株式会社フェニックスバイオ

HBVZ10, an AAV8 vector-based new HBV therapy candidate for cccDNA elimination

Zhang, B. H. Zhou, Y. Horrigan, S. Luckenbaugh, L. Hu, J. Zoulim, F. Zhang, Y. Y.
Mol Ther Methods Clin Dev. 2025 Nov 19;33(4):101646. doi: 10.1016/j.omtm.2025.101646.

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Novel tetravalent bispecific antibody, PSMA/TRAIL‑R2 REGULGENT™, induces selective tumor cell apoptosis without hepatotoxicity

Nakayama, M. Takagi-Maeda, S. Machino, Y. Nihira, K. Inoue, M. Takahashi, N. Usami, K.
Oncol Rep. 2025 Nov;54(5):155. doi: 10.3892/or.2025.8988.

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An evaluation of the human relevance of the hepatocellular tumors observed in mice treated with synthetic fungicide, pyridachlometyl, based on mode of action

Kawamoto, K. Shimotsuma, Y. Maeda, K. Matsunaga, K. Asano, H. Cohen, S. M. Yamada, T.

Arch Toxicol. 2025 Sep;99(9):3803-3824. doi: 10.1007/s00204-025-04099-9.

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Replication-driven HBV cccDNA loss in chimeric mice with humanized livers

Zhang, B. H. Zhou, Y. Horrigan, S. Zoulim, F. Hu, J. Zhang, Y. Y.
J Virol. 2025 Nov 6:e0129525. doi: 10.1128/jvi.01295-25.

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Quantitative prediction of CYP2C9-mediated drug disposition using humanized mice

Fujita, Yuito Tsutsui, Haruka Hirabayashi, Manabu Shimojo, Tomofumi Tachibana, Tatsuhiko Emoto, Chie Shindoh, Hidetoshi Terao, Kimio Miyake, Taiji
Drug Metab Dispos. 2025 Oct 17;53(12):100185. doi: 10.1016/j.dmd.2025.100185.

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Mode of action analysis for mouse liver tumor formation by MGK-264 and human relevance

Yano, J. Kawamoto, K. Shimotsuma, Y. Ogata, K. Matsunaga, K. Abe, J. Fukunaga, S. Osimitz, T. G. Lake, B. G. Asano, H.
Regul Toxicol Pharmacol. 2025 Dec;163:105929. doi: 10.1016/j.yrtph.2025.105929.

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Species-specific gene expression manipulation in humanized livers of chimeric mice via siRNA-encapsulated lipid nanoparticle treatment

Yamazaki, K. Kubara, K. Sugahara, G. Muto, H. Yamamoto, M. Mano, Y. Mitsuhashi, K. Yamasaki, C. Ishida, Y. Tateno, C. Suzuki, Y.
Mol Ther Methods Clin Dev. 2025 Apr 14;33(2):101466. doi: 10.1016/j.omtm.2025.101466.

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Prediction of human pharmacokinetics of procymidone and its major phase I and II metabolites using a PBPK__ model with enterohepatic circulation

Hirasawa, K. Adachi, T. Takeuchi, H. Kuroda, T. Abe, J. Nakajima, M.
Toxicol Appl Pharmacol. 2025 Aug 19;504:117525. doi: 10.1016/j.taap.2025.117525.

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Therapy with murinized tobevibart and elebsiran is efficacious in a liver-chimeric mouse model of HDV infection

Zhou, J. Kaiser, H. Rocha, E. Terrell, A. N. Corti, D. Purcell, L. A. Lempp, F. A. Puschnik, A. S.
JHEP Rep. 2025 Mar 22;7(6):101400. doi: 10.1016/j.jhepr.2025.101400. eCollection

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An evaluation of the human relevance of the hepatocellular tumors observed in mice treated with synthetic fungicide, pyridachlometyl, based on mode of action

Kawamoto, K.Shimotsuma, Y.Maeda, K. Matsunaga, K. Asano, H. Cohen, S. M. Yamada, T.
Arch Toxicol. 2025 Jun 9. doi: 10.1007/s00204-025-04099-9.

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Quantitative Prediction of Drug-Drug Interactions Arising from CYP3A4 Induction using Chimeric Mice with Humanized Liver

Nakayama, K. Negoro, T. Takubo, H. Hayashi, A. Taniguchi, T. Nomura, Y. Iwanaga, K.
Xenobiotica. 2025 Jun 11:1-19. doi: 10.1080/00498254.2025.2518239.

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Clinical potential of SAG-524: A novel HBV RNA destabilizer with a unique mechanism of action

Tanaka, Yasuhito
Glob Health Med. 2025 Feb 28;7(1):64-66. doi: 10.35772/ghm.2024.01078.

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Application of humanized mice to toxicology studies: properties of chimeric mice with humanized liver (PXB-mice) for hepatotoxicity

Sultana, N. Izawa, T. Kamei, T. Fujiwara, S. Ito, Y. Takami, Y. Kuwamura, M.
Drug Metab Dispos. 2025 Feb;53(2):100025. doi: 10.1016/j.dmd.2024.100025.

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Quantitative prediction of drug disposition for uridine diphosphate-glucuronosyltransferase substrates using humanized mice

Miyake, T. Fujita, Y. Hirabayashi, M. Komiyama, N. Morita, K. Tachibana, T. Terao, K.
Drug Metab Dispos. 2025 Feb 10;53(4):100050. doi: 10.1016/j.dmd.2025.100050.

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Development of human growth hormone-treated chimeric mice with humanized livers for an evaluation model of drug-induced fatty liver disease

Morioka, S. Sanoh, S. Ishida, Y. Furukawa, S. Ogawa, Y.Kotake, Y. Tateno, C.
Arch Toxicol. 2025 Feb 21. doi: 10.1007/s00204-025-03986-5.

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Investigation of Biotransformation Pathways in a Chimeric Mouse with a Humanized Liver

Karlsson, I. B. Ekdahl, A. Etchingham-Coll, H. Li, X. Q. Ericsson, C. Ahlqvist, M. Samuelsson, K.
Int J Mol Sci. 2025 Jan 28;26(3):1141. doi: 10.3390/ijms26031141

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Endothelial lipase-binding peptides similar to netrin-1 inhibit hepatitis B virus infection

Ide, M. Tabata, N. Murai, K. Yonemura, Y. Wang, Y. Ishida, A. Shirasaki, T. Kaneko, S. Ito, S. Honda, M. Yanagawa, H.
FEBS Lett. 2025 Jan 25. doi: 10.1002/1873-3468.15101.

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Induction of phospholipase A2 group 4C by HCV infection regulates lipid droplet formation

Ito, M. Liu, J. Fukasawa, M. Tsutsumi, K. Kanegae, Y. Setou, M. Kohara, M. Suzuki, T.
JHEP Rep. 2024 Sep 30;7(1):101225. doi: 10.1016/j.jhepr.2024.101225.

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Hepatitis B virus genotypes A1 and A2 have distinct replication phenotypes due to polymorphisms in the HBx gene

Zhang, M. Mouzannar, K. Zhang, Z. Teraoka, Y. Piotrowski, J. Ishida, Y. Tateno-Mukaidani, C. Saito, T.Abe-Chayama, H. Chayama, K.Liang, T. J.
PLoS Pathog. 2025 Jan 9;21(1):e1012803. doi: 10.1371/journal.ppat.1012803.

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Theoretical modeling of hepatitis C acute infection in liver-humanized mice support pre-clinical assessment of candidate viruses for controlled-human-infection studies

Shi, Z. Mhlanga, A. Ishida, Y. Josephson, A. Collier, N. T. Abe-Chayama, H. Tateno-Mukaidani, C. Cotler, S. J. Ozik, J. Major, M. Feld, J. J. Chayama, K. Dahari, H.
Sci Rep. 2024 Dec 30;14(1):31826. doi: 10.1038/s41598-024-83104-0.

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研究発表

HBVZ10, an AAV8 vector-based new HBV therapy candidate for cccDNA elimination

Novel tetravalent bispecific antibody, PSMA/TRAIL‑R2 REGULGENT™, induces selective tumor cell apoptosis without hepatotoxicity

An evaluation of the human relevance of the hepatocellular tumors observed in mice treated with synthetic fungicide, pyridachlometyl, based on mode of action

Replication-driven HBV cccDNA loss in chimeric mice with humanized livers

Quantitative prediction of CYP2C9-mediated drug disposition using humanized mice

Mode of action analysis for mouse liver tumor formation by MGK-264 and human relevance

Species-specific gene expression manipulation in humanized livers of chimeric mice via siRNA-encapsulated lipid nanoparticle treatment

Prediction of human pharmacokinetics of procymidone and its major phase I and II metabolites using a PBPK__ model with enterohepatic circulation

Therapy with murinized tobevibart and elebsiran is efficacious in a liver-chimeric mouse model of HDV infection

An evaluation of the human relevance of the hepatocellular tumors observed in mice treated with synthetic fungicide, pyridachlometyl, based on mode of action

Quantitative Prediction of Drug-Drug Interactions Arising from CYP3A4 Induction using Chimeric Mice with Humanized Liver

Clinical potential of SAG-524: A novel HBV RNA destabilizer with a unique mechanism of action

Application of humanized mice to toxicology studies: properties of chimeric mice with humanized liver (PXB-mice) for hepatotoxicity

Quantitative prediction of drug disposition for uridine diphosphate-glucuronosyltransferase substrates using humanized mice

Development of human growth hormone-treated chimeric mice with humanized livers for an evaluation model of drug-induced fatty liver disease

Investigation of Biotransformation Pathways in a Chimeric Mouse with a Humanized Liver

Endothelial lipase-binding peptides similar to netrin-1 inhibit hepatitis B virus infection

Induction of phospholipase A2 group 4C by HCV infection regulates lipid droplet formation

Hepatitis B virus genotypes A1 and A2 have distinct replication phenotypes due to polymorphisms in the HBx gene

Theoretical modeling of hepatitis C acute infection in liver-humanized mice support pre-clinical assessment of candidate viruses for controlled-human-infection studies