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研究発表

研究発表

ヒト肝細胞キメラマウスを利用したB型 肝炎ウイルス/D型肝炎ウイルス共感染モデル

加国 雅和
Medical Science Digest(MSD) 2021;47(14):26-27

Variation in Expression of Cytochrome P450 3A Isoforms and Toxicological Effects: Endo- and Exogenous Substances as Regulatory Factors and Substrates

    Fujino, C. Sanoh, S. Katsura, T.
    Biol Pharm Bull. 2021;44(11):1617-1634. doi: 10.1248/bpb.b21-00332.

    Are Humanized Mouse Models Useful for Basic Research of Hepatocarcinogenesis through Chronic Hepatitis B Virus Infection?

      Masataka Tsuge
      Viruses. 2021 Sep 24;13(10). pii: v13101920. doi: 10.3390/v13101920.

      Elucidation of the species differences of epyrifenacil-induced hepatotoxicity between mice and humans by mass spectrometry imaging analysis in chimeric mice with humanized liver

        Matsunaga, K. Abe, J. Ogata, K. Fukunaga, S. Kitamoto, S.
        J Toxicol Sci. 2021;46(12):601-609. doi: 10.2131/jts.46.601.

        Estimating Drug Efficacy with a Diet-Induced NASH Model in Chimeric Mice with Humanized Livers

          Kisoh, K. Sugahara, G. Ogawa, Y. Furukawa, S. Ishida, Y. Okanoue, T. Kohara, M. Tateno, C.
          Biomedicines. 2021 Nov 9;9(11):1647. doi: 10.3390/biomedicines9111647.

          Utility of Gottingen minipigs for the prediction of human pharmacokinetic profiles after intravenous drug administration

            Ding, N. Yamamoto, S. Chisaki, I. Nakayama, M. Matsumoto, S. I. Hirabayashi, H.
            Drug Metab Pharmacokinet. 2021 Dec;41:100408. doi: 10.1016/j.dmpk.2021.100408. Epub 2021 Jun 9.

            Hexa Histidine-Tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species

              Dat, N. Q. Thuy, L. T. T. Hieu, V. N. Hai, H. Hoang, D. V. Thi Thanh Hai, N. Thuy, T. T. V. Komiya, T. Rombouts, K. Dong, M. P. Hanh, N. V. Hoang, T. H. Sato-Matsubara, M. Daikoku, A. Kadono, C. Oikawa, D. Yoshizato, K. Tokunaga, F. Pinzani, M. Kawada, N.
              Hepatology. 2021 Jun;73(6):2527-2545. doi: 10.1002/hep.31752. Epub 2021 May 22.

              Bile acid dysmetabolism in the gut-microbiota-liver axis under hepatitis C virus infection

                Inoue, T. Funatsu, Y. Ohnishi, M. Isogawa, M. Kawashima, K. Tanaka, M. Moriya, K. Kawaratani, H. Momoda, R. Iio, E. Nakagawa, H. Suzuki, Y. Matsuura, K. Fujiwara, K. Nakajima, A. Yoshiji, H. Nakayama, J. Tanaka, Y.

                Liver Int. 2021 Aug 19. doi: 10.1111/liv.15041.

                HBx-induced degradation of Smc5/6 complex impairs homologous recombination-mediated repair of damaged DNA

                  Sekiba, K. Otsuka, M. Funato, K. Miyakawa, Y. Tanaka, E. Seimiya, T. Yamagami, M. Tsutsumi, T. Okushin, K. Miyakawa, K. Ryo, A. Koike, K.

                  J Hepatol. 2021 Aug 25. pii: S0168-8278(21)02005-5. doi: 10.1016/j.jhep.2021.08.010.

                  Infection courses, virological features and IFN-alpha responses of HBV genotypes in cell culture and animal models

                    Zhang, M. Zhang, Z. Imamura, M. Osawa, M. Teraoka, Y. Piotrowski, J. Ishida, Y. Sozzi, V. Revill, P. A. Saito, T. Chayama, K. Liang, T. J.

                    J Hepatol. 2021 Aug 4. pii: S0168-8278(21)01960-7. doi: 10.1016/j.jhep.2021.07.030.

                    Chimeric Mouse With Humanized Liver Is an Appropriate Animal Model to Investigate Mode of Action for Porphyria-Mediated Hepatocytotoxicity

                      Toxicol Pathol. 2021 Jul 9:1926233211027474. doi: 10.1177/01926233211027474.

                      Eguchi, A. Fukunaga, S. Ogata, K. Kushida, M. Asano, H. Cohen, S. M. Sukata, T.

                      Application of humanized mice to toxicology studies: Evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)

                        Journal Toxicologic Pathology 2021; 34(4): 283-297. doi: https://doi.org/10.1293/tox.2021-0027

                        Tomoya Yamada

                         

                        Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)

                          Yamada, T. Cohen, S. M. Lake, B. G.

                          Crit Rev Toxicol. 2021;51(5):373-394. doi:10.1080/10408444.2021.1939654. Epub 2021 Jul 15.

                          MafF is an antiviral host factor that suppresses transcription from Hepatitis B Virus core promoter

                            Marwa K. Ibrahim, Tawfeek H. Abdelhafez, Junko S. Takeuchi, Kosho Wakae, Masaya Sugiyama, Masataka Tsuge, Masahiko Ito, Koichi Watashi, Mohamed El. Kassas, Takanobu Kato, Asako Murayama, Tetsuro Suzuki, Kazuaki Chayama, Kunitada Shimotohno, Masamichi Muramatsu, Hussein H. Aly, Takaji Wakita

                            J Virol. 2021 Jul 12;95(15): e0076721. doi: 10.1128/JVI.00767-21. Epub 2021 Jul 12.

                            Cholesterol-binding translocator protein TSPO regulates steatosis and bile acid synthesis in nonalcoholic fatty liver disease

                              Li, Y. Chen, L. Li, L. Sottas, C. Petrillo, S. K. Lazaris, A. Metrakos, P. Wu, H. Ishida, Y. Saito, T. Golden-Mason, L. Rosen, H. R. Wolff, J. J. Silvescu, C. I. Garza, S. Cheung, G. Huang, T. Fan, J. Culty, M. Stiles, B. Asahina, K. Papadopoulos, V.

                              iScience. 2021 May 1;24(5):102457. doi: 10.1016/j.isci.2021.102457.

                              Loss of lysophosphatidic acid receptor 1 in hepatocytes reduces steatosis via down-regulation of CD36

                                Lua, I. Balog, S. Yanagi, A. Tateno, C. Asahina, K.

                                Prostaglandins Other Lipid Mediat. 2021 Jun 17:106577. doi: 10.1016/j.prostaglandins.2021.106577.

                                Novel drug resistance-associated substitutions against pibrentasvir emerged in genotype 1b hepatitis C virus-infected human hepatocyte transplanted mice

                                  Ohya, K. Imamura, M. Teraoka, Y. Uchida, T. Fujino, H. Nakahara, T. Ono, A. Murakami, E. Yamauchi, M. Kawaoka, T. Miki, D. Tsuge, M. Abe-Chayama, H. Hayes, C. N. Aikata, H. Ishida, Y. Tateno, C. Song, H. Miyayama, Y. Hijikata, M. Chayama, K.

                                  Biochem Biophys Res Commun. 2021 Jun 25;559:78-83. doi: 10.1016/j.bbrc.2021.04.062. Epub 2021 Apr 29.

                                  Prediction of human pharmacokinetics for low-clearance compounds using pharmacokinetic data from chimeric mice with humanized livers

                                    Yoshida, K. Doi, Y. Iwazaki, N. Yasuhara, H. Ikenaga, Y. Shimizu, H. Nakada, T. Watanabe, T. Tateno, C. Sanoh, S.Kotake, Y.

                                    Clin Transl Sci. 2021 Jun 3. doi: 10.1111/cts.13070.

                                    Safety and Efficacy of Avaren-Fc Lectibody Targeting HCV High-Mannose Glycans in a Human Liver Chimeric Mouse Model

                                      Dent, M. Hamorsky, K. Vausselin, T. Dubuisson, J. Miyata, Y. Morikawa, Y. Matoba, N.
                                      Cell Mol Gastroenterol Hepatol. 2021;11(1):185-198. doi: 10.1016/j.jcmgh.2020.08.009. Epub 2020 Aug 27.

                                      Interferon signaling suppresses the unfolded protein response and induces cell death in hepatocytes accumulating hepatitis B surface antigen

                                        Baudi, I. Isogawa, M. Moalli, F. Onishi, M. Kawashima, K. Ishida, Y. Tateno, C. Sato, Y. Harashima, H. Ito, H. Ishikawa, T. Wakita, T. Iannacone, M. Tanaka, Y.
                                        PLoS Pathog. 2021 May 12;17(5):e1009228. doi: 10.1371/journal.ppat.1009228.