Phoenix Bio

研究発表

研究発表

Quantitative prediction of drug disposition for uridine diphosphate-glucuronosyltransferase substrates using humanized mice

    Miyake, T. Fujita, Y. Hirabayashi, M. Komiyama, N. Morita, K. Tachibana, T. Terao, K.
    Drug Metab Dispos. 2025 Feb 10;53(4):100050. doi: 10.1016/j.dmd.2025.100050.

    Development of human growth hormone-treated chimeric mice with humanized livers for an evaluation model of drug-induced fatty liver disease

      Morioka, S. Sanoh, S. Ishida, Y. Furukawa, S. Ogawa, Y.Kotake, Y. Tateno, C.
      Arch Toxicol. 2025 Feb 21. doi: 10.1007/s00204-025-03986-5.

      Investigation of Biotransformation Pathways in a Chimeric Mouse with a Humanized Liver

        Karlsson, I. B. Ekdahl, A. Etchingham-Coll, H. Li, X. Q. Ericsson, C. Ahlqvist, M. Samuelsson, K.
        Int J Mol Sci. 2025 Jan 28;26(3):1141. doi: 10.3390/ijms26031141

        Endothelial lipase-binding peptides similar to netrin-1 inhibit hepatitis B virus infection

          Ide, M. Tabata, N. Murai, K. Yonemura, Y. Wang, Y. Ishida, A. Shirasaki, T. Kaneko, S. Ito, S. Honda, M. Yanagawa, H.
          FEBS Lett. 2025 Jan 25. doi: 10.1002/1873-3468.15101.

          Induction of phospholipase A2 group 4C by HCV infection regulates lipid droplet formation

            Ito, M. Liu, J. Fukasawa, M. Tsutsumi, K. Kanegae, Y. Setou, M. Kohara, M. Suzuki, T.
            JHEP Rep. 2024 Sep 30;7(1):101225. doi: 10.1016/j.jhepr.2024.101225.

            Hepatitis B virus genotypes A1 and A2 have distinct replication phenotypes due to polymorphisms in the HBx gene

              Zhang, M. Mouzannar, K. Zhang, Z. Teraoka, Y. Piotrowski, J. Ishida, Y. Tateno-Mukaidani, C. Saito, T.Abe-Chayama, H. Chayama, K.Liang, T. J.
              PLoS Pathog. 2025 Jan 9;21(1):e1012803. doi: 10.1371/journal.ppat.1012803.

              Theoretical modeling of hepatitis C acute infection in liver-humanized mice support pre-clinical assessment of candidate viruses for controlled-human-infection studies

                Shi, Z. Mhlanga, A. Ishida, Y. Josephson, A. Collier, N. T. Abe-Chayama, H. Tateno-Mukaidani, C. Cotler, S. J. Ozik, J. Major, M. Feld, J. J. Chayama, K. Dahari, H.
                Sci Rep. 2024 Dec 30;14(1):31826. doi: 10.1038/s41598-024-83104-0.

                Alteration of Gene Expression After Entecavir and Pegylated Interferon Therapy in HBV-Infected Chimeric Mouse Liver

                  Bao, H. Murakami, S. Tsuge, M. Uchida, T. Uchikawa, S. Fujino, H. Ono, A. Murakami, E. Kawaoka, T. Miki, D. Hayes, C. N. Oka, S.
                  Viruses. 2024 Nov 6;16(11):1743. doi: 10.3390/v16111743.

                  An atlas of the human liver diurnal transcriptome and its perturbation by hepatitis C virus infection

                    Mukherji, A. Jühling, F. Simanjuntak, Y. Crouchet, E. Del Zompo, F. Teraoka, Y. Haller, A. Baltzinger, P. Paritala, S. Rasha, F. Fujiwara, N. Gadenne, C. Slovic, N. Oudot, M. A. Durand, S. C.
                    Nat Commun. 2024 Aug 29;15(1):7486. doi: 10.1038/s41467-024-51698-8.

                    Plasma and urinary CP I and CP III concentrations in chimeric mice with human hepatocytes after rifampicin administration

                      Shishido, Y. Yoshida, T. Oshida, K. Uchida, M.
                      Pharmacol Res Perspect. 2024 Oct;12(5):e70017. doi: 10.1002/prp2.70017.

                      Infectivity of Hepatitis B Virus Surface Antigen-Positive Plasma With Undetectable HBV-DNA: Can HBsAg Screening Be Discontinued in Egyptian Blood Donors?

                        El Ekiaby, M. Tanaka, J. van Drimmelen, H. Allain, J. P. Lelie, N.
                        J Viral Hepat. 2024 Aug 10. doi: 10.1111/jvh.13990.

                        Interferon alpha induces a stronger antiviral effect than interferon lambda in HBV/HDV infected humanized mice

                          Duehren, S. Uchida, T. Tsuge, M. Hiraga, N. Uprichard, S. L. Etzion, O. Glenn, J. Koh, C. Heller, T. Cotler, S. J. Oka, S. Chayama, K. Dahari, H.
                          Virus Res. 2024 Aug 26;349:199451. doi: 10.1016/j.virusres.2024.199451.

                          Lipid nanoparticle-encapsulated DOCK11-siRNA efficiently reduces hepatitis B virus cccDNA level in infected mice

                            Okada, H. Sakamoto, T. Nio, K. Li, Y. Kuroki, K. Sugimoto, S. Shimakami, T. Doi, N. Honda, M. Seiki, M. Kaneko, S. Yamashita, T.
                            Mol Ther Methods Clin Dev. 2024 Jun 24;32(3):101289. doi: 10.1016/j.omtm.2024.101289.

                            Human Hepatocytes Can Give Rise to Intrahepatic Cholangiocarcinomas

                              Hsu, Bernadette Y. Driscoll, Julia. Tateno, Chise. Mattis, Aras N. Kelley, Robin K. Willenbring, Holger
                              Gastroenterology. 2024 Oct;167(5):1029-1032.e7. doi: 10.1053/j.gastro.2024.05.033.

                              Utility of Chimeric Mice with Humanized Livers for Predicting Hepatic Organic Anion – Transporting Polypeptide 1B (OATP1B) – Mediated Clinical Drug-Drug Interactions

                                Feng, B. Liang, G. Zetterberg, C. Li, S. Huang, H. Williams, J.Gao, H. Morikawa, Y. Kumar, S.
                                Drug Metab Dispos. 2024 Aug 5:DMD-AR-2024-001792. doi: 10.1124/dmd.124.001792.

                                Selective depletion of HBV-infected hepatocytes by class A capsid assembly modulators requires high levels of intrahepatic HBV core protein

                                  Kornyeyev, D. Song, Z. Eng, S. Soulette, C. Ramirez, R. Tang, J. Yue, Q. Subramanian, R. Zaboli, S. Moon, C. Tam, J. Brodbeck, J. Aggarwal, A. Diehl, L. Fletcher, S. P. Hyrina, A. Holdorf, M. M. Burdette, D.
                                  Antimicrob Agents Chemother. 2024 Jul 9;68(7):e0042024. doi: 10.1128/aac.00420-24.

                                  Development of an effective single-chain variable fragment recognizing a novel epitope in the hepatitis C virus E2 protein that restricts virus entry into hepatocytes

                                    Das, S. Behera, P. Shewale, D. J. Bodele, J. Das, S. Karande, A. A.
                                    Arch Virol. 2024 Apr 29;169(5):112. doi: 10.1007/s00705-024-06024-4.

                                    Multi-omics analysis of a fatty liver model using human hepatocyte chimeric mice

                                      Ichikawa, A. Miki, D. Hayes, C. N. Teraoka, Y. Nakahara, H. Tateno, C. Ishida, Y. Chayama, K. Oka, S.
                                      Sci Rep. 2024 Feb 9;14(1):3362. doi: 10.1038/s41598-024-53890-8.

                                      Hepatitis B virus evades the immune system by suppressing the NF-kappaB signaling pathway with DENND2A

                                        Ide, M. Tabata, N. Yonemura, Y. Murai, K. Wang, Y. Ishida, A. Honda, M. Kaneko, S. Ito, S. Yanagawa, H.
                                        Microbiol Spectr. 2024 Jan 19:e0378523. doi: 10.1128/spectrum.03785-23.

                                        2024/03/29

                                        PXBマウス・PXB-cells関連研究発表のご案内:APASL 2024 Kyoto

                                        アジア太平洋肝臓学会(APASL) 2024 Kyotoでのミルテニーバイオテク株式会社主催のランチョンセミナーにて、
                                        当社のPXBマウスを用いたアプリケーションが紹介されましたのでご案内申し上げます。