Phoenix Bio

論文一覧

論文一覧

論文一覧

Characterization of novel entecavir resistance mutations

    Hayashi, S. Murakami, S. Omagari, K. Matsui, T. Iio, E. Isogawa, M. Watanabe, T. Karino, Y. Tanaka, Y.

    J Hepatol. 2015 Sep;63(3):546-53. doi: 10.1016/j.jhep.2015.03.020. Epub 2015 Mar 25.

    Preclinical characterization andin vivoefficacy of GSK8853, a small molecule inhibitor of the Hepatitis C virus NS4B protein

      Pouliot, Jeffrey J. Thomson, Michael Xie, Mi Horton, Joseph Johnson, John Krull, David Mathis, Amanda Morikawa, Yoshio Parks, Derek Peterson, Richard, Shimada, Takashi Thomas, Elizabeth Vamathevan, Jessica Van Horn, Stephanie Xiong, Zhiping Hamatake, Robert  Peat, Andrew J.

      Antimicrob. Agents Chemother. doi:10.1128/AAC.00813-15

      Association between hepatitis B virus and MHC class I polypeptide-related chain A in human hepatocytes derived from human-mouse chimeric mouse liver

        Sasaki, R. Kanda, T. Wu, S. Nakamoto, S. Haga, Y. Jiang, X. Nakamura, M.

        Shirasawa, H. Yokosuka, O.

        Journal: Biochem Biophys Res Commun. 2015 Jul 23. pii: S0006-291X(15)30332-6.

        doi: 10.1016/j.bbrc.2015.07.102.

        4′-modified nucleoside analogs: Potent inhibitors active against entecavir-resistant hepatitis B virus

          Takamatsu, Y. Tanaka, Y. Kohgo, S. Murakami, S. Singh, K. Das, D. Venzon, D.  J. Amano, M. Kuwata,N. Aoki, M. Delino, N. S. Hayashi, S. Takahashi, S. Sukenaga, Y. Haraguchi, K. Sarafianos, S. G. Maeda, K. Mitsuya, H.

          Journal: Hepatology. 2015 Jun 29. doi: 10.1002/hep.27962.

          Efficient engraftmentof human iPS cell-derived hepatocyte-like cells in uPA/SCID mice by overexpression of FNK, a Bcl-xmutant gene

            Nagamoto, Y. Takayama, K. Tashiro, K. Tateno, C. Sakurai, F. Tachibana, M. Kawabata, K. Ikeda, K. Tanaka, Y. Mizuguchi, H.
            Cell Transplant. 2014 May 6.

            Development of Murine Cyp3a Knockout Chimeric Mice with Humanized Liver

              Kato, K. Ohbuchi, M. Hamamura, S. Ohshita, H. Kazuki, Y. Oshimura, M. Sato, K. Nakada, N. Kawamura, A. Usui, T. Kamimura, H. Tateno, C.

              Drug Metab Dispos. 2015 Aug;43(8):1208-17.

               

              Prevention of hepatitis C virus infection and spread in human liver chimeric mice by an anti-CD81 monoclonal antibody

                Ji, C. Liu, Y. Pamulapati, C. Bohini, S. Fertig, G. Schraeml, M. Rubas, W. Brandt, M. Ries, S. Ma, H. Klumpp, K.

                Hepatology. 2015 Apr;61(4):1136-44.

                Identification and characterization of metabolites of ASP015K, a novel oral Janus kinase inhibitor, in rats, chimeric mice with humanized liver, and humans

                  Nakada, N. Oda, K.

                  Xenobiotica. 2015 Apr 14:1-9.

                  Monoclonal Antibodies against Extracellular Domains of Claudin-1 Block Hepatitis C Virus Infection in a Mouse Model

                    Fukasawa, M. Nagase, S. Shirasago, Y. Iida, M. Yamashita, M. Endo, K. Yagi, K. Suzuki, T. Wakita, T. Hanada, K. Kuniyasu, H. Kondoh, M.

                    J Virol. 2015 May 1;89(9):4866-79.

                    Postexposure Prophylactic Effect of Hepatitis B Virus (HBV)-Active Antiretroviral Therapy against HBV Infection

                      Watanabe, T. Hamada-Tsutsumi, S. Yokomaku, Y. Imamura, J. Sugiura, W. Tanaka, Y.

                      Antimicrob Agents Chemother. 2015 Feb;59(2):1292-8.

                      Discovering novel direct acting antiviral agents for HBV using in silico screening

                        Murakami, Y. Hayakawa, M. Yano, Y. Tanahashi, T. Enomoto, M. Tamori, A. Kawada, N. Iwadate, M. Umeyama, H.

                        Biochem Biophys Res Commun. 2015 Jan 2;456(1):20-8.

                        Novel robust in vitro hepatitis B virus infection model using fresh human hepatocytes isolated from humanized mice

                          Ishida Y, Yamasaki C, Yanagi A, Yoshizane Y, Fujikawa K, Watashi K, Abe H, Wakita T, Hayes CN, Chayama K, Tateno C

                          Am J Pathol. 2015 May;185(5):1275-85. doi: 10.1016/j.ajpath.2015.01.028. Epub 2015 Mar 17.

                          Predictability of plasma concentration-time curves in humans using single-species allometric scaling of chimeric mice with humanized liver

                            Sanoh, S. Naritomi, Y. Fujimoto, M. Sato, K. Kawamura, A. Horiguchi, A.Sugihara, K. Kotake, Y. Ohshita, H. Tateno, C. Horie, T. Kitamura, S. Ohta, S.

                            Xenobiotica. 2015 Mar 3:1-10.

                            The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus

                              Sato, S. Li, K. Kameyama, T. Hayashi, T. Ishida, Y. Murakami, S. Watanabe, T. Iijima, S. Sakurai, Y. Watashi, K. Tsutsumi, S. Sato, Y. Akita, H. Wakita, T. Rice, C. M. Harashima, H. Kohara, M.Tanaka, Y.Takaoka, A.

                              Immunity. 2015 Jan 20;42(1):123-32.

                              Validation of cross-genotype neutralization by hepatitis B virus-specific monoclonal antibodies by in vitro and in vivo infection

                                Hamada-Tsutsumi, S. Iio, E. Watanabe, T. Murakami, S. Isogawa, M. Iijima, S. Inoue, T. Matsunami, K. Tajiri, K. Ozawa, T. Kishi, H. Muraguchi, A. Joh, T. Tanaka, Y.

                                PLoS One. 2015 Feb 18;10(2):e0118062.

                                Hepatitis C Virus Core Protein Suppresses Mitophagy by Interacting with Parkin in the Context of Mitochondrial Depolarization

                                  Hara, Y. Yanatori, I. Ikeda, M. Kiyokage, E. Nishina, S. Tomiyama, Y. Toida, K. Kishi, F. Kato, N. Imamura, M. Chayama, K. Hino, K.

                                  Am J Pathol. 2014 Sep 19. pii: S0002-9440(14)00483-0. doi: 10.1016/j.ajpath.2014.07.024.

                                  In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus

                                    Watanabe, T. Hatakeyama, H. Matsuda-Yasui, C. Sato, Y. Sudoh, M. Takagi, A. Hirata, Y. Ohtsuki, T. Arai, M. Inoue, K. Harashima, H. Kohara, M.

                                    Sci Rep. 2014 Apr 23;4:4750. doi: 10.1038/srep04750.

                                     

                                     

                                    Human microRNA hsa-miR-1231 suppresses hepatitis B virus replication by targeting core mRNA

                                      Kohno, T. Tsuge, M. Murakami, E. Hiraga, N. Abe, H. Miki, D. Imamura, M. Ochi,

                                      H. Hayes, C. N. Chayama, K.

                                      J Viral Hepat. 2014 Sep;21(9):e89-97. doi: 10.1111/jvh.12240. Epub 2014 May 16.

                                      Zone analysis by two-dimensional electrophoresis with accelerator mass spectrometry of in vivo protein bindings of idiosyncratic hepatotoxicants troglitazone and flutamide bioactivated in chimeric mice with humanized liver

                                        Yamazaki, H. Kuribayashi, S. Inoue, T. Honda,T. Tateno, C. Oofusa, K. Ninomiya, S.Ikedag , T. Izumi, T and Horie, T

                                        Toxicology Research

                                        Human Hepatocytes Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogen Sodium Phenobarbital in an In Vivo Study Using a Chimeric Mouse with Humanized Liver

                                          Yamada, T. Okuda, Y. Kushida, M. Sumida, K. Takeuchi, H. Nagahori, H. Fukuda, T. Lake, B. G. Cohen, S. M. Kawamura, S.

                                          Toxicol Sci. 2014 Aug 21. pii: kfu173.