Phoenix Bio

研究開発

研究開発

Signal activation of hepatitis B virus-related hepatocarcinogenesis by upregulation of SUV39h1

    Takeuchi, Y. Tsuge, M. Tsushima, K. Suehiro, Y. Fujino, H. Ono, A. Yamauchi, M. Makokha, G. N. Nakahara, T. Murakami, E. Abe-Chayama, H. Kawaoka, T. Miki, D. Imamura, M. Aikata, H. Hayes, C. N. Tateno, C. Chayama, K.

    J Infect Dis. 2020 Jun 9:jiaa317. doi: 10.1093/infdis/jiaa317.

    Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation

      Steeneck, C. Kinzel, O. Anderhub, S. Hornberger, M. Pinto, S. Morschhaeuser, B. Braun, F. Kleymann, G. Hoffmann, T.

      ACS Med Chem Lett. 2020 Jan 27;11(2):179-187. doi: 10.1021/acsmedchemlett.9b00572. eCollection 2020 Feb 13.

      Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: Integration with hepatic drug metabolism

        Sanoh, S. Naritomi, Y. Kitamura, S. Shinagawa, A. Kakuni, M. Tateno, C. Ohta, S.

        Xenobiotica. 2020 Jun 5:1-10. doi: 10.1080/00498254.2020.1769229.

        Species differences in liver accumulation and metabolism of nucleotide prodrug sofosbuvir

          Wang, T. Babusis, D. Park, Y. Niu, C. Kim, C. Zhao, X. Lu, B. Ma, B. Muench, R. C. Sperger, D. Ray, A. S. Murakami, E.

          Drug Metab Pharmacokinet. 2020 Jun;35(3):334-340. doi: 10.1016/j.dmpk.2020.04.333. Epub 2020 Apr 16.

          Art of Making Artificial Liver: Depicting Human Liver Biology and Diseases in Mice

            Sugahara, G. Ishida, Y. Sun, J. Tateno, C. Saito, T.

            Semin Liver Dis. 2020 Feb 19. doi: 10.1055/s-0040-1701444.

            Characterization and applications of chimeric mice with humanized livers for preclinical drug development

              Tateno, Chise;   Kojima, Yuha

              Laboratory Animal Research volume 36, Article number: 2 (2020)

              Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection

                Cheng, X. Uchida, T. Xia, Y. Umarova, R. Liu, C. J. Chen, P. J. Gaggar, A. Suri, V. Mucke, M. M. Vermehren, J. Zeuzem, S. Teraoka, Y. Osawa, M. Aikata, H. Tsuji, K. Mori, N. Hige, S. Karino, Y. Imamura, M. Chayama, K. Liang, T. J.

                J Clin Invest. 2020 Mar 12. pii: 135616. doi: 10.1172/JCI135616.

                Application of a Novel Mass Spectral Data Acquisition Approach to Lipidomic Analysis of Liver Extracts from Sitaxentan-treated Liver-Humanized PXB Mice

                  King, A. Baginski, M. Morikawa, Y. Rainville, P. D. Gethings, L. A. Wilson, I. D. Plumb, R. S.

                  J Proteome Res. 2019 Oct 8. doi: 10.1021/acs.jproteome.9b00334..

                  Efficacy of glecaprevir and pibrentasvir treatment for genotype 1b hepatitis C virus drug resistance-associated variants in humanized mice

                    Osawa, M. Uchida, T. Imamura, M. Teraoka, Y. Fujino, H. Nakahara, T. Ono, A. Murakami, E. Kawaoka, T. Miki, D. Tsuge, M. Hiramatsu, A. Abe-Chayama, H. Hayes, C. N.

                    J Gen Virol. 2019 Jul;100(7):1123-1131.

                    Effect of Rifampicin on the Plasma Concentrations of Bile Acid-O-Sulfates in Monkeys and Human Liver-Transplanted Chimeric Mice With or Without Bile Flow Diversion

                      Takehara, I. Watanabe, N. Mori, D. Ando, O. Kusuhara, H.

                      J Pharm Sci. 2019 Mar 21.

                      Anti-HBV activity of retinoid drugs in vitro versus in vivo

                        Birkus, G. Snyder, C. Jordan, R. Kobayashi, T. Dick, R. Puscau, V. Li, L. Ramirez, R. Willkom, M. Morikawa, Y. Delaney, W. Schmitz, U.

                        Antiviral Res. 2019 Jun 18:104538. doi: 10.1016/j.antiviral.2019.104538.

                        2019/07/25

                        第29回抗ウイルス療法学会学術集会でのPXBマウス及びPXB-cells関連研究発表のご案内

                        2019年7月18日(木)~7月20日(土)に開催されました 第29回抗ウイルス療法学会学術集会にて、PXBマウス及びPXB-cells関連の研究発表がありましたのでご案内を致します。

                        Humanized Mouse Models for the Study of Hepatitis C and Host Interactions

                          Yong, K. S. M. Her, Z. Chen, Q.

                          Cells. 2019 Jun 17;8(6). pii: cells8060604.

                          Utility of Chimeric Mice with Humanized Liver for Predicting Human Pharmacokinetics in Drug Discovery: Comparison with in Vitro-in Vivo Extrapolation and Allometric Scaling

                            Naritomi, Y. Sanoh, S. Ohta, S.

                            Biol Pharm Bull. 2019;42(3):327-336. doi: 10.1248/bpb.b18-00754.

                            Mice with Chimeric Human Livers and Their Applications

                              Douglas, D. N. Kneteman, N. M.

                              Methods Mol Biol. 2019;1911:459-479.

                              Changes in Bile Acid Concentrations after Administration of Ketoconazole or Rifampicin to Chimeric Mice with Humanized Liver

                              Seigo Sanoh*,a, Yuka Tamuraa, Chieri Fujinoa, Go Sugaharab, Yasumi Yoshizaneb, Ami Yanagib, Keishi Kisohb, Yuji Ishidab,c, Chise Tatenob,c, Shigeru Ohtaa,d, and Yaichiro Kotakea.

                              BPB Reports

                              Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly

                                Kang, J. A. Kim, S. Park, M. Park, H. J. Kim, J. H. Park, S. Hwang, J. R. Kim, Y. C. Jun Kim, Y. Cho, Y. Sun Jin, M. Park, S. G.

                                Nat Commun. 2019 May 16;10(1):2184. doi: 10.1038/s41467-019-10200-5.

                                Changes in Bile Acid Concentrations in Chimeric Mice Transplanted with Different Replacement Indexes of Human Hepatocytes

                                  Chieri Fujino,a Seigo Sanoh,*,a Yuka Tamura,a Yuji Ishida,b,c Chise Tateno,b,c Shigeru Ohta,a,d and Yaichiro Kotakea.

                                  BPB Reports 2, 29-34 (2019)

                                  Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of HCV-infected Cells and Liver to Identify Pathways Associated With Disease Development

                                    Lupberger, J. Croonenborghs, T. Roca Suarez, A. A. Van Renne, N. Juhling, F. Oudot, M. A. Virzi, A. Bandiera, S. Jamey, C. Meszaros, G. Brumaru, D. Mukherji, A. Durand, S. C. Heydmann, L. Verrier, E. R. El Saghire, H. Hamdane, N. Bartenschlager, R. Fereshetian, S. Ramberger, E. Sinha, R. Nabian, M. Everaert, C. Jovanovic, M. Mertins, P. Carr, S. A. Chayama, K. Dali-Youcef, N. Ricci, R. Bardeesy, N. M. Fujiwara, N. Gevaert, O. Zeisel, M. B. Hoshida, Y. Pochet, N. Baumert, T. F.

                                    Gastroenterology. 2019 Apr 9. pii: S0016-5085(19)35670-7. doi: 10.1053/j.gastro.2019.04.003.

                                    Prediction of human pharmacokinetics of typical compounds by a physiologically based method using chimeric mice with humanized liver

                                      Nakayama, K. Ito, S. Suzuki, M. Takubo, H. Yamazaki, H. Nomura, Y.

                                      Xenobiotica. 2019 Apr; 49(4):404-414.  doi:10.1080/00498254.2018.1460516. Epub 2018 Apr 19.