Phoenix Bio

論文一覧

論文一覧

論文一覧

新規核酸アナログ4′-C-cyano-2′-deoxyadenosine, 4′-C-cyano-2′-deoxyguanosineは薬剤耐性B型肝炎ウイルス変異種に対して有効である(短報)

林 佐奈衣、高松悠樹、前田賢次、村上周子,尾曲克已、松居剛志、五十川正記、渡邊網正、狩野吉康、向後悟、濱屋裕明、田中靖人

肝臓 2016; 57(6):299-301

Halogenated hydrocarbon solvent-related cholangiocarcinoma risk: biliary excretion of glutathione conjugates of 1,2-dichloropropane evidenced by untargeted metabolomics analysis

    Toyoda, Y. Takada, T. Suzuki, H.

    Sci Rep. 2016 Apr 18;6:24586. doi: 10.1038/srep24586.

    Antiviral effects of anti-HBs immunoglobulin and vaccine on HBs antigen seroclearance for chronic hepatitis B infection

      Tsuge, M. Hiraga, N. Uchida, T. Kan, H. Miyaki, E. Masaki, K. Ono, A. Nakahara, T. Abe-Chayama, H. Zhang, Y. Naswa, M. G. Kawaoka, T. Miki, D. Imamura, M. Kawakami, Y. Aikata, H. Ochi, H. Hayes, C. N. Chayama, K.

      J Gastroenterol. 2016 Mar 4.

      Possible Involvement of Hepatitis B Virus Infection of Hepatocytes in the Attenuation of Apoptosis in Hepatic Stellate Cells

        Sasaki, R. Kanda, T. Nakamura, M. Nakamoto, S. Haga, Y. Wu, S. Shirasawa, H. Yokosuka, O.

        PLoS One. 2016 Jan 5;11(1):e0146314. doi: 10.1371/journal.pone.0146314. eCollection 2016.

        A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide

          Kaneko, M. Watashi, K. Kamisuki, S. Matsunaga, H. Iwamoto, M. Kawai, F. Ohashi, H. Tsukuda, S. Shimura, S. Suzuki, R. Aizaki, H. Sugiyama, M. Park, S. Y. Ito, T. Ohtani, N. Sugawara, F. Tanaka, Y. Mizokami, M. Sureau, C. Wakita, T.

          J Virol. 2015 Dec;89(23):11945-53. doi: 10.1128/JVI.01855-15.

          Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound

            Kamimura, H. Ito, S.

            Xenobiotica. 2015 Oct 7:1-13.

            動物モデルを用いた発癌研究

            森屋恭爾、三好秀征、小池和彦

            新ウイルス性肝炎学 2015 page74-78

            肝炎ウイルスの動物モデルと治療開発

            茶山一彰、今村道雄

            新ウイルス性肝炎学 2015 page69-73

            ヒト肝細胞キメラマウスを用いたin vivoおよびin vitro HBV感染モデル

            石田雄二、横道博、加国雅和、立野知世

            新ウイルス性肝炎学 2015 page386-391

            Human Cytotoxic T Lymphocyte-Mediated Acute Liver Failure and Rescue by Immunoglobulin in Human Hepatocyte Transplant TK-NOG Mice

              Uchida, T. Hiraga, N. Imamura, M. Tsuge, M. Abe, H. Hayes, C. N. Aikata, H. Ishida, Y. Tateno, C. Yoshizato, K. Ohdan, H. Murakami, K. Chayama, K.

              J Virol. 2015 Oct;89(19):10087-96. doi: 10.1128/JVI.01126-15. Epub 2015 Aug 5.

              In Vitro and in Vivo Assessments of Drug-induced Hepatotoxicity and Drug Metabolism in Humans (In Japanese)(ヒトにおける医薬品の肝毒性及び代謝物のin vtro, in vivo予測評価系の構築に関する研究)

                Sanoh, S.

                Yakugaku Zasshi. 2015;135(11):1273-9. doi: 10.1248/yakushi.15-00200.

                Novel pH-sensitive multifunctional envelope-type nanodevice for siRNA-based treatments for chronic HBV infection

                  Yamamoto, N. Sato, Y. Munakata, T. Kakuni, M. Tateno, C. Sanada, T. Hirata, Y. Murakami, S.  Tanaka, Y. Chayama, K. Hatakeyama, H. Hyodo, M. Harashima, H. Kohara, M.

                  J Hepatol. 2015 Oct 23. pii: S0168-8278(15)00713-8. doi: 10.1016/j.jhep.2015.10.014.

                  Elimination of HCV via a non-ISG-mediated mechanism by vaniprevir andBMS-788329 combination therapy in human hepatocyte chimeric mice

                    Uchida, T. Hiraga, N. mamura, M. Yoshimi, S. Kan, H. Miyaki, E. Tsuge, M. Abe, H. Hayes, C. N. Aikata, H. Ishida, Y. Tateno, C. Ellis, J. D. Chayama, K.

                    Virus Res. 2015 Nov 10. pii: S0168-1702(15)30117-9. doi: 10.1016/j.virusres.2015.11.010.

                    Combination therapies with daclatasvir and asunaprevir on NS3-D168 mutated HCV in human hepatocyte chimeric mice

                      Kan, H. Hiraga, N. Imamura, M. Hayes, C. N. Uchida, T. Miyaki, E. Tsuge, M. Abe, H. Aikata, H. Miki, D. Ochi, H. Ishida, Y. Tateno, C. Chayama, K.

                      Antivir Ther. 2015 Nov 12. doi: 10.3851/IMP3009.

                      Effect of tenofovir disoproxil fumarate on drug-resistant HBV clones

                        Murakami, E. Tsuge, M. Hiraga,  N.Kan, H. Uchida, T. Masaki, K. Nakahara, T. Ono, A. Miki, D. Kawaoka, T. Abe, H.Imamura, M. Aikata, H. Ochi, H. Hayes, C. N. Akita, T. Tanaka, J. Chayama, K.

                        J Infect. 2015 Oct 26. pii: S0163-4453(15)00339-4. doi: 10.1016/j.jinf.2015.09.038.

                        Generation of Novel Chimeric Mice with Humanized Livers by Using Hemizygous cDNA-uPA/SCID Mice

                          Tateno, C. Kawase, Y. Tobita, Y. Hamamura, S. Ohshita, H. Yokomichi, H. Sanada, H. Kakuni, M. Shiota, A. Kojima, Y. Ishida, Y. Shitara, H. Wada, N. A. Tateishi, H. Sudoh, M. Nagatsuka, S. Jishage, K. Kohara, M.

                          PLoS One. 2015 Nov 4;10(11):e0142145. doi: 10.1371/journal.pone.0142145. eCollection 2015.

                          A novel reporter system to monitor early stages of the HBV life cycle

                            Nishitsuji, H. Ujino, S. Shimizu, Y. Harada, K. Zhang, J. Sugiyama, M. Mizokami, M. Shimotohno, K.

                            Cancer Sci. 2015 Aug 27. doi: 10.1111/cas.12799.

                            Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound

                              Kamimura, H. Ito, S.

                              Xenobiotica. 2015 Oct 7:1-13.

                              Murine Cyp3a knockout chimeric mice with humanized liver: prediction of the metabolic profile of nefazodone in humans

                                Nakada, N. Kawamura, A. Kamimura, H. Sato, K. Kazuki, Y. Kakuni, M. Ohbuchi, M. Kato, K. Tateno, C. Oshimura, M. Usui, T.

                                Biopharm Drug Dispos. 2015 Sep 9. doi: 10.1002/bdd.1990.

                                Lack of infectivity of HBV in feces from patients with chronic hepatitis B virus infection, and infection using chimeric mice

                                  Komatsu, H. Inui, A. Murano, T. Tsunoda, T. Sogo, T. Fujisawa, T.

                                  BMC Res Notes. 2015 Aug 20;8:366. doi: 10.1186/s13104-015-1337-z.