Phoenix Bio

研究開発

研究開発

Successful energy shift from glycolysis to mitochondrial oxidative phosphorylation in freshly isolated hepatocytes from humanized mice liver

    Ikeyama, Y. Sato, T. Takemura, A. Sekine, S. Ito, K.

    Toxicol In Vitro. 2020 Jan 25:104785. doi: 10.1016/j.tiv.2020.104785.

    Prediction of human pharmacokinetics of long half-life compounds using chimeric mice with humanised liver

      Miyamoto, M. Iwasaki, S. Chisaki, I. Nakagawa, S. Amano, N. Kosugi, Y. Hirabayashi, H.

      Xenobiotica. 2019 Feb 12:1-31. doi: 10.1080/00498254.2019.1579394.

      MicroRNAs Enable mRNA Therapeutics to Selectively Program Cancer Cells to Self-Destruct

        Jain, R. Frederick, J. P. Huang, E. Y. Burke, K. E. Mauger, D. M. Andrianova, E. A. Farlow, S. J.Siddiqui, S. Pimentel, J. Cheung-Ong, K. McKinney, K. M. Kohrer, C. Moore, M. J. Chakraborty, T.

        Nucleic Acid Ther. 2018 Oct;28(5):285-296.

        Chimeric mice with human hepatocytes: A new system for genotoxicity studies

          C. Tateno, M. Fukumuro, S. Masumori, M. Kakuni, Y. Ishida, T. Shimada, M. Hayashi

          Mutat Res. 2019 Mar;839:9-12

          Lack of human relevance for procymidone’s developmental toxicity attributable to species difference in its kinetics and metabolism

            Tomigahara, Y. Tarui, H. Matsui, M. Kurosawa, M. Kawamura, S. Isobe, N.

            J Pestic Sci. 2018 May 20;43(2):114-123. doi: 10.1584/jpestics.D17-085.

            The whole transcriptome effects of the PPARalpha agonist fenofibrate on livers of hepatocyte humanized mice

              de la Rosa Rodriguez, M. A. Sugahara, G. Hooiveld, Gjej Ishida, Y. Tateno, C. Kersten, S.

              BMC Genomics. 2018 Jun 7;19(1):443. doi: 10.1186/s12864-018-4834-3.

              Assessment of amiodarone-induced phospholipidosis in chimeric mice with a humanized liver

                Sanoh, S. Yamachika, Y. Tamura, Y. Kotake, Y. Yoshizane, Y. Ishida, Y. Tateno, C. Ohta, S.

                J Toxicol Sci. 2017;42(5):589-596. doi: 10.2131/jts.42.589.

                Halogenated hydrocarbon solvent-related cholangiocarcinoma risk: biliary excretion of glutathione conjugates of 1,2-dichloropropane evidenced by untargeted metabolomics analysis

                  Toyoda, Y. Takada, T. Suzuki, H.

                  Sci Rep. 2016 Apr 18;6:24586. doi: 10.1038/srep24586.

                  Zone analysis by two-dimensional electrophoresis with accelerator mass spectrometry of in vivo protein bindings of idiosyncratic hepatotoxicants troglitazone and flutamide bioactivated in chimeric mice with humanized liver

                    Yamazaki, H. Kuribayashi, S. Inoue, T. Honda,T. Tateno, C. Oofusa, K. Ninomiya, S.Ikedag , T. Izumi, T and Horie, T

                    Toxicology Research

                    Human Hepatocytes Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogen Sodium Phenobarbital in an In Vivo Study Using a Chimeric Mouse with Humanized Liver

                      Yamada, T. Okuda, Y. Kushida, M. Sumida, K. Takeuchi, H. Nagahori, H. Fukuda, T. Lake, B. G. Cohen, S. M. Kawamura, S.

                      Toxicol Sci. 2014 Aug 21. pii: kfu173.

                      Endogenous and xenobiotic metabolite profiling of liver extracts from SCID and chimeric humanized mice following repeated oral administration of troglitazone

                        Barnes, A. J. Baker, D. R. Hobby, K. Ashton, S. Michopoulos, F. Spagou, K. Loftus, N. J. Wilson, I. D.
                        Xenobiotica. 2014 Jan; 44(2): 174-85.

                        Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers.

                          Schulz-Utermoehl T, Sarda S, Foster JR, Jacobsen M, Kenna JG, Morikawa Y, Salmu J, Gross G, Wilson ID.
                          Xenobiotica. 2012 Jun;42(6):503-17.

                          Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury

                            Masakazu Kakuni, Mayu Morita, Kentaro Matsuo, Yumiko Katoh, Miki Nakajima,Chise Tateno, Tsuyoshi Yokoi
                            Toxicology Letters 214 (2012) 9-18

                            Differential Effect of Troglitazone on the Human Bile Acid Transporters, MRP2 and BSEP, in the PXB Hepatic Chimeric Mouse

                              Foster JR, Jacobsen M, Kenna G, Schulz-Utermoehl T, Morikawa Y, Salmu J, Wilson ID.
                              Toxicologic Pathology, 2012 Dec;40(8):1106-16.

                              Approach for in vivo protein binding of 5-n-butyl-pyrazolo[1,5-a]pyrimidine bioactivated in chimeric mice with humanized liver by two-dimensional electrophoresis with accelerator mass spectrometry.

                                Yamazaki H, Kuribayashi S, Inoue T, Tateno C, Nishikura Y, Oofusa K, Harada D, Naito S, Horie T, Ohta S.
                                Chem Res Toxicol. 2010 Jan;23(1):152-8.

                                Evaluation of human hepatocyte chimeric mice as a model for toxicological investigation using panomic approaches–effect of acetaminophen on the expression profiles of proteins and endogenous metabolites in liver, plasma and urine

                                  Yamamoto T, Tomizawa K, Fujikawa M, Sato Y, Yamada H, Horii I.
                                  J Toxicol Sci. 2007 Aug;32(3):205-15.