Cyclosporin derivatives inhibit hepatitis B virus entry without interfering with NTCP transporter activity

Shimura, S. Watashi, K. Fukano, K. Peel, M. Sluder, A. Kawai, F. Iwamoto, M. Tsukuda, S. Takeuchi, J. S. Miyake, T. Sugiyama, M. Ogasawara, Y. Park, S. Y. Tanaka, Y. Kusuhara, H. Mizokami, M. Sureau, C. Wakita, T.

J Hepatol. 2016 Nov 24. pii: S0168-8278(16)30683-3. doi: 10.1016/j.jhep.2016.11.009.

A new class of hepatitis B and D virus entry inhibitors, proanthocyanidin and its analogs, that directly act on the viral large surface proteins

Tsukuda, S. Watashi, K. Hojima, T. Isogawa, M. Iwamoto, M. Omagari, K. Suzuki, R. Aizaki, H. Kojima, S. Sugiyama, M. Saito, A. Tanaka, Y. Mizokami, M. Sureau, C. Wakita, T.

Hepatology. 2016 Nov 18. doi: 10.1002/hep.28952.

Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation

Tanaka, T. Okuyama-Dobashi, K. Murakami, S. Chen, W. Okamoto, T. Ueda, K. Hosoya, T. Matsuura, Y. Ryo, A. Tanaka, Y. Hagiwara, M. Moriishi, K.

Antiviral Res. 2016 Aug 8. pii: S0166-3542(16)30357-6.

新規核酸アナログ4′-C-cyano-2′-deoxyadenosine, 4′-C-cyano-2′-deoxyguanosineは薬剤耐性B型肝炎ウイルス変異種に対して有効である(短報)

林　佐奈衣、高松悠樹、前田賢次、村上周子，尾曲克已、松居剛志、五十川正記、渡邊網正、狩野吉康、向後悟、濱屋裕明、田中靖人

肝臓 2016; 57(6):299-301

Antiviral effects of anti-HBs immunoglobulin and vaccine on HBs antigen seroclearance for chronic hepatitis B infection

Tsuge, M. Hiraga, N. Uchida, T. Kan, H. Miyaki, E. Masaki, K. Ono, A. Nakahara, T. Abe-Chayama, H. Zhang, Y. Naswa, M. G. Kawaoka, T. Miki, D. Imamura, M. Kawakami, Y. Aikata, H. Ochi, H. Hayes, C. N. Chayama, K.

J Gastroenterol. 2016 Mar 4.

Possible Involvement of Hepatitis B Virus Infection of Hepatocytes in the Attenuation of Apoptosis in Hepatic Stellate Cells

Sasaki, R. Kanda, T. Nakamura, M. Nakamoto, S. Haga, Y. Wu, S. Shirasawa, H. Yokosuka, O.

PLoS One. 2016 Jan 5;11(1):e0146314. doi: 10.1371/journal.pone.0146314. eCollection 2016.

A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide

Kaneko, M. Watashi, K. Kamisuki, S. Matsunaga, H. Iwamoto, M. Kawai, F. Ohashi, H. Tsukuda, S. Shimura, S. Suzuki, R. Aizaki, H. Sugiyama, M. Park, S. Y. Ito, T. Ohtani, N. Sugawara, F. Tanaka, Y. Mizokami, M. Sureau, C. Wakita, T.

J Virol. 2015 Dec;89(23):11945-53. doi: 10.1128/JVI.01855-15.

ヒト肝細胞キメラマウスを用いたin vivoおよびin vitro HBV感染モデル

石田雄二、横道博、加国雅和、立野知世

新ウイルス性肝炎学 2015 page386-391

Novel pH-sensitive multifunctional envelope-type nanodevice for siRNA-based treatments for chronic HBV infection

Yamamoto, N. Sato, Y. Munakata, T. Kakuni, M. Tateno, C. Sanada, T. Hirata, Y. Murakami, S.  Tanaka, Y. Chayama, K. Hatakeyama, H. Hyodo, M. Harashima, H. Kohara, M.

J Hepatol. 2015 Oct 23. pii: S0168-8278(15)00713-8. doi: 10.1016/j.jhep.2015.10.014.

Effect of tenofovir disoproxil fumarate on drug-resistant HBV clones

Murakami, E. Tsuge, M. Hiraga,  N.Kan, H. Uchida, T. Masaki, K. Nakahara, T. Ono, A. Miki, D. Kawaoka, T. Abe, H.Imamura, M. Aikata, H. Ochi, H. Hayes, C. N. Akita, T. Tanaka, J. Chayama, K.

J Infect. 2015 Oct 26. pii: S0163-4453(15)00339-4. doi: 10.1016/j.jinf.2015.09.038.

A novel reporter system to monitor early stages of the HBV life cycle

Nishitsuji, H. Ujino, S. Shimizu, Y. Harada, K. Zhang, J. Sugiyama, M. Mizokami, M. Shimotohno, K.

Cancer Sci. 2015 Aug 27. doi: 10.1111/cas.12799.

2015年 11月22日(日)～24日(火)に福岡国際会議場(福岡市博多区)にて開催の第63回日本ウイルス学会学術集会にてPXBマウス・PXB-cells関連研究発表がありましたので、ご案内申し上げます。

Lack of infectivity of HBV in feces from patients with chronic hepatitis B virus infection, and infection using chimeric mice

Komatsu, H. Inui, A. Murano, T. Tsunoda, T. Sogo, T. Fujisawa, T.

BMC Res Notes. 2015 Aug 20;8:366. doi: 10.1186/s13104-015-1337-z.

Characterization of novel entecavir resistance mutations

Hayashi, S. Murakami, S. Omagari, K. Matsui, T. Iio, E. Isogawa, M. Watanabe, T. Karino, Y. Tanaka, Y.

J Hepatol. 2015 Sep;63(3):546-53. doi: 10.1016/j.jhep.2015.03.020. Epub 2015 Mar 25.

Association between hepatitis B virus and MHC class I polypeptide-related chain A in human hepatocytes derived from human-mouse chimeric mouse liver

Sasaki, R. Kanda, T. Wu, S. Nakamoto, S. Haga, Y. Jiang, X. Nakamura, M.

Shirasawa, H. Yokosuka, O.

Journal: Biochem Biophys Res Commun. 2015 Jul 23. pii: S0006-291X(15)30332-6.

doi: 10.1016/j.bbrc.2015.07.102.

4′-modified nucleoside analogs: Potent inhibitors active against entecavir-resistant hepatitis B virus

Takamatsu, Y. Tanaka, Y. Kohgo, S. Murakami, S. Singh, K. Das, D. Venzon, D.  J. Amano, M. Kuwata,N. Aoki, M. Delino, N. S. Hayashi, S. Takahashi, S. Sukenaga, Y. Haraguchi, K. Sarafianos, S. G. Maeda, K. Mitsuya, H.

Journal: Hepatology. 2015 Jun 29. doi: 10.1002/hep.27962.

Postexposure Prophylactic Effect of Hepatitis B Virus (HBV)-Active Antiretroviral Therapy against HBV Infection

Watanabe, T. Hamada-Tsutsumi, S. Yokomaku, Y. Imamura, J. Sugiura, W. Tanaka, Y.

Antimicrob Agents Chemother. 2015 Feb;59(2):1292-8.

Discovering novel direct acting antiviral agents for HBV using in silico screening

Murakami, Y. Hayakawa, M. Yano, Y. Tanahashi, T. Enomoto, M. Tamori, A. Kawada, N. Iwadate, M. Umeyama, H.

Biochem Biophys Res Commun. 2015 Jan 2;456(1):20-8.

Novel robust in vitro hepatitis B virus infection model using fresh human hepatocytes isolated from humanized mice

Ishida Y, Yamasaki C, Yanagi A, Yoshizane Y, Fujikawa K, Watashi K, Abe H, Wakita T, Hayes CN, Chayama K, Tateno C

Am J Pathol. 2015 May;185(5):1275-85. doi: 10.1016/j.ajpath.2015.01.028. Epub 2015 Mar 17.

The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus

Sato, S. Li, K. Kameyama, T. Hayashi, T. Ishida, Y. Murakami, S. Watanabe, T. Iijima, S. Sakurai, Y. Watashi, K. Tsutsumi, S. Sato, Y. Akita, H. Wakita, T. Rice, C. M. Harashima, H. Kohara, M.Tanaka, Y.Takaoka, A.

Immunity. 2015 Jan 20;42(1):123-32.