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研究開発

研究開発

Art of Making Artificial Liver: Depicting Human Liver Biology and Diseases in Mice

    Sugahara, G. Ishida, Y. Sun, J. Tateno, C. Saito, T.

    Semin Liver Dis. 2020 Feb 19. doi: 10.1055/s-0040-1701444.

    Characterization and applications of chimeric mice with humanized livers for preclinical drug development

      Tateno, Chise;   Kojima, Yuha

      Laboratory Animal Research volume 36, Article number: 2 (2020)

      Contribution of chimeric mice with a humanized liver to the evaluation of pharmacology, toxicity, and pharmacokinetics in drug discovery and development

        Sanoh, S. Ohta, S.

        Nihon Yakurigaku Zasshi. 2018;151(5):213-220

        Chimeric mice with humanized liver: Application in drug metabolism and pharmacokinetics studies for drug discovery

          Naritomi, Y. Sanoh, S. Ohta, S.

          Drug Metab Pharmacokinet. 2017 Nov 9. pii: S1347-4367(17)30150-7. doi: 10.1016/j.dmpk.2017.11.001.

          Significance of aldehyde oxidase during drug development: Effects on drug metabolism, pharmacokinetics, toxicity, and efficacy

            Sanoh, S. Tayama, Y. Sugihara, K. Kitamura, S. Ohta, S.

            Drug Metab Pharmacokinet. 2015 Feb;30(1):52-63.

            Assessing the Therapeutic Potential of Lab-Made Hepatocytes

            Rezvani, M. Grimm, A. Willenbring, H.

            Hepatology. 2016 Mar 25. doi: 10.1002/hep.28569

            動物モデルを用いた発癌研究

            森屋恭爾、三好秀征、小池和彦

            新ウイルス性肝炎学 2015 page74-78

            肝炎ウイルスの動物モデルと治療開発

            茶山一彰、今村道雄

            新ウイルス性肝炎学 2015 page69-73

            ヒト肝細胞キメラマウスを用いたin vivoおよびin vitro HBV感染モデル

            石田雄二、横道博、加国雅和、立野知世

            新ウイルス性肝炎学 2015 page386-391

            In Vitro and in Vivo Assessments of Drug-induced Hepatotoxicity and Drug Metabolism in Humans (In Japanese)(ヒトにおける医薬品の肝毒性及び代謝物のin vtro, in vivo予測評価系の構築に関する研究)

              Sanoh, S.

              Yakugaku Zasshi. 2015;135(11):1273-9. doi: 10.1248/yakushi.15-00200.

              Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound

                Kamimura, H. Ito, S.

                Xenobiotica. 2015 Oct 7:1-13.

                Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics

                  Sanoh, S. Ohta, S.
                  Biopharm Drug Dispos. 2014 Mar;35(2):71-86.

                  Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver

                    Kitamura, S. Sugihara, K.
                    Xenobiotica. 2014 Jan; 44(2): 123-34.

                    A mouse with humanized liver as an animal model for predicting drug effects and for studying hepatic viral infection: where to next?

                      Yoshizato, K. Tateno, C.

                      Expert Opin Drug Metab Toxicol. 2013 Nov;9(11):1419-35.

                      Mice with liver composed of human hepatocytes as an animal model for drug testing.

                        Yoshizato K, Tateno C, Utoh R.

                        Curr Drug Discov Technol. 2012 Mar;9(1):63-76. Review.

                        Chimeric mice with humanized liver: mechanism of hepatic hyperplasia induction.

                        Tateno C.

                        生化学 2012 Aug;84(8):699-706.

                        Impact of interleukin-28B genotype on in vitro and in vivo systems of hepatitis C virus replication.

                          Chayama K, Hayes CN, Imamura M.
                          Hepatol Res. 2012 Sep;42(9):841-53.

                          ヒト肝細胞キメラマウスを用いた抗肝炎ウイルス薬効評価系

                          加国雅和、立野知世

                          ファルマシア 2012; 48(10): 956-958

                          An experimental mouse model for hepatitis C virus.

                            Kimura K, Kohara M.

                            Exp Anim. 2011;60(2):93-100. Review.

                            PBXマウス由来新鮮肝細胞を用いたインビトロ代謝試験

                            安達弥長

                            HAB Newsleter 2011; 18(1): 21-23