Phoenix Bio

研究発表

研究発表

Ongoing viral replication and production of infectious virus in patients with chronic hepatitis B virus suppressed below the limit of quantitation on long-term nucleos(t)ide therapy

    Burdette, D. L. Lazerwith, S. Yang, J. Chan, H. L. Y. Delaney Iv, W. E. Fletcher, S. P. Cihlar, T. Feierbach, B.
    PLoS One. 2022 Apr 1;17(4):e0262516. doi: 10.1371/journal.pone.0262516.

    Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1beta to downregulate PPARalpha and FOXO3

      Li, Y. Zhu, Y. Feng, S. Ishida, Y. Chiu, T. P. Saito, T. Wang, S. Ann, D. K. Ou, J. J.
      Cell Rep. 2022 Jan 25;38(4):110284. doi: 10.1016/j.celrep.2021.110284.

      HBV upregulates TRAIL-R3 expression in hepatocytes for escaping both cell apoptosis and suppression of their replication by TRAIL

        Suehiro, Y. Tsuge, M. Kurihara, M. Uchida, T. Fujino, H. Ono, A. Yamauchi, M. Makokha, G. N. Nakahara, T. Murakami, E. Abe-Chayama, H. Kawaoka, T. Miki, D. Imamura, M. Aikata, H. Hayes, C. N. Fujita, T. Chayama, K.
        J Infect Dis. 2022 Feb 28. pii: 6534478. doi: 10.1093/infdis/jiac044.

        Droplet digital PCR assay provides intrahepatic HBV cccDNA quantification tool for clinical application

          Hayashi, S. Isogawa, M. Kawashima, K. Ito, K. Chuaypen, N. Morine, Y. Shimada, M. Higashi-Kuwata, N. Watanabe, T. Tangkijvanich, P. Mitsuya, H. Tanaka, Y.
          Sci Rep. 2022 Feb 8;12(1):2133. doi: 10.1038/s41598-022-05882-9.

          ヒト肝細胞キメラマウスを利用したB型 肝炎ウイルス/D型肝炎ウイルス共感染モデル

          加国 雅和
          Medical Science Digest(MSD) 2021;47(14):26-27

          Are Humanized Mouse Models Useful for Basic Research of Hepatocarcinogenesis through Chronic Hepatitis B Virus Infection?

            Masataka Tsuge
            Viruses. 2021 Sep 24;13(10). pii: v13101920. doi: 10.3390/v13101920.

            HBx-induced degradation of Smc5/6 complex impairs homologous recombination-mediated repair of damaged DNA

              Sekiba, K. Otsuka, M. Funato, K. Miyakawa, Y. Tanaka, E. Seimiya, T. Yamagami, M. Tsutsumi, T. Okushin, K. Miyakawa, K. Ryo, A. Koike, K.

              J Hepatol. 2021 Aug 25. pii: S0168-8278(21)02005-5. doi: 10.1016/j.jhep.2021.08.010.

              Infection courses, virological features and IFN-alpha responses of HBV genotypes in cell culture and animal models

                Zhang, M. Zhang, Z. Imamura, M. Osawa, M. Teraoka, Y. Piotrowski, J. Ishida, Y. Sozzi, V. Revill, P. A. Saito, T. Chayama, K. Liang, T. J.

                J Hepatol. 2021 Aug 4. pii: S0168-8278(21)01960-7. doi: 10.1016/j.jhep.2021.07.030.

                Epidermal growth factor receptor is a host-entry cofactor triggering hepatitis B virus internalization

                  Iwamoto, M. Saso, W. Sugiyama, R. Ishii, K. Ohki, M. Nagamori, S. Suzuki, R. Aizaki, H. Ryo, A. Yun, J. H. Park, S. Y. Ohtani, N. Muramatsu, M. Iwami, S. Tanaka, Y. Sureau, C. Wakita, T. Watashi, K.
                  Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8487-8492. doi: 10.1073/pnas.1811064116. Epub 2019 Apr 5.

                  MafF is an antiviral host factor that suppresses transcription from Hepatitis B Virus core promoter

                    Marwa K. Ibrahim, Tawfeek H. Abdelhafez, Junko S. Takeuchi, Kosho Wakae, Masaya Sugiyama, Masataka Tsuge, Masahiko Ito, Koichi Watashi, Mohamed El. Kassas, Takanobu Kato, Asako Murayama, Tetsuro Suzuki, Kazuaki Chayama, Kunitada Shimotohno, Masamichi Muramatsu, Hussein H. Aly, Takaji Wakita

                    J Virol. 2021 Jul 12;95(15): e0076721. doi: 10.1128/JVI.00767-21. Epub 2021 Jul 12.

                    Geranylgeranylacetone decreases the production of hepatitis B virus-related antigen by comprehensive downregulation of mRNA transcription activity

                      Haraguchi, M. Miuma, S. Yamamoto, K. Nakao, Y. Ichikawa, T. Kanda, Y. Sasaki, R. Fukushima, M. Akazawa, Y. Miyaaki, H. Nakao, K.
                      J Gastroenterol Hepatol. 2021 Jan 4. doi: 10.1111/jgh.15394.

                      Interferon signaling suppresses the unfolded protein response and induces cell death in hepatocytes accumulating hepatitis B surface antigen

                        Baudi, I. Isogawa, M. Moalli, F. Onishi, M. Kawashima, K. Ishida, Y. Tateno, C. Sato, Y. Harashima, H. Ito, H. Ishikawa, T. Wakita, T. Iannacone, M. Tanaka, Y.
                        PLoS Pathog. 2021 May 12;17(5):e1009228. doi: 10.1371/journal.ppat.1009228.

                        Understanding hepatitis B virus dynamics and the antiviral effect of interferon-alpha treatment in humanized chimeric mice

                          Reinharz, V. Ishida, Y. Tsuge, M. Durso-Cain, K. Chung, T. L. Tateno, C. Perelson, A. S. Uprichard, S. L. Chayama, K. Dahari, H.
                          J Virol. 2021 Apr 28. pii: JVI.00492-20. doi: 10.1128/JVI.00492-20.

                          Identification of a novel long-acting 4′-modified nucleoside reverse transcriptase inhibitor against HBV

                            Higashi-Kuwata, N. Hayashi, S. Kumamoto, H. Ogata-Aoki, H. Das, D. Venzon, D. Hattori, S. I. Bulut, H. Hashimoto, M. Otagiri, M. Takamune, N. Kishimoto, N. Davis, D. A. Misumi, S. Kakuni, M.
                            J Hepatol. 2020 Dec 15. pii: S0168-8278(20)33843-5. doi: 10.1016/j.jhep.2020.12.006.

                            cccDNA_Pathway_Involvement of Host ATR-CHK1 Pathway in Hepatitis B Virus Covalently Closed Circular DNA Formation

                              Luo, J. Luckenbaugh, L. Hu, H. Yan, Z. Gao, L. Hu, J.
                              mBio. 2020 Feb 18;11(1):e03423-19. doi: 10.1128/mBio.03423-19.

                              Dual Agonist of Farnesoid X Receptor and G Protein-coupled Receptor TGR5 Inhibits Hepatitis B Virus Infection in Vitro and in Vivo

                                Ito, K. Okumura, A. S. Takeuchi J Watashi, K. Inoue, R. Yamauchi, T. Sakamoto, K. Yamashita, Y. Iguchi, Y. Une, M. Wakita, T. Umezawa, K. Yoneda, M.

                                Hepatology. 2021 Jan 12. doi: 10.1002/hep.31712.

                                Suppression of hepatitis B virus through therapeutic activation of RIG-I and IRF3 signaling in hepatocytes

                                  Sooyoung Lee, Ashish Goyal, Alan S. Perelson, Yuji Ishida, Takeshi Saito, Michael Gale, Jr.

                                  iScience. 2021 Jan 4;24(1):101969. doi: 10.1016/j.isci.2020.101969. eCollection 2021 Jan 22.

                                  Role of Hepatitis B virus capsid phosphorylation in nucleocapsid disassembly and covalently closed circular DNA formation

                                    Luo, J. Xi, J. Gao, L. Hu, J.

                                    PLoS Pathog. 2020 Mar 30;16(3):e1008459. doi: 10.1371/journal.ppat.1008459. eCollection 2020 Mar.

                                    Development of an in vivo delivery system for CRISPR/Cas9-mediated targeting of hepatitis B virus cccDNA

                                      Kayesh, M. E. H. Amako, Y. Hashem, M. A. Murakami, S. Ogawa, S. Yamamoto, N. Hifumi, T. Miyoshi, N. Sugiyama, M. Tanaka, Y. Mizokami, M. Kohara, M. Tsukiyama-Kohara, K.

                                      Virus Res. 2020 Oct 10;290:198191. doi: 10.1016/j.virusres.2020.198191.

                                      PXBマウス・PXB-cells関連研究発表のご案内:肝炎関連3学会

                                      2020年7月~8月に開催されました、以下の肝炎関連学会(3学会:日本消化器病学会、EASL、日本肝臓学会)にて、PXBマウス及びPXB-cells関連の研究発表がありました。