2021/7/21

2021年4月～6月に公開されました、PXBマウス及びPXB-cells関連の論文に関して、
「12報」の公開がございましたので、ご案内申し上げます。

 

(１)自治医科大学

Key Word：PXB-cells、AAV

演題：Engineered adeno-associated virus 3 vector with reduced reactivity to serum antibodies

演者：Dr. Mika Ito et al.

掲載：Sci Rep. 2021 Apr 29;11(1):9322. doi: 10.1038/s41598-021-88614-9.

URL: https://www.ncbi.nlm.nih.gov/pubmed/33927271

 

(２)Université du Québec/広島大学

Key Word：PXBマウス、HBV

演題：Understanding hepatitis B virus dynamics and the antiviral effect of interferon-alpha treatment in

演者：Dr. Vladimir Reinharz et al.

掲載：J Virol. 2021 Apr 28. pii: JVI.00492-20. doi: 10.1128/JVI.00492-20.

URL: https://www.ncbi.nlm.nih.gov/pubmed/33910953

 

(３) 名古屋市立大学

Key Word：PXBマウス、HBV

演題：Interferon signaling suppresses the unfolded protein response and induces cell death in hepatocytes

演者：Dr. Ian Baudi et al.

掲載：PLoS Pathog. 2021 May 12;17(5):e1009228. doi: 10.1371/journal.ppat.1009228.

URL: https://www.ncbi.nlm.nih.gov/pubmed/33979382

 

(４) University of Louisville School of Medicine

Key Word：PXBマウス、HBV

演題：Safety and Efficacy of Avaren-Fc Lectibody Targeting HCV High-Mannose Glycans in a Human Liver

演者：Dr. Matthew Dent et al.

掲載：Cell Mol Gastroenterol Hepatol. 2021;11(1):185-198. doi: 10.1016/j.jcmgh.2020.08.009. Epub 2020 Aug 27.

URL: https://pubmed.ncbi.nlm.nih.gov/32861832/

 

(５) 武田薬品工業株式会社

Key Word：PXB-cells、Reactive Metabolite

演題：Cell-based high-throughput screening for the evaluation of reactive metabolite formation potential

演者：Dr. Kosuke Harada et al.

掲載：Toxicol In Vitro. 2021 Aug;74:105159. doi: 10.1016/j.tiv.2021.105159. Epub 2021 Apr 3.

URL: https://pubmed.ncbi.nlm.nih.gov/33823239/

 

(６) 長崎大学

Key Word：PXB-cells、HBV

演題：Geranylgeranylacetone decreases the production of hepatitis B virus-related antigen by comprehensive

演者：Dr. Masafumi Haraguchi et al.

掲載：J Gastroenterol Hepatol. 2021 Jan 4. doi: 10.1111/jgh.15394.

URL: https://www.ncbi.nlm.nih.gov/pubmed/33393671

 

(７) 東京大学

Key Word：PXB-cells、MPS

演題：Coculture with hiPS-derived intestinal cells enhanced human hepatocyte functions in a pneumatic-pressure-driven

演者：Dr. Marie Shinohara et al.

掲載：Sci Rep. 2021 Mar 8;11(1):5437. doi: 10.1038/s41598-021-84861-y

URL: https://www.ncbi.nlm.nih.gov/pubmed/33686099

 

(８) 田辺三菱製薬株式会社

Key Word：PXBマウス、ヒトPK予測

演題：Prediction of human pharmacokinetics for low-clearance compounds using pharmacokinetic data from chimeric mice

演者：Dr. Kousuke Yoshida et al.

掲載：Clin Transl Sci. 2021 Jun 3. doi: 10.1111/cts.13070.

URL: https://pubmed.ncbi.nlm.nih.gov/34080287/

 

(９) 広島大学

Key Word：PXBマウス、HCV

演題：Novel drug resistance-associated substitutions against pibrentasvir emerged in genotype 1b hepatitis C virus-

演者：Dr. Kazuki Ohya et al.

掲載：Biochem Biophys Res Commun. 2021 Jun 25;559:78-83. doi: 10.1016/j.bbrc.2021.04.062. Epub 2021 Apr 29.

URL: https://pubmed.ncbi.nlm.nih.gov/33932902/

 

(10) University of Southern California

Key Word：PXBマウス、Steatosis

演題：Loss of lysophosphatidic acid receptor 1 in hepatocytes reduces steatosis via down-regulation of CD36

演者：Dr. Ingrid Lua et al.

掲載：Prostaglandins Other Lipid Mediat. 2021 Jun 17:106577. doi: 10.1016/j.prostaglandins.2021.106577.

URL: https://pubmed.ncbi.nlm.nih.gov/34147666/

 

(11) University of Southern California

Key Word：PXBマウス、NASH

演題：Cholesterol-binding translocator protein TSPO regulates steatosis and bile acid synthesis in nonalcoholic

演者：Dr. Yuchang Li et al.

掲載：iScience. 2021 May 1;24(5):102457. doi: 10.1016/j.isci.2021.102457.

URL: https://www.ncbi.nlm.nih.gov/pubmed/34013171

 

(12) 国立感染症研究所

Key Word：PXBマウス、HBV

演題：MafF is an antiviral host factor that suppresses transcription from Hepatitis B Virus core promoter

演者：Dr. Marwa K Iburahim Li et al.

掲載：J Virol. 2021 Jul 12;95(15):　e0076721. doi: 10.1128/JVI.00767-21. Epub 2021 Jul 12.

URL: https://pubmed.ncbi.nlm.nih.gov/33980595/