Phoenix Bio

研究開発

研究開発

Dual Agonist of Farnesoid X Receptor and G Protein-coupled Receptor TGR5 Inhibits Hepatitis B Virus Infection in Vitro and in Vivo

    Ito, K. Okumura, A. S. Takeuchi J Watashi, K. Inoue, R. Yamauchi, T. Sakamoto, K. Yamashita, Y. Iguchi, Y. Une, M. Wakita, T. Umezawa, K. Yoneda, M.

    Hepatology. 2021 Jan 12. doi: 10.1002/hep.31712.

    Evaluation of the Utility of PXB Chimeric Mice for Predicting Human Liver Partitioning of Hepatic Organic Anion-Transporting Polypeptide Transporter Substrates

      Feng, B. Pemberton, R. Dworakowski, W. Ye, Z. Zetterberg, C. Wang, G. Morikawa, Y. Kumar, S.

      Drug Metab Dispos. 2021 Mar;49(3):254-264. doi: 10.1124/dmd.120.000276. Epub 2020 Dec 29.

      Development of an in vivo delivery system for CRISPR/Cas9-mediated targeting of hepatitis B virus cccDNA

        Kayesh, M. E. H. Amako, Y. Hashem, M. A. Murakami, S. Ogawa, S. Yamamoto, N. Hifumi, T. Miyoshi, N. Sugiyama, M. Tanaka, Y. Mizokami, M. Kohara, M. Tsukiyama-Kohara, K.

        Virus Res. 2020 Oct 10;290:198191. doi: 10.1016/j.virusres.2020.198191.

        Fluoxazolevir inhibits hepatitis C virus infection in humanized chimeric mice by blocking viral membrane fusion

          Ma, C. D. Imamura, M. Talley, D. C. Rolt, A. Xu, X. Wang, A. Q. Le, D. Uchida, T. Osawa, M. Teraoka, Y. Li, K. Hu, X. Park, S. B. Chalasani, N. Irvin, P. H. Dulcey, A. E. Southall, N. Marugan, J. J. Hu, Z. Chayama, K. Frankowski, K. J. Liang, T. J.

          Nat Microbiol. 2020 Aug 31. doi: 10.1038/s41564-020-0781-2.

          Detection of acute toxicity of aflatoxin B1 to human hepatocytes in vitro and in vivo using chimeric mice with humanized livers

            Ishida, Y. Yamasaki, C. Iwanari, H. Yamashita, H. Ogawa, Y. Yanagi, A. Furukawa, S. Kojima, Y. Chayama, K. Kamiie, J. Tateno, C.

            PLoS One. 2020 Sep 23;15(9):e0239540. doi: 10.1371/journal.pone.0239540.

            Comparison of the hepatic effects of phenobarbital in chimeric mice containing either rat or human hepatocytes with humanized constitutive androstane receptor (CAR) and pregnane X receptor (PXR) mice (hCAR/hPXR mice)

              Yamada, T. Ohara, A. Ozawa, N. Maeda, K. Kondo, M. Okuda, Y. Abe, J. Cohen, S. M. Lake, B. G.

              Toxicol Sci. 2020 Jul 31. pii: 5879297. doi: 10.1093/toxsci/kfaa125.

              Characterization of plasma protein binding in two mouse models of humanized liver, PXB mouse and humanized TK-NOG mouse

                Miyamoto, M. Kosugi, Y. Iwasaki, S. Chisaki, I. Nakagawa, S. Amano, N. Hirabayashi, H.

                Xenobiotica. 2020 Aug 25:1-10. doi: 10.1080/00498254.2020.1808735

                Prediction of Human Disproportionate and Biliary Excreted Metabolites Using Chimeric Mice with Humanized Liver

                  Kato, S. Shah, A. Plesescu, M. Miyata, Y. Bolleddula, J. Chowdhury, S. Zhu, X.

                  Drug Metab Dispos. 2020 Jul 14. pii: dmd.120.000128. doi: 10.1124/dmd.120.000128.

                  2020/09/11

                  PXBマウス関連の学術論文のご紹介:武田薬品工業株式会社

                    武田薬品工業様より、PXBマウス関連の学術論文が発表されましたのでご紹介申し上げます。

                    【詳細】

                    掲載雑誌名:Xenobiotica. 2020 Aug 25; 1-10.  doi:10.1080/00498254.2020.1808735

                    掲載日:2020年8月25日

                    論文名:Characterization of plasma protein binding in two mouse models of humanized liver, PXB mouse and humanized

                    TK-NOG mouse.

                    著者:Maki Miyamoto, et. al.(武田薬品工業株式会社)

                    概要:ヒトPK予測の重要な指標となる血漿中タンパク結合率について、2種類のヒト肝細胞キメラマウスである “PXBマ

                    ウス” と “Hu-Liver TK-NOGマウス” を用 いて、ヒト予測精度を比較した。
                    臨床データとの相関性は、PXBマウスは39化合物中34化合物(87.2%)、 Hu- Liver TK-NOGマウスは24化合物中15化合物(62.5%)であり、PXBマウスの方が高い予測精度を示した。

                    PXBマウス・PXB-cells関連研究発表のご案内:肝炎関連3学会

                    2020年7月~8月に開催されました、以下の肝炎関連学会(3学会:日本消化器病学会、EASL、日本肝臓学会)にて、PXBマウス及びPXB-cells関連の研究発表がありました。

                    PXBマウス関連の学術論文のご紹介:住友化学

                      住友化学株式会社様より、PXBマウス関連の学術論文が発表されましたのでご紹介申し上げます。

                      【詳細】

                      掲載雑誌名:Toxicological Science, kfaa125, https://doi.org/10.1093/toxsci/kfaa125

                      掲載日:2020年7月31日

                      論文名:Comparison of the hepatic effects of phenobarbital in chimeric mice containing either

                      rat or human hepatocytes with humanized constitutive androstane receptor (CAR) and
                      pregnane X receptor (PXR) mice (hCAR/hPXR mice).

                      著者:Yamada, et. al.(住友化学株式会社)

                      概要:化学品のヒト肝毒性予測において、ヒトの肝臓をもつキメラマウス(PXBマウス)が有用であることを、

                      PXBマウスが、ラットの肝臓をもつキメラマウスや遺伝子組換え動物(hCAR/hPXRマウス)との反応性において

                      差異があることを示すことで、科学的に実証した。

                      Signal activation of hepatitis B virus-related hepatocarcinogenesis by upregulation of SUV39h1

                        Takeuchi, Y. Tsuge, M. Tsushima, K. Suehiro, Y. Fujino, H. Ono, A. Yamauchi, M. Makokha, G. N. Nakahara, T. Murakami, E. Abe-Chayama, H. Kawaoka, T. Miki, D. Imamura, M. Aikata, H. Hayes, C. N. Tateno, C. Chayama, K.

                        J Infect Dis. 2020 Jun 9:jiaa317. doi: 10.1093/infdis/jiaa317.

                        Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation

                          Steeneck, C. Kinzel, O. Anderhub, S. Hornberger, M. Pinto, S. Morschhaeuser, B. Braun, F. Kleymann, G. Hoffmann, T.

                          ACS Med Chem Lett. 2020 Jan 27;11(2):179-187. doi: 10.1021/acsmedchemlett.9b00572. eCollection 2020 Feb 13.

                          Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: Integration with hepatic drug metabolism

                            Sanoh, S. Naritomi, Y. Kitamura, S. Shinagawa, A. Kakuni, M. Tateno, C. Ohta, S.

                            Xenobiotica. 2020 Jun 5:1-10. doi: 10.1080/00498254.2020.1769229.

                            Species differences in liver accumulation and metabolism of nucleotide prodrug sofosbuvir

                              Wang, T. Babusis, D. Park, Y. Niu, C. Kim, C. Zhao, X. Lu, B. Ma, B. Muench, R. C. Sperger, D. Ray, A. S. Murakami, E.

                              Drug Metab Pharmacokinet. 2020 Jun;35(3):334-340. doi: 10.1016/j.dmpk.2020.04.333. Epub 2020 Apr 16.

                              Art of Making Artificial Liver: Depicting Human Liver Biology and Diseases in Mice

                                Sugahara, G. Ishida, Y. Sun, J. Tateno, C. Saito, T.

                                Semin Liver Dis. 2020 Feb 19. doi: 10.1055/s-0040-1701444.

                                Characterization and applications of chimeric mice with humanized livers for preclinical drug development

                                  Tateno, Chise;   Kojima, Yuha

                                  Laboratory Animal Research volume 36, Article number: 2 (2020)

                                  Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection

                                    Cheng, X. Uchida, T. Xia, Y. Umarova, R. Liu, C. J. Chen, P. J. Gaggar, A. Suri, V. Mucke, M. M. Vermehren, J. Zeuzem, S. Teraoka, Y. Osawa, M. Aikata, H. Tsuji, K. Mori, N. Hige, S. Karino, Y. Imamura, M. Chayama, K. Liang, T. J.

                                    J Clin Invest. 2020 Mar 12. pii: 135616. doi: 10.1172/JCI135616.

                                    Application of a Novel Mass Spectral Data Acquisition Approach to Lipidomic Analysis of Liver Extracts from Sitaxentan-treated Liver-Humanized PXB Mice

                                      King, A. Baginski, M. Morikawa, Y. Rainville, P. D. Gethings, L. A. Wilson, I. D. Plumb, R. S.

                                      J Proteome Res. 2019 Oct 8. doi: 10.1021/acs.jproteome.9b00334..

                                      Efficacy of glecaprevir and pibrentasvir treatment for genotype 1b hepatitis C virus drug resistance-associated variants in humanized mice

                                        Osawa, M. Uchida, T. Imamura, M. Teraoka, Y. Fujino, H. Nakahara, T. Ono, A. Murakami, E. Kawaoka, T. Miki, D. Tsuge, M. Hiramatsu, A. Abe-Chayama, H. Hayes, C. N.

                                        J Gen Virol. 2019 Jul;100(7):1123-1131.