Phoenix Bio

研究開発

研究開発

Development of an in vivo delivery system for CRISPR/Cas9-mediated targeting of hepatitis B virus cccDNA

    Kayesh, M. E. H. Amako, Y. Hashem, M. A. Murakami, S. Ogawa, S. Yamamoto, N. Hifumi, T. Miyoshi, N. Sugiyama, M. Tanaka, Y. Mizokami, M. Kohara, M. Tsukiyama-Kohara, K.

    Virus Res. 2020 Oct 10;290:198191. doi: 10.1016/j.virusres.2020.198191.

    PXBマウス・PXB-cells関連研究発表のご案内:肝炎関連3学会

    2020年7月~8月に開催されました、以下の肝炎関連学会(3学会:日本消化器病学会、EASL、日本肝臓学会)にて、PXBマウス及びPXB-cells関連の研究発表がありました。

    Signal activation of hepatitis B virus-related hepatocarcinogenesis by upregulation of SUV39h1

      Takeuchi, Y. Tsuge, M. Tsushima, K. Suehiro, Y. Fujino, H. Ono, A. Yamauchi, M. Makokha, G. N. Nakahara, T. Murakami, E. Abe-Chayama, H. Kawaoka, T. Miki, D. Imamura, M. Aikata, H. Hayes, C. N. Tateno, C. Chayama, K.

      J Infect Dis. 2020 Jun 9:jiaa317. doi: 10.1093/infdis/jiaa317.

      Engineering Cellular Biosensors with Customizable Antiviral Responses Targeting Hepatitis B Virus

        Matsunaga, S. Jeremiah, S. S. Miyakawa, K. Kurotaki, D. Shizukuishi, S. Watashi, K. Nishitsuji, H. Kimura, H. Tamura, T. Yamamoto, N. Shimotohno, K. Wakita, T. Ryo, A.

        iScience. 2020 Mar 27;23(3):100867. doi: 10.1016/j.isci.2020.100867. Epub 2020 Feb 26.

        Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection

          Cheng, X. Uchida, T. Xia, Y. Umarova, R. Liu, C. J. Chen, P. J. Gaggar, A. Suri, V. Mucke, M. M. Vermehren, J. Zeuzem, S. Teraoka, Y. Osawa, M. Aikata, H. Tsuji, K. Mori, N. Hige, S. Karino, Y. Imamura, M. Chayama, K. Liang, T. J.

          J Clin Invest. 2020 Mar 12. pii: 135616. doi: 10.1172/JCI135616.

          Anti-HBV activity of retinoid drugs in vitro versus in vivo

            Birkus, G. Snyder, C. Jordan, R. Kobayashi, T. Dick, R. Puscau, V. Li, L. Ramirez, R. Willkom, M. Morikawa, Y. Delaney, W. Schmitz, U.

            Antiviral Res. 2019 Jun 18:104538. doi: 10.1016/j.antiviral.2019.104538.

            An interferon-like small chemical compound CDM-3008 suppresses hepatitis B virus through induction of interferon-stimulated genes

              Furutani, Y. Toguchi, M. Shiozaki-Sato, Y. Qin, X. Y. Ebisui, E. Higuchi, S. Sudoh, M. Suzuki, H. Takahashi, N. Watashi, K. Wakita, T. Kakeya, H. Kojima, S.

              PLoS One. 2019 Jun 12;14(6):e0216139. doi: 10.1371/journal.pone.0216139. eCollection 2019.

              Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly

                Kang, J. A. Kim, S. Park, M. Park, H. J. Kim, J. H. Park, S. Hwang, J. R. Kim, Y. C. Jun Kim, Y. Cho, Y. Sun Jin, M. Park, S. G.

                Nat Commun. 2019 May 16;10(1):2184. doi: 10.1038/s41467-019-10200-5.

                PAPD5/7 Are Host Factors That Are Required for Hepatitis B Virus RNA Stabilization

                  Mueller, H. Lopez, A. Tropberger, P. Wildum, S. Schmaler, J. Pedersen, L. Han, X. Wang, Y. Ottosen, S. Yang, S. Young, J. A. T. Javanbakht, H.

                  Hepatology. 2019 Apr;69(4):1398-1411. doi: 10.1002/hep.30329. Epub 2019 Mar 1.

                  An Association Between Core Mutations in Hepatitis B Virus Genotype F1b and Hepatocellular Carcinoma in Alaskan Native People

                    Hayashi, S. Khan, A. Simons, B. C. Homan, C. Matsui, T. Ogawa, K. Kawashima, K. Murakami, S. Takahashi, S. Isogawa, M. Ikeo, K. Mizokami, M. McMahon, B. J. Tanaka, Y.

                    Hepatology. 2019 Jan;69(1):19-33. doi: 10.1002/hep.30111. Epub 2018 Dec 10.

                    Early Multiphasic HBV Infection Initiation Kinetics Is Not Clone-Specific and Is Not Affected by Hepatitis D Virus (HDV) Infection

                      Tsuge, M. Uchida, T. Walsh, K. Ishida, Y. Tateno, C. Kumar, U. Glenn, J. S. Koh, C. Heller, T. Uprichard, S. L. Dahari, H. Chayama, K.

                      Viruses. 2019 Mar 15;11(3). pii: v11030263. doi: 10.3390/v11030263.

                      Comparison of intracellular responses between HBV genotype A and C infection in human hepatocyte chimeric mice

                        Tsushima, K. Tsuge, M. Hiraga, N. Uchida, T. Murakami, E. Makokha, G. N. Kurihara, M. Nomura, M. Hiyama, Y. Fujino, H. Ono, A. Nakahara, T. Yamauchi, M. Abe-Chayama, H. Kawaoka, T. Miki, D. Imamura, M. Aikata, H. Hayes, C. N. Chayama, K.

                        J Gastroenterol. 2019 Feb 21. pii: 10.1007/s00535-019-01558-w. doi: 10.1007/s00535-019-01558-w.

                        Functional Analysis of Human Hepatocytes Isolated From Chimeric Mouse Liver

                          Harimoto, N. Nakagawara, H. Shirabe, K. Yoshizumi, T. Itoh, S. Ikegami, T. Soejima, Y. Maehara, Y. Ishida, Y. Tateno, C. Tanaka, Y.

                          Transplant Proc. 2018 Dec;50(10):3858-3862. doi: 10.1016/j.transproceed.2018.06.035.

                          Hepatitis B Virus Therapeutic Agent ARB-1740 Has Inhibitory Effect on Hepatitis Delta Virus in a New Dually-Infected Humanized Mouse Model

                            Ye, X. Tateno, C. Thi, E. P. Kakuni, M. Snead, N. M. Ishida, Y. Barnard, T. R. Sofia, M. Shimada, T. Lee, A. C. H.

                            ACS Infect Dis. 2018 Nov 8. doi: 10.1021/acsinfecdis.8b00192.

                            ARB-1740, a RNA Interference Therapeutic for Chronic Hepatitis B Infection

                              Thi, E. P. Dhillon, A. P. Ardzinski, A. Bidirici-Ertekin, L. Cobarrubias, K. D. Cuconati, A. Kondratowicz, A. S. Kwak, K. Li, A. H. L. Miller, A. Pasetka, C. Pei, L.Phelps, J. R. Snead, N. M. Wang, X. Ye, X. Sofia, M. J. Lee, A. C. H.

                              ACS Infect Dis. 2018 Nov 19. doi: 10.1021/acsinfecdis.8b00191.

                              Endoplasmic reticulum-mediated induction of interleukin-8 occurs by hepatitis B virus infection and contributes to suppression of interferon responsiveness in human hepatocytes

                                Tsuge, M. Hiraga, N. Zhang, Y. Yamashita, M.  Sato, O. Oka, N. Shiraishi, K. Izaki, Y. Makokha, G. N. Uchida, T. Kurihara, M. Nomura, M. Tsushima, K. Nakahara, T. Murakami, E. Abe-Chayama, H. Kawaoka, T. Miki, D. Imamura, M. Kawakami, Y. Aikata, H. Ochi, H. Hayes, C. N. Fujita, T. Chayama, K.

                                Virology. 2018 Sep 18;525:48-61. doi: 10.1016/j.virol.2018.08.020.

                                CTL-associated and NK cell-associated immune responses induce different HBV DNA reduction patterns in chronic hepatitis B patients

                                  Nomura, M. Tsuge, M. Uchida, T. Hiraga, N. Kurihara, M. Tsushima, K. Fujino, H. Nakahara, T. Murakami, E. Abe-Chayama, H. Kawaoka, T. Miki, D. Hiramatsu, A. Imamura, M. Kawakami, Y. Aikata, H. Ochi, H. Zhang, Y. Makokha, G. N. Hayes, C. N. Tanaka, S. Chayama, K.

                                  J Viral Hepat. 2018 Jul 11. doi: 10.1111/jvh.12970.

                                  Inhibitory effect of fasiglifam on hepatitis B virus infections through suppression of the sodium taurocholate cotransporting polypeptide

                                    Nio, Y. Akahori, Y. Okamura, H. Watashi, K. Wakita, T. Hijikata, M.

                                    Biochem Biophys Res Commun. 2018 Jun 27;501(3):820-825.

                                    Inhibitory effect of silibinin on hepatitis B virus entry

                                      Umetsu, T. Inoue, J. Kogure, T. Kakazu, E. Ninomiya, M. Iwata, T. Takai, S. Nakamura, T.Sano, A. Shimosegawa, T.

                                      Biochem Biophys Rep. 2018 Mar 31;14:20-25.

                                      Characterization of HBV integration patterns and timing in liver cancer and HBV-infected livers

                                        Furuta, M. Tanaka, H. Shiraishi, Y. Unida, T. mamura, M. Fujimoto, A. Fujita, M. Sasaki-Oku, A. Maejima, K. Nakano, K. Kawakami, Y. Arihiro, K. Aikata, H. Ueno, M. Hayami, S. Ariizumi, S. I. Yamamoto, M. Gotoh, K. Ohdan, H. Yamaue, H. Miyano, S. Chayama, K. Nakagawa, H.

                                        Oncotarget. 2018 May 18;9(38):25075-25088.