Phoenix Bio

研究発表

研究発表

MafF is an antiviral host factor that suppresses transcription from Hepatitis B Virus core promoter

    Marwa K. Ibrahim, Tawfeek H. Abdelhafez, Junko S. Takeuchi, Kosho Wakae, Masaya Sugiyama, Masataka Tsuge, Masahiko Ito, Koichi Watashi, Mohamed El. Kassas, Takanobu Kato, Asako Murayama, Tetsuro Suzuki, Kazuaki Chayama, Kunitada Shimotohno, Masamichi Muramatsu, Hussein H. Aly, Takaji Wakita

    J Virol. 2021 Jul 12;95(15): e0076721. doi: 10.1128/JVI.00767-21. Epub 2021 Jul 12.

    Geranylgeranylacetone decreases the production of hepatitis B virus-related antigen by comprehensive downregulation of mRNA transcription activity

      Haraguchi, M. Miuma, S. Yamamoto, K. Nakao, Y. Ichikawa, T. Kanda, Y. Sasaki, R. Fukushima, M. Akazawa, Y. Miyaaki, H. Nakao, K.
      J Gastroenterol Hepatol. 2021 Jan 4. doi: 10.1111/jgh.15394.

      Interferon signaling suppresses the unfolded protein response and induces cell death in hepatocytes accumulating hepatitis B surface antigen

        Baudi, I. Isogawa, M. Moalli, F. Onishi, M. Kawashima, K. Ishida, Y. Tateno, C. Sato, Y. Harashima, H. Ito, H. Ishikawa, T. Wakita, T. Iannacone, M. Tanaka, Y.
        PLoS Pathog. 2021 May 12;17(5):e1009228. doi: 10.1371/journal.ppat.1009228.

        Understanding hepatitis B virus dynamics and the antiviral effect of interferon-alpha treatment in humanized chimeric mice

          Reinharz, V. Ishida, Y. Tsuge, M. Durso-Cain, K. Chung, T. L. Tateno, C. Perelson, A. S. Uprichard, S. L. Chayama, K. Dahari, H.
          J Virol. 2021 Apr 28. pii: JVI.00492-20. doi: 10.1128/JVI.00492-20.

          Identification of a novel long-acting 4′-modified nucleoside reverse transcriptase inhibitor against HBV

            Higashi-Kuwata, N. Hayashi, S. Kumamoto, H. Ogata-Aoki, H. Das, D. Venzon, D. Hattori, S. I. Bulut, H. Hashimoto, M. Otagiri, M. Takamune, N. Kishimoto, N. Davis, D. A. Misumi, S. Kakuni, M.
            J Hepatol. 2020 Dec 15. pii: S0168-8278(20)33843-5. doi: 10.1016/j.jhep.2020.12.006.

            cccDNA_Pathway_Involvement of Host ATR-CHK1 Pathway in Hepatitis B Virus Covalently Closed Circular DNA Formation

              Luo, J. Luckenbaugh, L. Hu, H. Yan, Z. Gao, L. Hu, J.
              mBio. 2020 Feb 18;11(1):e03423-19. doi: 10.1128/mBio.03423-19.

              Dual Agonist of Farnesoid X Receptor and G Protein-coupled Receptor TGR5 Inhibits Hepatitis B Virus Infection in Vitro and in Vivo

                Ito, K. Okumura, A. S. Takeuchi J Watashi, K. Inoue, R. Yamauchi, T. Sakamoto, K. Yamashita, Y. Iguchi, Y. Une, M. Wakita, T. Umezawa, K. Yoneda, M.

                Hepatology. 2021 Jan 12. doi: 10.1002/hep.31712.

                Suppression of hepatitis B virus through therapeutic activation of RIG-I and IRF3 signaling in hepatocytes

                  Sooyoung Lee, Ashish Goyal, Alan S. Perelson, Yuji Ishida, Takeshi Saito, Michael Gale, Jr.

                  iScience. 2021 Jan 4;24(1):101969. doi: 10.1016/j.isci.2020.101969. eCollection 2021 Jan 22.

                  Role of Hepatitis B virus capsid phosphorylation in nucleocapsid disassembly and covalently closed circular DNA formation

                    Luo, J. Xi, J. Gao, L. Hu, J.

                    PLoS Pathog. 2020 Mar 30;16(3):e1008459. doi: 10.1371/journal.ppat.1008459. eCollection 2020 Mar.

                    Development of an in vivo delivery system for CRISPR/Cas9-mediated targeting of hepatitis B virus cccDNA

                      Kayesh, M. E. H. Amako, Y. Hashem, M. A. Murakami, S. Ogawa, S. Yamamoto, N. Hifumi, T. Miyoshi, N. Sugiyama, M. Tanaka, Y. Mizokami, M. Kohara, M. Tsukiyama-Kohara, K.

                      Virus Res. 2020 Oct 10;290:198191. doi: 10.1016/j.virusres.2020.198191.

                      PXBマウス・PXB-cells関連研究発表のご案内:肝炎関連3学会

                      2020年7月~8月に開催されました、以下の肝炎関連学会(3学会:日本消化器病学会、EASL、日本肝臓学会)にて、PXBマウス及びPXB-cells関連の研究発表がありました。

                      Signal activation of hepatitis B virus-related hepatocarcinogenesis by upregulation of SUV39h1

                        Takeuchi, Y. Tsuge, M. Tsushima, K. Suehiro, Y. Fujino, H. Ono, A. Yamauchi, M. Makokha, G. N. Nakahara, T. Murakami, E. Abe-Chayama, H. Kawaoka, T. Miki, D. Imamura, M. Aikata, H. Hayes, C. N. Tateno, C. Chayama, K.

                        J Infect Dis. 2020 Jun 9:jiaa317. doi: 10.1093/infdis/jiaa317.

                        Engineering Cellular Biosensors with Customizable Antiviral Responses Targeting Hepatitis B Virus

                          Matsunaga, S. Jeremiah, S. S. Miyakawa, K. Kurotaki, D. Shizukuishi, S. Watashi, K. Nishitsuji, H. Kimura, H. Tamura, T. Yamamoto, N. Shimotohno, K. Wakita, T. Ryo, A.

                          iScience. 2020 Mar 27;23(3):100867. doi: 10.1016/j.isci.2020.100867. Epub 2020 Feb 26.

                          Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection

                            Cheng, X. Uchida, T. Xia, Y. Umarova, R. Liu, C. J. Chen, P. J. Gaggar, A. Suri, V. Mucke, M. M. Vermehren, J. Zeuzem, S. Teraoka, Y. Osawa, M. Aikata, H. Tsuji, K. Mori, N. Hige, S. Karino, Y. Imamura, M. Chayama, K. Liang, T. J.

                            J Clin Invest. 2020 Mar 12. pii: 135616. doi: 10.1172/JCI135616.

                            Anti-HBV activity of retinoid drugs in vitro versus in vivo

                              Birkus, G. Snyder, C. Jordan, R. Kobayashi, T. Dick, R. Puscau, V. Li, L. Ramirez, R. Willkom, M. Morikawa, Y. Delaney, W. Schmitz, U.

                              Antiviral Res. 2019 Jun 18:104538. doi: 10.1016/j.antiviral.2019.104538.

                              An interferon-like small chemical compound CDM-3008 suppresses hepatitis B virus through induction of interferon-stimulated genes

                                Furutani, Y. Toguchi, M. Shiozaki-Sato, Y. Qin, X. Y. Ebisui, E. Higuchi, S. Sudoh, M. Suzuki, H. Takahashi, N. Watashi, K. Wakita, T. Kakeya, H. Kojima, S.

                                PLoS One. 2019 Jun 12;14(6):e0216139. doi: 10.1371/journal.pone.0216139. eCollection 2019.

                                Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly

                                  Kang, J. A. Kim, S. Park, M. Park, H. J. Kim, J. H. Park, S. Hwang, J. R. Kim, Y. C. Jun Kim, Y. Cho, Y. Sun Jin, M. Park, S. G.

                                  Nat Commun. 2019 May 16;10(1):2184. doi: 10.1038/s41467-019-10200-5.

                                  PAPD5/7 Are Host Factors That Are Required for Hepatitis B Virus RNA Stabilization

                                    Mueller, H. Lopez, A. Tropberger, P. Wildum, S. Schmaler, J. Pedersen, L. Han, X. Wang, Y. Ottosen, S. Yang, S. Young, J. A. T. Javanbakht, H.

                                    Hepatology. 2019 Apr;69(4):1398-1411. doi: 10.1002/hep.30329. Epub 2019 Mar 1.

                                    An Association Between Core Mutations in Hepatitis B Virus Genotype F1b and Hepatocellular Carcinoma in Alaskan Native People

                                      Hayashi, S. Khan, A. Simons, B. C. Homan, C. Matsui, T. Ogawa, K. Kawashima, K. Murakami, S. Takahashi, S. Isogawa, M. Ikeo, K. Mizokami, M. McMahon, B. J. Tanaka, Y.

                                      Hepatology. 2019 Jan;69(1):19-33. doi: 10.1002/hep.30111. Epub 2018 Dec 10.

                                      Early Multiphasic HBV Infection Initiation Kinetics Is Not Clone-Specific and Is Not Affected by Hepatitis D Virus (HDV) Infection

                                        Tsuge, M. Uchida, T. Walsh, K. Ishida, Y. Tateno, C. Kumar, U. Glenn, J. S. Koh, C. Heller, T. Uprichard, S. L. Dahari, H. Chayama, K.

                                        Viruses. 2019 Mar 15;11(3). pii: v11030263. doi: 10.3390/v11030263.