Phoenix Bio

研究開発

研究開発

Suppression of hepatitis B virus through therapeutic activation of RIG-I and IRF3 signaling in hepatocytes

    Sooyoung Lee, Ashish Goyal, Alan S. Perelson, Yuji Ishida, Takeshi Saito, Michael Gale, Jr.

    iScience. 2021 Jan 4;24(1):101969. doi: 10.1016/j.isci.2020.101969. eCollection 2021 Jan 22.

    PXB-cells, fresh primary hepatocytes from humanized mouse livers, exhibit nonalcoholic fatty liver like properties, including large very low density lipoprotein

      Sayaka Tomatsu 1, Masaki Takahashi 2, Masakazu Kakuni 2, Gen Toshima 3, Fumiko Kimura 3, Junichiro Takahashi 3, Yui Umekawa 1, Akira Sasaki 1, Keishi Hata

      J. Biol. Macromol., 21 (1), 51-52 (2021)

      Role of Hepatitis B virus capsid phosphorylation in nucleocapsid disassembly and covalently closed circular DNA formation

        Luo, J. Xi, J. Gao, L. Hu, J.

        PLoS Pathog. 2020 Mar 30;16(3):e1008459. doi: 10.1371/journal.ppat.1008459. eCollection 2020 Mar.

        Decomposition profile data analysis of multiple drug effects identifies endoplasmic reticulum stress-inducing ability as an unrecognized factor

          Morita, K. Mizuno, T. Kusuhara, H.

          Sci Rep. 2020 Aug 4;10(1):13139. doi: 10.1038/s41598-020-70140-9.

          Utility of Three-Dimensional Cultures of Primary Human Hepatocytes (Spheroids) as Pharmacokinetic Models

            Mizoi, K. Arakawa, H. Yano, K. Koyama, S. Kojima, H. Ogihara, T.

            Biomedicines. 2020 Sep 23;8(10). pii: biomedicines8100374. doi: 10.3390/biomedicines8100374.

            Detection of acute toxicity of aflatoxin B1 to human hepatocytes in vitro and in vivo using chimeric mice with humanized livers

              Ishida, Y. Yamasaki, C. Iwanari, H. Yamashita, H. Ogawa, Y. Yanagi, A. Furukawa, S. Kojima, Y. Chayama, K. Kamiie, J. Tateno, C.

              PLoS One. 2020 Sep 23;15(9):e0239540. doi: 10.1371/journal.pone.0239540.

              Culture density contributes to hepatic functions of fresh human hepatocytes isolated from chimeric mice with humanized livers: Novel, long-term, functional two-dimensional in vitro tool for developing new drugs

                Yamasaki, C. Ishida, Y. Yanagi, A. Yoshizane, Y. Kojima, Y. Ogawa, Y. Kageyama, Y. Iwasaki, Y. Ishida, S. Chayama, K. Tateno, C.

                PLoS One. 2020 Sep 11;15(9):e0237809. doi: 10.1371/journal.pone.0237809. eCollection 2020.

                PXBマウス・PXB-cells関連研究発表のご案内:肝炎関連3学会

                2020年7月~8月に開催されました、以下の肝炎関連学会(3学会:日本消化器病学会、EASL、日本肝臓学会)にて、PXBマウス及びPXB-cells関連の研究発表がありました。

                A novel evaluation method for determining drug-induced hepatotoxicity using 3D bio-printed human liver tissue

                  Ide, I. Nagao, E. Kajiyama, S. Mizoguchi, N.

                  Toxicol Mech Methods. 2020 Mar;30(3):189-196. doi: 10.1080/15376516.2019.1686795. Epub 2019 Nov 21.

                  Engineering Cellular Biosensors with Customizable Antiviral Responses Targeting Hepatitis B Virus

                    Matsunaga, S. Jeremiah, S. S. Miyakawa, K. Kurotaki, D. Shizukuishi, S. Watashi, K. Nishitsuji, H. Kimura, H. Tamura, T. Yamamoto, N. Shimotohno, K. Wakita, T. Ryo, A.

                    iScience. 2020 Mar 27;23(3):100867. doi: 10.1016/j.isci.2020.100867. Epub 2020 Feb 26.

                    Lipoprotein profile and lipid metabolism of PXB-cells((R)), human primary hepatocytes from liver-humanized mice: proposal of novel in vitro system for screening anti-lipidemic drugs

                      Hata, K. Sayaka, T. Takahashi, M. Sasaki, A. Umekawa, Y. Miyashita, K. Ogura, K. Toshima, G. Maeda, M. Takahashi, J. Kakuni, M.

                      Biomed Res. 2020;41(1):33-42. doi: 10.2220/biomedres.41.33.

                      Successful energy shift from glycolysis to mitochondrial oxidative phosphorylation in freshly isolated hepatocytes from humanized mice liver

                        Ikeyama, Y. Sato, T. Takemura, A. Sekine, S. Ito, K.

                        Toxicol In Vitro. 2020 Jan 25:104785. doi: 10.1016/j.tiv.2020.104785.

                        High-throughput screening to evaluate inhibition of bile acid transporters using human hepatocytes isolated from chimeric mice

                          Kohara, H. Bajaj, P. Yamanaka, K. Miyawaki, A. Harada, K. Miyamoto, K. Matsui, T. Okai, Y. Wagoner, M. Shinozawa, T.

                          Toxicol Sci. 2019 Nov 13. pii: 5625164. doi: 10.1093/toxsci/kfz229.

                          Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

                            Katsuda, T. Matsuzaki, J. Yamaguchi, T. Yamada, Y. Prieto-Vila, M. Hosaka, K. Takeuchi, A. Saito, Y. Ochiya, T.

                            Elife. 2019 Aug 8;8. pii: 47313. doi: 10.7554/eLife.47313.

                            An interferon-like small chemical compound CDM-3008 suppresses hepatitis B virus through induction of interferon-stimulated genes

                              Furutani, Y. Toguchi, M. Shiozaki-Sato, Y. Qin, X. Y. Ebisui, E. Higuchi, S. Sudoh, M. Suzuki, H. Takahashi, N. Watashi, K. Wakita, T. Kakeya, H. Kojima, S.

                              PLoS One. 2019 Jun 12;14(6):e0216139. doi: 10.1371/journal.pone.0216139. eCollection 2019.

                              2019/07/25

                              第29回抗ウイルス療法学会学術集会でのPXBマウス及びPXB-cells関連研究発表のご案内

                              2019年7月18日(木)~7月20日(土)に開催されました 第29回抗ウイルス療法学会学術集会にて、PXBマウス及びPXB-cells関連の研究発表がありましたのでご案内を致します。

                              Study of the Metabolism of New Drugs of Abuse

                                Kanamori, T.

                                Yakugaku Zasshi. 2019;139(5):699-704. doi: 10.1248/yakushi.18-00166-3.

                                Metabolism of Butyrylfentanyl in Fresh Human Hepatocytes: Chemical Synthesis of Authentic Metabolite Standards for Definitive Identification

                                  Kanamori, T. Iwata, Y. T. Segawa, H. Yamamuro, T. Kuwayama, K. Tsujikawa, K. Inoue, H.

                                  Biol Pharm Bull. 2019;42(4):623-630. doi: 10.1248/bpb.b18-00765.

                                  PAPD5/7 Are Host Factors That Are Required for Hepatitis B Virus RNA Stabilization

                                    Mueller, H. Lopez, A. Tropberger, P. Wildum, S. Schmaler, J. Pedersen, L. Han, X. Wang, Y. Ottosen, S. Yang, S. Young, J. A. T. Javanbakht, H.

                                    Hepatology. 2019 Apr;69(4):1398-1411. doi: 10.1002/hep.30329. Epub 2019 Mar 1.

                                    Prediction of Human Hepatic Clearance for Cytochrome P450 Substrates via a New Culture Method Using the Collagen Vitrigel Membrane Chamber and Fresh Hepatocytes Isolated from Liver Humanized Mice

                                      Watari, R. Kakiki, M. Yamasaki, C. Ishida, Y. Tateno, C. Kuroda, Y. Ishida, S. Kusano, K.

                                      Biol Pharm Bull. 2019;42(3):348-353. doi: 10.1248/bpb.b18-00582.