Phoenix Bio

研究開発

研究開発

Utility of Three-Dimensional Cultures of Primary Human Hepatocytes (Spheroids) as Pharmacokinetic Models

    Mizoi, K. Arakawa, H. Yano, K. Koyama, S. Kojima, H. Ogihara, T.

    Biomedicines. 2020 Sep 23;8(10). pii: biomedicines8100374. doi: 10.3390/biomedicines8100374.

    Art of Making Artificial Liver: Depicting Human Liver Biology and Diseases in Mice

      Sugahara, G. Ishida, Y. Sun, J. Tateno, C. Saito, T.

      Semin Liver Dis. 2020 Feb 19. doi: 10.1055/s-0040-1701444.

      Characterization and applications of chimeric mice with humanized livers for preclinical drug development

        Tateno, Chise;   Kojima, Yuha

        Laboratory Animal Research volume 36, Article number: 2 (2020)

        Contribution of chimeric mice with a humanized liver to the evaluation of pharmacology, toxicity, and pharmacokinetics in drug discovery and development

          Sanoh, S. Ohta, S.

          Nihon Yakurigaku Zasshi. 2018;151(5):213-220

          Chimeric mice with humanized liver: Application in drug metabolism and pharmacokinetics studies for drug discovery

            Naritomi, Y. Sanoh, S. Ohta, S.

            Drug Metab Pharmacokinet. 2017 Nov 9. pii: S1347-4367(17)30150-7. doi: 10.1016/j.dmpk.2017.11.001.

            Significance of aldehyde oxidase during drug development: Effects on drug metabolism, pharmacokinetics, toxicity, and efficacy

              Sanoh, S. Tayama, Y. Sugihara, K. Kitamura, S. Ohta, S.

              Drug Metab Pharmacokinet. 2015 Feb;30(1):52-63.

              Assessing the Therapeutic Potential of Lab-Made Hepatocytes

              Rezvani, M. Grimm, A. Willenbring, H.

              Hepatology. 2016 Mar 25. doi: 10.1002/hep.28569

              動物モデルを用いた発癌研究

              森屋恭爾、三好秀征、小池和彦

              新ウイルス性肝炎学 2015 page74-78

              肝炎ウイルスの動物モデルと治療開発

              茶山一彰、今村道雄

              新ウイルス性肝炎学 2015 page69-73

              ヒト肝細胞キメラマウスを用いたin vivoおよびin vitro HBV感染モデル

              石田雄二、横道博、加国雅和、立野知世

              新ウイルス性肝炎学 2015 page386-391

              In Vitro and in Vivo Assessments of Drug-induced Hepatotoxicity and Drug Metabolism in Humans (In Japanese)(ヒトにおける医薬品の肝毒性及び代謝物のin vtro, in vivo予測評価系の構築に関する研究)

                Sanoh, S.

                Yakugaku Zasshi. 2015;135(11):1273-9. doi: 10.1248/yakushi.15-00200.

                Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound

                  Kamimura, H. Ito, S.

                  Xenobiotica. 2015 Oct 7:1-13.

                  Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics

                    Sanoh, S. Ohta, S.
                    Biopharm Drug Dispos. 2014 Mar;35(2):71-86.

                    Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver

                      Kitamura, S. Sugihara, K.
                      Xenobiotica. 2014 Jan; 44(2): 123-34.

                      A mouse with humanized liver as an animal model for predicting drug effects and for studying hepatic viral infection: where to next?

                        Yoshizato, K. Tateno, C.

                        Expert Opin Drug Metab Toxicol. 2013 Nov;9(11):1419-35.

                        Mice with liver composed of human hepatocytes as an animal model for drug testing.

                          Yoshizato K, Tateno C, Utoh R.

                          Curr Drug Discov Technol. 2012 Mar;9(1):63-76. Review.

                          Chimeric mice with humanized liver: mechanism of hepatic hyperplasia induction.

                          Tateno C.

                          生化学 2012 Aug;84(8):699-706.

                          Impact of interleukin-28B genotype on in vitro and in vivo systems of hepatitis C virus replication.

                            Chayama K, Hayes CN, Imamura M.
                            Hepatol Res. 2012 Sep;42(9):841-53.

                            ヒト肝細胞キメラマウスを用いた抗肝炎ウイルス薬効評価系

                            加国雅和、立野知世

                            ファルマシア 2012; 48(10): 956-958

                            An experimental mouse model for hepatitis C virus.

                              Kimura K, Kohara M.

                              Exp Anim. 2011;60(2):93-100. Review.