Phoenix Bio

論文一覧

論文一覧

論文一覧

Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver

    Miyamoto, M. Iwasaki, S.  Chisaki, I. Nakagawa, S. Amano, N. Hirabayashi, H.

    Xenobiotica. 2016 Nov 28:1-54.

    Cyclosporin derivatives inhibit hepatitis B virus entry without interfering with NTCP transporter activity

      Shimura, S. Watashi, K. Fukano, K. Peel, M. Sluder, A. Kawai, F. Iwamoto, M. Tsukuda, S. Takeuchi, J. S. Miyake, T. Sugiyama, M. Ogasawara, Y. Park, S. Y. Tanaka, Y. Kusuhara, H. Mizokami, M. Sureau, C. Wakita, T.

      J Hepatol. 2016 Nov 24. pii: S0168-8278(16)30683-3. doi: 10.1016/j.jhep.2016.11.009.

      A new class of hepatitis B and D virus entry inhibitors, proanthocyanidin and its analogs, that directly act on the viral large surface proteins

        Tsukuda, S. Watashi, K. Hojima, T. Isogawa, M. Iwamoto, M. Omagari, K. Suzuki, R. Aizaki, H. Kojima, S. Sugiyama, M. Saito, A. Tanaka, Y. Mizokami, M. Sureau, C. Wakita, T.

        Hepatology. 2016 Nov 18. doi: 10.1002/hep.28952.

        Lack of exposure in a first-in-man study due to aldehyde oxidase metabolism: Investigated by use of 14C-microdose, humanized mice, monkey pharmacokinetics and in vitro methods

          Jensen, K. G. Jacobsen, A. M. Bundgaard, C. Nilausen, D. O. Thale, Z. Chandrasena, G. Jorgensen, M.

          Drug Metab Dispos. 2016 Oct 13. pii: dmd.116.072793.

          Assessing the Therapeutic Potential of Lab-Made Hepatocytes

          Rezvani, M. Grimm, A. Willenbring, H.

          Hepatology. 2016 Mar 25. doi: 10.1002/hep.28569

          Protease inhibitor resistance remains even after mutant strains become undetectable using deep sequencing

            Kan, H. Imamura, M. Uchida, T. Hiraga, N. Hayes, C. N. Tsuge, M. Abe, H. Aikata, H. Makokha, G. N. Chowdhury, S. Miki, D. Ochi, H. Ishida, Y. Tateno, C. Chayama, K.

            J Infect Dis. 2016 Sep 20. pii: jiw437.

            Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation

              Tanaka, T. Okuyama-Dobashi, K. Murakami, S. Chen, W. Okamoto, T. Ueda, K. Hosoya, T. Matsuura, Y. Ryo, A. Tanaka, Y. Hagiwara, M. Moriishi, K.

              Antiviral Res. 2016 Aug 8. pii: S0166-3542(16)30357-6.

              Hepatitis C virus dynamics and cellular gene expression in uPA-SCID chimeric mice with humanized livers during intravenous silibinin monotherapy

                DebRoy, S.  Hiraga, N. Imamura, M. Hayes, C. N. Akamatsu, S. Canini, L. Perelson, A. S. Pohl, R. T. Persiani, S. Uprichard, S. L. Tateno, C. Dahari, H. Chayama, K.

                J Viral Hepat. 2016 Jun 8. doi: 10.1111/jvh.12551.

                新規核酸アナログ4′-C-cyano-2′-deoxyadenosine, 4′-C-cyano-2′-deoxyguanosineは薬剤耐性B型肝炎ウイルス変異種に対して有効である(短報)

                林 佐奈衣、高松悠樹、前田賢次、村上周子,尾曲克已、松居剛志、五十川正記、渡邊網正、狩野吉康、向後悟、濱屋裕明、田中靖人

                肝臓 2016; 57(6):299-301

                Halogenated hydrocarbon solvent-related cholangiocarcinoma risk: biliary excretion of glutathione conjugates of 1,2-dichloropropane evidenced by untargeted metabolomics analysis

                  Toyoda, Y. Takada, T. Suzuki, H.

                  Sci Rep. 2016 Apr 18;6:24586. doi: 10.1038/srep24586.

                  Antiviral effects of anti-HBs immunoglobulin and vaccine on HBs antigen seroclearance for chronic hepatitis B infection

                    Tsuge, M. Hiraga, N. Uchida, T. Kan, H. Miyaki, E. Masaki, K. Ono, A. Nakahara, T. Abe-Chayama, H. Zhang, Y. Naswa, M. G. Kawaoka, T. Miki, D. Imamura, M. Kawakami, Y. Aikata, H. Ochi, H. Hayes, C. N. Chayama, K.

                    J Gastroenterol. 2016 Mar 4.

                    Possible Involvement of Hepatitis B Virus Infection of Hepatocytes in the Attenuation of Apoptosis in Hepatic Stellate Cells

                      Sasaki, R. Kanda, T. Nakamura, M. Nakamoto, S. Haga, Y. Wu, S. Shirasawa, H. Yokosuka, O.

                      PLoS One. 2016 Jan 5;11(1):e0146314. doi: 10.1371/journal.pone.0146314. eCollection 2016.

                      A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide

                        Kaneko, M. Watashi, K. Kamisuki, S. Matsunaga, H. Iwamoto, M. Kawai, F. Ohashi, H. Tsukuda, S. Shimura, S. Suzuki, R. Aizaki, H. Sugiyama, M. Park, S. Y. Ito, T. Ohtani, N. Sugawara, F. Tanaka, Y. Mizokami, M. Sureau, C. Wakita, T.

                        J Virol. 2015 Dec;89(23):11945-53. doi: 10.1128/JVI.01855-15.

                        Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound

                          Kamimura, H. Ito, S.

                          Xenobiotica. 2015 Oct 7:1-13.

                          動物モデルを用いた発癌研究

                          森屋恭爾、三好秀征、小池和彦

                          新ウイルス性肝炎学 2015 page74-78

                          肝炎ウイルスの動物モデルと治療開発

                          茶山一彰、今村道雄

                          新ウイルス性肝炎学 2015 page69-73

                          ヒト肝細胞キメラマウスを用いたin vivoおよびin vitro HBV感染モデル

                          石田雄二、横道博、加国雅和、立野知世

                          新ウイルス性肝炎学 2015 page386-391

                          Human Cytotoxic T Lymphocyte-Mediated Acute Liver Failure and Rescue by Immunoglobulin in Human Hepatocyte Transplant TK-NOG Mice

                            Uchida, T. Hiraga, N. Imamura, M. Tsuge, M. Abe, H. Hayes, C. N. Aikata, H. Ishida, Y. Tateno, C. Yoshizato, K. Ohdan, H. Murakami, K. Chayama, K.

                            J Virol. 2015 Oct;89(19):10087-96. doi: 10.1128/JVI.01126-15. Epub 2015 Aug 5.

                            In Vitro and in Vivo Assessments of Drug-induced Hepatotoxicity and Drug Metabolism in Humans (In Japanese)(ヒトにおける医薬品の肝毒性及び代謝物のin vtro, in vivo予測評価系の構築に関する研究)

                              Sanoh, S.

                              Yakugaku Zasshi. 2015;135(11):1273-9. doi: 10.1248/yakushi.15-00200.

                              Novel pH-sensitive multifunctional envelope-type nanodevice for siRNA-based treatments for chronic HBV infection

                                Yamamoto, N. Sato, Y. Munakata, T. Kakuni, M. Tateno, C. Sanada, T. Hirata, Y. Murakami, S.  Tanaka, Y. Chayama, K. Hatakeyama, H. Hyodo, M. Harashima, H. Kohara, M.

                                J Hepatol. 2015 Oct 23. pii: S0168-8278(15)00713-8. doi: 10.1016/j.jhep.2015.10.014.