Phoenix Bio

論文一覧

論文一覧

論文一覧

Utility of Three-Dimensional Cultures of Primary Human Hepatocytes (Spheroids) as Pharmacokinetic Models

    Mizoi, K. Arakawa, H. Yano, K. Koyama, S. Kojima, H. Ogihara, T.

    Biomedicines. 2020 Sep 23;8(10). pii: biomedicines8100374. doi: 10.3390/biomedicines8100374.

    Development of an in vivo delivery system for CRISPR/Cas9-mediated targeting of hepatitis B virus cccDNA

      Kayesh, M. E. H. Amako, Y. Hashem, M. A. Murakami, S. Ogawa, S. Yamamoto, N. Hifumi, T. Miyoshi, N. Sugiyama, M. Tanaka, Y. Mizokami, M. Kohara, M. Tsukiyama-Kohara, K.

      Virus Res. 2020 Oct 10;290:198191. doi: 10.1016/j.virusres.2020.198191.

      Fluoxazolevir inhibits hepatitis C virus infection in humanized chimeric mice by blocking viral membrane fusion

        Ma, C. D. Imamura, M. Talley, D. C. Rolt, A. Xu, X. Wang, A. Q. Le, D. Uchida, T. Osawa, M. Teraoka, Y. Li, K. Hu, X. Park, S. B. Chalasani, N. Irvin, P. H. Dulcey, A. E. Southall, N. Marugan, J. J. Hu, Z. Chayama, K. Frankowski, K. J. Liang, T. J.

        Nat Microbiol. 2020 Aug 31. doi: 10.1038/s41564-020-0781-2.

        Detection of acute toxicity of aflatoxin B1 to human hepatocytes in vitro and in vivo using chimeric mice with humanized livers

          Ishida, Y. Yamasaki, C. Iwanari, H. Yamashita, H. Ogawa, Y. Yanagi, A. Furukawa, S. Kojima, Y. Chayama, K. Kamiie, J. Tateno, C.

          PLoS One. 2020 Sep 23;15(9):e0239540. doi: 10.1371/journal.pone.0239540.

          Culture density contributes to hepatic functions of fresh human hepatocytes isolated from chimeric mice with humanized livers: Novel, long-term, functional two-dimensional in vitro tool for developing new drugs

            Yamasaki, C. Ishida, Y. Yanagi, A. Yoshizane, Y. Kojima, Y. Ogawa, Y. Kageyama, Y. Iwasaki, Y. Ishida, S. Chayama, K. Tateno, C.

            PLoS One. 2020 Sep 11;15(9):e0237809. doi: 10.1371/journal.pone.0237809. eCollection 2020.

            Comparison of the hepatic effects of phenobarbital in chimeric mice containing either rat or human hepatocytes with humanized constitutive androstane receptor (CAR) and pregnane X receptor (PXR) mice (hCAR/hPXR mice)

              Yamada, T. Ohara, A. Ozawa, N. Maeda, K. Kondo, M. Okuda, Y. Abe, J. Cohen, S. M. Lake, B. G.

              Toxicol Sci. 2020 Jul 31. pii: 5879297. doi: 10.1093/toxsci/kfaa125.

              Characterization of plasma protein binding in two mouse models of humanized liver, PXB mouse and humanized TK-NOG mouse

                Miyamoto, M. Kosugi, Y. Iwasaki, S. Chisaki, I. Nakagawa, S. Amano, N. Hirabayashi, H.

                Xenobiotica. 2020 Aug 25:1-10. doi: 10.1080/00498254.2020.1808735

                Prediction of Human Disproportionate and Biliary Excreted Metabolites Using Chimeric Mice with Humanized Liver

                  Kato, S. Shah, A. Plesescu, M. Miyata, Y. Bolleddula, J. Chowdhury, S. Zhu, X.

                  Drug Metab Dispos. 2020 Jul 14. pii: dmd.120.000128. doi: 10.1124/dmd.120.000128.

                  Signal activation of hepatitis B virus-related hepatocarcinogenesis by upregulation of SUV39h1

                    Takeuchi, Y. Tsuge, M. Tsushima, K. Suehiro, Y. Fujino, H. Ono, A. Yamauchi, M. Makokha, G. N. Nakahara, T. Murakami, E. Abe-Chayama, H. Kawaoka, T. Miki, D. Imamura, M. Aikata, H. Hayes, C. N. Tateno, C. Chayama, K.

                    J Infect Dis. 2020 Jun 9:jiaa317. doi: 10.1093/infdis/jiaa317.

                    Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation

                      Steeneck, C. Kinzel, O. Anderhub, S. Hornberger, M. Pinto, S. Morschhaeuser, B. Braun, F. Kleymann, G. Hoffmann, T.

                      ACS Med Chem Lett. 2020 Jan 27;11(2):179-187. doi: 10.1021/acsmedchemlett.9b00572. eCollection 2020 Feb 13.

                      Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: Integration with hepatic drug metabolism

                        Sanoh, S. Naritomi, Y. Kitamura, S. Shinagawa, A. Kakuni, M. Tateno, C. Ohta, S.

                        Xenobiotica. 2020 Jun 5:1-10. doi: 10.1080/00498254.2020.1769229.

                        A novel evaluation method for determining drug-induced hepatotoxicity using 3D bio-printed human liver tissue

                          Ide, I. Nagao, E. Kajiyama, S. Mizoguchi, N.

                          Toxicol Mech Methods. 2020 Mar;30(3):189-196. doi: 10.1080/15376516.2019.1686795. Epub 2019 Nov 21.

                          Engineering Cellular Biosensors with Customizable Antiviral Responses Targeting Hepatitis B Virus

                            Matsunaga, S. Jeremiah, S. S. Miyakawa, K. Kurotaki, D. Shizukuishi, S. Watashi, K. Nishitsuji, H. Kimura, H. Tamura, T. Yamamoto, N. Shimotohno, K. Wakita, T. Ryo, A.

                            iScience. 2020 Mar 27;23(3):100867. doi: 10.1016/j.isci.2020.100867. Epub 2020 Feb 26.

                            Species differences in liver accumulation and metabolism of nucleotide prodrug sofosbuvir

                              Wang, T. Babusis, D. Park, Y. Niu, C. Kim, C. Zhao, X. Lu, B. Ma, B. Muench, R. C. Sperger, D. Ray, A. S. Murakami, E.

                              Drug Metab Pharmacokinet. 2020 Jun;35(3):334-340. doi: 10.1016/j.dmpk.2020.04.333. Epub 2020 Apr 16.

                              Art of Making Artificial Liver: Depicting Human Liver Biology and Diseases in Mice

                                Sugahara, G. Ishida, Y. Sun, J. Tateno, C. Saito, T.

                                Semin Liver Dis. 2020 Feb 19. doi: 10.1055/s-0040-1701444.

                                Characterization and applications of chimeric mice with humanized livers for preclinical drug development

                                  Tateno, Chise;   Kojima, Yuha

                                  Laboratory Animal Research volume 36, Article number: 2 (2020)

                                  Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection

                                    Cheng, X. Uchida, T. Xia, Y. Umarova, R. Liu, C. J. Chen, P. J. Gaggar, A. Suri, V. Mucke, M. M. Vermehren, J. Zeuzem, S. Teraoka, Y. Osawa, M. Aikata, H. Tsuji, K. Mori, N. Hige, S. Karino, Y. Imamura, M. Chayama, K. Liang, T. J.

                                    J Clin Invest. 2020 Mar 12. pii: 135616. doi: 10.1172/JCI135616.

                                    Lipoprotein profile and lipid metabolism of PXB-cells((R)), human primary hepatocytes from liver-humanized mice: proposal of novel in vitro system for screening anti-lipidemic drugs

                                      Hata, K. Sayaka, T. Takahashi, M. Sasaki, A. Umekawa, Y. Miyashita, K. Ogura, K. Toshima, G. Maeda, M. Takahashi, J. Kakuni, M.

                                      Biomed Res. 2020;41(1):33-42. doi: 10.2220/biomedres.41.33.

                                      Successful energy shift from glycolysis to mitochondrial oxidative phosphorylation in freshly isolated hepatocytes from humanized mice liver

                                        Ikeyama, Y. Sato, T. Takemura, A. Sekine, S. Ito, K.

                                        Toxicol In Vitro. 2020 Jan 25:104785. doi: 10.1016/j.tiv.2020.104785.

                                        High-throughput screening to evaluate inhibition of bile acid transporters using human hepatocytes isolated from chimeric mice

                                          Kohara, H. Bajaj, P. Yamanaka, K. Miyawaki, A. Harada, K. Miyamoto, K. Matsui, T. Okai, Y. Wagoner, M. Shinozawa, T.

                                          Toxicol Sci. 2019 Nov 13. pii: 5625164. doi: 10.1093/toxsci/kfz229.