Phoenix Bio

R&D OVERVIEW

R&D OVERVIEW

Propagation of Human Hepatocytes in uPA/SCID Mice: Producing Chimeric Mice with Humanized Liver

Ohshita, H. Tateno, C.

Methods Mol Biol. 2017;1506:91-100. (Book of Hepatocyte Transplantation)

 

Assessing the Therapeutic Potential of Lab-Made Hepatocytes

Rezvani, M. Grimm, A. Willenbring, H.

Hepatology. 2016 Mar 25. doi: 10.1002/hep.28569

Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound

    Kamimura, H. Ito, S.

    Xenobiotica. 2015 Oct 7:1-13.

    In Vitro and in Vivo Assessments of Drug-induced Hepatotoxicity and Drug Metabolism in Humans (In Japanese)

      Sanoh, S.

      Yakugaku Zasshi. 2015;135(11):1273-9. doi: 10.1248/yakushi.15-00200.

      Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound

        Kamimura, H. Ito, S.

        Xenobiotica. 2015 Oct 7:1-13.

        Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics

          Sanoh, S. Ohta, S.
          Biopharm Drug Dispos. 2014 Mar;35(2):71-86.

          Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver

            Kitamura, S. Sugihara, K.
            Xenobiotica. 2014 Jan;44(2):123-34.

            A mouse with humanized liver as an animal model for predicting drug effects and for studying hepatic viral infection: where to next?

              Yoshizato, K. Tateno, C.

              Expert Opin Drug Metab Toxicol. 2013 Nov;9(11):1419-35.

              Impact of interleukin-28B genotype on in vitro and in vivo systems of hepatitis C virus replication.

                Chayama K, Hayes CN, Imamura M.
                Hepatol Res. 2012 Sep;42(9):841-53.

                Mice with liver composed of human hepatocytes as an animal model for drug testing.

                  Yoshizato K, Tateno C, Utoh R.

                  Curr Drug Discov Technol. 2012 Mar;9(1):63-76. Review.