Human hepatocytes in PXB-mouse liver constitute normal liver tissue, produce human albumin, and exhibit human-like biliary excretion.
3. Expression of human genes, enzymes and transporters
More than 95% of mRNA expressed in normal human liver is expressed in liver tissue, and expression of normal metabolic enzymes and transporters has also been confirmed.
4. Infection with human hepatitis viruses (HBV, HCV)
HBV and HCV are well known as high species specific pathogens. PXB-mice can be efficiently infected with these viruses to develop chronic infection. Therefore, the anti-viral efficacy of drugs such as Interferon, can directly be observed in PXB-mice infected with HBV or HCV.