株式会社フェニックスバイオ

Guiding Hepatic Differentiation of Pluripotent Stem Cells Using 3D Microfluidic Co-Cultures with Human Hepatocytes

Fattahi, P. de Hoyos-Vega, J. M. Choi, J. H. Duffy, C. D. Gonzalez-Suarez, A. M. Ishida, Y. Nguyen, K. M. Gwon, K. Peterson, Q. P. Saito, T. Stybayeva, G. Revzin, A.
Cells. 2023 Aug 1;12(15):1982. doi: 10.3390/cells12151982.

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Modeling suggests that virion production cycles within individual cells is key to understanding acute hepatitis B virus infection kinetics

Hailegiorgis, A. Ishida, Y. Collier, N. Imamura, M. Shi, Z. Reinharz, V. Tsuge, M. Barash, D. Hiraga, N. Yokomichi, H. Tateno, C. Ozik, J. Uprichard, S. L. Chayama, K. Dahari, H.
PLoS Comput Biol. 2023 Aug 3;19(8):e1011309. doi: 10.1371/journal.pcbi.1011309.

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Super-Resolution Microscopy Analysis of Hepatitis B Viral cccDNA and Host Factors

Doan, P. T. B. Nio, K. Shimakami, T. Kuroki, K. Li, Y. Y. Sugimoto, S. Takayama, H. Okada, H. Kaneko, S. Honda, M. Yamashita, T.
Viruses. 2023 May 16;15(5):1178. doi: 10.3390/v15051178.

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Persistent hepatic IFN system activation in HBV-HDV infection determines viral replication dynamics and therapeutic response

Chida, T. Ishida, Y. Morioka, S. Sugahara, G. Han, C. Lam, B. Yamasaki, C. Sugahara, R. Li, M. Tanaka, Y. Liang, T. J. Tateno, C. Saito, T.
JCI Insight. 2023 May 8;8(9):e162404. doi: 10.1172/jci.insight.162404.

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Amentoflavone inhibits hepatitis B virus infection via the suppression of preS1 binding to host cells

Aoki-Utsubo, C. Indrasetiawan, P. Fukano, K. Muramatsu, M. Artanti, N. Hanafi, M. Hotta, H. Kameoka, M.
Microbiol Immunol. 2023 Mar 16. doi: 10.1111/1348-0421.13064.

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Downregulation of SOCS1 increases interferon-induced ISGylation during differentiation of induced-pluripotent stem cells to hepatocytes

Edwards, J. S. Delabat, S. A. Badilla, A. D. DiCaprio, R. C. Hyun, J. Burgess, R. A. Silva, T. Dykxhoorn, D. M. Chen, S. X. Wang, L. Ishida, Y. Saito, T. Thomas, E.
JHEP Rep. 2022 Sep 23;4(12):100592. doi: 10.1016/j.jhepr.2022.100592. eCollection 2022 Dec.

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The Gut-Organ-Axis Concept: Advances the Application of Gut-on-Chip Technology

Guo, Y. Chen, X. Gong, P.Li, G. Yao, W. Yang, W.
Int J Mol Sci. 2023 Feb 17;24(4):4089. doi: 10.3390/ijms24044089.

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The Synthesis and Anti-Cytomegalovirus Activity of Piperidine-4-Carboxamides

Guo, X Ghosh, A. K. Keyes, R. F. Peterson, F. Forman, M. Meyers, D. J. Arav-Boger, R.
Viruses. 2022 Jan 25;14(2):234. doi: 10.3390/v14020234.

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Development of Recombinant Infectious Hepatitis E Virus Harboring the nanoKAZ Gene and Its Application in Drug Screening

Primadharsini, P. P. Nagashima, S. Nishiyama, T. Takahashi, M. Murata, K. Okamoto, H.
J Virol. 2022 Mar 23;96(6):e0190621. doi: 10.1128/jvi.01906-21. Epub 2022 Feb 2.

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Novel Neplanocin A Derivatives as Selective Inhibitors of Hepatitis B Virus with a Unique Mechanism of Action

Toyama, M. Watashi, K. Ikeda, M. Yamashita, A. Okamoto, M. Moriishi, K. Muramatsu, M. Wakita, T. Sharon, A. Baba, M.
Antimicrob Agents Chemother. 2022 Jun 21;66(6):e0207321. doi: 10.1128/aac.02073-21. Epub 2022 May 23.

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Hepatitis B virus X protein counteracts high mobility group box 1 protein-mediated epigenetic silencing of covalently closed circular DNA

Kim, E. S. Zhou, J. Zhang, H. Marchetti, A. van de Klundert, M. Cai, D.Yu, X. Mitra, B. Liu, Y. Wang, M. Protzer, U. Guo, H.
PLoS Pathog. 2022 Jun 9;18(6):e1010576. doi: 10.1371/journal.ppat.1010576.

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Autophagic membranes participate in hepatitis B virus nucleocapsid assembly, precore and core protein trafficking, and viral release

Chu, J. Y. K. Chuang, Y. C. Tsai, K. N. Pantuso, J. Ishida, Y. Saito, T. Ou, J. J.

Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2201927119. doi: 10.1073/pnas.2201927119. Epub 2022 Jul 18.

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Guanine nucleotide exchange factor DOCK11-binding peptide fused with a single chain antibody inhibits hepatitis B virus infection and replication

Ide, M. Tabata, N. Yonemura, Y. Shirasaki, T. Murai, K. Wang, Y. Ishida, A. Okada, H. Honda, M. Kaneko, S. Doi, N. Ito, S. Yanagawa, H.
J Biol Chem. 2022 Jul;298(7):102097. doi: 10.1016/j.jbc.2022.102097. Epub 2022 Jun 2.

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Establishment of a Monoclonal Antibody against Human NTCP That Blocks Hepatitis B Virus Infection

Takemori, T. Sugimoto-Ishige, A. Nishitsuji, H. Futamura, Y. Harada, M. Kimura-Someya, T. Matsumoto, T. Honma, T. Tanaka, M. Yaguchi, M. Isono, K. Koseki, H. Osada, H. Miki, D. Saito, T. Tanaka, T. Fukami, T. Goto, T. Shirouzu, M. Shimotohno, K. Chayama, K.
J Virol. 2022 Mar 9;96(5):e0168621. doi: 10.1128/JVI.01686-21. Epub 2022 Jan 5.

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Antiviral Compounds Screening Targeting HBx Protein of the Hepatitis B Virus

Ma, Y. Nakamoto, S. Ao, J. Qiang, N. Kogure, T. Ogawa, K. Nakagawa, M. Fujiwara, K. Iwanaga, T. Kojima, R. Kanzaki, H. Koroki, K. Kobayashi, K. Kanogawa, N. Kiyono, S. Nakamura, M. Kondo, T. Nakagawa, R. Ogasawara, S. Muroyama, R. Chiba, T. Kato, J. Kato, N.
Int J Mol Sci. 2022 Oct 10;23(19):12015. doi: 10.3390/ijms231912015.

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N6-methyladenosine Modification of Hepatitis B Virus RNA in the Coding Region of HBx

Murata, T. Iwahori, S. Okuno, Y. Nishitsuji, H. Yanagi, Y. Watashi, K. Wakita, T. Kimura, H. Shimotohno, K.
Int J Mol Sci. 2023 Jan 23;24(3):2265. doi: 10.3390/ijms24032265.

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A Novel Anti-HBV Agent, E-CFCP, restores Hepatitis B virus (HBV)-induced Senescence-associated Cellular Markers Perturbation in Human Hepatocytes

Takamatsu, Y. Hayashi, S. Kumamoto, H. Imoto, S. Tanaka, Y. Mitsuya, H. Higashi-Kuwata, N.
Virus Res. 2023 Mar 23;329:199094. doi: 10.1016/j.virusres.2023.199094.

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Establishment of hyperoxic cell culture system for predicting drug-induced liver injury: reducing accumulated lipids in hepatocytes derived from chimeric mice with humanized liver

Ohtsuki, Y. Sanoh, S. Yamao, M. Kojima, Y. Kotake, Y. Tateno, C.
J Toxicol Sci. 2023;48(2):99-108. doi: 10.2131/jts.48.99.

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Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases

Yarnall, M. T. N. Ioannidi, E. I. Schmitt-Ulms, C. Krajeski, R. N. Lim, J. Villiger, L. Zhou, W. Jiang, K. Garushyants, S. K. Roberts, N. Zhang, L. Vakulskas, C. A. Walker, J. A., 2nd. Kadina, A. P. Zepeda, A. E. Holden, K. Ma, H. Xie, J. Gao, G. Foquet, L. Bial, G. Donnelly, S. K. Miyata, Y. Radiloff, D. R. Henderson, J. M. Ujita, A. Abudayyeh, O. O. Gootenberg, J. S.
Nat Biotechnol. 2022 Nov 24. doi: 10.1038/s41587-022-01527-4.

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Discovery of a first-in-class orally available HBV cccDNA inhibitor

Wang, L. Zhu, Q. Zhang, J. D. Zhang, Y. Ni, X. Xiang, K. Jiang, J. Li, B. Yu, Y. Hu, H. Zhang, M. Wu, W. Zeng, J. Yan, Z. Dai, J. Sun, K. Zhang, X. Chen, D. Feng, S. Sach Peltason, L. Young, J. A. T. Gao, L.
J Hepatol. 2022 Dec 29:S0168-8278(22)03466-3. doi: 10.1016/j.jhep.2022.12.014.

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研究発表

Guiding Hepatic Differentiation of Pluripotent Stem Cells Using 3D Microfluidic Co-Cultures with Human Hepatocytes

Modeling suggests that virion production cycles within individual cells is key to understanding acute hepatitis B virus infection kinetics

Super-Resolution Microscopy Analysis of Hepatitis B Viral cccDNA and Host Factors

Persistent hepatic IFN system activation in HBV-HDV infection determines viral replication dynamics and therapeutic response

Amentoflavone inhibits hepatitis B virus infection via the suppression of preS1 binding to host cells

Downregulation of SOCS1 increases interferon-induced ISGylation during differentiation of induced-pluripotent stem cells to hepatocytes

The Gut-Organ-Axis Concept: Advances the Application of Gut-on-Chip Technology

The Synthesis and Anti-Cytomegalovirus Activity of Piperidine-4-Carboxamides

Development of Recombinant Infectious Hepatitis E Virus Harboring the nanoKAZ Gene and Its Application in Drug Screening

Novel Neplanocin A Derivatives as Selective Inhibitors of Hepatitis B Virus with a Unique Mechanism of Action

Hepatitis B virus X protein counteracts high mobility group box 1 protein-mediated epigenetic silencing of covalently closed circular DNA

Autophagic membranes participate in hepatitis B virus nucleocapsid assembly, precore and core protein trafficking, and viral release

Guanine nucleotide exchange factor DOCK11-binding peptide fused with a single chain antibody inhibits hepatitis B virus infection and replication

Establishment of a Monoclonal Antibody against Human NTCP That Blocks Hepatitis B Virus Infection

Antiviral Compounds Screening Targeting HBx Protein of the Hepatitis B Virus

N6-methyladenosine Modification of Hepatitis B Virus RNA in the Coding Region of HBx

A Novel Anti-HBV Agent, E-CFCP, restores Hepatitis B virus (HBV)-induced Senescence-associated Cellular Markers Perturbation in Human Hepatocytes

Establishment of hyperoxic cell culture system for predicting drug-induced liver injury: reducing accumulated lipids in hepatocytes derived from chimeric mice with humanized liver

Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases

Discovery of a first-in-class orally available HBV cccDNA inhibitor