Phoenix Bio

R&D OVERVIEW

R&D OVERVIEW

Candidate genes responsible for early key events of phenobarbital-promoted mouse hepatocellular tumorigenesis based on differentiation of regulating genes between wild type mice and humanized chimeric mice

    Ohara A , Takahashi Y,  Kondo  M,  Okuda Y, Takeda  S,  Kushida M, Kobayashi  K,  Sumida K, Yamada T

    Toxicol Res. 2017; 6(6): 795-813

    Evaluation of the human relevance of the constitutive androstane receptor-mediated mode of action for rat hepatocellular tumor formation by the synthetic pyrethroid momfluorothrin

      Okuda, Y. Kushida, M. Kikumoto, H. Nakamura, Y. Higuchi, H. Kawamura, S. Cohen, S. M. Lake, B. G. Yamada, T.

      J Toxicol Sci. 2017;42(6):773-788. doi: 10.2131/jts.42.773.

      Organic anion transporting polypeptides (OATPs)-mediated drug-drug interaction study between rosuvastatin and cyclosporine A in chimeric mice with humanized liver

        Uchida, M. Tajima, Y. Kakuni, M. Kageyama, Y. Okada, T. Sakudara, E. Tateno, C. Hayashi, R.

        Drug Metab Dispos. 2017 Oct 19. pii: dmd.117.075994. doi: 10.1124/dmd.117.075994.

        Assessment of amiodarone-induced phospholipidosis in chimeric mice with a humanized liver

          Sanoh, S. Yamachika, Y. Tamura, Y. Kotake, Y. Yoshizane, Y. Ishida, Y. Tateno, C. Ohta, S.

          J Toxicol Sci. 2017;42(5):589-596. doi: 10.2131/jts.42.589.

          Downregulation of the Complement Cascade In Vitro, in Mice and in Patients with Cardiovascular Disease by the BET Protein Inhibitor Apabetalone (RVX-208)

            Wasiak, S. Gilham, D. Tsujikawa, L. M. Halliday, C. Calosing, C. Jahagirdar, R. Johansson, J. Sweeney, M. Wong, N. C. Kulikowski, E.

            J Cardiovasc Transl Res. 2017 May 31. doi: 10.1007/s12265-017-9755-z.

            Evaluation of the Utility of Chimeric Mice with Humanized Livers for the Characterization and Profiling of the Metabolites of a Selective Inhibitor (YM543) of the Sodium-Glucose Cotransporter 2

              Nakada, N.

              Pharm Res. 2017 Feb 13. doi: 10.1007/s11095-017-2116-4.

              Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver

                Miyamoto, M. Iwasaki, S.  Chisaki, I. Nakagawa, S. Amano, N. Hirabayashi, H.

                Xenobiotica. 2016 Nov 28:1-54.

                Lack of exposure in a first-in-man study due to aldehyde oxidase metabolism: Investigated by use of 14C-microdose, humanized mice, monkey pharmacokinetics and in vitro methods

                  Jensen, K. G. Jacobsen, A. M. Bundgaard, C. Nilausen, D. O. Thale, Z. Chandrasena, G. Jorgensen, M.

                  Drug Metab Dispos. 2016 Oct 13. pii: dmd.116.072793.

                  Halogenated hydrocarbon solvent-related cholangiocarcinoma risk: biliary excretion of glutathione conjugates of 1,2-dichloropropane evidenced by untargeted metabolomics analysis

                    Toyoda, Y. Takada, T. Suzuki, H.

                    Sci Rep. 2016 Apr 18;6:24586. doi: 10.1038/srep24586.

                    Murine Cyp3a knockout chimeric mice with humanized liver: prediction of the metabolic profile of nefazodone in humans

                      Nakada, N. Kawamura, A. Kamimura, H. Sato, K. Kazuki, Y. Kakuni, M. Ohbuchi, M. Kato, K. Tateno, C. Oshimura, M. Usui, T.

                      Biopharm Drug Dispos. 2015 Sep 9. doi: 10.1002/bdd.1990.