Chimeric Mouse With Humanized Liver Is an Appropriate Animal Model to Investigate Mode of Action for Porphyria-Mediated Hepatocytotoxicity

Toxicol Pathol. 2021 Jul 9:1926233211027474. doi: 10.1177/01926233211027474.

Eguchi, A. Fukunaga, S. Ogata, K. Kushida, M. Asano, H. Cohen, S. M. Sukata, T.

Application of humanized mice to toxicology studies: Evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)

Journal Toxicologic Pathology 2021; 34(4): 283-297. doi: https://doi.org/10.1293/tox.2021-0027

Tomoya Yamada

Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)

Yamada, T. Cohen, S. M. Lake, B. G.

Crit Rev Toxicol. 2021;51(5):373-394. doi:10.1080/10408444.2021.1939654. Epub 2021 Jul 15.

Detection of acute toxicity of aflatoxin B1 to human hepatocytes in vitro and in vivo using chimeric mice with humanized livers

Ishida, Y. Yamasaki, C. Iwanari, H. Yamashita, H. Ogawa, Y. Yanagi, A. Furukawa, S. Kojima, Y. Chayama, K. Kamiie, J. Tateno, C.

PLoS One. 2020 Sep 23;15(9):e0239540. doi: 10.1371/journal.pone.0239540.

Comparison of the hepatic effects of phenobarbital in chimeric mice containing either rat or human hepatocytes with humanized constitutive androstane receptor (CAR) and pregnane X receptor (PXR) mice (hCAR/hPXR mice)

Yamada, T. Ohara, A. Ozawa, N. Maeda, K. Kondo, M. Okuda, Y. Abe, J. Cohen, S. M. Lake, B. G.

Toxicol Sci. 2020 Jul 31. pii: 5879297. doi: 10.1093/toxsci/kfaa125.

住友化学株式会社様より、PXBマウス関連の学術論文が発表されましたのでご紹介申し上げます。

【詳細】

掲載雑誌名：Toxicological Science, kfaa125, https://doi.org/10.1093/toxsci/kfaa125

掲載日：2020年7月31日

論文名：Comparison of the hepatic effects of phenobarbital in chimeric mice containing either

著者：Yamada, et. al.（住友化学株式会社）

概要：化学品のヒト肝毒性予測において、ヒトの肝臓をもつキメラマウス（PXBマウス）が有用であることを、

PXBマウスが、ラットの肝臓をもつキメラマウスや遺伝子組換え動物（hCAR/hPXRマウス）との反応性において

差異があることを示すことで、科学的に実証した。

Successful energy shift from glycolysis to mitochondrial oxidative phosphorylation in freshly isolated hepatocytes from humanized mice liver

Ikeyama, Y. Sato, T. Takemura, A. Sekine, S. Ito, K.

Toxicol In Vitro. 2020 Jan 25:104785. doi: 10.1016/j.tiv.2020.104785.

Prediction of human pharmacokinetics of long half-life compounds using chimeric mice with humanised liver

Miyamoto, M. Iwasaki, S. Chisaki, I. Nakagawa, S. Amano, N. Kosugi, Y. Hirabayashi, H.

Xenobiotica. 2019 Feb 12:1-31. doi: 10.1080/00498254.2019.1579394.

MicroRNAs Enable mRNA Therapeutics to Selectively Program Cancer Cells to Self-Destruct

Jain, R. Frederick, J. P. Huang, E. Y. Burke, K. E. Mauger, D. M. Andrianova, E. A. Farlow, S. J.Siddiqui, S. Pimentel, J. Cheung-Ong, K. McKinney, K. M. Kohrer, C. Moore, M. J. Chakraborty, T.

Nucleic Acid Ther. 2018 Oct;28(5):285-296.

Chimeric mice with human hepatocytes: A new system for genotoxicity studies

C. Tateno, M. Fukumuro, S. Masumori, M. Kakuni, Y. Ishida, T. Shimada, M. Hayashi

Mutat Res. 2019 Mar;839:9-12

Lack of human relevance for procymidone’s developmental toxicity attributable to species difference in its kinetics and metabolism

Tomigahara, Y. Tarui, H. Matsui, M. Kurosawa, M. Kawamura, S. Isobe, N.

J Pestic Sci. 2018 May 20;43(2):114-123. doi: 10.1584/jpestics.D17-085.

The whole transcriptome effects of the PPARalpha agonist fenofibrate on livers of hepatocyte humanized mice

de la Rosa Rodriguez, M. A. Sugahara, G. Hooiveld, Gjej Ishida, Y. Tateno, C. Kersten, S.

BMC Genomics. 2018 Jun 7;19(1):443. doi: 10.1186/s12864-018-4834-3.

Assessment of amiodarone-induced phospholipidosis in chimeric mice with a humanized liver

Sanoh, S. Yamachika, Y. Tamura, Y. Kotake, Y. Yoshizane, Y. Ishida, Y. Tateno, C. Ohta, S.

J Toxicol Sci. 2017;42(5):589-596. doi: 10.2131/jts.42.589.

Halogenated hydrocarbon solvent-related cholangiocarcinoma risk: biliary excretion of glutathione conjugates of 1,2-dichloropropane evidenced by untargeted metabolomics analysis

Toyoda, Y. Takada, T. Suzuki, H.

Sci Rep. 2016 Apr 18;6:24586. doi: 10.1038/srep24586.

Zone analysis by two-dimensional electrophoresis with accelerator mass spectrometry of in vivo protein bindings of idiosyncratic hepatotoxicants troglitazone and flutamide bioactivated in chimeric mice with humanized liver

Yamazaki, H. Kuribayashi, S. Inoue, T. Honda,T. Tateno, C. Oofusa, K. Ninomiya, S.Ikedag , T. Izumi, T and Horie, T

Toxicology Research

Human Hepatocytes Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogen Sodium Phenobarbital in an In Vivo Study Using a Chimeric Mouse with Humanized Liver

Yamada, T. Okuda, Y. Kushida, M. Sumida, K. Takeuchi, H. Nagahori, H. Fukuda, T. Lake, B. G. Cohen, S. M. Kawamura, S.

Toxicol Sci. 2014 Aug 21. pii: kfu173.

Endogenous and xenobiotic metabolite profiling of liver extracts from SCID and chimeric humanized mice following repeated oral administration of troglitazone

Barnes, A. J. Baker, D. R. Hobby, K. Ashton, S. Michopoulos, F. Spagou, K. Loftus, N. J. Wilson, I. D.
Xenobiotica. 2014 Jan; 44(2): 174-85.

Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers.

Schulz-Utermoehl T, Sarda S, Foster JR, Jacobsen M, Kenna JG, Morikawa Y, Salmu J, Gross G, Wilson ID.
Xenobiotica.　2012 Jun;42(6):503-17.

Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury

Masakazu Kakuni, Mayu Morita, Kentaro Matsuo, Yumiko Katoh, Miki Nakajima,Chise Tateno, Tsuyoshi Yokoi
Toxicology Letters 214 (2012) 9-18

Differential Effect of Troglitazone on the Human Bile Acid Transporters, MRP2 and BSEP, in the PXB Hepatic Chimeric Mouse

Foster JR, Jacobsen M, Kenna G, Schulz-Utermoehl T, Morikawa Y, Salmu J, Wilson ID.
Toxicologic Pathology, 2012 Dec;40(8):1106-16.