PhoenixBio is pleased to be participating in the 2021 Society of Toxicology Annual Meeting. Please visit our exhibition booth #2322 and meet members of the PhoenixBio team who can answer any questions you may have regarding our products and services. Do not miss an opportunity to check out poster #2133 (poster board 126) “Construction of Hepatic Vascular Model and Toxicity Assessment System That Can Predict DILI Compounds” at the “Liver: in vitro” poster session on March 17th, 2021, at 11:15 am – 1:00 pm EDT. Naito Y. from Toppan Printing Co. Ltd. (Japan) will present the development of a hepatic vascular model for the assessment of toxicity and drug induced liver injury (DILI). The authors constructed a liver-like tissue model consisting of human hepatocytes (PXB-cells®), sinusoidal endothelial cells (SEC), and hepatic stellate cells (LX-2) with the cell-cell adhesion in this model being supported by the addition of collagen and heparin. The model, with an initial content of close to 65% hepatocytes, was able to maintain albumin secretion for at least 14 days without a significant decrease in secreted levels. The authors confirmed the possibility to predict DILI using ten testing compounds. Contact Us for more details.
In our previous post we summarized 2020 publications where PXB-cells® were used in lipid metabolism, drug metabolism and hepatitis B studies. Here we bring to your attention five 2020 publications which discuss the use of PXB-cells® in toxicity-related applications (in 2D and in 3D formats).
Here we summarize 2020 publications where PXB-cells® were used in such application areas as lipid metabolism, drug metabolism and hepatitis B. In Part II we will review 2020 publications where PXB-cells® were used in toxicity-related applications.