Comparison of the hepatic effects of phenobarbital in chimeric mice containing either
rat or human hepatocytes with humanized constitutive androstane receptor (CAR) and
pregnane X receptor (PXR) mice (hCAR/hPXR mice).

Yamada, et. al.（住友化学株式会社）

Toxicological Science, kfaa125

READ MORE

Chimeric mice with humanized livers demonstrate human-specific hepatotoxicity caused by a therapeutic antibody against TRAIL-receptor 2/death receptor 5

Nihira, K. Nan-Ya, K. I. Kakuni, M. Ono, Y. Yoshikawa, Y. Ota, T. Hiura, M. Yoshinari, K.

Toxicol Sci. 2019 Jan 1;167(1):190-201.

READ MORE

Effect of Rifampicin on the Plasma Concentrations of Bile Acid-O-Sulfates in Monkeys and Human Liver-Transplanted Chimeric Mice With or Without Bile Flow Diversion

Takehara,I. Watanabe,N. Mori,D. Ando,O. Kusuhara,H.

J Pharm Sci. 2019 Mar 21.

READ MORE

Chimeric mice with human hepatocytes: A new system for genotoxicity studies

Tateno, C. Fukumuro, M. Masumori, S. Kakuni, M. Ishida, Y. Shimada, T. Hayashi, M.

Mutat Res. 2019 Mar;839:9-12.

READ MORE

The whole transcriptome effects of the PPARalpha agonist fenofibrate on livers of hepatocyte humanized mice

de la Rosa Rodriguez, M. A. Sugahara, G. Hooiveld, Gjej Ishida, Y. Tateno, C. Kersten, S.

BMC Genomics. 2018 Jun 7;19(1):443

READ MORE

Assessment of amiodarone-induced phospholipidosis in chimeric mice with a humanized liver

Sanoh, S. Yamachika, Y. Tamura, Y. Kotake, Y. Yoshizane, Y. Ishida, Y. Tateno, C. Ohta, S.

J Toxicol Sci. 2017;42(5):589-96

 READ MORE

Evaluation of the human relevance of the constitutive androstane receptor-mediated mode of action for rat hepatocellular tumor formation by the synthetic pyrethroid momfluorothrin

Okuda, Y. Kushida, M. Kikumoto, H. Nakamura, Y. Higuchi, H. Kawamura, S. Cohen, S. M. Lake, B. G. Yamada, T.

J Toxicol Sci. 2017;42(6):773-88

 READ MORE

Candidate genes responsible for early key events of phenobarbital-promoted mouse hepatocellular tumorigenesis based on differentiation of regulating genes between wild type mice and humanized chimeric mice

Ohara A , Takahashi Y,  Kondo  M,  Okuda Y, Takeda  S,  Kushida M, Kobayashi  K,  Sumida K, Yamada T

Toxicol Res (Camb). 2017 Aug 24;6(6):795-813

READ MORE

Halogenated hydrocarbon solvent-related cholangiocarcinoma risk: biliary excretion of glutathione conjugates of 1,2-dichloropropane evidenced by untargeted metabolomics analysis

Toyoda, Y. Takada, T. Suzuki, H.

Sci Rep. 2016 Apr 18;6:24586

 READ MORE

Zone analysis by two-dimensional electrophoresis with accelerator mass spectrometry of in vivo protein bindings of idiosyncratic hepatotoxicants troglitazone and flutamide bioactivated in chimeric mice with humanized liver

Yamazaki, Hiroshi, Kuribayashi, Shunji Inoue, Tae Honda, Tomohiro Tateno, Chise Oofusa, Ken Ninomiya, Shinichi Ikeda, ToshihikoIzumi, Takashi Horie, Toru

Toxicol. Res. ,2015, 4:106–11

 READ MORE

Chimeric Mice with Hepatocyte-humanized Liver as an Appropriate Model to Study Human Peroxisome Proliferator-activated Receptor-alpha

Tateno, C. Yamamoto, T. Utoh, R. Yamasaki, C. Ishida, Y. Myoken, Y. Oofusa, K. Okada, M. Tsutsui, N. Yoshizato, K.

Toxicol Pathol. 2015 Feb;43(2):233-48

READ MORE

Human Hepatocytes Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogen Sodium Phenobarbital in an In Vivo Study Using a Chimeric Mouse with Humanized Liver

Yamada, T. Okuda, Y. Kushida, M. Sumida, K. Takeuchi, H. Nagahori, H. Fukuda, T. Lake, B. G. Cohen, S. M. Kawamura, S.

Toxicol Sci. 2014 Nov;142(1):137-57

READ MORE

Endogenous and xenobiotic metabolite profiling of liver extracts from SCID and chimeric humanized mice following repeated oral administration of troglitazone

Barnes, A. J. Baker, D. R. Hobby, K. Ashton, S. Michopoulos, F. Spagou, K.Loftus, N. J. Wilson, I. D.

Xenobiotica. 2014 Jan;44(2):174-85

READ MORE

Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers

Schulz-Utermoehl, T. Sarda, S. Foster, J. R. Jacobsen, M. Kenna, J. G. Morikawa, Y. Salmu, J. Gross, G. Wilson, I. D.

Xenobiotica. 2012 Jun;42(6):503-17

 READ MORE

Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury

Kakuni, M. Morita, M. Matsuo, K. Katoh, Y. Nakajima, M. Tateno, C. Yokoi, T.

Toxicol Lett. 2012 Oct 2;214(1):9-18

READ MORE

Characterization of plasma protein binding in two mouse models of humanized liver, PXB mouse and humanized

TK-NOG mouse.

Maki Miyamoto, et. al.（武田薬品工業株式会社）

Xenobiotica. 2020 Aug 25; 1-10. 　doi:10.1080/00498254.2020.1808735

READ MORE

Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation

Steeneck, C. Kinzel, O. Anderhub, S. Hornberger, M. Pinto, S. Morschhaeuser, B. Braun, F. Kleymann, G. Hoffmann, T.

ACS Med Chem Lett. 2020 Jan 27;11(2):179-187. doi: 10.1021/acsmedchemlett.9b00572. eCollection 2020 Feb 13.

READ MORE

Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: Integration with hepatic drug metabolism

Sanoh, S. Naritomi, Y. Kitamura, S. Shinagawa, A. Kakuni, M. Tateno, C. Ohta, S.

Xenobiotica. 2020 Jun 5:1-10. doi: 10.1080/00498254.2020.1769229.

READ MORE

Prediction of human pharmacokinetics of long half-life compounds using chimeric mice with humanised liver

Miyamoto, M. Iwasaki, S. Chisaki, I. Nakagawa, S. Amano, N. Kosugi, Y. Hirabayashi, H.

Xenobiotica. 2019 Dec;49(12):1379-1387.

READ MORE

Changes in Bile Acid Concentrations after Administration of Ketoconazole or Rifampicin to Chimeric Mice with Humanized Liver

Sanoh, S. Tamura, Y. Fujino, C. Sugahara, G. Yoshizane, Y. Yanagi, A. Kisoh, K. Ishida, Y. Tateno, C. Ohta, S. Kotake, Y.

Biol Pharm Bull. 2019;42(8):1366-1375.

Changes in Bile Acid Concentrations in Chimeric Mice Transplanted with Different Replacement Indexes of Human Hepatocytes

Fujino C, Sanoh S,* Tamura Y, Ishida Y, Tateno C, Ohta S and  Kotakea Y

BPB Reports 2, 29-34 (2019)

READ MORE

Organic anion transporting polypeptides (OATPs)-mediated drug-drug interaction study between rosuvastatin and cyclosporine A in chimeric mice with humanized liver

Uchida, M. Tajima, Y. Kakuni, M. Kageyama, Y. Okada, T. Sakudara, E. Tateno, C. Hayashi, R.

Drug Metab Dispos. 2018 Jan;46(1):11-19.

READ MORE

Inhibitory effects of drugs on the metabolic activity of mouse and human aldehyde oxidases and influence on drug-drug interactions

Takaoka, N. Sanoh, S. Okuda, K. Kotake, Y. Sugahara, G. Yanagi, A. Ishida, Y. Tateno, C. Tayama, Y. Sugihara, K. Kitamura, S. Kurosaki, M. Terao, M. Garattini, E. Ohta, S.

Biochem Pharmacol. 2018 Aug;154:28-38

READ MORE

FXR Activation by Obeticholic Acid or Non-Steroidal Agonists Induces a Human-Like Lipoprotein Cholesterol Change in Mice with Humanized Chimeric Liver

Papazyan, R. Liu, X. Liu, J. Dong, B. Plummer, E. M. Lewis, R. D., 2nd Roth, J. D. Young, M. A.

J Lipid Res. 2018 Jun;59(6):982-93

READ MORE

Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver

Miyamoto, M. Iwasaki, S.  Chisaki, I. Nakagawa, S. Amano, N. Hirabayashi, H.

Xenobiotica. 2017 Dec;47(12):1052-63

READ MORE

Murine Cyp3a knockout chimeric mice with humanized liver: prediction of the metabolic profile of nefazodone in humans

Nakada, N. Kawamura, A. Kamimura, H. Sato, K. Kazuki, Y. Kakuni, M. Ohbuchi, M. Kato, K. Tateno, C. Oshimura, M. Usui, T.

Biopharm Drug Dispos. 2016 Jan;37(1):3-14

READ MORE

Development of Murine Cyp3a Knockout Chimeric Mice with Humanized Liver

Kato, K. Ohbuchi, M. Hamamura, S. Ohshita, H. Kazuki, Y. Oshimura, M. Sato, K. Nakada, N. Kawamura, A. Usui, T. Kamimura, H. Tateno, C.

Drug Metab Dispos. 2015 Aug;43(8):1208-17

READ MORE

Application of Chimeric Mice with Humanized Liver for Study of Human-Specific Drug Metabolism

Bateman, T. Reddy, V. B. Kakuni, M. Morikawa, Y. Kumar, S.

Drug Metab Dispos. 2014 Jun;42(6):1055-65

READ MORE

Validation of uPA/SCID mouse with humanized liver as a human liver model: protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases by LC-MS/MS

Ohtsuki, S. Kawakami, H. Inoue, T. Nakamura, K. Tateno, C. Katsukura, Y. Obuchi, W. Uchida, Y. Kamiie, J. Horie, T. Terasaki, T.

Drug Metab Dispos June 2014 42:1039-43

READ MORE

Prediction of human metabolism of FK3453 by aldehyde oxidase using chimeric mice transplanted with human or rat hepatocytes

Sanoh, S. Nozaki, K. Murai, H. Terashita, S. Teramura, T. Ohta, S.

Drug Metab Dispos. 2012 Jan;40(1):76-82

READ MORE

Pharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers

Samuelsson, K. Pickup, K. Sarda, S. Swales, J. G. Morikawa, Y. Schulz-Utermoehl, T. Hutchison, M. Wilson, I. D.

Xenobiotica. 2012 Nov;42(11):1128-37

READ MORE

Investigation of drug-drug interactions caused by human pregnane X receptor-mediated induction of CYP3A4 and CYP2C subfamilies in chimeric mice with a humanized liver

Hasegawa, M. Tahara, H. Inoue, R. Kakuni, M. Tateno, C. Ushiki, J.

Drug Metab Dispos. 2012 Mar;40(3):474-80.

READ MORE

Evaluation of a chimeric (uPA+/+)/SCID mouse model with a humanized liver for prediction of human metabolism

De Serres, M. Bowers, G. Boyle, G. Beaumont, C. Castellino, S. Sigafoos, J. Dave, M. Roberts, A. Shah, V. Olson, K. Patel, D. Wagner, D. Yeager, R. Serabjit-Singh, C.

Xenobiotica. 2011 Jun;41(6):464-75

READ MORE

Bezafibrate induces multidrug-resistance P-Glycoprotein 3 expression in cultured human hepatocytes and humanized livers of chimeric mice

Shoda, J. Okada, K. Inada, Y. Kusama, H. Utsunomiya, H. Oda, K. Yokoi, T. Yoshizato, K. Suzuki, H.

Hepatol Res. 2007 Jul;37(7):548-56

READ MORE

Evaluation of mRNA expression of human drug-metabolizing enzymes and transporters in chimeric mouse with humanized liver

Nishimura, M. Yoshitsugu, H. Yokoi, T. Tateno, C. Kataoka, M. Horie, T. Yoshizato, K. Naito, S.

Xenobiotica. 2005 Sep;35(9):877-90

READ MORE

In vivo induction of human cytochrome P450 enzymes expressed in chimeric mice with humanized liver

Katoh, M. Matsui, T. Nakajima, M. Tateno, C. Soeno, Y. Horie, T. Iwasaki, K. Yoshizato, K. Yokoi, T.

Drug Metab Dispos. 2005 Jun;33(6):754-63

READ MORE

Expression of human phase II enzymes in chimeric mice with humanized liver

Katoh, M. Matsui, T. Okumura, H. Nakajima, M. Nishimura, M. Naito, S.Tateno, C. Yoshizato, K. Yokoi, T.

Drug Metab Dispos. 2005 Sep;33(9):1333-40

READ MORE

Near completely humanized liver in mice shows human-type metabolic responses to drugs

Tateno, C. Yoshizane, Y. Saito, N. Kataoka, M. Utoh, R. Yamasaki, C. Tachibana, A. Soeno, Y. Asahina, K. Hino, H. Asahara, T. Yokoi, T. Furukawa, T. Yoshizato, K.

Am J Pathol. 2004 Sep;165(3):901-12.

READ MORE

Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection

Cheng,X. Uchida,T.Xia,Y. Umarova R. Liu,C. J. Chen,P. J.Gaggar,A. Suri,V. Mucke,M. M. Vermehren,J. Zeuzem,S. Teraoka,Y. Osawa,M. Aikata,H. Tsuji,K. Mori,N. Hige,S. Karino,Y. Imamura,M. Chayama,K. Liang,T.J.

J Clin Invest. 2020 Mar 12. pii: 135616. doi: 10.1172/JCI135616.

READ MORE

An Association Between Core Mutations in Hepatitis B Virus Genotype F1b and Hepatocellular Carcinoma in Alaskan Native People

Hayashi, S. Khan, A. Simons, B. C. Homan, C. Matsui, T. Ogawa, K. Kawashima, K. Murakami, S. Takahashi, S. Isogawa, M. Ikeo, K. Mizokami, M. McMahon, B. J. Tanaka, Y.

Hepatology. 2019 Jan;69(1):19-33.

READ MORE

CTL-associated and NK cell-associated immune responses induce different HBV DNA reduction patterns in chronic hepatitis B patients

Nomura, M. Tsuge, M. Uchida, T. Hiraga, N. Kurihara, M. Tsushima, K. Fujino, H. Nakahara, T. Murakami, E. Abe-Chayama, H. Kawaoka, T. Miki, D. Hiramatsu, A. Imamura, M. Kawakami, Y. Aikata, H. Ochi, H. Zhang, Y. Makokha, G. N. Hayes, C. N. Tanaka, S. Chayama, K.

J Viral Hepat. 2018 Jul 11.

READ MORE

ARB-1740, a RNA Interference Therapeutic for Chronic Hepatitis B Infection

Thi, E. P. Dhillon, A. P. Ardzinski, A. Bidirici-Ertekin, L. Cobarrubias, K. D. Cuconati, A. Kondratowicz, A. S. Kwak, K. Li, A. H. L. Miller, A. Pasetka, C. Pei, L.Phelps, J. R. Snead, N. M. Wang, X. Ye, X. Sofia, M. J. Lee, A. C. H.

Gastroenterology. 2018 Feb;154(3):652-662

READ MORE

Efficacy of NVR 3-778, Alone and in Combination With Pegylated Interferon, vs Entecavir in uPA/SCID Mice With Humanized Livers and HBV Infection

Klumpp, K. Shimada, T. Allweiss, L. Volz, T. Lutgehetmann, M. Hartman, G. Flores, O. A. Lam, A. M. Dandri, M.

Gastroenterology. 2018 Feb;154(3):652-662

READ MORE

Acute HBV infection in humanized chimeric mice has multiphasic viral kinetics

Ishida, Y. Chung, T. L. Imamura, M. Hiraga, N. Sen, S. Yokomichi, H. Tateno, C. Canini, L. Perelson, A. S. Uprichard, S. L. Dahari, H. Chayama, K.

Hepatology. 2018 Aug;68(2):473-484

READ MORE

Characterization of HBV integration patterns and timing in liver cancer and HBV-infected livers

Furuta, M. Tanaka, H. Shiraishi, Y. Unida, T. mamura, M. Fujimoto, A. Fujita, M. Sasaki-Oku, A. Maejima, K. Nakano, K. Kawakami, Y. Arihiro, K. Aikata, H. Ueno, M. Hayami, S. Ariizumi, S. I. Yamamoto, M. Gotoh, K. Ohdan, H. Yamaue, H. Miyano, S. Chayama, K. Nakagawa, H.

Oncotarget. 2018 May 18;9(38):25075-25088.

READ MORE

Development of a Novel Site-Specific Pegylated Interferon Beta for Antiviral Therapy of Chronic Hepatitis B Virus

Tsuge, M. Uchida, T. Hiraga, N. Kan, H. Makokha, G. N. Abe-Chayama, H. Miki, D. Imamura, M. Ochi, H. Hayes, C. N. Shimozono, R. Iwamura, T.Narumi, H. Suzuki, T  Kainoh, M. Taniguchi, T. Chayama, K.

Antimicrob Agents Chemother. 2017 May 24;61(6).

READ MORE

The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection

Niu, C. Livingston, C. M. Li, L. Beran, R. K. Daffis, S. Ramakrishnan, D. Burdette, D. Peiser, L. Salas, E. Ramos, H. Yu, M. Cheng, G. Strubin, M. Delaney Iv, W. E. Fletcher, S. P.

PLoS One. 2017 Jan 17;12(1):e0169648

READ MORE

A Novel Orally Available Small Molecule That Inhibits Hepatitis B Virus Expression

Mueller, H. Wildum, S. Luangsay, S. Walther, J. Lopez, A. Tropberger, P. Ottaviani, G. Lu, W. John Parrott, N. Zhang, J. D. Schmucki, R. Racek, T. Hoflack, J. C. Kueng, E. Point, F. Zhou, X. Steiner, G. Lutgehetmann, M. Rapp, G. Volz, T. Dandri, M. Yang, S. Young, J. A. T. Javanbakht, H.

J Hepatol. 2018 Mar;68(3):412-420

READ MORE

Hepatitis B virus evades innate immunity of hepatocytes but activates cytokine production by macrophages

Cheng, X. Xia, Y. Serti, E. Block, P. D. Chung, M. Chayama, K. Rehermann, B. Liang, T. J.

Hepatology. 2017 Dec;66(6):1779-1793

 READ MORE

Antiviral effects of anti-HBs immunoglobulin and vaccine on HBs antigen seroclearance for chronic hepatitis B infection

Tsuge, M. Hiraga, N. Uchida, T. Kan, H. Miyaki, E. Masaki, K. Ono, A. Nakahara, T. Abe-Chayama, H. Zhang, Y. Naswa, M. G. Kawaoka, T. Miki, D. Imamura, M. Kawakami, Y. Aikata, H. Ochi, H. Hayes, C. N. Chayama, K.

J Gastroenterol. 2016 Nov;51(11):1073-1080

READ MORE

Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor

Decorsiere, A. Mueller, H. van Breugel, P. C. Abdul, F. Gerossier, L. Beran, R. K. Livingston, C. M. Niu, C. Fletcher, S. P. Hantz, O. Strubin, M.

Nature. 2016 Mar 17;531(7594):386-9

 READ MORE

Lack of infectivity of HBV in feces from patients with chronic hepatitis B virus infection, and infection using chimeric mice

Komatsu, H. Inui, A. Murano, T. Tsunoda, T. Sogo, T. Fujisawa, T.

BMC Res Notes. 2015 Aug 20;8:366

 READ MORE

HBx protein is indispensable for development of viraemia in human hepatocyte chimeric mice

Tsuge, M. Hiraga, N. Akiyama, R. Tanaka, S. Matsushita, M. Mitsui, F. Abe, H. Kitamura, S. Hatakeyama, T. Kimura, T. Miki, D. Mori, N. Imamura, M. Takahashi, S. Hayes, C. N. Chayama, K.

J Gen Virol. 2010 Jul;91(Pt 7):1854-64.

 READ MORE

Species differences in liver accumulation and metabolism of nucleotide prodrug sofosbuvir

Wang, T. Babusis, D. Park, Y. Niu, C. Kim, C. Zhao, X. Lu, B. Ma, B. Muench, R. C. Sperger, D. Ray, A. S. Murakami, E.

Drug Metab Pharmacokinet. 2020 Jun;35(3):334-340. doi: 10.1016/j.dmpk.2020.04.333. Epub 2020 Apr 16.

 READ MORE

Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of HCV-infected Cells and Liver to Identify Pathways Associated With Disease Development

Lupberger, J. Croonenborghs, T. Roca Suarez, A. A. Van Renne, N. Juhling, F. Oudot, M. A. Virzi, A. Bandiera, S. Jamey, C. Meszaros, G. Brumaru, D. Mukherji, A. Durand, S. C. Heydmann, L. Verrier, E. R. El Saghire, H. Hamdane, N. Bartenschlager, R. Fereshetian, S. Ramberger, E. Sinha, R. Nabian, M. Everaert, C. Jovanovic, M. Mertins, P. Carr, S. A. Chayama, K. Dali-Youcef, N. Ricci, R. Bardeesy, N. M. Fujiwara, N. Gevaert, O. Zeisel, M. B. Hoshida, Y. Pochet, N. Baumert, T. F.

Gastroenterology. 2019 Aug;157(2):537-551.e9.

 READ MORE

HCV-induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response

Hamdane, N. Juhling, F. Crouchet, E. El Saghire, H. Thumann, C. Oudot, M. A. Bandiera, S. Saviano, A. Ponsolles, C. Roca Suarez, A. A. Li, S. Fujiwara, N. Ono, A. Davidson, I. Bardeesy, N. Schmidl, C. Bock, C. Schuster, C. Lupberger, J. Habersetzer, F. Doffoel, M. Piardi, T. Sommacale, D. mamura, M. Uchida, T. Ohdan, H. Aikata, H. Chayama, K. Boldanova, T. Pessaux, P. Fuchs, B. C. Hoshida, Y. Zeisel, M. B. Duong, F. H. T. Baumert, T. F.

Gastroenterology. 2019 Jun;156(8):2313-2329.e7.

READ MORE

Prevalence of NS5A resistance associated variants in NS5A inhibitor treatment failures and an effective treatment for NS5A-P32 deleted hepatitis C virus in humanized mice

Teraoka, Y. Uchida, T. Imamura, M. Osawa, M. Tsuge, M. Abe-Chayama, H. Hayes, C. N. Makokha, G. N. Aikata, H. Miki, D. Ochi, H. Ishida, Y. Tateno, C. Chayama, K.

Biochem Biophys Res Commun. 2018 Jun 2;500(2):152-157.

READ MORE

Usefulness of humanized cDNA-uPA/SCID mice for the study of hepatitis B virus and hepatitis C virus virology

Uchida, T. Imamura, M. Kan, H. Hiraga, N. Hayes, C. N. Tsuge, M. Abe-Chayama, H. Aikata, H. Makokha, G. N. Miki, D. Ochi, H. Ishida, Y. Tateno, C. Chayama, K.

J Gen Virol. 2017 May;98(5):1040-1047

 READ MORE

Interferon alpha treatment stimulates interferon gamma expression in type I NKT cells and enhances their antiviral effect against hepatitis C virus

Miyaki, E. Hiraga, N. Imamura, M. Uchida, T.  Kan, H.  Tsuge, M. Abe-Chayama, H. Hayes, C. N. Makokha, G. N. Serikawa, M. Aikata, H. Ochi, H. Ishida, Y. Tateno, C. Ohdan, H. Chayama, K.

PLoS One. 2017 Mar 2;12(3):e0172412

 READ MORE

Evaluation of antiviral effect of type I, II, and III interferons on direct-acting antiviral-resistant hepatitis C virus

Hamana, A. Takahashi, Y. Uchida, T. Nishikawa, M. Imamura, M. Chayama, K. Takakura, Y.

Antiviral Res.2017 Oct;146:130-138

 READ MORE

Critical role of CREBH-mediated induction of TGF-beta2 by HCV infection in fibrogenic responses in hepatic stellate cells

Chida, T. Ito, M. Nakashima, K. Kanegae, Y. Aoshima, T. Takabayashi, S. Kawata, K. Nakagawa, Y. Yamamoto, M. Shimano, H. Matsuura, T. Kobayashi, Y. Suda, T. Suzuki, T.

Hepatology. 2017 Nov;66(5):1430-1443

 READ MORE

Protease inhibitor resistance remains even after mutant strains become undetectable using deep sequencing

Kan, H. Imamura, M. Uchida, T. Hiraga, N. Hayes, C. N. Tsuge, M. Abe, H. Aikata, H. Makokha, G. N. Chowdhury, S. Miki, D. Ochi, H. Ishida, Y. Tateno, C. Chayama, K.

J Infect Dis. 2016 Dec 1;214(11):1687-1694

 READ MORE

In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus

Watanabe, T. Hatakeyama, H. Matsuda-Yasui, C. Sato, Y. Sudoh, M. Takagi, A. Hirata, Y. Ohtsuki, T. Arai, M. Inoue, K. Harashima, H. Kohara, M.

Sci Rep. 2014 Apr 23;4:4750

 READ MORE

Hepatitis C Virus Core Protein Suppresses Mitophagy by Interacting with Parkin in the Context of Mitochondrial Depolarization

Hara, Y. Yanatori, I. Ikeda, M. Kiyokage, E. Nishina, S. Tomiyama, Y. Toida, K. Kishi, F. Kato, N. Imamura, M. Chayama, K. Hino, K.

Am J Pathol. 2014 Nov;184(11):3026-39

 READ MORE

Hepatitis C virus kinetics by administration of pegylated interferon-alpha in human and chimeric mice carrying human hepatocytes with variants of the IL28B gene

Watanabe, T. Sugauchi, F. Tanaka, Y. Matsuura, K. Yatsuhashi, H. Murakami, S. Iijima, S. Iio, E. Sugiyama, M. Shimada, T. Kakuni, M. Kohara, M. Mizokami, M.

Gut. 2013 Sep;62(9):1340-6

 READ MORE

Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor

Sainz, B., Jr. Barretto, N. Martin, D. N. Hiraga, N. Imamura, M. Hussain, S. Marsh, K. A. Yu, X. Chayama, K. Alrefai, W. A. Uprichard, S. L.

Nat Med. 2012 Jan 8;18(2):281-5

 READ MORE

EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy

Lupberger, J. Zeisel, M. B. Xiao, F. Thumann, C. Fofana, I. Zona, L. Davis, C. Mee, C. J. Turek, M. Gorke, S. Royer, C. Fischer, B. Zahid, M. N. Lavillette, D. Fresquet, J. Cosset, F. L. Rothenberg, S. M. Pietschmann, T. Patel, A. H.Pessaux, P. Doffoel, M. Raffelsberger, W. Poch, O. McKeating, J. A. Brino, L. Baumert, T. F.

Nat Med. 2011 May;17(5):589-95

 READ MORE