Phoenix Bio

R&D OVERVIEW

R&D OVERVIEW

Contribution of chimeric mice with a humanized liver to the evaluation of pharmacology, toxicity, and pharmacokinetics in drug discovery and development

    Sanoh, S. Ohta, S.

    Nihon Yakurigaku Zasshi. 2018;151(5):213-220

    Chimeric mice with humanized liver: Application in drug metabolism and pharmacokinetics studies for drug discovery

      Naritomi, Y. Sanoh, S. Ohta, S.

      Drug Metab Pharmacokinet. 2017 Nov 9. pii: S1347-4367(17)30150-7. doi: 10.1016/j.dmpk.2017.11.001.

      Significance of aldehyde oxidase during drug development: Effects on drug metabolism, pharmacokinetics, toxicity, and efficacy

        Sanoh, S. Tayama, Y. Sugihara, K. Kitamura, S. Ohta, S.

        Drug Metab Pharmacokinet. 2015 Feb;30(1):52-63.

        Propagation of Human Hepatocytes in uPA/SCID Mice: Producing Chimeric Mice with Humanized Liver

        Ohshita, H. Tateno, C.

        Methods Mol Biol. 2017;1506:91-100. (Book of Hepatocyte Transplantation)

         

        Assessing the Therapeutic Potential of Lab-Made Hepatocytes

        Rezvani, M. Grimm, A. Willenbring, H.

        Hepatology. 2016 Mar 25. doi: 10.1002/hep.28569

        In Vitro and in Vivo Assessments of Drug-induced Hepatotoxicity and Drug Metabolism in Humans (In Japanese)

          Sanoh, S.

          Yakugaku Zasshi. 2015;135(11):1273-9. doi: 10.1248/yakushi.15-00200.

          Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound

            Kamimura, H. Ito, S.

            Xenobiotica. 2015 Oct 7:1-13.

            Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics

              Sanoh, S. Ohta, S.
              Biopharm Drug Dispos. 2014 Mar;35(2):71-86.

              Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver

                Kitamura, S. Sugihara, K.
                Xenobiotica. 2014 Jan;44(2):123-34.

                A mouse with humanized liver as an animal model for predicting drug effects and for studying hepatic viral infection: where to next?

                  Yoshizato, K. Tateno, C.

                  Expert Opin Drug Metab Toxicol. 2013 Nov;9(11):1419-35.