Phoenix Bio

研究開発

研究開発

Monoclonal Antibodies against Extracellular Domains of Claudin-1 Block Hepatitis C Virus Infection in a Mouse Model

    Fukasawa, M. Nagase, S. Shirasago, Y. Iida, M. Yamashita, M. Endo, K. Yagi, K. Suzuki, T. Wakita, T. Hanada, K. Kuniyasu, H. Kondoh, M.

    J Virol. 2015 May 1;89(9):4866-79.

    Postexposure Prophylactic Effect of Hepatitis B Virus (HBV)-Active Antiretroviral Therapy against HBV Infection

      Watanabe, T. Hamada-Tsutsumi, S. Yokomaku, Y. Imamura, J. Sugiura, W. Tanaka, Y.

      Antimicrob Agents Chemother. 2015 Feb;59(2):1292-8.

      Discovering novel direct acting antiviral agents for HBV using in silico screening

        Murakami, Y. Hayakawa, M. Yano, Y. Tanahashi, T. Enomoto, M. Tamori, A. Kawada, N. Iwadate, M. Umeyama, H.

        Biochem Biophys Res Commun. 2015 Jan 2;456(1):20-8.

        Novel robust in vitro hepatitis B virus infection model using fresh human hepatocytes isolated from humanized mice

          Ishida Y, Yamasaki C, Yanagi A, Yoshizane Y, Fujikawa K, Watashi K, Abe H, Wakita T, Hayes CN, Chayama K, Tateno C

          Am J Pathol. 2015 May;185(5):1275-85. doi: 10.1016/j.ajpath.2015.01.028. Epub 2015 Mar 17.

          Predictability of plasma concentration-time curves in humans using single-species allometric scaling of chimeric mice with humanized liver

            Sanoh, S. Naritomi, Y. Fujimoto, M. Sato, K. Kawamura, A. Horiguchi, A.Sugihara, K. Kotake, Y. Ohshita, H. Tateno, C. Horie, T. Kitamura, S. Ohta, S.

            Xenobiotica. 2015 Mar 3:1-10.

            The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus

              Sato, S. Li, K. Kameyama, T. Hayashi, T. Ishida, Y. Murakami, S. Watanabe, T. Iijima, S. Sakurai, Y. Watashi, K. Tsutsumi, S. Sato, Y. Akita, H. Wakita, T. Rice, C. M. Harashima, H. Kohara, M.Tanaka, Y.Takaoka, A.

              Immunity. 2015 Jan 20;42(1):123-32.

              Hepatitis C Virus Core Protein Suppresses Mitophagy by Interacting with Parkin in the Context of Mitochondrial Depolarization

                Hara, Y. Yanatori, I. Ikeda, M. Kiyokage, E. Nishina, S. Tomiyama, Y. Toida, K. Kishi, F. Kato, N. Imamura, M. Chayama, K. Hino, K.

                Am J Pathol. 2014 Sep 19. pii: S0002-9440(14)00483-0. doi: 10.1016/j.ajpath.2014.07.024.

                In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus

                  Watanabe, T. Hatakeyama, H. Matsuda-Yasui, C. Sato, Y. Sudoh, M. Takagi, A. Hirata, Y. Ohtsuki, T. Arai, M. Inoue, K. Harashima, H. Kohara, M.

                  Sci Rep. 2014 Apr 23;4:4750. doi: 10.1038/srep04750.

                   

                   

                  Human microRNA hsa-miR-1231 suppresses hepatitis B virus replication by targeting core mRNA

                    Kohno, T. Tsuge, M. Murakami, E. Hiraga, N. Abe, H. Miki, D. Imamura, M. Ochi,

                    H. Hayes, C. N. Chayama, K.

                    J Viral Hepat. 2014 Sep;21(9):e89-97. doi: 10.1111/jvh.12240. Epub 2014 May 16.

                    Zone analysis by two-dimensional electrophoresis with accelerator mass spectrometry of in vivo protein bindings of idiosyncratic hepatotoxicants troglitazone and flutamide bioactivated in chimeric mice with humanized liver

                      Yamazaki, H. Kuribayashi, S. Inoue, T. Honda,T. Tateno, C. Oofusa, K. Ninomiya, S.Ikedag , T. Izumi, T and Horie, T

                      Toxicology Research

                      Human Hepatocytes Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogen Sodium Phenobarbital in an In Vivo Study Using a Chimeric Mouse with Humanized Liver

                        Yamada, T. Okuda, Y. Kushida, M. Sumida, K. Takeuchi, H. Nagahori, H. Fukuda, T. Lake, B. G. Cohen, S. M. Kawamura, S.

                        Toxicol Sci. 2014 Aug 21. pii: kfu173.

                        Chimeric Mice with Hepatocyte-humanized Liver as an Appropriate Model to Study Human Peroxisome Proliferator-activated Receptor-alpha

                          Tateno, C. Yamamoto, T. Utoh, R. Yamasaki, C. Ishida, Y. Myoken, Y. Oofusa, K. Okada, M. Tsutsui, N. Yoshizato, K.
                          Toxicol Pathol. 2014 Aug 8. pii: 0192623314544378.

                          Inhibition of hepatitis C virus in chimeric mice by short synthetic hairpin RNAs: sequence analysis of surviving virus shows added selective pressure of combination therapy

                            Dallas, A. Ilves, H. Ma, H. Chin, D. J. Maclachlan, I. Klumpp, K. Johnston, B. H.
                            J Virol. 2014 May;88(9):4647-4656.

                            Application of Chimeric Mice with Humanized Liver for Study of Human-Specific Drug Metabolism

                              Bateman, T. Reddy, V. B. Kakuni, M. Morikawa, Y. Kumar, S.
                              Drug Metab Dispos. 2014 Jun;42(6):1055-65.

                              Validation of uPA/SCID mouse with humanized liver as a human liver model: protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases by LC-MS/MS

                                Ohtsuki, S. Kawakami, H. Inoue, T. Nakamura, K. Tateno, C. Katsukura, Y. Obuchi, W. Uchida, Y. Kamiie, J. Horie, T. Terasaki, T.
                                Drug Metab Dispos. 2014 Jun;42(6):1039-43.

                                Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics

                                  Sanoh, S. Ohta, S.
                                  Biopharm Drug Dispos. 2014 Mar;35(2):71-86.

                                  Chimeric Mice with Humanized Livers: A Unique Tool for in Vivo and in Vitro Enzyme Induction Studies

                                    Masakazu Kakuni, Chihiro Yamasaki, Asato Tachibana, Yasumi Yoshizane, Yuji Ishida and Chise Tateno
                                    Int. J. Mol. Sci. 2014, 15, 58-74

                                    Hepatitis Virus Infection Affects DNA Methylation in Mice with Humanized Livers

                                      Okamoto, Y. Shinjo, K., Shimizu, Y. Sano, T. Yamao, K. Gao, W. Fujii, M. Osada, H. Sekido, Y. Murakami, S. Tanaka, Y. Joh, T. Sato, S. Takahashi, S. Wakita, T. Zhu, J.Issa, J. P. Kondo, Y.
                                      Gastroenterology. 2014 Feb;146(2):562-72.

                                      Long-Term Elimination of Hepatitis C Virus from Human Hepatocyte Chimeric Mice After Interferon-gamma Gene Transfer

                                        Takahashi, Y. Ando, M. Nishikawa, M. Hiraga, N. Imamura, M. Chayama, K. Takakura, Y.

                                        Hum Gene Ther Clin Dev. 2014 Mar;25(1):28-39.

                                        Formulated Minimal-Length Synthetic Small Hairpin RNAs are Potent Inhibitors of Hepatitis C Virus in Mice with Humanized Livers

                                          Ma, H. Dallas, A. Ilves, H. Shorenstein, J. Maclachlan, I. Klumpp, K. Johnston, B. H.
                                          Gastroenterology. 2014 Jan;146(1):63-6.