Comparison of the hepatic effects of phenobarbital in chimeric mice containing either rat or human hepatocytes with humanized constitutive androstane receptor (CAR) and pregnane X receptor (PXR) mice (hCAR/hPXR mice)

Yamada, T. Ohara, A. Ozawa, N. Maeda, K. Kondo, M. Okuda, Y. Abe, J. Cohen, S. M. Lake, B. G.

Toxicol Sci. 2020 Jul 31. pii: 5879297. doi: 10.1093/toxsci/kfaa125.

Characterization of plasma protein binding in two mouse models of humanized liver, PXB mouse and humanized TK-NOG mouse

Miyamoto, M. Kosugi, Y. Iwasaki, S. Chisaki, I. Nakagawa, S. Amano, N. Hirabayashi, H.

Xenobiotica. 2020 Aug 25:1-10. doi: 10.1080/00498254.2020.1808735

Prediction of Human Disproportionate and Biliary Excreted Metabolites Using Chimeric Mice with Humanized Liver

Kato, S. Shah, A. Plesescu, M. Miyata, Y. Bolleddula, J. Chowdhury, S. Zhu, X.

Drug Metab Dispos. 2020 Jul 14. pii: dmd.120.000128. doi: 10.1124/dmd.120.000128.

武田薬品工業様より、PXBマウス関連の学術論文が発表されましたのでご紹介申し上げます。

【詳細】

掲載雑誌名：Xenobiotica. 2020 Aug 25; 1-10. 　doi:10.1080/00498254.2020.1808735

掲載日：2020年8月25日

論文名：Characterization of plasma protein binding in two mouse models of humanized liver, PXB mouse and humanized

著者：Maki Miyamoto, et. al.（武田薬品工業株式会社）

概要：ヒトPK予測の重要な指標となる血漿中タンパク結合率について、2種類のヒト肝細胞キメラマウスである “PXBマ

2020年7月～8月に開催されました、以下の肝炎関連学会（3学会：日本消化器病学会、EASL、日本肝臓学会）にて、PXBマウス及びPXB-cells関連の研究発表がありました。

住友化学株式会社様より、PXBマウス関連の学術論文が発表されましたのでご紹介申し上げます。

【詳細】

掲載雑誌名：Toxicological Science, kfaa125, https://doi.org/10.1093/toxsci/kfaa125

掲載日：2020年7月31日

論文名：Comparison of the hepatic effects of phenobarbital in chimeric mice containing either

著者：Yamada, et. al.（住友化学株式会社）

概要：化学品のヒト肝毒性予測において、ヒトの肝臓をもつキメラマウス（PXBマウス）が有用であることを、

PXBマウスが、ラットの肝臓をもつキメラマウスや遺伝子組換え動物（hCAR/hPXRマウス）との反応性において

差異があることを示すことで、科学的に実証した。

Signal activation of hepatitis B virus-related hepatocarcinogenesis by upregulation of SUV39h1

Takeuchi, Y. Tsuge, M. Tsushima, K. Suehiro, Y. Fujino, H. Ono, A. Yamauchi, M. Makokha, G. N. Nakahara, T. Murakami, E. Abe-Chayama, H. Kawaoka, T. Miki, D. Imamura, M. Aikata, H. Hayes, C. N. Tateno, C.　Chayama, K.

J Infect Dis. 2020 Jun 9:jiaa317. doi: 10.1093/infdis/jiaa317.

Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation

Steeneck, C. Kinzel, O. Anderhub, S. Hornberger, M. Pinto, S. Morschhaeuser, B. Braun, F. Kleymann, G. Hoffmann, T.

ACS Med Chem Lett. 2020 Jan 27;11(2):179-187. doi: 10.1021/acsmedchemlett.9b00572. eCollection 2020 Feb 13.

Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: Integration with hepatic drug metabolism

Sanoh, S. Naritomi, Y. Kitamura, S. Shinagawa, A. Kakuni, M. Tateno, C. Ohta, S.

Xenobiotica. 2020 Jun 5:1-10. doi: 10.1080/00498254.2020.1769229.

Species differences in liver accumulation and metabolism of nucleotide prodrug sofosbuvir

Wang, T. Babusis, D. Park, Y. Niu, C. Kim, C. Zhao, X. Lu, B. Ma, B. Muench, R. C. Sperger, D. Ray, A. S. Murakami, E.

Drug Metab Pharmacokinet. 2020 Jun;35(3):334-340. doi: 10.1016/j.dmpk.2020.04.333. Epub 2020 Apr 16.

Art of Making Artificial Liver: Depicting Human Liver Biology and Diseases in Mice

Sugahara, G. Ishida, Y. Sun, J. Tateno, C. Saito, T.

Semin Liver Dis. 2020 Feb 19. doi: 10.1055/s-0040-1701444.

Characterization and applications of chimeric mice with humanized livers for preclinical drug development

Tateno, Chise;   Kojima, Yuha

Laboratory Animal Research volume 36, Article number: 2 (2020)

Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection

Cheng, X. Uchida, T. Xia, Y. Umarova, R. Liu, C. J. Chen, P. J. Gaggar, A. Suri, V. Mucke, M. M. Vermehren, J. Zeuzem, S. Teraoka, Y. Osawa, M. Aikata, H. Tsuji, K. Mori, N. Hige, S. Karino, Y. Imamura, M. Chayama, K. Liang, T. J.

J Clin Invest. 2020 Mar 12. pii: 135616. doi: 10.1172/JCI135616.

Application of a Novel Mass Spectral Data Acquisition Approach to Lipidomic Analysis of Liver Extracts from Sitaxentan-treated Liver-Humanized PXB Mice

King, A. Baginski, M. Morikawa, Y. Rainville, P. D. Gethings, L. A. Wilson, I. D. Plumb, R. S.

J Proteome Res. 2019 Oct 8. doi: 10.1021/acs.jproteome.9b00334..

Efficacy of glecaprevir and pibrentasvir treatment for genotype 1b hepatitis C virus drug resistance-associated variants in humanized mice

Osawa, M. Uchida, T. Imamura, M. Teraoka, Y. Fujino, H. Nakahara, T. Ono, A. Murakami, E. Kawaoka, T. Miki, D. Tsuge, M. Hiramatsu, A. Abe-Chayama, H. Hayes, C. N.

J Gen Virol. 2019 Jul;100(7):1123-1131.

Effect of Rifampicin on the Plasma Concentrations of Bile Acid-O-Sulfates in Monkeys and Human Liver-Transplanted Chimeric Mice With or Without Bile Flow Diversion

Takehara, I. Watanabe, N. Mori, D. Ando, O. Kusuhara, H.

J Pharm Sci. 2019 Mar 21.

Anti-HBV activity of retinoid drugs in vitro versus in vivo

Birkus, G. Snyder, C. Jordan, R. Kobayashi, T. Dick, R. Puscau, V. Li, L. Ramirez, R. Willkom, M. Morikawa, Y. Delaney, W. Schmitz, U.

Antiviral Res. 2019 Jun 18:104538. doi: 10.1016/j.antiviral.2019.104538.

2019年7月18日(木)～7月20日(土)に開催されました 第29回抗ウイルス療法学会学術集会にて、PXBマウス及びPXB-cells関連の研究発表がありましたのでご案内を致します。

Humanized Mouse Models for the Study of Hepatitis C and Host Interactions

Yong, K. S. M. Her, Z. Chen, Q.

Cells. 2019 Jun 17;8(6). pii: cells8060604.

Utility of Chimeric Mice with Humanized Liver for Predicting Human Pharmacokinetics in Drug Discovery: Comparison with in Vitro-in Vivo Extrapolation and Allometric Scaling

Naritomi, Y. Sanoh, S. Ohta, S.

Biol Pharm Bull. 2019;42(3):327-336. doi: 10.1248/bpb.b18-00754.