Ca. 80% of a PXB-Mouse liver consists of human hepatocytes, allowing for PXB-mice to express most of the genes that a normal human liver does.
Drug candidates exhibiting both on-target and off-target effects on the hepatocytes target human-specific nucleic acid sequences or protein structures, such as RNA drugs, antibody drugs, or molecularly targeted drugs. Since human hepatocytes retain and exhibit normal function in the PXB-Mouse liver, these drug candidates can be evaluated using the PXB-mice.
Please use the link below to look up specific human gene expression levels found in our PXB-Mouse, and see if our mouse model is capable of expressing your gene of interest.