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R&D OVERVIEW

R&D OVERVIEW

Chimeric mice with humanized liver: Application in drug metabolism and pharmacokinetics studies for drug discovery

    Naritomi, Y. Sanoh, S. Ohta, S.

    Drug Metab Pharmacokinet. 2017 Nov 9. pii: S1347-4367(17)30150-7. doi: 10.1016/j.dmpk.2017.11.001.

    Significance of aldehyde oxidase during drug development: Effects on drug metabolism, pharmacokinetics, toxicity, and efficacy

      Sanoh, S. Tayama, Y. Sugihara, K. Kitamura, S. Ohta, S.

      Drug Metab Pharmacokinet. 2015 Feb;30(1):52-63.

      Propagation of Human Hepatocytes in uPA/SCID Mice: Producing Chimeric Mice with Humanized Liver

      Ohshita, H. Tateno, C.

      Methods Mol Biol. 2017;1506:91-100. (Book of Hepatocyte Transplantation)

       

      Assessing the Therapeutic Potential of Lab-Made Hepatocytes

      Rezvani, M. Grimm, A. Willenbring, H.

      Hepatology. 2016 Mar 25. doi: 10.1002/hep.28569

      In Vitro and in Vivo Assessments of Drug-induced Hepatotoxicity and Drug Metabolism in Humans (In Japanese)

        Sanoh, S.

        Yakugaku Zasshi. 2015;135(11):1273-9. doi: 10.1248/yakushi.15-00200.

        Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound

          Kamimura, H. Ito, S.

          Xenobiotica. 2015 Oct 7:1-13.

          Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics

            Sanoh, S. Ohta, S.
            Biopharm Drug Dispos. 2014 Mar;35(2):71-86.

            Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver

              Kitamura, S. Sugihara, K.
              Xenobiotica. 2014 Jan;44(2):123-34.

              A mouse with humanized liver as an animal model for predicting drug effects and for studying hepatic viral infection: where to next?

                Yoshizato, K. Tateno, C.

                Expert Opin Drug Metab Toxicol. 2013 Nov;9(11):1419-35.

                Impact of interleukin-28B genotype on in vitro and in vivo systems of hepatitis C virus replication.

                  Chayama K, Hayes CN, Imamura M.
                  Hepatol Res. 2012 Sep;42(9):841-53.