株式会社フェニックスバイオ

Identification of glycogen synthase kinase 3alpha/beta as a host factor required for HBV transcription using high-throughput screening

Nishitsuji, H. Naito, Y. Murakami, Y. Sugiyama, M. Mizokami, M. Shoji, I. Murata, T. Shimotohno, K.
Hepatology. 2025 Jan 23. doi: 10.1097/HEP.0000000000001239.

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Identification of novel antiviral host factors by functional gene expression analysis using in vitro HBV infection assay systems

Nosaka, T. Naito, T. Akazawa, Y. Takahashi, K. Matsuda, H. Ohtani, M. Nishizawa, T. Okamoto, H. Nakamoto, Y.
PLoS One. 2025 Mar 6;20(3):e0314581. doi: 10.1371/journal.pone.0314581.

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Endothelial lipase-binding peptides similar to netrin-1 inhibit hepatitis B virus infection

Ide, M. Tabata, N. Murai, K. Yonemura, Y. Wang, Y. Ishida, A. Shirasaki, T. Kaneko, S. Ito, S. Honda, M. Yanagawa, H.
FEBS Lett. 2025 Jan 25. doi: 10.1002/1873-3468.15101.

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Hepatitis B virus genotypes A1 and A2 have distinct replication phenotypes due to polymorphisms in the HBx gene

Zhang, M. Mouzannar, K. Zhang, Z. Teraoka, Y. Piotrowski, J. Ishida, Y. Tateno-Mukaidani, C. Saito, T.Abe-Chayama, H. Chayama, K.Liang, T. J.
PLoS Pathog. 2025 Jan 9;21(1):e1012803. doi: 10.1371/journal.ppat.1012803.

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Alteration of Gene Expression After Entecavir and Pegylated Interferon Therapy in HBV-Infected Chimeric Mouse Liver

Bao, H. Murakami, S. Tsuge, M. Uchida, T. Uchikawa, S. Fujino, H. Ono, A. Murakami, E. Kawaoka, T. Miki, D. Hayes, C. N. Oka, S.
Viruses. 2024 Nov 6;16(11):1743. doi: 10.3390/v16111743.

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Modelling of hepatitis B virus kinetics and accumulation of cccDNA in primary human hepatocytes

Louis Shekhtman, Yuji Ishida, Masataka Tsuge, Vladimir Reinharz, Mikaru Yamao, Masaki Takahashi, Chise Tateno, Susan L. Uprichard, Harel Dahari, Kazuaki Chayama
JHEP Reports https://doi.org/10.1016/j.jhepr.2024.101311.

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Infectivity of Hepatitis B Virus Surface Antigen-Positive Plasma With Undetectable HBV-DNA: Can HBsAg Screening Be Discontinued in Egyptian Blood Donors?

El Ekiaby, M. Tanaka, J. van Drimmelen, H. Allain, J. P. Lelie, N.
J Viral Hepat. 2024 Aug 10. doi: 10.1111/jvh.13990.

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Interferon alpha induces a stronger antiviral effect than interferon lambda in HBV/HDV infected humanized mice

Duehren, S. Uchida, T. Tsuge, M. Hiraga, N. Uprichard, S. L. Etzion, O. Glenn, J. Koh, C. Heller, T. Cotler, S. J. Oka, S. Chayama, K. Dahari, H.
Virus Res. 2024 Aug 26;349:199451. doi: 10.1016/j.virusres.2024.199451.

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Lipid nanoparticle-encapsulated DOCK11-siRNA efficiently reduces hepatitis B virus cccDNA level in infected mice

Okada, H. Sakamoto, T. Nio, K. Li, Y. Kuroki, K. Sugimoto, S. Shimakami, T. Doi, N. Honda, M. Seiki, M. Kaneko, S. Yamashita, T.
Mol Ther Methods Clin Dev. 2024 Jun 24;32(3):101289. doi: 10.1016/j.omtm.2024.101289.

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Selective depletion of HBV-infected hepatocytes by class A capsid assembly modulators requires high levels of intrahepatic HBV core protein

Kornyeyev, D. Song, Z. Eng, S. Soulette, C. Ramirez, R. Tang, J. Yue, Q. Subramanian, R. Zaboli, S. Moon, C. Tam, J. Brodbeck, J. Aggarwal, A. Diehl, L. Fletcher, S. P. Hyrina, A. Holdorf, M. M. Burdette, D.
Antimicrob Agents Chemother. 2024 Jul 9;68(7):e0042024. doi: 10.1128/aac.00420-24.

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Antiviral effect of peptoids on hepatitis B virus infection in cell culture

Murayama, A. Igarashi, H. Yamada, N. Aly, H. H. Molchanova, N. Lin, J. S. Nishitsuji, H. Shimotohno, K. Muramatsu, M. Barron, A. E. Kato, T.
Antiviral Res. 2024 Mar;223:105821. doi: 10.1016/j.antiviral.2024.105821.

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An allosteric inhibitor of sirtuin 2 blocks hepatitis B virus covalently closed circular DNA establishment and its transcriptional activity

Tang, L. Remiszewski, S. Snedeker, A. Chiang, L. W. Shenk, T.
Antiviral Res. 2024 Jun;226:105888. doi: 10.1016/j.antiviral.2024.105888.

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A novel, small anti-HBV compound reduces HBsAg and HBV-DNA by destabilizing HBV-RNA

Watanabe, T. Hayashi, S. Zhaoyu, Y. Inada, H. Nagaoka, K. Tateyama, M. Tanaka, Y.
J Gastroenterol. 2024 Apr;59(4):315-328. doi: 10.1007/s00535-023-02070-y. Epub 2024 Feb 5.

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Nucleos(t)ide analogs for hepatitis B virus infection differentially regulate the growth factor signaling in hepatocytes

Shimizu, R. Murai, K. Tanaka, K. Sato, Y. Takeda, N. Nakasyo, S. Shirasaki, T. Kawaguchi, K. Shimakami, T. Nio, K. Nakaya, Y. Kagiwada, H. Horimoto, K. Mizokami, M. Kaneko, S. Murata, K. Yamashita, T. Honda, M.
Hepatol Commun. 2024 Jan 5;8(1):e0351. doi: 10.1097/HC9.0000000000000351. eCollection 2024 Jan 1.

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Hepatitis B virus evades the immune system by suppressing the NF-kappaB signaling pathway with DENND2A

Ide, M. Tabata, N. Yonemura, Y. Murai, K. Wang, Y. Ishida, A. Honda, M. Kaneko, S. Ito, S. Yanagawa, H.
Microbiol Spectr. 2024 Jan 19:e0378523. doi: 10.1128/spectrum.03785-23.

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A small molecule iCDM-34 identified by in silico screening suppresses HBV DNA through activation of aryl hydrocarbon receptor

Furutani, Y. Hirano, Y. Toguchi, M. Higuchi, S. Qin, X. Y. Yanaka, K. Sato-Shiozaki, Y. Takahashi, N. Sakai, M. Kongpracha, P. Suzuki, T. Dohmae, N. Kukimoto-Niino, M. Shirouzu, M. Nagamori, S. Suzuki, H. Kobayashi, K. Masaki, T. Koyama, H. Sekiba, K. Otsuka, M. Koike, K. Kohara, M. Kojima, S. Kakeya, H. Matsuura, T.
Cell Death Discov. 2023 Dec 22;9(1):467. doi: 10.1038/s41420-023-01755-w.

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SRPKIN-1 as an inhibitor against hepatitis B virus blocking the viral particle formation and the early step of the viral infection

Li, X. Nakashima, K. Ito, M. Matsuda, M. Chida, T. Sekihara, K. Takahashi, H. Kato, T. Sawasaki, T. Suzuki, T.
Antiviral Res. 2023 Dec;220:105756. doi: 10.1016/j.antiviral.2023.105756. Epub 2023 Nov 20.

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A versatile method to profile hepatitis B virus DNA integration

Fukano, K. Wakae, K. Nao, N. Saito, M. Tsubota, A. Toyoshima, T. Aizaki, H. Iijima, H. Matsudaira, T. Kimura, M. Watashi, K. Sugiura, W. Muramatsu, M.
Hepatol Commun. 2023 Dec 1;7(12):e0328. doi: 10.1097/HC9.0000000000000328. eCollection 2023 Dec 1.

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Functional involvement of endothelial lipase in hepatitis B virus infection

Shirasaki, T. Murai, K. Ishida, A. Kuroki, K. Kawaguchi, K. Wang, Y. Yamanaka, S. Yasukawa, R. Kawasaki, N. Li, Y. Y. Shimakami, T. Sumiyadorj, A. Nio, K. Sugimoto, S. Orita, N. Takayama, H. Okada, H. Thi Bich, P. D. Iwabuchi, S. Hashimoto, S. Ide, M. Tabata, N. Ito, S. Matsushima, K. Yanagawa, H. Yamashita, T. Kaneko, S. Honda, M.
Hepatol Commun. 2023 Aug 31;7(9):e0206.

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Modeling suggests that virion production cycles within individual cells is key to understanding acute hepatitis B virus infection kinetics

Hailegiorgis, A. Ishida, Y. Collier, N. Imamura, M. Shi, Z. Reinharz, V. Tsuge, M. Barash, D. Hiraga, N. Yokomichi, H. Tateno, C. Ozik, J. Uprichard, S. L. Chayama, K. Dahari, H.
PLoS Comput Biol. 2023 Aug 3;19(8):e1011309. doi: 10.1371/journal.pcbi.1011309.

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研究発表

Identification of glycogen synthase kinase 3alpha/beta as a host factor required for HBV transcription using high-throughput screening

Identification of novel antiviral host factors by functional gene expression analysis using in vitro HBV infection assay systems

Endothelial lipase-binding peptides similar to netrin-1 inhibit hepatitis B virus infection

Hepatitis B virus genotypes A1 and A2 have distinct replication phenotypes due to polymorphisms in the HBx gene

Alteration of Gene Expression After Entecavir and Pegylated Interferon Therapy in HBV-Infected Chimeric Mouse Liver

Modelling of hepatitis B virus kinetics and accumulation of cccDNA in primary human hepatocytes

Infectivity of Hepatitis B Virus Surface Antigen-Positive Plasma With Undetectable HBV-DNA: Can HBsAg Screening Be Discontinued in Egyptian Blood Donors?

Interferon alpha induces a stronger antiviral effect than interferon lambda in HBV/HDV infected humanized mice

Lipid nanoparticle-encapsulated DOCK11-siRNA efficiently reduces hepatitis B virus cccDNA level in infected mice

Selective depletion of HBV-infected hepatocytes by class A capsid assembly modulators requires high levels of intrahepatic HBV core protein

Antiviral effect of peptoids on hepatitis B virus infection in cell culture

An allosteric inhibitor of sirtuin 2 blocks hepatitis B virus covalently closed circular DNA establishment and its transcriptional activity

A novel, small anti-HBV compound reduces HBsAg and HBV-DNA by destabilizing HBV-RNA

Nucleos(t)ide analogs for hepatitis B virus infection differentially regulate the growth factor signaling in hepatocytes

Hepatitis B virus evades the immune system by suppressing the NF-kappaB signaling pathway with DENND2A

A small molecule iCDM-34 identified by in silico screening suppresses HBV DNA through activation of aryl hydrocarbon receptor

SRPKIN-1 as an inhibitor against hepatitis B virus blocking the viral particle formation and the early step of the viral infection

A versatile method to profile hepatitis B virus DNA integration

Functional involvement of endothelial lipase in hepatitis B virus infection

Modeling suggests that virion production cycles within individual cells is key to understanding acute hepatitis B virus infection kinetics