2021/7/21
2021年4月~6月に公開されました、PXBマウス及びPXB-cells関連の論文に関して、
「12報」の公開がございましたので、ご案内申し上げます。
(1)自治医科大学
Key Word:PXB-cells、AAV
演題:Engineered adeno-associated virus 3 vector with reduced reactivity to serum antibodies
演者:Dr. Mika Ito et al.
掲載:Sci Rep. 2021 Apr 29;11(1):9322. doi: 10.1038/s41598-021-88614-9.
URL: https://www.ncbi.nlm.nih.gov/pubmed/33927271
(2)Université du Québec/広島大学
Key Word:PXBマウス、HBV
演題:Understanding hepatitis B virus dynamics and the antiviral effect of interferon-alpha treatment in
演者:Dr. Vladimir Reinharz et al.
掲載:J Virol. 2021 Apr 28. pii: JVI.00492-20. doi: 10.1128/JVI.00492-20.
URL: https://www.ncbi.nlm.nih.gov/pubmed/33910953
(3) 名古屋市立大学
Key Word:PXBマウス、HBV
演題:Interferon signaling suppresses the unfolded protein response and induces cell death in hepatocytes
演者:Dr. Ian Baudi et al.
掲載:PLoS Pathog. 2021 May 12;17(5):e1009228. doi: 10.1371/journal.ppat.1009228.
URL: https://www.ncbi.nlm.nih.gov/pubmed/33979382
(4) University of Louisville School of Medicine
Key Word:PXBマウス、HBV
演題:Safety and Efficacy of Avaren-Fc Lectibody Targeting HCV High-Mannose Glycans in a Human Liver
演者:Dr. Matthew Dent et al.
掲載:Cell Mol Gastroenterol Hepatol. 2021;11(1):185-198. doi: 10.1016/j.jcmgh.2020.08.009. Epub 2020 Aug 27.
URL: https://pubmed.ncbi.nlm.nih.gov/32861832/
(5) 武田薬品工業株式会社
Key Word:PXB-cells、Reactive Metabolite
演題:Cell-based high-throughput screening for the evaluation of reactive metabolite formation potential
演者:Dr. Kosuke Harada et al.
掲載:Toxicol In Vitro. 2021 Aug;74:105159. doi: 10.1016/j.tiv.2021.105159. Epub 2021 Apr 3.
URL: https://pubmed.ncbi.nlm.nih.gov/33823239/
(6) 長崎大学
Key Word:PXB-cells、HBV
演題:Geranylgeranylacetone decreases the production of hepatitis B virus-related antigen by comprehensive
演者:Dr. Masafumi Haraguchi et al.
掲載:J Gastroenterol Hepatol. 2021 Jan 4. doi: 10.1111/jgh.15394.
URL: https://www.ncbi.nlm.nih.gov/pubmed/33393671
(7) 東京大学
Key Word:PXB-cells、MPS
演題:Coculture with hiPS-derived intestinal cells enhanced human hepatocyte functions in a pneumatic-pressure-driven
演者:Dr. Marie Shinohara et al.
掲載:Sci Rep. 2021 Mar 8;11(1):5437. doi: 10.1038/s41598-021-84861-y
URL: https://www.ncbi.nlm.nih.gov/pubmed/33686099
(8) 田辺三菱製薬株式会社
Key Word:PXBマウス、ヒトPK予測
演題:Prediction of human pharmacokinetics for low-clearance compounds using pharmacokinetic data from chimeric mice
演者:Dr. Kousuke Yoshida et al.
掲載:Clin Transl Sci. 2021 Jun 3. doi: 10.1111/cts.13070.
URL: https://pubmed.ncbi.nlm.nih.gov/34080287/
(9) 広島大学
Key Word:PXBマウス、HCV
演題:Novel drug resistance-associated substitutions against pibrentasvir emerged in genotype 1b hepatitis C virus-
演者:Dr. Kazuki Ohya et al.
掲載:Biochem Biophys Res Commun. 2021 Jun 25;559:78-83. doi: 10.1016/j.bbrc.2021.04.062. Epub 2021 Apr 29.
URL: https://pubmed.ncbi.nlm.nih.gov/33932902/
(10) University of Southern California
Key Word:PXBマウス、Steatosis
演題:Loss of lysophosphatidic acid receptor 1 in hepatocytes reduces steatosis via down-regulation of CD36
演者:Dr. Ingrid Lua et al.
掲載:Prostaglandins Other Lipid Mediat. 2021 Jun 17:106577. doi: 10.1016/j.prostaglandins.2021.106577.
URL: https://pubmed.ncbi.nlm.nih.gov/34147666/
(11) University of Southern California
Key Word:PXBマウス、NASH
演題:Cholesterol-binding translocator protein TSPO regulates steatosis and bile acid synthesis in nonalcoholic
演者:Dr. Yuchang Li et al.
掲載:iScience. 2021 May 1;24(5):102457. doi: 10.1016/j.isci.2021.102457.
URL: https://www.ncbi.nlm.nih.gov/pubmed/34013171
(12) 国立感染症研究所
Key Word:PXBマウス、HBV
演題:MafF is an antiviral host factor that suppresses transcription from Hepatitis B Virus core promoter
演者:Dr. Marwa K Iburahim Li et al.
掲載:J Virol. 2021 Jul 12;95(15): e0076721. doi: 10.1128/JVI.00767-21. Epub 2021 Jul 12.