An evaluation of the human relevance of the hepatocellular tumors observed in mice treated with synthetic fungicide, pyridachlometyl, based on mode of action

Kawamoto, K. Shimotsuma, Y. Maeda, K. Matsunaga, K. Asano, H. Cohen, S. M. Yamada, T.

Arch Toxicol. 2025 Sep;99(9):3803-3824. doi: 10.1007/s00204-025-04099-9.

Mode of action analysis for mouse liver tumor formation by MGK-264 and human relevance

Yano, J. Kawamoto, K. Shimotsuma, Y. Ogata, K. Matsunaga, K. Abe, J. Fukunaga, S. Osimitz, T. G. Lake, B. G. Asano, H.
Regul Toxicol Pharmacol. 2025 Dec;163:105929. doi: 10.1016/j.yrtph.2025.105929.

An evaluation of the human relevance of the hepatocellular tumors observed in mice treated with synthetic fungicide, pyridachlometyl, based on mode of action

Kawamoto, K.Shimotsuma, Y.Maeda, K. Matsunaga, K. Asano, H. Cohen, S. M. Yamada, T.
Arch Toxicol. 2025 Jun 9. doi: 10.1007/s00204-025-04099-9.

Prediction of the human pharmacokinetics of epyrifenacil and its major metabolite, S-3100-CA, by a physiologically based pharmacokinetic modeling using chimeric mice with humanized liver

Hirasawa, K. Abe, J. Nagahori, H. Kitamoto, S.
Toxicol Appl Pharmacol. 2022 Mar 15;439:115912. doi: 10.1016/j.taap.2022.115912.

Evaluation of the mode of action and human relevance of liver tumors in male mice treated with epyrifenacil

Fukunaga, S. Ogata, K. Eguchi, A. Matsunaga, K. Sakurai, K. Abe, J. Cohen, S. M. Asano, H.
Regul Toxicol Pharmacol. 2022 Oct 6;136:105268. doi: 10.1016/j.yrtph.2022.105268.

Elucidation of the species differences of epyrifenacil-induced hepatotoxicity between mice and humans by mass spectrometry imaging analysis in chimeric mice with humanized liver

Matsunaga, K. Abe, J. Ogata, K. Fukunaga, S. Kitamoto, S.
J Toxicol Sci. 2021;46(12):601-609. doi: 10.2131/jts.46.601.

Chimeric Mouse With Humanized Liver Is an Appropriate Animal Model to Investigate Mode of Action for Porphyria-Mediated Hepatocytotoxicity

Toxicol Pathol. 2021 Jul 9:1926233211027474. doi: 10.1177/01926233211027474.

Eguchi, A. Fukunaga, S. Ogata, K. Kushida, M. Asano, H. Cohen, S. M. Sukata, T.

Application of humanized mice to toxicology studies: Evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)

Journal Toxicologic Pathology 2021; 34(4): 283-297. doi: https://doi.org/10.1293/tox.2021-0027

Tomoya Yamada

Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)

Yamada, T. Cohen, S. M. Lake, B. G.

Crit Rev Toxicol. 2021;51(5):373-394. doi:10.1080/10408444.2021.1939654. Epub 2021 Jul 15.

Detection of acute toxicity of aflatoxin B1 to human hepatocytes in vitro and in vivo using chimeric mice with humanized livers

Ishida, Y. Yamasaki, C. Iwanari, H. Yamashita, H. Ogawa, Y. Yanagi, A. Furukawa, S. Kojima, Y. Chayama, K. Kamiie, J. Tateno, C.

PLoS One. 2020 Sep 23;15(9):e0239540. doi: 10.1371/journal.pone.0239540.

Comparison of the hepatic effects of phenobarbital in chimeric mice containing either rat or human hepatocytes with humanized constitutive androstane receptor (CAR) and pregnane X receptor (PXR) mice (hCAR/hPXR mice)

Yamada, T. Ohara, A. Ozawa, N. Maeda, K. Kondo, M. Okuda, Y. Abe, J. Cohen, S. M. Lake, B. G.

Toxicol Sci. 2020 Jul 31. pii: 5879297. doi: 10.1093/toxsci/kfaa125.

住友化学株式会社様より、PXBマウス関連の学術論文が発表されましたのでご紹介申し上げます。

【詳細】

掲載雑誌名：Toxicological Science, kfaa125, https://doi.org/10.1093/toxsci/kfaa125

掲載日：2020年7月31日

論文名：Comparison of the hepatic effects of phenobarbital in chimeric mice containing either

著者：Yamada, et. al.（住友化学株式会社）

概要：化学品のヒト肝毒性予測において、ヒトの肝臓をもつキメラマウス（PXBマウス）が有用であることを、

PXBマウスが、ラットの肝臓をもつキメラマウスや遺伝子組換え動物（hCAR/hPXRマウス）との反応性において

差異があることを示すことで、科学的に実証した。

Successful energy shift from glycolysis to mitochondrial oxidative phosphorylation in freshly isolated hepatocytes from humanized mice liver

Ikeyama, Y. Sato, T. Takemura, A. Sekine, S. Ito, K.

Toxicol In Vitro. 2020 Jan 25:104785. doi: 10.1016/j.tiv.2020.104785.

Prediction of human pharmacokinetics of long half-life compounds using chimeric mice with humanised liver

Miyamoto, M. Iwasaki, S. Chisaki, I. Nakagawa, S. Amano, N. Kosugi, Y. Hirabayashi, H.

Xenobiotica. 2019 Feb 12:1-31. doi: 10.1080/00498254.2019.1579394.

MicroRNAs Enable mRNA Therapeutics to Selectively Program Cancer Cells to Self-Destruct

Jain, R. Frederick, J. P. Huang, E. Y. Burke, K. E. Mauger, D. M. Andrianova, E. A. Farlow, S. J.Siddiqui, S. Pimentel, J. Cheung-Ong, K. McKinney, K. M. Kohrer, C. Moore, M. J. Chakraborty, T.

Nucleic Acid Ther. 2018 Oct;28(5):285-296.

Chimeric mice with human hepatocytes: A new system for genotoxicity studies

C. Tateno, M. Fukumuro, S. Masumori, M. Kakuni, Y. Ishida, T. Shimada, M. Hayashi

Mutat Res. 2019 Mar;839:9-12

Lack of human relevance for procymidone’s developmental toxicity attributable to species difference in its kinetics and metabolism

Tomigahara, Y. Tarui, H. Matsui, M. Kurosawa, M. Kawamura, S. Isobe, N.

J Pestic Sci. 2018 May 20;43(2):114-123. doi: 10.1584/jpestics.D17-085.

The whole transcriptome effects of the PPARalpha agonist fenofibrate on livers of hepatocyte humanized mice

de la Rosa Rodriguez, M. A. Sugahara, G. Hooiveld, Gjej Ishida, Y. Tateno, C. Kersten, S.

BMC Genomics. 2018 Jun 7;19(1):443. doi: 10.1186/s12864-018-4834-3.

Assessment of amiodarone-induced phospholipidosis in chimeric mice with a humanized liver

Sanoh, S. Yamachika, Y. Tamura, Y. Kotake, Y. Yoshizane, Y. Ishida, Y. Tateno, C. Ohta, S.

J Toxicol Sci. 2017;42(5):589-596. doi: 10.2131/jts.42.589.

Halogenated hydrocarbon solvent-related cholangiocarcinoma risk: biliary excretion of glutathione conjugates of 1,2-dichloropropane evidenced by untargeted metabolomics analysis

Toyoda, Y. Takada, T. Suzuki, H.

Sci Rep. 2016 Apr 18;6:24586. doi: 10.1038/srep24586.