Utility of Three-Dimensional Cultures of Primary Human Hepatocytes (Spheroids) as Pharmacokinetic Models

Mizoi, K. Arakawa, H. Yano, K. Koyama, S. Kojima, H. Ogihara, T.

Biomedicines. 2020 Sep 23;8(10). pii: biomedicines8100374. doi: 10.3390/biomedicines8100374.

Art of Making Artificial Liver: Depicting Human Liver Biology and Diseases in Mice

Sugahara, G. Ishida, Y. Sun, J. Tateno, C. Saito, T.

Semin Liver Dis. 2020 Feb 19. doi: 10.1055/s-0040-1701444.

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Laboratory Animal Research volume 36, Article number: 2 (2020)

Contribution of chimeric mice with a humanized liver to the evaluation of pharmacology, toxicity, and pharmacokinetics in drug discovery and development

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Nihon Yakurigaku Zasshi. 2018;151(5):213-220

Chimeric mice with humanized liver: Application in drug metabolism and pharmacokinetics studies for drug discovery

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Drug Metab Pharmacokinet. 2017 Nov 9. pii: S1347-4367(17)30150-7. doi: 10.1016/j.dmpk.2017.11.001.

Significance of aldehyde oxidase during drug development: Effects on drug metabolism, pharmacokinetics, toxicity, and efficacy

Sanoh, S. Tayama, Y. Sugihara, K. Kitamura, S. Ohta, S.

Drug Metab Pharmacokinet. 2015 Feb;30(1):52-63.

Assessing the Therapeutic Potential of Lab-Made Hepatocytes

Rezvani, M. Grimm, A. Willenbring, H.

Hepatology. 2016 Mar 25. doi: 10.1002/hep.28569

動物モデルを用いた発癌研究

森屋恭爾、三好秀征、小池和彦

新ウイルス性肝炎学 2015 page74-78

肝炎ウイルスの動物モデルと治療開発

茶山一彰、今村道雄

新ウイルス性肝炎学 2015 page69-73

ヒト肝細胞キメラマウスを用いたin vivoおよびin vitro HBV感染モデル

石田雄二、横道博、加国雅和、立野知世

新ウイルス性肝炎学 2015 page386-391

In Vitro and in Vivo Assessments of Drug-induced Hepatotoxicity and Drug Metabolism in Humans (In Japanese)(ヒトにおける医薬品の肝毒性及び代謝物のin vtro, in vivo予測評価系の構築に関する研究）

Sanoh, S.

Yakugaku Zasshi. 2015;135(11):1273-9. doi: 10.1248/yakushi.15-00200.

Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound

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Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics

Sanoh, S. Ohta, S.
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Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver

Kitamura, S. Sugihara, K.
Xenobiotica. 2014 Jan; 44(2): 123-34.

A mouse with humanized liver as an animal model for predicting drug effects and for studying hepatic viral infection: where to next?

Yoshizato, K. Tateno, C.

Expert Opin Drug Metab Toxicol. 2013 Nov;9(11):1419-35.

Mice with liver composed of human hepatocytes as an animal model for drug testing.

Yoshizato K, Tateno C, Utoh R.

Curr Drug Discov Technol. 2012 Mar;9(1):63-76. Review.

Chimeric mice with humanized liver: mechanism of hepatic hyperplasia induction.

Tateno C.

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ヒト肝細胞キメラマウスを用いた抗肝炎ウイルス薬効評価系

加国雅和、立野知世

ファルマシア 2012; 48(10): 956-958

An experimental mouse model for hepatitis C virus.

Kimura K, Kohara M.

Exp Anim. 2011;60(2):93-100. Review.