Phoenix Bio

論文一覧

論文一覧

論文一覧

PXBマウス関連の学術論文のご紹介:武田薬品工業株式会社

    武田薬品工業様より、PXBマウス関連の学術論文が発表されましたのでご紹介申し上げます。

    【詳細】

    掲載雑誌名:Xenobiotica. 2020 Aug 25; 1-10.  doi:10.1080/00498254.2020.1808735

    掲載日:2020年8月25日

    論文名:Characterization of plasma protein binding in two mouse models of humanized liver, PXB mouse and humanized

    TK-NOG mouse.

    著者:Maki Miyamoto, et. al.(武田薬品工業株式会社)

    概要:ヒトPK予測の重要な指標となる血漿中タンパク結合率について、2種類のヒト肝細胞キメラマウスである “PXBマ

    ウス” と “Hu-Liver TK-NOGマウス” を用 いて、ヒト予測精度を比較した。
    臨床データとの相関性は、PXBマウスは39化合物中34化合物(87.2%)、 Hu- Liver TK-NOGマウスは24化合物中15化合物(62.5%)であり、PXBマウスの方が高い予測精度を示した。

    PXBマウス関連の学術論文のご紹介:住友化学

      住友化学株式会社様より、PXBマウス関連の学術論文が発表されましたのでご紹介申し上げます。

      【詳細】

      掲載雑誌名:Toxicological Science, kfaa125, https://doi.org/10.1093/toxsci/kfaa125

      掲載日:2020年7月31日

      論文名:Comparison of the hepatic effects of phenobarbital in chimeric mice containing either

      rat or human hepatocytes with humanized constitutive androstane receptor (CAR) and
      pregnane X receptor (PXR) mice (hCAR/hPXR mice).

      著者:Yamada, et. al.(住友化学株式会社)

      概要:化学品のヒト肝毒性予測において、ヒトの肝臓をもつキメラマウス(PXBマウス)が有用であることを、

      PXBマウスが、ラットの肝臓をもつキメラマウスや遺伝子組換え動物(hCAR/hPXRマウス)との反応性において

      差異があることを示すことで、科学的に実証した。

      Signal activation of hepatitis B virus-related hepatocarcinogenesis by upregulation of SUV39h1

        Takeuchi, Y. Tsuge, M. Tsushima, K. Suehiro, Y. Fujino, H. Ono, A. Yamauchi, M. Makokha, G. N. Nakahara, T. Murakami, E. Abe-Chayama, H. Kawaoka, T. Miki, D. Imamura, M. Aikata, H. Hayes, C. N. Tateno, C. Chayama, K.

        J Infect Dis. 2020 Jun 9:jiaa317. doi: 10.1093/infdis/jiaa317.

        Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation

          Steeneck, C. Kinzel, O. Anderhub, S. Hornberger, M. Pinto, S. Morschhaeuser, B. Braun, F. Kleymann, G. Hoffmann, T.

          ACS Med Chem Lett. 2020 Jan 27;11(2):179-187. doi: 10.1021/acsmedchemlett.9b00572. eCollection 2020 Feb 13.

          Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: Integration with hepatic drug metabolism

            Sanoh, S. Naritomi, Y. Kitamura, S. Shinagawa, A. Kakuni, M. Tateno, C. Ohta, S.

            Xenobiotica. 2020 Jun 5:1-10. doi: 10.1080/00498254.2020.1769229.

            A novel evaluation method for determining drug-induced hepatotoxicity using 3D bio-printed human liver tissue

              Ide, I. Nagao, E. Kajiyama, S. Mizoguchi, N.

              Toxicol Mech Methods. 2020 Mar;30(3):189-196. doi: 10.1080/15376516.2019.1686795. Epub 2019 Nov 21.

              Engineering Cellular Biosensors with Customizable Antiviral Responses Targeting Hepatitis B Virus

                Matsunaga, S. Jeremiah, S. S. Miyakawa, K. Kurotaki, D. Shizukuishi, S. Watashi, K. Nishitsuji, H. Kimura, H. Tamura, T. Yamamoto, N. Shimotohno, K. Wakita, T. Ryo, A.

                iScience. 2020 Mar 27;23(3):100867. doi: 10.1016/j.isci.2020.100867. Epub 2020 Feb 26.

                Species differences in liver accumulation and metabolism of nucleotide prodrug sofosbuvir

                  Wang, T. Babusis, D. Park, Y. Niu, C. Kim, C. Zhao, X. Lu, B. Ma, B. Muench, R. C. Sperger, D. Ray, A. S. Murakami, E.

                  Drug Metab Pharmacokinet. 2020 Jun;35(3):334-340. doi: 10.1016/j.dmpk.2020.04.333. Epub 2020 Apr 16.

                  Art of Making Artificial Liver: Depicting Human Liver Biology and Diseases in Mice

                    Sugahara, G. Ishida, Y. Sun, J. Tateno, C. Saito, T.

                    Semin Liver Dis. 2020 Feb 19. doi: 10.1055/s-0040-1701444.

                    Characterization and applications of chimeric mice with humanized livers for preclinical drug development

                      Tateno, Chise;   Kojima, Yuha

                      Laboratory Animal Research volume 36, Article number: 2 (2020)

                      Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection

                        Cheng, X. Uchida, T. Xia, Y. Umarova, R. Liu, C. J. Chen, P. J. Gaggar, A. Suri, V. Mucke, M. M. Vermehren, J. Zeuzem, S. Teraoka, Y. Osawa, M. Aikata, H. Tsuji, K. Mori, N. Hige, S. Karino, Y. Imamura, M. Chayama, K. Liang, T. J.

                        J Clin Invest. 2020 Mar 12. pii: 135616. doi: 10.1172/JCI135616.

                        Lipoprotein profile and lipid metabolism of PXB-cells((R)), human primary hepatocytes from liver-humanized mice: proposal of novel in vitro system for screening anti-lipidemic drugs

                          Hata, K. Sayaka, T. Takahashi, M. Sasaki, A. Umekawa, Y. Miyashita, K. Ogura, K. Toshima, G. Maeda, M. Takahashi, J. Kakuni, M.

                          Biomed Res. 2020;41(1):33-42. doi: 10.2220/biomedres.41.33.

                          Successful energy shift from glycolysis to mitochondrial oxidative phosphorylation in freshly isolated hepatocytes from humanized mice liver

                            Ikeyama, Y. Sato, T. Takemura, A. Sekine, S. Ito, K.

                            Toxicol In Vitro. 2020 Jan 25:104785. doi: 10.1016/j.tiv.2020.104785.

                            High-throughput screening to evaluate inhibition of bile acid transporters using human hepatocytes isolated from chimeric mice

                              Kohara, H. Bajaj, P. Yamanaka, K. Miyawaki, A. Harada, K. Miyamoto, K. Matsui, T. Okai, Y. Wagoner, M. Shinozawa, T.

                              Toxicol Sci. 2019 Nov 13. pii: 5625164. doi: 10.1093/toxsci/kfz229.

                              Application of a Novel Mass Spectral Data Acquisition Approach to Lipidomic Analysis of Liver Extracts from Sitaxentan-treated Liver-Humanized PXB Mice

                                King, A. Baginski, M. Morikawa, Y. Rainville, P. D. Gethings, L. A. Wilson, I. D. Plumb, R. S.

                                J Proteome Res. 2019 Oct 8. doi: 10.1021/acs.jproteome.9b00334..

                                Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

                                  Katsuda, T. Matsuzaki, J. Yamaguchi, T. Yamada, Y. Prieto-Vila, M. Hosaka, K. Takeuchi, A. Saito, Y. Ochiya, T.

                                  Elife. 2019 Aug 8;8. pii: 47313. doi: 10.7554/eLife.47313.

                                  Efficacy of glecaprevir and pibrentasvir treatment for genotype 1b hepatitis C virus drug resistance-associated variants in humanized mice

                                    Osawa, M. Uchida, T. Imamura, M. Teraoka, Y. Fujino, H. Nakahara, T. Ono, A. Murakami, E. Kawaoka, T. Miki, D. Tsuge, M. Hiramatsu, A. Abe-Chayama, H. Hayes, C. N.

                                    J Gen Virol. 2019 Jul;100(7):1123-1131.

                                    Effect of Rifampicin on the Plasma Concentrations of Bile Acid-O-Sulfates in Monkeys and Human Liver-Transplanted Chimeric Mice With or Without Bile Flow Diversion

                                      Takehara, I. Watanabe, N. Mori, D. Ando, O. Kusuhara, H.

                                      J Pharm Sci. 2019 Mar 21.

                                      Anti-HBV activity of retinoid drugs in vitro versus in vivo

                                        Birkus, G. Snyder, C. Jordan, R. Kobayashi, T. Dick, R. Puscau, V. Li, L. Ramirez, R. Willkom, M. Morikawa, Y. Delaney, W. Schmitz, U.

                                        Antiviral Res. 2019 Jun 18:104538. doi: 10.1016/j.antiviral.2019.104538.

                                        An interferon-like small chemical compound CDM-3008 suppresses hepatitis B virus through induction of interferon-stimulated genes

                                          Furutani, Y. Toguchi, M. Shiozaki-Sato, Y. Qin, X. Y. Ebisui, E. Higuchi, S. Sudoh, M. Suzuki, H. Takahashi, N. Watashi, K. Wakita, T. Kakeya, H. Kojima, S.

                                          PLoS One. 2019 Jun 12;14(6):e0216139. doi: 10.1371/journal.pone.0216139. eCollection 2019.