Phoenix Bio

研究発表

研究発表

Novel robust in vitro hepatitis B virus infection model using fresh human hepatocytes isolated from humanized mice

    Ishida Y, Yamasaki C, Yanagi A, Yoshizane Y, Fujikawa K, Watashi K, Abe H, Wakita T, Hayes CN, Chayama K, Tateno C

    Am J Pathol. 2015 May;185(5):1275-85. doi: 10.1016/j.ajpath.2015.01.028. Epub 2015 Mar 17.

    The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus

      Sato, S. Li, K. Kameyama, T. Hayashi, T. Ishida, Y. Murakami, S. Watanabe, T. Iijima, S. Sakurai, Y. Watashi, K. Tsutsumi, S. Sato, Y. Akita, H. Wakita, T. Rice, C. M. Harashima, H. Kohara, M.Tanaka, Y.Takaoka, A.

      Immunity. 2015 Jan 20;42(1):123-32.

      Validation of cross-genotype neutralization by hepatitis B virus-specific monoclonal antibodies by in vitro and in vivo infection

        Hamada-Tsutsumi, S. Iio, E. Watanabe, T. Murakami, S. Isogawa, M. Iijima, S. Inoue, T. Matsunami, K. Tajiri, K. Ozawa, T. Kishi, H. Muraguchi, A. Joh, T. Tanaka, Y.

        PLoS One. 2015 Feb 18;10(2):e0118062.

        Human microRNA hsa-miR-1231 suppresses hepatitis B virus replication by targeting core mRNA

          Kohno, T. Tsuge, M. Murakami, E. Hiraga, N. Abe, H. Miki, D. Imamura, M. Ochi,

          H. Hayes, C. N. Chayama, K.

          J Viral Hepat. 2014 Sep;21(9):e89-97. doi: 10.1111/jvh.12240. Epub 2014 May 16.

          Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP)

            Watashi, K. Sluder, A. Daito, T. Matsunaga, S. Ryo, A. Nagamori, S. wamoto, M. Nakajima, S. Tsukuda, S. Borroto-Esoda, K. Sugiyama, M. Tanaka, Y. Kanai, Y. Kusuhara, H. Mizokami, M. Wakita, T.

            Hepatology. 2014 May;59(5):1726-37.

            Severe necroinflammatory reaction caused by natural killer by Fas/FasL interaction and dendritic cells in human hepatocyte chimeric mouse.

              Okazaki A, Hiraga N, Imamura M, Nelson Hayes C, Tsuge M, Takahashi S, Aikata H, Abe H, Miki D, Ochi H, Tateno C, Yoshizato K, Ohdan H, Chayama K.
              Hepatology. 2012 Aug;56(2):555-66.

              Effects of hepatitis B virus infection on the interferon response in immunodeficient human hepatocyte chimeric mice.

                Tsuge M, Takahashi S, Hiraga N, Fujimoto Y, Zhang Y, Mitsui F, Abe H, Kawaoka T, Imamura M, Ochi H, Hayes CN, Chayama K.
                J Infect Dis. 2011 Jul 15;204(2):224-8.

                Transmissibility of hepatitis B virus (HBV) infection through blood transfusion from blood donors with occult HBV infection.

                  Yuen MF, Wong DK, Lee CK, Tanaka Y, Allain JP, Fung J, Leung J, Lin CK, Sugiyama M, Sugauchi F, Mizokami M, Lai CL.
                  Clin Infect Dis. 2011 Mar;52(5):624-32

                  Cross-species transmission of gibbon and orangutan hepatitis B virus to uPA/SCID mice with human hepatocytes.

                    Sa-Nguanmoo P, Tanaka Y, Ratanakorn P, Sugiyama M, Murakami S, Payungporn S, Sommanustweechai A, Mizokami M, Poovorawan Y.
                    Virus Res. 2011 Jun;158(1-2):209-15

                    HBx protein is indispensable for development of viraemia in human hepatocyte chimeric mice.

                      Tsuge M, Hiraga N, Akiyama R, Tanaka S, Matsushita M, Mitsui F, Abe H, Kitamura S, Hatakeyama T, Kimura T, Miki D, Mori N, Imamura M, Takahashi S, Hayes CN, Chayama K.

                      J Gen Virol. 2010 Jul;91(Pt 7):1854-64.

                      Absence of viral interference and different susceptibility to interferon between hepatitis B virus and hepatitis C virus in human hepatocyte chimeric mice.

                        Hiraga N, Imamura M, Hatakeyama T, Kitamura S, Mitsui F, Tanaka S, Tsuge M, Takahashi S, Abe H, Maekawa T, Ochi H, Tateno C, Yoshizato K, Wakita T, Chayama K.
                        J Hepatol. 2009 Dec;51(6):1046-54. Epub 2009 Sep 23.

                        A genetic variant of hepatitis B virus divergent from known human and ape genotypes isolated from a Japanese patient and provisionally assigned to new genotype J.

                          Tatematsu K, Tanaka Y, Kurbanov F, Sugauchi F, Mano S, Maeshiro T, Nakayoshi T, Wakuta M, Miyakawa Y, Mizokami M.

                          J Virol. 2009 Oct;83(20):10538-47.

                          Direct cytopathic effects of particular hepatitis B virus genotypes in severe combined immunodeficiency transgenic with urokinase-type plasminogen activator mouse with human hepatocytes.

                            Sugiyama M, Tanaka Y, Kurbanov F, Maruyama I, Shimada T, Takahashi S, Shirai T, Hino K, Sakaida I, Mizokami M.
                            Gastroenterology. 2009 Feb;136(2):652-62

                            Titration of hepatitis B virus infectivity in the sera of pre-acute and late acute phases of HBV infection: transmission experiments to chimeric mice with human liver repopulated hepatocytes.

                              Tabuchi A, Tanaka J, Katayama K, Mizui M, Matsukura H, Yugi H, Shimada T, Miyakawa Y, Yoshizawa H.
                              J Med Virol. 2008 Dec;80(12):2064-8.

                              Characteristics of hepatitis B virus genotype G coinfected with genotype H in chimeric mice carrying human hepatocytes.

                                Tanaka Y, Sanchez LV, Sugiyama M, Sakamoto T, Kurbanov F, Tatematsu K, Roman S, Takahashi S, Shirai T, Panduro A, Mizokami M.
                                Virology. 2008 Jul 5;376(2):408-15. Epub 2008 May 13.

                                Susceptibility of chimeric mice with livers repopulated by serially subcultured human hepatocytes to hepatitis B virus.

                                  Utoh R, Tateno C, Yamasaki C, Hiraga N, Kataoka M, Shimada T, Chayama K, Yoshizato K.
                                  Hepatology. 2008 Feb;47(2):435-46.

                                  Early Dynamics of Hepatitis B Virus in Chimeric Mice Carrying Human Hepatocytes Monoinfected or Coinfected with Genotype G

                                    Sugiyama M, Tanaka Y, Sakamoto T, Maruyama I, Shimada T, Takahashi S, Shirai T, Kato H, Nagao M, Miyakawa Y, Mizokami M.
                                    Hepatology. 2007 Apr;45(4):929-37.

                                    Influence of Hepatitis B Virus Genotypes on the Intra- and Extracellular Expression of Viral DNA and Antigens

                                      Sugiyama M, Tanaka Y, Kato T, Orito E, Ito K, Acharya SK, Gish RG, Kramvis A, Shimada T, Izumi N, Kaito M, Miyakawa Y, Mizokami M.

                                      Hepatology. 2006 Oct;44(4):915-24.

                                      Emergence of a Novel Lamivudine-Resistant Hepatitis B Virus Variant with a Substitution Outside the YMDD Motif

                                        Yatsuji H, Noguchi C, Hiraga N, Mori N, Tsuge M, Imamura M, Takahashi S, Iwao E, Fujimoto Y, Ochi H, Abe H, Maekawa T, Tateno C, Yoshizato K, Suzuki F, Kumada H, Chayama K.
                                        Antimicrob Agents Chemother. 2006 Nov;50(11):3867-74. Epub 2006 Sep 18.

                                        Infection of Human Hepatocyte Chimeric Mouse With Genetically Engineered Hepatitis B Virus

                                          Tsuge M, Hiraga N, Takaishi H, Noguchi C, Oga H, Imamura M, Takahashi S, Iwao E, Fujimoto Y, Ochi H, Chayama K, Tateno C, Yoshizato K.

                                          Hepatology. 2005 Nov;42(5):1046-54.