Phoenix Bio

研究発表

研究発表

Induction of open-form bile canaliculus formation by hepatocytes for evaluation of biliary drug excretion

    Arakawa, H. Nakazono, Y. Matsuoka, N. Hayashi, M. Shirasaka, Y. Hirao, A. Tamai, I.
    Commun Biol. 2023 Aug 22;6(1):866. doi: 10.1038/s42003-023-05216-z.

    Function of hepatocyte spheroids in bioactive microcapsules is enhanced by endogenous and exogenous hepatocyte growth factor

      Gwon, K. Choi, D. de Hoyos-Vega, J. M. Baskaran, H. Gonzalez-Suarez, A. M. Lee, S. Hong, H. J. Nguyen, K. M.n Dharmesh, E. Sugahara, G. Ishida, Y. Saito, T. Stybayeva, G. Revzin, A.
      Bioact Mater. 2023 May 24;28:183-195. doi: 10.1016/j.bioactmat.2023.05.009.

      Guiding Hepatic Differentiation of Pluripotent Stem Cells Using 3D Microfluidic Co-Cultures with Human Hepatocytes

        Fattahi, P. de Hoyos-Vega, J. M. Choi, J. H. Duffy, C. D. Gonzalez-Suarez, A. M. Ishida, Y. Nguyen, K. M. Gwon, K. Peterson, Q. P. Saito, T. Stybayeva, G. Revzin, A.
        Cells. 2023 Aug 1;12(15):1982. doi: 10.3390/cells12151982.

        Efficient gene transduction in pigs and macaques with the engineered AAV vector AAV.GT5 for hemophilia B gene therapy

          Kashiwakura, Y. Endo, K. Ugajin, A. Kikuchi, T. Hishikawa, S. Nakamura, H. Katakai, Y. Baatartsogt, N. Hiramoto, T. Hayakawa, M. Kamoshita, N. Yamazaki, S. Kume, A. Mori, H. Sata, N. Sakata, Y. Muramatsu, S. I. Ohmori, T.
          Mol Ther Methods Clin Dev. 2023 Aug 22;30:502-514. doi: 10.1016/j.omtm.2023.08.016.

          The Gut-Organ-Axis Concept: Advances the Application of Gut-on-Chip Technology

            Guo, Y. Chen, X. Gong, P.Li, G. Yao, W. Yang, W.
            Int J Mol Sci. 2023 Feb 17;24(4):4089. doi: 10.3390/ijms24044089.

            Novel AAV-mediated genome editing therapy improves health and survival in a mouse model of methylmalonic acidemia

              Zhang, S. Bastille, A. Gordo, S. Ramesh, N. Vora, J. McCarthy, E.Zhang, X. Frank, D. Ko, C. W. Wu, C. Walsh, N. Amarwani, S. Liao, J. Xiong, Q. Drouin, L. Hebben, M. Chiang, K. Chau, B. N.
              PLoS One. 2022 Sep 20;17(9):e0274774. doi: 10.1371/journal.pone.0274774.

              Novel approach for verification of a human PBPK modeling strategy using chimeric mice in the health risk assessment of epyrifenacil

                Hirasawa, K. Abe, J. Nagahori, H. Kitamoto, S
                Toxicol Appl Pharmacol. 2023 Apr 15;465:116439. doi: 10.1016/j.taap.2023.116439. Epub 2023 Feb 27.

                Identification of SARS-CoV-2 M(pro) inhibitors containing P1′ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2

                  Higashi-Kuwata, N. Tsuji, K. Hayashi, H. Bulut, H. Kiso, M. Imai, M. Ogata-Aoki, H. .Ishii, T. Kobayakawa, T. Nakano, K. Takamune, N. Kishimoto, N. Hattori, S. I. Das, D. Uemura, Y. Shimizu, Y. Aoki, M. Hasegawa, K. Suzuki, S. Nishiyama, A. Saruwatari, J. Shimizu, Y. Sukenaga, Y. Takamatsu, Y. Tsuchiya, K. Maeda, K. Yoshimura, K. Iida, S. Ozono, S. Suzuki, T. Okamura, T. Misumi, S. Kawaoka, Y. Tamamura, H. Mitsuya, H.
                  Nat Commun. 2023 Feb 25;14(1):1076. doi: 10.1038/s41467-023-36729-0.

                  Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases

                    Yarnall, M. T. N. Ioannidi, E. I. Schmitt-Ulms, C. Krajeski, R. N. Lim, J. Villiger, L. Zhou, W. Jiang, K. Garushyants, S. K. Roberts, N. Zhang, L. Vakulskas, C. A. Walker, J. A., 2nd. Kadina, A. P. Zepeda, A. E. Holden, K. Ma, H. Xie, J. Gao, G. Foquet, L. Bial, G. Donnelly, S. K. Miyata, Y. Radiloff, D. R. Henderson, J. M. Ujita, A. Abudayyeh, O. O. Gootenberg, J. S.
                    Nat Biotechnol. 2022 Nov 24. doi: 10.1038/s41587-022-01527-4.

                    A novel cDNA-uPA/SCID/Rag2(-/-) /Jak3(-/-) mouse model for hepatitis virus infection and reconstruction of human immune system

                      Uchida, T. Yuji, T. Imamura, M. Abe-Chayama, H. Makokha, G. N. Hayes, C. N. Aikata, H. Hamamura, S. Ishida, Y. Tateno, C. Shirouzu, T. Kawai, S. Tanaka, Y. Ohdan, H. Okada, S. Chayama, K.
                      J Viral Hepat. 2022 Dec 27. doi: 10.1111/jvh.13793. https://www.ncbi.nlm.nih.gov/pubmed/36575861

                      Characterization and Prevention of Hypovitaminosis C in Chimeric Mice with Humanized Livers

                        Touchette, Erin K. Bates, Maria C. Johnson, Mitch C. O’Brien, Tracy C. Melton, Roger J. Long, Kelly R. Kakuni, Masakazu, Baginski, Matthew, Radiloff, Daniel R. Sagartz, John E.
                        Comparative Medicine 2022, 72(6): 355-363.

                        Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions

                          Sakai, K. Sugano-Nakamura, N. Mihara, E. Rojas-Chaverra, N. M. Watanabe, S. Sato, H. Imamura, R. Voon, D. C. Sakai, I. Yamasaki, C. Tateno, C. Shibata, M. Suga, H. Takagi, J. Matsumoto, K.
                          Nat Biomed Eng. 2022 Nov 7. doi: 10.1038/s41551-022-00955-6.

                          Letrozole ameliorates liver fibrosis through the inhibition of the CTGF pathway and 17β-hydroxysteroid dehydrogenase 13 expression

                            Sakai, N. Kamimura, K. Miyamoto, H. Ko, M. Nagoya, T. Setsu, T. Sakamaki, A. Yokoo, T. Kamimura, H. Soki, H. Tokunaga, A. Inamine, T. Nakashima, M. Enomoto, H. Kousaka, K. Tachiki, H.
                            J Gastroenterol. 2022 Oct 27. doi: 10.1007/s00535-022-01929-w.

                            IL-31 Levels Correlate with Pruritus in Patients with Cholestatic and Metabolic Liver Diseases and is FXR Responsive in NASH

                              Xu, J. Wang, Y. Khoshdeli, M. Peach, M. Chuang, J. C. Lin, J. Tsai, W. W. Mahadevan, S. Minto, W. Diehl, L. Gupta, R. Trauner, M. Patel, K. Noureddin, M. Kowdley, K. V. Gulamhusein, A. Bowlus, C. L. Huss, R. S. Myers, R. P. Chung, C. Billin, A. N.
                              Hepatology. 2022 Jun 10. doi: 10.1002/hep.32599.

                              Variation in Expression of Cytochrome P450 3A Isoforms and Toxicological Effects: Endo- and Exogenous Substances as Regulatory Factors and Substrates

                                Fujino, C. Sanoh, S. Katsura, T.
                                Biol Pharm Bull. 2021;44(11):1617-1634. doi: 10.1248/bpb.b21-00332.

                                Estimating Drug Efficacy with a Diet-Induced NASH Model in Chimeric Mice with Humanized Livers

                                  Kisoh, K. Sugahara, G. Ogawa, Y. Furukawa, S. Ishida, Y. Okanoue, T. Kohara, M. Tateno, C.
                                  Biomedicines. 2021 Nov 9;9(11):1647. doi: 10.3390/biomedicines9111647.

                                  Hexa Histidine-Tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species

                                    Dat, N. Q. Thuy, L. T. T. Hieu, V. N. Hai, H. Hoang, D. V. Thi Thanh Hai, N. Thuy, T. T. V. Komiya, T. Rombouts, K. Dong, M. P. Hanh, N. V. Hoang, T. H. Sato-Matsubara, M. Daikoku, A. Kadono, C. Oikawa, D. Yoshizato, K. Tokunaga, F. Pinzani, M. Kawada, N.
                                    Hepatology. 2021 Jun;73(6):2527-2545. doi: 10.1002/hep.31752. Epub 2021 May 22.

                                    Cholesterol-binding translocator protein TSPO regulates steatosis and bile acid synthesis in nonalcoholic fatty liver disease

                                      Li, Y. Chen, L. Li, L. Sottas, C. Petrillo, S. K. Lazaris, A. Metrakos, P. Wu, H. Ishida, Y. Saito, T. Golden-Mason, L. Rosen, H. R. Wolff, J. J. Silvescu, C. I. Garza, S. Cheung, G. Huang, T. Fan, J. Culty, M. Stiles, B. Asahina, K. Papadopoulos, V.

                                      iScience. 2021 May 1;24(5):102457. doi: 10.1016/j.isci.2021.102457.

                                      Loss of lysophosphatidic acid receptor 1 in hepatocytes reduces steatosis via down-regulation of CD36

                                        Lua, I. Balog, S. Yanagi, A. Tateno, C. Asahina, K.

                                        Prostaglandins Other Lipid Mediat. 2021 Jun 17:106577. doi: 10.1016/j.prostaglandins.2021.106577.