Phoenix Bio

研究発表

研究発表

A small molecule iCDM-34 identified by in silico screening suppresses HBV DNA through activation of aryl hydrocarbon receptor

    Furutani, Y. Hirano, Y. Toguchi, M. Higuchi, S. Qin, X. Y. Yanaka, K. Sato-Shiozaki, Y. Takahashi, N. Sakai, M. Kongpracha, P. Suzuki, T. Dohmae, N. Kukimoto-Niino, M. Shirouzu, M. Nagamori, S. Suzuki, H. Kobayashi, K. Masaki, T. Koyama, H. Sekiba, K. Otsuka, M. Koike, K. Kohara, M. Kojima, S. Kakeya, H. Matsuura, T.
    Cell Death Discov. 2023 Dec 22;9(1):467. doi: 10.1038/s41420-023-01755-w.

    Induction of open-form bile canaliculus formation by hepatocytes for evaluation of biliary drug excretion

      Arakawa, H. Nakazono, Y. Matsuoka, N. Hayashi, M. Shirasaka, Y. Hirao, A. Tamai, I.
      Commun Biol. 2023 Aug 22;6(1):866. doi: 10.1038/s42003-023-05216-z.

      SRPKIN-1 as an inhibitor against hepatitis B virus blocking the viral particle formation and the early step of the viral infection

        Li, X. Nakashima, K. Ito, M. Matsuda, M. Chida, T. Sekihara, K. Takahashi, H. Kato, T. Sawasaki, T. Suzuki, T.
        Antiviral Res. 2023 Dec;220:105756. doi: 10.1016/j.antiviral.2023.105756. Epub 2023 Nov 20.

        A versatile method to profile hepatitis B virus DNA integration

          Fukano, K. Wakae, K. Nao, N. Saito, M. Tsubota, A. Toyoshima, T. Aizaki, H. Iijima, H. Matsudaira, T. Kimura, M. Watashi, K. Sugiura, W. Muramatsu, M.
          Hepatol Commun. 2023 Dec 1;7(12):e0328. doi: 10.1097/HC9.0000000000000328. eCollection 2023 Dec 1.

          Development and characterization of secondary standards for nucleic acid amplification technology (NAAT) assays for detection of hepatitis E virus

            Fares-Gusmao, R. Jiang, Z. Subramaniam, S. Visser, B. J. Scott, A. Ishida, Y. Saito, T. Baylis, S. A. McGivern, D. R. H. E. V. Standard Calibration Study Group
            J Clin Virol. 2022 Dec;157:105325. doi: 10.1016/j.jcv.2022.105325.

            Functional involvement of endothelial lipase in hepatitis B virus infection

              Shirasaki, T. Murai, K. Ishida, A. Kuroki, K. Kawaguchi, K. Wang, Y. Yamanaka, S. Yasukawa, R. Kawasaki, N. Li, Y. Y. Shimakami, T. Sumiyadorj, A. Nio, K. Sugimoto, S. Orita, N. Takayama, H. Okada, H. Thi Bich, P. D. Iwabuchi, S. Hashimoto, S. Ide, M. Tabata, N. Ito, S. Matsushima, K. Yanagawa, H. Yamashita, T. Kaneko, S. Honda, M.
              Hepatol Commun. 2023 Aug 31;7(9):e0206.

              Function of hepatocyte spheroids in bioactive microcapsules is enhanced by endogenous and exogenous hepatocyte growth factor

                Gwon, K. Choi, D. de Hoyos-Vega, J. M. Baskaran, H. Gonzalez-Suarez, A. M. Lee, S. Hong, H. J. Nguyen, K. M.n Dharmesh, E. Sugahara, G. Ishida, Y. Saito, T. Stybayeva, G. Revzin, A.
                Bioact Mater. 2023 May 24;28:183-195. doi: 10.1016/j.bioactmat.2023.05.009.

                Guiding Hepatic Differentiation of Pluripotent Stem Cells Using 3D Microfluidic Co-Cultures with Human Hepatocytes

                  Fattahi, P. de Hoyos-Vega, J. M. Choi, J. H. Duffy, C. D. Gonzalez-Suarez, A. M. Ishida, Y. Nguyen, K. M. Gwon, K. Peterson, Q. P. Saito, T. Stybayeva, G. Revzin, A.
                  Cells. 2023 Aug 1;12(15):1982. doi: 10.3390/cells12151982.

                  Modeling suggests that virion production cycles within individual cells is key to understanding acute hepatitis B virus infection kinetics

                    Hailegiorgis, A. Ishida, Y. Collier, N. Imamura, M. Shi, Z. Reinharz, V. Tsuge, M. Barash, D. Hiraga, N. Yokomichi, H. Tateno, C. Ozik, J. Uprichard, S. L. Chayama, K. Dahari, H.
                    PLoS Comput Biol. 2023 Aug 3;19(8):e1011309. doi: 10.1371/journal.pcbi.1011309.

                    Super-Resolution Microscopy Analysis of Hepatitis B Viral cccDNA and Host Factors

                      Doan, P. T. B. Nio, K. Shimakami, T. Kuroki, K. Li, Y. Y. Sugimoto, S. Takayama, H. Okada, H. Kaneko, S. Honda, M. Yamashita, T.
                      Viruses. 2023 May 16;15(5):1178. doi: 10.3390/v15051178.

                      Persistent hepatic IFN system activation in HBV-HDV infection determines viral replication dynamics and therapeutic response

                        Chida, T. Ishida, Y. Morioka, S. Sugahara, G. Han, C. Lam, B. Yamasaki, C. Sugahara, R. Li, M. Tanaka, Y. Liang, T. J. Tateno, C. Saito, T.
                        JCI Insight. 2023 May 8;8(9):e162404. doi: 10.1172/jci.insight.162404.

                        Amentoflavone inhibits hepatitis B virus infection via the suppression of preS1 binding to host cells

                          Aoki-Utsubo, C. Indrasetiawan, P. Fukano, K. Muramatsu, M. Artanti, N. Hanafi, M. Hotta, H. Kameoka, M.
                          Microbiol Immunol. 2023 Mar 16. doi: 10.1111/1348-0421.13064.

                          Downregulation of SOCS1 increases interferon-induced ISGylation during differentiation of induced-pluripotent stem cells to hepatocytes

                            Edwards, J. S. Delabat, S. A. Badilla, A. D. DiCaprio, R. C. Hyun, J. Burgess, R. A. Silva, T. Dykxhoorn, D. M. Chen, S. X. Wang, L. Ishida, Y. Saito, T. Thomas, E.
                            JHEP Rep. 2022 Sep 23;4(12):100592. doi: 10.1016/j.jhepr.2022.100592. eCollection 2022 Dec.

                            The Gut-Organ-Axis Concept: Advances the Application of Gut-on-Chip Technology

                              Guo, Y. Chen, X. Gong, P.Li, G. Yao, W. Yang, W.
                              Int J Mol Sci. 2023 Feb 17;24(4):4089. doi: 10.3390/ijms24044089.

                              The Synthesis and Anti-Cytomegalovirus Activity of Piperidine-4-Carboxamides

                                Guo, X Ghosh, A. K. Keyes, R. F. Peterson, F. Forman, M. Meyers, D. J. Arav-Boger, R.
                                Viruses. 2022 Jan 25;14(2):234. doi: 10.3390/v14020234.

                                Development of Recombinant Infectious Hepatitis E Virus Harboring the nanoKAZ Gene and Its Application in Drug Screening

                                  Primadharsini, P. P. Nagashima, S. Nishiyama, T. Takahashi, M. Murata, K. Okamoto, H.
                                  J Virol. 2022 Mar 23;96(6):e0190621. doi: 10.1128/jvi.01906-21. Epub 2022 Feb 2.

                                  Novel Neplanocin A Derivatives as Selective Inhibitors of Hepatitis B Virus with a Unique Mechanism of Action

                                    Toyama, M. Watashi, K. Ikeda, M. Yamashita, A. Okamoto, M. Moriishi, K. Muramatsu, M. Wakita, T. Sharon, A. Baba, M.
                                    Antimicrob Agents Chemother. 2022 Jun 21;66(6):e0207321. doi: 10.1128/aac.02073-21. Epub 2022 May 23.

                                    Hepatitis B virus X protein counteracts high mobility group box 1 protein-mediated epigenetic silencing of covalently closed circular DNA

                                      Kim, E. S. Zhou, J. Zhang, H. Marchetti, A. van de Klundert, M. Cai, D.Yu, X. Mitra, B. Liu, Y. Wang, M. Protzer, U. Guo, H.
                                      PLoS Pathog. 2022 Jun 9;18(6):e1010576. doi: 10.1371/journal.ppat.1010576.

                                      Autophagic membranes participate in hepatitis B virus nucleocapsid assembly, precore and core protein trafficking, and viral release

                                        Chu, J. Y. K. Chuang, Y. C. Tsai, K. N. Pantuso, J. Ishida, Y. Saito, T. Ou, J. J.

                                        Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2201927119. doi: 10.1073/pnas.2201927119. Epub 2022 Jul 18.

                                        Guanine nucleotide exchange factor DOCK11-binding peptide fused with a single chain antibody inhibits hepatitis B virus infection and replication

                                          Ide, M. Tabata, N. Yonemura, Y. Shirasaki, T. Murai, K. Wang, Y. Ishida, A. Okada, H. Honda, M. Kaneko, S. Doi, N. Ito, S. Yanagawa, H.
                                          J Biol Chem. 2022 Jul;298(7):102097. doi: 10.1016/j.jbc.2022.102097. Epub 2022 Jun 2.