, S.
            Biopharm Drug Dispos. 2014 Mar;35(2):71-86.

            Chimeric Mice with Humanized Livers: A Unique Tool for in Vivo and in Vitro Enzyme Induction Studies

              Masakazu Kakuni, Chihiro Yamasaki, Asato Tachibana, Yasumi Yoshizane, Yuji Ishida and Chise Tateno
              Int. J. Mol. Sci. 2014, 15, 58-74

              Hepatitis Virus Infection Affects DNA Methylation in Mice with Humanized Livers

                Okamoto, Y. Shinjo, K., Shimizu, Y. Sano, T. Yamao, K. Gao, W. Fujii, M. Osada, H. Sekido, Y. Murakami, S. Tanaka, Y. Joh, T. Sato, S. Takahashi, S. Wakita, T. Zhu, J.Issa, J. P. Kondo, Y.
                Gastroenterology. 2014 Feb;146(2):562-72.

                Long-Term Elimination of Hepatitis C Virus from Human Hepatocyte Chimeric Mice After Interferon-gamma Gene Transfer

                  Takahashi, Y. Ando, M. Nishikawa, M. Hiraga, N. Imamura, M. Chayama, K. Takakura, Y.

                  Hum Gene Ther Clin Dev. 2014 Mar;25(1):28-39.

                  Formulated Minimal-Length Synthetic Small Hairpin RNAs are Potent Inhibitors of Hepatitis C Virus in Mice with Humanized Livers

                    Ma, H. Dallas, A. Ilves, H. Shorenstein, J. Maclachlan, I. Klumpp, K. Johnston, B. H.
                    Gastroenterology. 2014 Jan;146(1):63-6.

                    In vitro and in vivo metabolism of a novel chymase inhibitor, SUN13834, and the predictability of human metabolism using mice with humanized liver

                      Igawa, Y. Fujitani, T. Shah, B. Oo, C. Kanai, Y.
                      Xenobiotica. 2014 Jan;44(2):154-63.

                      Endogenous and xenobiotic metabolite profiling of liver extracts from SCID and chimeric humanized mice following repeated oral administration of troglitazone

                        Barnes, A. J. Baker, D. R. Hobby, K. Ashton, S. Michopoulos, F. Spagou, K. Loftus, N. J. Wilson, I. D.
                        Xenobiotica. 2014 Jan; 44(2): 174-85.

                        Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver

                          Kitamura, S. Sugihara, K.
                          Xenobiotica. 2014 Jan; 44(2): 123-34.

                          Isolation and characterization of highly replicable hepatitis C virus genotype 1a strain

                            Arai M, Tokunaga Y, Takagi A, Tobita Y, Hirata Y, Ishida Y, TatenoC, Kohara M
                            PLoS One. 2013 Dec 16;8(12):e82527.

                            HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-beta type I receptor

                              Sakata, K. Hara, M. Terada, T. Watanabe, N. Takaya, D. Yaguchi, S. Matsumoto, T. Matsuura, T. Shirouzu, M. Yokoyama, S. Yamaguchi, T. Miyazawa, K. Aizaki, H. Suzuki, T. Wakita, T. Imoto, M. Kojima, S.
                              Sci Rep. 2013 Nov 22;3:3243. doi: 10.1038/srep03243.

                              Transplantation of engineered chimeric liver with autologous hepatocytes and xenobiotic scaffold

                                Hata T, Uemoto S, Fujimoto Y, Murakami T, Tateno C, Yoshizato K, Kobayashi E.
                                Ann Surg. 2013 Mar;257(3):542-7.

                                Hepatitis C virus kinetics by administration of pegylated interferon-α in human and chimeric mice carrying human hepatocytes with variants of the IL28B gene.

                                  Watanabe T, Sugauchi F, Tanaka Y, Matsuura K, Yatsuhashi H, Murakami S, Iijima S, Iio E, Sugiyama M, Shimada T, Kakuni M, Kohara M, Mizokami M.
                                  Gut. 2013 Sep;62(9):1340-6

                                  Targeted induction of interferon-λ in humanized chimeric mouse liver abrogates hepatotropic virus infection.

                                    Nakagawa S, Hirata Y, Kameyama T, Tokunaga Y, Nishito Y, Hirabayashi K, Yano J, Ochiya T, Tateno C, Tanaka Y, Mizokami M, Tsukiyama-Kohara K, Inoue K, Yoshiba M, Takaoka A, Kohara M.
                                    PLoS One. 2013;8(3):e59611.

                                    Thromboxane A2 Synthase Inhibitors Prevent Production of Infectious Hepatitis C Virus in Mice with Humanized Livers.

                                      Abe Y, Aly HH, Hiraga N, Imamura M, Wakita T, Shimotohno K, Chayama K, Hijikata M
                                      Gastroenterology. 2013 Sep;145(3):658-67.e11.

                                      A Serine Palmitoyltransferase Inhibitor Inhibits Hepatitis C Virus Replication in Human Hepatocytes.

                                        Katsume A, Tokunaga Y, Hirata Y, Munakata T, Saito M, Hayashi H, Okamoto K, Ohmori Y, Kusanagi I, Fujiwara S, Tsukuda T, Aoki Y, Klumpp K, Tsukiyama-Kohara K, El-Gohary A, Sudoh M, Kohara M.
                                        Gastroenterology. 2013 Oct;145(4):865-73.

                                        Demonstration of hepatitis C virus RNA with in situ hybridization employing a locked nucleic Acid probe in humanized liver of infected chimeric mice and in needle-biopsied human liver.

                                          Shiogama K, Inada K, Kohara M, Teramoto H, Mizutani Y, Onouchi T, Tsutsumi Y.
                                          Int J Hepatol. 2013;2013:249535. doi: 10.1155/2013/249535. Epub 2013 Jun 18.