2023/04/10

 

2022年1月～2023年3月に公開されました、PXBマウス及びPXB-cells関連の論文に関して、
「50報」の公開がございましたので、ご案内申し上げます（敬称略）。

 

（１）Bristol Myers Squibb
題名：Simultaneous Measurement of Mouse and Human Albumin in Chimeric Mice with Humanized Livers
著者：France Landry et al.
掲載：Bioanalysis. 2022 Mar;14(5):267-278. doi: 10.4155/bio-2021-0250. Epub 2022 Feb 23.
URL：https://pubmed.ncbi.nlm.nih.gov/35195037/

 

（２）熊本大学
題名：Droplet digital PCR assay provides intrahepatic HBV cccDNA quantification tool for clinical application
著者：Sanae Hayashi et al.
掲載：Sci Rep. 2022 Feb 8;12(1):2133. doi: 10.1038/s41598-022-05882-9.
URL：https://www.ncbi.nlm.nih.gov/pubmed/35136096

 

（３）広島大学
題名：HBV upregulates TRAIL-R3 expression in hepatocytes for escaping both cell apoptosis and suppression of

著者：Yosuke Suehiro et al.
掲載：J Infect Dis. 2022 Feb 28. pii: 6534478. doi: 10.1093/infdis/jiac044.
URL：https://www.ncbi.nlm.nih.gov/pubmed/35226068

 

（４）University of Southern California
題名：Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via

著者：Li Y. et al.
掲載：Cell Rep. 2022 Jan 25;38(4):110284. doi: 10.1016/j.celrep.2021.110284.
URL：https://www.ncbi.nlm.nih.gov/pubmed/35081341

 

（５）Gilead Sciences
題名：Ongoing viral replication and production of infectious virus in patients with chronic hepatitis B virus

著者：Dara L Burdette et al.
掲載：PLoS One. 2022 Apr 1;17(4):e0262516. doi: 10.1371/journal.pone.0262516.
URL：https://www.ncbi.nlm.nih.gov/pubmed/35363817

 

（６）University of Southern California
題名：Loss of mitochondrial ATPase ATAD3A contributes to non-alcoholic fatty liver disease through

著者：Liting Chen et al.
掲載：J Biol Chem. 2022 May 2;298(6):102008. doi: 10.1016/j.jbc.2022.102008.
URL：https://www.ncbi.nlm.nih.gov/pubmed/35513069

 

（７）Indiana University School of Medicine
題名：Insights from a high-fat diet fed mouse model with a humanized liver
著者：Romi Saxena et al.
掲載：PLoS One. 2022 May 9;17(5):e0268260. doi: 10.1371/journal.pone.0268260. eCollection 2022.
URL：https://www.ncbi.nlm.nih.gov/pubmed/35533183

 

（8）金沢大学
題名：A single hepatitis B virus genome with a reporter allows the entire viral life cycle to be monitored

著者：Ariunaa Sumiyadorj et al.
掲載：Hepatol Commun. 2022 Jun 12. doi: 10.1002/hep4.2018.
URL：https://pubmed.ncbi.nlm.nih.gov/35691027/

 

（9）国立感染症研究所
題名：The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization

著者：Sameh A Gad et al.
掲載：PLoS Pathog. 2022 Mar 21;18(3):e1009983. doi: 10.1371/journal.ppat.1009983. eCollection 2022 Mar.
URL：https://pubmed.ncbi.nlm.nih.gov/35312737/

 

（10）Gilead Sciences
題名：IL-31 Levels Correlate with Pruritus in Patients with Cholestatic and Metabolic Liver Diseases and is FXR

著者：Jun Xu et al.
掲載：Hepatology. 2022 Jun 10. doi: 10.1002/hep.32599.
URL：https://pubmed.ncbi.nlm.nih.gov/35686937/

 

（11）広島大学
題名：Assessment of metabolic activation of felbamate in chimeric mice with humanized liver in combination with

著者：Koya Sato et al.
掲載：J Toxicol Sci. 2022;47(7):277-288. doi: 10.2131/jts.47.277.
URL：https://pubmed.ncbi.nlm.nih.gov/35786679/

 

（12）東邦大学
題名：Signature of chronic hepatitis B virus infection in nails and hair
著者：Haruki Komatsu et al.
掲載：BMC Infect Dis. 2022 May 4;22(1):431. doi: 10.1186/s12879-022-07400-8.
URL：https://pubmed.ncbi.nlm.nih.gov/35509029/

 

（13）Anti-Doping Laboratory Qatar
題名：Downregulation of CYP17A1 by 20-hydroxyecdysone: plasma progesterone and its vasodilatory properties
著者：Maneera Y Aljaber et al.
掲載：Future Sci OA. 2022 Jul 7;8(6):FSO805. doi: 10.2144/fsoa-2022-0006. eCollection 2022 Jul.
URL：https://pubmed.ncbi.nlm.nih.gov/35909994/

 

（14）Gilead Sciences
題名：Targeting lipid biosynthesis pathways for hepatitis B virus cure
著者：Anastasia Hyrina et al.
掲載：PLoS One. 2022 Aug 4;17(8):e0270273. doi: 10.1371/journal.pone.0270273. eCollection 2022.
URL：https://pubmed.ncbi.nlm.nih.gov/35925919/

 

（15）新潟大学
題名：Letrozole ameliorates liver fibrosis through the inhibition of the CTGF pathway and 17β-hydroxysteroid

著者：Norihiro Sakai et al.
掲載：J Gastroenterol. 2022 Oct 27. doi: 10.1007/s00535-022-01929-w.
URL：https://pubmed.ncbi.nlm.nih.gov/36301364/

 

（16）金沢大学
題名：Hepatitis B virus utilizes a retrograde trafficking route via the trans-Golgi network to avoid lysosomal degradation
著者：Ying-Yi Li et al.
掲載：Cell Mol Gastroenterol Hepatol. 2022 Oct 19. pii: S2352-345X(22)00219-3. doi: 10.1016/j.jcmgh.2022.10.008.
URL：https://www.ncbi.nlm.nih.gov/pubmed/36270602

 

（17）北海道大学
題名：Involvement of SLC16A1/MCT1 and SLC16A3/MCT4 in l-lactate transport in the hepatocellular carcinoma cell line
著者：Yuto Mukai et al.
掲載：Biopharm Drug Dispos. 2022 Oct;43(5):183-191. doi: 10.1002/bdd.2329. Epub 2022 Sep 22.
URL：https://pubmed.ncbi.nlm.nih.gov/36104287/

 

（18）国立感染症研究所
題名：Fungal Secondary Metabolite Exophillic Acid Selectively Inhibits the Entry of Hepatitis B and D Viruses
著者：Chisa Kobayashi et al.
掲載：Viruses. 2022 Apr 6;14(4). pii: v14040764. doi: 10.339/v14040764.
URL：https://www.ncbi.nlm.nih.gov/pubmed/35458494

 

（19）住友化学
題名：Evaluation of the mode of action and human relevance of liver tumors in male mice treated with epyrifenacil
著者：Satoki Fukunaga et al.
掲載：Regul Toxicol Pharmacol. 2022 Oct 6;136:105268. doi: 10.1016/j.yrtph.2022.105268.
URL：https://www.ncbi.nlm.nih.gov/pubmed/36210011

 

（20）金沢大学
題名：Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment

著者：Katsuya Sakai et al.
掲載：Nat Biomed Eng. 2022 Nov 7. doi: 10.1038/s41551-022-00955-6.
URL：https://pubmed.ncbi.nlm.nih.gov/36344661/

 

（21）第一三共
題名：Physiologically based pharmacokinetic modeling for quantitative prediction of exposure to a human

著者：Daigo Asano et al.
掲載：Drug Metab Dispos. 2023 Jan;51(1):67-80. doi: 10.1124/dmd.122.001000. Epub 2022 Oct 23.
URL：https://www.ncbi.nlm.nih.gov/pubmed/36273823

 

（22）名古屋市立大学
題名：Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA2
著者：Anna Nakanishi et al.
掲載：Viruses. 2022 Nov 8;14(11):2468. doi: 10.3390/v14112468.
URL：https://pubmed.ncbi.nlm.nih.gov/36366568/

 

（23）Gilead Sciences
題名：Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus
著者：Sarah A Gilmore et al.
掲載：PLoS One. 2022 Dec 7;17(12):e0271145. doi: 10.1371/journal.pone.0271145. eCollection 2022.
URL：https://pubmed.ncbi.nlm.nih.gov/36477212/

 

（24）香川大学
題名：Pegylated interferon therapy-related microRNA-6126 downregulates sodium taurocholate cotransporting

著者：Koji Fujita et al.
掲載：Gene. 2022 Nov 24;853:147068. doi: 10.1016/j.gene.2022.147068.
URL：https://pubmed.ncbi.nlm.nih.gov/36427676/

 

（25）Inotiv
題名：Characterization and Prevention of Hypovitaminosis C in Chimeric Mice with Humanized Livers
著者：Erin K Touchette et al.
掲載：Comparative Medicine 2022, 72(6): 355-363.
URL：https://www.ncbi.nlm.nih.gov/pubmed/36744513

 

（26）KMT Hepatech
題名：Freshly Isolated Hepatocytes from Chimeric Humanized Liver Mice for the In Vitro Assessment of Drug Metabolism,

著者：Masakazu Kakuni
掲載：Curr Protoc. 2022 May;2(5):e429. doi: 10.1002/cpz1.429.
URL：https://pubmed.ncbi.nlm.nih.gov/35598301/

 

（27）Massachusetts Institute of Technology
題名：Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-

著者：Matthew T N Yarnall et al.
掲載：Nat Biotechnol. 2022 Nov 24. doi: 10.1038/s41587-022-01527-4.
URL：https://www.ncbi.nlm.nih.gov/pubmed/36424489

 

（28）住友化学
題名：Prediction of the human pharmacokinetics of epyrifenacil and its major metabolite, S-3100-CA, by a physiologically

著者：Kota Hirasawa et al.
掲載：Toxicol Appl Pharmacol. 2022 Mar 15;439:115912. doi: 10.1016/j.taap.2022.115912.
URL：https://pubmed.ncbi.nlm.nih.gov/35143805/

 

（29）東レ
題名：Patient-derived monoclonal antibody neutralizes HCV infection in vitro and vivo without generating escape mutants
著者：Hiroshi Yokokawa et al.
掲載：PLoS One. 2022 Sep 22;17(9):e0274283. doi: 10.1371/journal.pone.0274283. eCollection 2022.
URL：https://www.ncbi.nlm.nih.gov/pubmed/36137152

 

（30）藤田医科大学
題名：N6-methyladenosine Modification of Hepatitis B Virus RNA in the Coding Region of HBx
著者：Takayuki Murata et al.
掲載：Int J Mol Sci. 2023 Jan 23;24(3):2265. doi: 10.3390/ijms24032265.
URL：https://pubmed.ncbi.nlm.nih.gov/36768585/

 

（31）千葉大学
題名：Antiviral Compounds Screening Targeting HBx Protein of the Hepatitis B Virus
著者：Yaojia Ma et al.
掲載：Int J Mol Sci. 2022 Oct 10;23(19):12015. doi: 10.3390/ijms231912015.
URL：https://pubmed.ncbi.nlm.nih.gov/36233317/

 

（32）理化学研究所
題名：Establishment of a Monoclonal Antibody against Human NTCP That Blocks Hepatitis B Virus Infection
著者：Toshitada Takemori et al.
掲載：J Virol. 2022 Mar 9;96(5):e0168621. doi: 10.1128/JVI.01686-21. Epub 2022 Jan 5.
URL：https://pubmed.ncbi.nlm.nih.gov/34985994/

 

（33）ピューロテックバイオ
題名：Guanine nucleotide exchange factor DOCK11-binding peptide fused with a single chain antibody inhibits hepatitis B

著者：Mayuko Ide et al.
掲載：J Biol Chem. 2022 Jul;298(7):102097. doi: 10.1016/j.jbc.2022.102097. Epub 2022 Jun 2.
URL：https://pubmed.ncbi.nlm.nih.gov/35660020/

 

（34）University of Southern California
題名：Autophagic membranes participate in hepatitis B virus nucleocapsid assembly, precore and core protein trafficking,

著者：Ja Yeon Kim Chu et al.
掲載：Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2201927119. doi: 10.1073/pnas.2201927119. Epub 2022 Jul 18.
URL：https://pubmed.ncbi.nlm.nih.gov/35858426/

 

（35）University of Pittsburgh School of Medicine
題名：Hepatitis B virus X protein counteracts high mobility group box 1 protein-mediated epigenetic silencing of covalently

著者：Elena S Kim et al.
掲載：PLoS Pathog. 2022 Jun 9;18(6):e1010576. doi: 10.1371/journal.ppat.1010576.
URL：https://www.ncbi.nlm.nih.gov/pubmed/35679251

 

（36）鹿児島大学
題名：Novel Neplanocin A Derivatives as Selective Inhibitors of Hepatitis B Virus with a Unique Mechanism of Action
著者：Masaaki Toyama et al.
掲載：Antimicrob Agents Chemother. 2022 Jun 21;66(6):e0207321. doi: 10.1128/aac.02073-21. Epub 2022 May 23.
URL：https://pubmed.ncbi.nlm.nih.gov/35604213/

 

（37）自治医科大学
題名：Development of Recombinant Infectious Hepatitis E Virus Harboring the nanoKAZ Gene and Its Application in Drug

著者：Putu Prathiwi Primadharsini et al.
掲載：J Virol. 2022 Mar 23;96(6):e0190621. doi: 10.1128/jvi.01906-21. Epub 2022 Feb 2.
URL：https://www.ncbi.nlm.nih.gov/pubmed/35107380

 

（38）Medical College of Wisconsin
題名：The Synthesis and Anti-Cytomegalovirus Activity of Piperidine-4-Carboxamides
著者：Xin Guo et al.
掲載：Viruses. 2022 Jan 25;14(2):234. doi: 10.3390/v14020234.
URL：https://pubmed.ncbi.nlm.nih.gov/35215828/

 

（39）LogicBio Therapeutics
題名：Novel AAV-mediated genome editing therapy improves health and survival in a mouse model of methylmalonic

著者：Shengwen Zhang et al.
掲載：PLoS One. 2022 Sep 20;17(9):e0274774. doi: 10.1371/journal.pone.0274774.
URL：https://www.ncbi.nlm.nih.gov/pubmed/36126056

 

（40）Shaanix University of Science and Technology
題名：The Gut-Organ-Axis Concept: Advances the Application of Gut-on-Chip Technology
著者：Yuxi Guo et al.
掲載：Int J Mol Sci. 2023 Feb 17;24(4):4089. doi: 10.3390/ijms24044089.
URL：hhttps://pubmed.ncbi.nlm.nih.gov/36835499/

 

（41）University of Miami Miller School of Medicine
題名：Downregulation of SOCS1 increases interferon-induced ISGylation during differentiation of induced-pluripotent

著者：Jasmine S Edwards et al.
掲載：JHEP Rep. 2022 Sep 23;4(12):100592. doi: 10.1016/j.jhepr.2022.100592. eCollection 2022 Dec.
URL：https://www.ncbi.nlm.nih.gov/pubmed/36439639

 

（42）広島大学
題名：A novel cDNA-uPA/SCID/Rag2(-/-) /Jak3(-/-) mouse model for hepatitis virus infection and reconstruction of human

著者：Takuro Uchida et al.
掲載：J Viral Hepat. 2022 Dec 27. doi: 10.1111/jvh.13793.
URL：https://www.ncbi.nlm.nih.gov/pubmed/36575861

 

（43）University of Southern California
題名：Long-term cell fate and functional maintenance of human hepatocyte through stepwise culture configuration
著者：Go Sugahara et al.
掲載：FASEB J. 2023 Feb;37(2):e22750. doi: 10.1096/fj.202201292RR.
URL：https://pubmed.ncbi.nlm.nih.gov/36607308/

 

（44）国立医薬品食品衛生研究所/崇城大学
題名：Consideration of Commercially Available Hepatocytes as Cell Sources for Liver-Microphysiological Systems by

著者：Shinichiro Horiuchi et al.
掲載：Pharmaceutics. 2022 Dec 24;15(1):55. doi: 10.3390/pharmaceutics15010055.
URL：https://pubmed.ncbi.nlm.nih.gov/36678684/

 

（45）Roche
題名：Discovery of a first-in-class orally available HBV cccDNA inhibitor
著者：Li Wang et al.
掲載：J Hepatol. 2022 Dec 29:S0168-8278(22)03466-3. doi: 10.1016/j.jhep.2022.12.014.
URL：https://www.ncbi.nlm.nih.gov/pubmed/36587899

 

（46）広島大学
題名：Establishment of hyperoxic cell culture system for predicting drug-induced liver injury: reducing accumulated lipids

著者：Yuya Ohtsuki et al.
掲載：J Toxicol Sci. 2023;48(2):99-108. doi: 10.2131/jts.48.99.
URL：https://www.ncbi.nlm.nih.gov/pubmed/36725025/

 

（47）国立国際医療研究センター
題名：Identification of SARS-CoV-2 M(pro) inhibitors containing P1′ 4-fluorobenzothiazole moiety highly active

著者：Nobuyo Higashi-Kuwata et al.
掲載：Nat Commun. 2023 Feb 25;14(1):1076. doi: 10.1038/s41467-023-36729-0.
URL：https://www.ncbi.nlm.nih.gov/pubmed/36841831

 

（48）広島大学
題名：HBV with precore and basal core promoter mutations exhibits a high replication phenotype and causes ER stress-

著者：Takuro Uchida et al.
掲載：Hepatology. 2023 Mar 13. doi: 10.1097/HEP.0000000000000335.
URL：https://www.ncbi.nlm.nih.gov/pubmed/36896966

 

（49）国立国際医療研究センター
題名：A Novel Anti-HBV Agent, E-CFCP, restores Hepatitis B virus (HBV)-induced Senescence-associated Cellular Markers

著者：Yuki Takamatsu et al.
掲載：Virus Res. 2023 Mar 23;329:199094. doi: 10.1016/j.virusres.2023.199094.
URL：https://pubmed.ncbi.nlm.nih.gov/36933835/

 

（50）住友化学
題名：Novel approach for verification of a human PBPK modeling strategy using chimeric mice in the health risk

著者：Kota Hirasawa et al.
掲載：Toxicol Appl Pharmacol. 2023 Apr 15;465:116439. doi: 10.1016/j.taap.2023.116439. Epub 2023 Feb 27.
URL：https://www.ncbi.nlm.nih.gov/pubmed/36858113