PXB-mouse studies can be conducted using the same dosing and material sampling methods as other in vivo studies. The in-house study service of PhoenixBio consists of conducting the in-life phase trials and the collection of samples which are then sent to the client for evaluation. Upon request we also perform chemical analysis of the samples. PhoenixBio also offers an additional service which includes the measurement of human Albumin levels within the mouse serum, as well as the expression and activity of metabolic enzymes and blood biochemical measurements.
Please find our and clients’ excellent publications related to human specific metabolites, enzyme activities and pharmacokinetics.
Similar to other standard in vivo experiments, the compounds can be administered using all valid dosing routes
Blood samples can be extracted on given time points using standard methods and techniques common to other in vivo experiments.
We provide our clients with the terminal livers harvested from PXB-mice on the completion of studies in snap frozen, formalin fixed or RNAlater stabilized.