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研究開発

研究開発

Predictability of plasma concentration-time curves in humans using single-species allometric scaling of chimeric mice with humanized liver

    Sanoh, S. Naritomi, Y. Fujimoto, M. Sato, K. Kawamura, A. Horiguchi, A.Sugihara, K. Kotake, Y. Ohshita, H. Tateno, C. Horie, T. Kitamura, S. Ohta, S.

    Xenobiotica. 2015 Mar 3:1-10.

    The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus

      Sato, S. Li, K. Kameyama, T. Hayashi, T. Ishida, Y. Murakami, S. Watanabe, T. Iijima, S. Sakurai, Y. Watashi, K. Tsutsumi, S. Sato, Y. Akita, H. Wakita, T. Rice, C. M. Harashima, H. Kohara, M.Tanaka, Y.Takaoka, A.

      Immunity. 2015 Jan 20;42(1):123-32.

      Hepatitis C Virus Core Protein Suppresses Mitophagy by Interacting with Parkin in the Context of Mitochondrial Depolarization

        Hara, Y. Yanatori, I. Ikeda, M. Kiyokage, E. Nishina, S. Tomiyama, Y. Toida, K. Kishi, F. Kato, N. Imamura, M. Chayama, K. Hino, K.

        Am J Pathol. 2014 Sep 19. pii: S0002-9440(14)00483-0. doi: 10.1016/j.ajpath.2014.07.024.

        In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus

          Watanabe, T. Hatakeyama, H. Matsuda-Yasui, C. Sato, Y. Sudoh, M. Takagi, A. Hirata, Y. Ohtsuki, T. Arai, M. Inoue, K. Harashima, H. Kohara, M.

          Sci Rep. 2014 Apr 23;4:4750. doi: 10.1038/srep04750.

           

           

          Human microRNA hsa-miR-1231 suppresses hepatitis B virus replication by targeting core mRNA

            Kohno, T. Tsuge, M. Murakami, E. Hiraga, N. Abe, H. Miki, D. Imamura, M. Ochi,

            H. Hayes, C. N. Chayama, K.

            J Viral Hepat. 2014 Sep;21(9):e89-97. doi: 10.1111/jvh.12240. Epub 2014 May 16.

            Zone analysis by two-dimensional electrophoresis with accelerator mass spectrometry of in vivo protein bindings of idiosyncratic hepatotoxicants troglitazone and flutamide bioactivated in chimeric mice with humanized liver

              Yamazaki, H. Kuribayashi, S. Inoue, T. Honda,T. Tateno, C. Oofusa, K. Ninomiya, S.Ikedag , T. Izumi, T and Horie, T

              Toxicology Research

              Human Hepatocytes Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogen Sodium Phenobarbital in an In Vivo Study Using a Chimeric Mouse with Humanized Liver

                Yamada, T. Okuda, Y. Kushida, M. Sumida, K. Takeuchi, H. Nagahori, H. Fukuda, T. Lake, B. G. Cohen, S. M. Kawamura, S.

                Toxicol Sci. 2014 Aug 21. pii: kfu173.

                Chimeric Mice with Hepatocyte-humanized Liver as an Appropriate Model to Study Human Peroxisome Proliferator-activated Receptor-alpha

                  Tateno, C. Yamamoto, T. Utoh, R. Yamasaki, C. Ishida, Y. Myoken, Y. Oofusa, K. Okada, M. Tsutsui, N. Yoshizato, K.
                  Toxicol Pathol. 2014 Aug 8. pii: 0192623314544378.

                  Inhibition of hepatitis C virus in chimeric mice by short synthetic hairpin RNAs: sequence analysis of surviving virus shows added selective pressure of combination therapy

                    Dallas, A. Ilves, H. Ma, H. Chin, D. J. Maclachlan, I. Klumpp, K. Johnston, B. H.
                    J Virol. 2014 May;88(9):4647-4656.

                    Application of Chimeric Mice with Humanized Liver for Study of Human-Specific Drug Metabolism

                      Bateman, T. Reddy, V. B. Kakuni, M. Morikawa, Y. Kumar, S.
                      Drug Metab Dispos. 2014 Jun;42(6):1055-65.

                      Validation of uPA/SCID mouse with humanized liver as a human liver model: protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases by LC-MS/MS

                        Ohtsuki, S. Kawakami, H. Inoue, T. Nakamura, K. Tateno, C. Katsukura, Y. Obuchi, W. Uchida, Y. Kamiie, J. Horie, T. Terasaki, T.
                        Drug Metab Dispos. 2014 Jun;42(6):1039-43.

                        Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics

                          Sanoh, S. Ohta, S.
                          Biopharm Drug Dispos. 2014 Mar;35(2):71-86.

                          Chimeric Mice with Humanized Livers: A Unique Tool for in Vivo and in Vitro Enzyme Induction Studies

                            Masakazu Kakuni, Chihiro Yamasaki, Asato Tachibana, Yasumi Yoshizane, Yuji Ishida and Chise Tateno
                            Int. J. Mol. Sci. 2014, 15, 58-74

                            Hepatitis Virus Infection Affects DNA Methylation in Mice with Humanized Livers

                              Okamoto, Y. Shinjo, K., Shimizu, Y. Sano, T. Yamao, K. Gao, W. Fujii, M. Osada, H. Sekido, Y. Murakami, S. Tanaka, Y. Joh, T. Sato, S. Takahashi, S. Wakita, T. Zhu, J.Issa, J. P. Kondo, Y.
                              Gastroenterology. 2014 Feb;146(2):562-72.

                              Long-Term Elimination of Hepatitis C Virus from Human Hepatocyte Chimeric Mice After Interferon-gamma Gene Transfer

                                Takahashi, Y. Ando, M. Nishikawa, M. Hiraga, N. Imamura, M. Chayama, K. Takakura, Y.

                                Hum Gene Ther Clin Dev. 2014 Mar;25(1):28-39.

                                Formulated Minimal-Length Synthetic Small Hairpin RNAs are Potent Inhibitors of Hepatitis C Virus in Mice with Humanized Livers

                                  Ma, H. Dallas, A. Ilves, H. Shorenstein, J. Maclachlan, I. Klumpp, K. Johnston, B. H.
                                  Gastroenterology. 2014 Jan;146(1):63-6.

                                  In vitro and in vivo metabolism of a novel chymase inhibitor, SUN13834, and the predictability of human metabolism using mice with humanized liver

                                    Igawa, Y. Fujitani, T. Shah, B. Oo, C. Kanai, Y.
                                    Xenobiotica. 2014 Jan;44(2):154-63.

                                    Endogenous and xenobiotic metabolite profiling of liver extracts from SCID and chimeric humanized mice following repeated oral administration of troglitazone

                                      Barnes, A. J. Baker, D. R. Hobby, K. Ashton, S. Michopoulos, F. Spagou, K. Loftus, N. J. Wilson, I. D.
                                      Xenobiotica. 2014 Jan; 44(2): 174-85.

                                      Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver

                                        Kitamura, S. Sugihara, K.
                                        Xenobiotica. 2014 Jan; 44(2): 123-34.

                                        Isolation and characterization of highly replicable hepatitis C virus genotype 1a strain

                                          Arai M, Tokunaga Y, Takagi A, Tobita Y, Hirata Y, Ishida Y, TatenoC, Kohara M
                                          PLoS One. 2013 Dec 16;8(12):e82527.