Phoenix Bio








(1)Bristol Myers Squibb
題名:Simultaneous Measurement of Mouse and Human Albumin in Chimeric Mice with Humanized Livers
著者:France Landry et al.
掲載:Bioanalysis. 2022 Mar;14(5):267-278. doi: 10.4155/bio-2021-0250. Epub 2022 Feb 23.


題名:Droplet digital PCR assay provides intrahepatic HBV cccDNA quantification tool for clinical application
著者:Sanae Hayashi et al.
掲載:Sci Rep. 2022 Feb 8;12(1):2133. doi: 10.1038/s41598-022-05882-9.


題名:HBV upregulates TRAIL-R3 expression in hepatocytes for escaping both cell apoptosis and suppression of

their replication by TRAIL

著者:Yosuke Suehiro et al.
掲載:J Infect Dis. 2022 Feb 28. pii: 6534478. doi: 10.1093/infdis/jiac044.


(4)University of Southern California
題名:Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via

IL-1beta to downregulate PPARalpha and FOXO3

著者:Li Y. et al.
掲載:Cell Rep. 2022 Jan 25;38(4):110284. doi: 10.1016/j.celrep.2021.110284.


(5)Gilead Sciences
題名:Ongoing viral replication and production of infectious virus in patients with chronic hepatitis B virus

suppressed below the limit of quantitation on long-term nucleos(t)ide therapy

著者:Dara L Burdette et al.
掲載:PLoS One. 2022 Apr 1;17(4):e0262516. doi: 10.1371/journal.pone.0262516.


(6)University of Southern California
題名:Loss of mitochondrial ATPase ATAD3A contributes to non-alcoholic fatty liver disease through

accumulation of lipids and damaged mitochondria

著者:Liting Chen et al.
掲載:J Biol Chem. 2022 May 2;298(6):102008. doi: 10.1016/j.jbc.2022.102008.


(7)Indiana University School of Medicine
題名:Insights from a high-fat diet fed mouse model with a humanized liver
著者:Romi Saxena et al.
掲載:PLoS One. 2022 May 9;17(5):e0268260. doi: 10.1371/journal.pone.0268260. eCollection 2022.


題名:A single hepatitis B virus genome with a reporter allows the entire viral life cycle to be monitored

in primary human hepatocytes

著者:Ariunaa Sumiyadorj et al.
掲載:Hepatol Commun. 2022 Jun 12. doi: 10.1002/hep4.2018.


題名:The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization

and can be targeted by RXR agonists in vitro

著者:Sameh A Gad et al.
掲載:PLoS Pathog. 2022 Mar 21;18(3):e1009983. doi: 10.1371/journal.ppat.1009983. eCollection 2022 Mar.


(10)Gilead Sciences
題名:IL-31 Levels Correlate with Pruritus in Patients with Cholestatic and Metabolic Liver Diseases and is FXR

Responsive in NASH

著者:Jun Xu et al.
掲載:Hepatology. 2022 Jun 10. doi: 10.1002/hep.32599.


題名:Assessment of metabolic activation of felbamate in chimeric mice with humanized liver in combination with

in vitro metabolic assays

著者:Koya Sato et al.
掲載:J Toxicol Sci. 2022;47(7):277-288. doi: 10.2131/jts.47.277.


題名:Signature of chronic hepatitis B virus infection in nails and hair
著者:Haruki Komatsu et al.
掲載:BMC Infect Dis. 2022 May 4;22(1):431. doi: 10.1186/s12879-022-07400-8.


(13)Anti-Doping Laboratory Qatar
題名:Downregulation of CYP17A1 by 20-hydroxyecdysone: plasma progesterone and its vasodilatory properties
著者:Maneera Y Aljaber et al.
掲載:Future Sci OA. 2022 Jul 7;8(6):FSO805. doi: 10.2144/fsoa-2022-0006. eCollection 2022 Jul.


(14)Gilead Sciences
題名:Targeting lipid biosynthesis pathways for hepatitis B virus cure
著者:Anastasia Hyrina et al.
掲載:PLoS One. 2022 Aug 4;17(8):e0270273. doi: 10.1371/journal.pone.0270273. eCollection 2022.


題名:Letrozole ameliorates liver fibrosis through the inhibition of the CTGF pathway and 17β-hydroxysteroid

dehydrogenase 13 expression

著者:Norihiro Sakai et al.
掲載:J Gastroenterol. 2022 Oct 27. doi: 10.1007/s00535-022-01929-w.


題名:Hepatitis B virus utilizes a retrograde trafficking route via the trans-Golgi network to avoid lysosomal degradation
著者:Ying-Yi Li et al.
掲載:Cell Mol Gastroenterol Hepatol. 2022 Oct 19. pii: S2352-345X(22)00219-3. doi: 10.1016/j.jcmgh.2022.10.008.


題名:Involvement of SLC16A1/MCT1 and SLC16A3/MCT4 in l-lactate transport in the hepatocellular carcinoma cell line
著者:Yuto Mukai et al.
掲載:Biopharm Drug Dispos. 2022 Oct;43(5):183-191. doi: 10.1002/bdd.2329. Epub 2022 Sep 22.


題名:Fungal Secondary Metabolite Exophillic Acid Selectively Inhibits the Entry of Hepatitis B and D Viruses
著者:Chisa Kobayashi et al.
掲載:Viruses. 2022 Apr 6;14(4). pii: v14040764. doi: 10.339/v14040764.


題名:Evaluation of the mode of action and human relevance of liver tumors in male mice treated with epyrifenacil
著者:Satoki Fukunaga et al.
掲載:Regul Toxicol Pharmacol. 2022 Oct 6;136:105268. doi: 10.1016/j.yrtph.2022.105268.


題名:Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment

crystallizable regions

著者:Katsuya Sakai et al.
掲載:Nat Biomed Eng. 2022 Nov 7. doi: 10.1038/s41551-022-00955-6.


題名:Physiologically based pharmacokinetic modeling for quantitative prediction of exposure to a human

disproportionate metabolite of the selective Na(v)1.7 inhibitor DS-1971a, a mixed substrate of cytochrome

P450 and aldehyde oxidase, using chimeric mice with humanized liver

著者:Daigo Asano et al.
掲載:Drug Metab Dispos. 2023 Jan;51(1):67-80. doi: 10.1124/dmd.122.001000. Epub 2022 Oct 23.


題名:Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA2
著者:Anna Nakanishi et al.
掲載:Viruses. 2022 Nov 8;14(11):2468. doi: 10.3390/v14112468.


(23)Gilead Sciences
題名:Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus
著者:Sarah A Gilmore et al.
掲載:PLoS One. 2022 Dec 7;17(12):e0271145. doi: 10.1371/journal.pone.0271145. eCollection 2022.


題名:Pegylated interferon therapy-related microRNA-6126 downregulates sodium taurocholate cotransporting

polypeptide expression in hepatocytes

著者:Koji Fujita et al.
掲載:Gene. 2022 Nov 24;853:147068. doi: 10.1016/j.gene.2022.147068.


題名:Characterization and Prevention of Hypovitaminosis C in Chimeric Mice with Humanized Livers
著者:Erin K Touchette et al.
掲載:Comparative Medicine 2022, 72(6): 355-363.


(26)KMT Hepatech
題名:Freshly Isolated Hepatocytes from Chimeric Humanized Liver Mice for the In Vitro Assessment of Drug Metabolism,

Inhibition/Induction, and Safety Studies

著者:Masakazu Kakuni
掲載:Curr Protoc. 2022 May;2(5):e429. doi: 10.1002/cpz1.429.


(27)Massachusetts Institute of Technology
題名:Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-

directed integrases

著者:Matthew T N Yarnall et al.
掲載:Nat Biotechnol. 2022 Nov 24. doi: 10.1038/s41587-022-01527-4.


題名:Prediction of the human pharmacokinetics of epyrifenacil and its major metabolite, S-3100-CA, by a physiologically

based pharmacokinetic modeling using chimeric mice with humanized liver

著者:Kota Hirasawa et al.
掲載:Toxicol Appl Pharmacol. 2022 Mar 15;439:115912. doi: 10.1016/j.taap.2022.115912.


題名:Patient-derived monoclonal antibody neutralizes HCV infection in vitro and vivo without generating escape mutants
著者:Hiroshi Yokokawa et al.
掲載:PLoS One. 2022 Sep 22;17(9):e0274283. doi: 10.1371/journal.pone.0274283. eCollection 2022.


題名:N6-methyladenosine Modification of Hepatitis B Virus RNA in the Coding Region of HBx
著者:Takayuki Murata et al.
掲載:Int J Mol Sci. 2023 Jan 23;24(3):2265. doi: 10.3390/ijms24032265.


題名:Antiviral Compounds Screening Targeting HBx Protein of the Hepatitis B Virus
著者:Yaojia Ma et al.
掲載:Int J Mol Sci. 2022 Oct 10;23(19):12015. doi: 10.3390/ijms231912015.


題名:Establishment of a Monoclonal Antibody against Human NTCP That Blocks Hepatitis B Virus Infection
著者:Toshitada Takemori et al.
掲載:J Virol. 2022 Mar 9;96(5):e0168621. doi: 10.1128/JVI.01686-21. Epub 2022 Jan 5.


題名:Guanine nucleotide exchange factor DOCK11-binding peptide fused with a single chain antibody inhibits hepatitis B

virus infection and replication

著者:Mayuko Ide et al.
掲載:J Biol Chem. 2022 Jul;298(7):102097. doi: 10.1016/j.jbc.2022.102097. Epub 2022 Jun 2.


(34)University of Southern California
題名:Autophagic membranes participate in hepatitis B virus nucleocapsid assembly, precore and core protein trafficking,

and viral release

著者:Ja Yeon Kim Chu et al.
掲載:Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2201927119. doi: 10.1073/pnas.2201927119. Epub 2022 Jul 18.


(35)University of Pittsburgh School of Medicine
題名:Hepatitis B virus X protein counteracts high mobility group box 1 protein-mediated epigenetic silencing of covalently

closed circular DNA

著者:Elena S Kim et al.
掲載:PLoS Pathog. 2022 Jun 9;18(6):e1010576. doi: 10.1371/journal.ppat.1010576.


題名:Novel Neplanocin A Derivatives as Selective Inhibitors of Hepatitis B Virus with a Unique Mechanism of Action
著者:Masaaki Toyama et al.
掲載:Antimicrob Agents Chemother. 2022 Jun 21;66(6):e0207321. doi: 10.1128/aac.02073-21. Epub 2022 May 23.


題名:Development of Recombinant Infectious Hepatitis E Virus Harboring the nanoKAZ Gene and Its Application in Drug


著者:Putu Prathiwi Primadharsini et al.
掲載:J Virol. 2022 Mar 23;96(6):e0190621. doi: 10.1128/jvi.01906-21. Epub 2022 Feb 2.


(38)Medical College of Wisconsin
題名:The Synthesis and Anti-Cytomegalovirus Activity of Piperidine-4-Carboxamides
著者:Xin Guo et al.
掲載:Viruses. 2022 Jan 25;14(2):234. doi: 10.3390/v14020234.


(39)LogicBio Therapeutics
題名:Novel AAV-mediated genome editing therapy improves health and survival in a mouse model of methylmalonic


著者:Shengwen Zhang et al.
掲載:PLoS One. 2022 Sep 20;17(9):e0274774. doi: 10.1371/journal.pone.0274774.


(40)Shaanix University of Science and Technology
題名:The Gut-Organ-Axis Concept: Advances the Application of Gut-on-Chip Technology
著者:Yuxi Guo et al.
掲載:Int J Mol Sci. 2023 Feb 17;24(4):4089. doi: 10.3390/ijms24044089.


(41)University of Miami Miller School of Medicine
題名:Downregulation of SOCS1 increases interferon-induced ISGylation during differentiation of induced-pluripotent

stem cells to hepatocytes

著者:Jasmine S Edwards et al.
掲載:JHEP Rep. 2022 Sep 23;4(12):100592. doi: 10.1016/j.jhepr.2022.100592. eCollection 2022 Dec.


題名:A novel cDNA-uPA/SCID/Rag2(-/-) /Jak3(-/-) mouse model for hepatitis virus infection and reconstruction of human

immune system

著者:Takuro Uchida et al.
掲載:J Viral Hepat. 2022 Dec 27. doi: 10.1111/jvh.13793.


(43)University of Southern California
題名:Long-term cell fate and functional maintenance of human hepatocyte through stepwise culture configuration
著者:Go Sugahara et al.
掲載:FASEB J. 2023 Feb;37(2):e22750. doi: 10.1096/fj.202201292RR.


題名:Consideration of Commercially Available Hepatocytes as Cell Sources for Liver-Microphysiological Systems by

Comparing Liver Characteristics

著者:Shinichiro Horiuchi et al.
掲載:Pharmaceutics. 2022 Dec 24;15(1):55. doi: 10.3390/pharmaceutics15010055.


題名:Discovery of a first-in-class orally available HBV cccDNA inhibitor
著者:Li Wang et al.
掲載:J Hepatol. 2022 Dec 29:S0168-8278(22)03466-3. doi: 10.1016/j.jhep.2022.12.014.


題名:Establishment of hyperoxic cell culture system for predicting drug-induced liver injury: reducing accumulated lipids

in hepatocytes derived from chimeric mice with humanized liver

著者:Yuya Ohtsuki et al.
掲載:J Toxicol Sci. 2023;48(2):99-108. doi: 10.2131/jts.48.99.


題名:Identification of SARS-CoV-2 M(pro) inhibitors containing P1′ 4-fluorobenzothiazole moiety highly active

against SARS-CoV-2

著者:Nobuyo Higashi-Kuwata et al.
掲載:Nat Commun. 2023 Feb 25;14(1):1076. doi: 10.1038/s41467-023-36729-0.


題名:HBV with precore and basal core promoter mutations exhibits a high replication phenotype and causes ER stress-

mediated cell death in humanized liver chimeric mice

著者:Takuro Uchida et al.
掲載:Hepatology. 2023 Mar 13. doi: 10.1097/HEP.0000000000000335.


題名:A Novel Anti-HBV Agent, E-CFCP, restores Hepatitis B virus (HBV)-induced Senescence-associated Cellular Markers

Perturbation in Human Hepatocytes

著者:Yuki Takamatsu et al.
掲載:Virus Res. 2023 Mar 23;329:199094. doi: 10.1016/j.virusres.2023.199094.


題名:Novel approach for verification of a human PBPK modeling strategy using chimeric mice in the health risk

assessment of epyrifenacil

著者:Kota Hirasawa et al.
掲載:Toxicol Appl Pharmacol. 2023 Apr 15;465:116439. doi: 10.1016/j.taap.2023.116439. Epub 2023 Feb 27.