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研究開発

研究開発

Changes in Bile Acid Concentrations in Chimeric Mice Transplanted with Different Replacement Indexes of Human Hepatocytes

    Chieri Fujino,a Seigo Sanoh,*,a Yuka Tamura,a Yuji Ishida,b,c Chise Tateno,b,c Shigeru Ohta,a,d and Yaichiro Kotakea.

    BPB Reports 2, 29-34 (2019)

    Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of HCV-infected Cells and Liver to Identify Pathways Associated With Disease Development

      Lupberger, J. Croonenborghs, T. Roca Suarez, A. A. Van Renne, N. Juhling, F. Oudot, M. A. Virzi, A. Bandiera, S. Jamey, C. Meszaros, G. Brumaru, D. Mukherji, A. Durand, S. C. Heydmann, L. Verrier, E. R. El Saghire, H. Hamdane, N. Bartenschlager, R. Fereshetian, S. Ramberger, E. Sinha, R. Nabian, M. Everaert, C. Jovanovic, M. Mertins, P. Carr, S. A. Chayama, K. Dali-Youcef, N. Ricci, R. Bardeesy, N. M. Fujiwara, N. Gevaert, O. Zeisel, M. B. Hoshida, Y. Pochet, N. Baumert, T. F.

      Gastroenterology. 2019 Apr 9. pii: S0016-5085(19)35670-7. doi: 10.1053/j.gastro.2019.04.003.

      Prediction of human pharmacokinetics of typical compounds by a physiologically based method using chimeric mice with humanized liver

        Nakayama, K. Ito, S. Suzuki, M. Takubo, H. Yamazaki, H. Nomura, Y.

        Xenobiotica. 2019 Apr; 49(4):404-414.  doi:10.1080/00498254.2018.1460516. Epub 2018 Apr 19.

        HCV-induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response

          Hamdane, N. Juhling, F. Crouchet, E. El Saghire, H. Thumann, C. Oudot, M. A. Bandiera, S. Saviano, A. Ponsolles, C. Roca Suarez, A. A. Li, S. Fujiwara, N. Ono, A. Davidson, I. Bardeesy, N. Schmidl, C. Bock, C. Schuster, C. Lupberger, J. Habersetzer, F. Doffoel, M. Piardi, T. Sommacale, D. mamura, M. Uchida, T. Ohdan, H. Aikata, H. Chayama, K. Boldanova, T. Pessaux, P. Fuchs, B. C. Hoshida, Y. Zeisel, M. B. Duong, F. H. T. Baumert, T. F.

          Gastroenterology. 2019 Mar 2. pii: S0016-5085(19)32506-5. doi: 10.1053/j.gastro.2019.02.038.

          An Association Between Core Mutations in Hepatitis B Virus Genotype F1b and Hepatocellular Carcinoma in Alaskan Native People

            Hayashi, S. Khan, A. Simons, B. C. Homan, C. Matsui, T. Ogawa, K. Kawashima, K. Murakami, S. Takahashi, S. Isogawa, M. Ikeo, K. Mizokami, M. McMahon, B. J. Tanaka, Y.

            Hepatology. 2019 Jan;69(1):19-33. doi: 10.1002/hep.30111. Epub 2018 Dec 10.

            Hepatic IFN-Induced Protein with Tetratricopeptide Repeats Regulation of HCV Infection

              Ishida, Y. Kakuni, M. Bang, B. R. Sugahara, G. Lau, D. T. Tateno-Mukaidani, C. Li, M. Gale, M., Jr. Saito, T.

              J Interferon Cytokine Res. 2019 Mar;39(3):133-146. doi: 10.1089/jir.2018.0103.

              Early Multiphasic HBV Infection Initiation Kinetics Is Not Clone-Specific and Is Not Affected by Hepatitis D Virus (HDV) Infection

                Tsuge, M. Uchida, T. Walsh, K. Ishida, Y. Tateno, C. Kumar, U. Glenn, J. S. Koh, C. Heller, T. Uprichard, S. L. Dahari, H. Chayama, K.

                Viruses. 2019 Mar 15;11(3). pii: v11030263. doi: 10.3390/v11030263.

                Ribonucleotide reductase M2 promotes RNA replication of hepatitis C virus by protecting NS5B protein from hPLIC1-dependent proteasomal degradation

                  Kitab, B. Satoh, M. Ohmori, Y. Munakata, T. Sudoh, M. Kohara, M. Tsukiyama-Kohara, K.

                  J Biol Chem. 2019 Feb 12. pii: RA118.004397. doi: 10.1074/jbc.RA118.004397.

                  Prediction of human pharmacokinetics of long half-life compounds using chimeric mice with humanised liver

                    Miyamoto, M. Iwasaki, S. Chisaki, I. Nakagawa, S. Amano, N. Kosugi, Y. Hirabayashi, H.

                    Xenobiotica. 2019 Feb 12:1-31. doi: 10.1080/00498254.2019.1579394.

                    Comparison of intracellular responses between HBV genotype A and C infection in human hepatocyte chimeric mice

                      Tsushima, K. Tsuge, M. Hiraga, N. Uchida, T. Murakami, E. Makokha, G. N. Kurihara, M. Nomura, M. Hiyama, Y. Fujino, H. Ono, A. Nakahara, T. Yamauchi, M. Abe-Chayama, H. Kawaoka, T. Miki, D. Imamura, M. Aikata, H. Hayes, C. N. Chayama, K.

                      J Gastroenterol. 2019 Feb 21. pii: 10.1007/s00535-019-01558-w. doi: 10.1007/s00535-019-01558-w.

                      MicroRNAs Enable mRNA Therapeutics to Selectively Program Cancer Cells to Self-Destruct

                        Jain, R. Frederick, J. P. Huang, E. Y. Burke, K. E. Mauger, D. M. Andrianova, E. A. Farlow, S. J.Siddiqui, S. Pimentel, J. Cheung-Ong, K. McKinney, K. M. Kohrer, C. Moore, M. J. Chakraborty, T.

                        Nucleic Acid Ther. 2018 Oct;28(5):285-296.

                        Chimeric mice with human hepatocytes: A new system for genotoxicity studies

                          C. Tateno, M. Fukumuro, S. Masumori, M. Kakuni, Y. Ishida, T. Shimada, M. Hayashi

                          Mutat Res. 2019 Mar;839:9-12

                          Functional Analysis of Human Hepatocytes Isolated From Chimeric Mouse Liver

                            Harimoto, N. Nakagawara, H. Shirabe, K. Yoshizumi, T. Itoh, S. Ikegami, T. Soejima, Y. Maehara, Y. Ishida, Y. Tateno, C. Tanaka, Y.

                            Transplant Proc. 2018 Dec;50(10):3858-3862. doi: 10.1016/j.transproceed.2018.06.035.

                            Lack of human relevance for procymidone’s developmental toxicity attributable to species difference in its kinetics and metabolism

                              Tomigahara, Y. Tarui, H. Matsui, M. Kurosawa, M. Kawamura, S. Isobe, N.

                              J Pestic Sci. 2018 May 20;43(2):114-123. doi: 10.1584/jpestics.D17-085.

                              Hepatitis B Virus Therapeutic Agent ARB-1740 Has Inhibitory Effect on Hepatitis Delta Virus in a New Dually-Infected Humanized Mouse Model

                                Ye, X. Tateno, C. Thi, E. P. Kakuni, M. Snead, N. M. Ishida, Y. Barnard, T. R. Sofia, M. Shimada, T. Lee, A. C. H.

                                ACS Infect Dis. 2018 Nov 8. doi: 10.1021/acsinfecdis.8b00192.

                                ARB-1740, a RNA Interference Therapeutic for Chronic Hepatitis B Infection

                                  Thi, E. P. Dhillon, A. P. Ardzinski, A. Bidirici-Ertekin, L. Cobarrubias, K. D. Cuconati, A. Kondratowicz, A. S. Kwak, K. Li, A. H. L. Miller, A. Pasetka, C. Pei, L.Phelps, J. R. Snead, N. M. Wang, X. Ye, X. Sofia, M. J. Lee, A. C. H.

                                  ACS Infect Dis. 2018 Nov 19. doi: 10.1021/acsinfecdis.8b00191.

                                  Endoplasmic reticulum-mediated induction of interleukin-8 occurs by hepatitis B virus infection and contributes to suppression of interferon responsiveness in human hepatocytes

                                    Tsuge, M. Hiraga, N. Zhang, Y. Yamashita, M.  Sato, O. Oka, N. Shiraishi, K. Izaki, Y. Makokha, G. N. Uchida, T. Kurihara, M. Nomura, M. Tsushima, K. Nakahara, T. Murakami, E. Abe-Chayama, H. Kawaoka, T. Miki, D. Imamura, M. Kawakami, Y. Aikata, H. Ochi, H. Hayes, C. N. Fujita, T. Chayama, K.

                                    Virology. 2018 Sep 18;525:48-61. doi: 10.1016/j.virol.2018.08.020.

                                    CTL-associated and NK cell-associated immune responses induce different HBV DNA reduction patterns in chronic hepatitis B patients

                                      Nomura, M. Tsuge, M. Uchida, T. Hiraga, N. Kurihara, M. Tsushima, K. Fujino, H. Nakahara, T. Murakami, E. Abe-Chayama, H. Kawaoka, T. Miki, D. Hiramatsu, A. Imamura, M. Kawakami, Y. Aikata, H. Ochi, H. Zhang, Y. Makokha, G. N. Hayes, C. N. Tanaka, S. Chayama, K.

                                      J Viral Hepat. 2018 Jul 11. doi: 10.1111/jvh.12970.

                                      The metabolic fate of fenclozic acid in chimeric mice with a humanized liver

                                        Ekdahl, A. Weidolf, L. Baginski, M. Morikawa, Y. Thompson, R. A. Wilson, I. D.

                                        Arch Toxicol. 2018 Sep;92(9):2819-2828.

                                        Contribution of chimeric mice with a humanized liver to the evaluation of pharmacology, toxicity, and pharmacokinetics in drug discovery and development

                                          Sanoh, S. Ohta, S.

                                          Nihon Yakurigaku Zasshi. 2018;151(5):213-220