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研究発表

研究発表

Chimeric Mouse With Humanized Liver Is an Appropriate Animal Model to Investigate Mode of Action for Porphyria-Mediated Hepatocytotoxicity

    Toxicol Pathol. 2021 Jul 9:1926233211027474. doi: 10.1177/01926233211027474.

    Eguchi, A. Fukunaga, S. Ogata, K. Kushida, M. Asano, H. Cohen, S. M. Sukata, T.

    Application of humanized mice to toxicology studies: Evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)

      Journal Toxicologic Pathology 2021; 34(4): 283-297. doi: https://doi.org/10.1293/tox.2021-0027

      Tomoya Yamada

       

      Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)

        Yamada, T. Cohen, S. M. Lake, B. G.

        Crit Rev Toxicol. 2021;51(5):373-394. doi:10.1080/10408444.2021.1939654. Epub 2021 Jul 15.

        Prediction of human pharmacokinetics for low-clearance compounds using pharmacokinetic data from chimeric mice with humanized livers

          Yoshida, K. Doi, Y. Iwazaki, N. Yasuhara, H. Ikenaga, Y. Shimizu, H. Nakada, T. Watanabe, T. Tateno, C. Sanoh, S.Kotake, Y.

          Clin Transl Sci. 2021 Jun 3. doi: 10.1111/cts.13070.

          Cell-based high-throughput screening for the evaluation of reactive metabolite formation potential

            Harada, K. Kohara, H. Yukawa, T. Matsumiya, K. Shinozawa, T.
            Toxicol In Vitro. 2021 Aug;74:105159. doi: 10.1016/j.tiv.2021.105159. Epub 2021 Apr 3.

            Evaluation of the Utility of PXB Chimeric Mice for Predicting Human Liver Partitioning of Hepatic Organic Anion-Transporting Polypeptide Transporter Substrates

              Feng, B. Pemberton, R. Dworakowski, W. Ye, Z. Zetterberg, C. Wang, G. Morikawa, Y. Kumar, S.

              Drug Metab Dispos. 2021 Mar;49(3):254-264. doi: 10.1124/dmd.120.000276. Epub 2020 Dec 29.

              Culture density contributes to hepatic functions of fresh human hepatocytes isolated from chimeric mice with humanized livers: Novel, long-term, functional two-dimensional in vitro tool for developing new drugs

                Yamasaki, C. Ishida, Y. Yanagi, A. Yoshizane, Y. Kojima, Y. Ogawa, Y. Kageyama, Y. Iwasaki, Y. Ishida, S. Chayama, K. Tateno, C.

                PLoS One. 2020 Sep 11;15(9):e0237809. doi: 10.1371/journal.pone.0237809. eCollection 2020.

                Comparison of the hepatic effects of phenobarbital in chimeric mice containing either rat or human hepatocytes with humanized constitutive androstane receptor (CAR) and pregnane X receptor (PXR) mice (hCAR/hPXR mice)

                  Yamada, T. Ohara, A. Ozawa, N. Maeda, K. Kondo, M. Okuda, Y. Abe, J. Cohen, S. M. Lake, B. G.

                  Toxicol Sci. 2020 Jul 31. pii: 5879297. doi: 10.1093/toxsci/kfaa125.

                  Characterization of plasma protein binding in two mouse models of humanized liver, PXB mouse and humanized TK-NOG mouse

                    Miyamoto, M. Kosugi, Y. Iwasaki, S. Chisaki, I. Nakagawa, S. Amano, N. Hirabayashi, H.

                    Xenobiotica. 2020 Aug 25:1-10. doi: 10.1080/00498254.2020.1808735

                    Prediction of Human Disproportionate and Biliary Excreted Metabolites Using Chimeric Mice with Humanized Liver

                      Kato, S. Shah, A. Plesescu, M. Miyata, Y. Bolleddula, J. Chowdhury, S. Zhu, X.

                      Drug Metab Dispos. 2020 Jul 14. pii: dmd.120.000128. doi: 10.1124/dmd.120.000128.

                      2020/09/11

                      PXBマウス関連の学術論文のご紹介:武田薬品工業株式会社

                        武田薬品工業様より、PXBマウス関連の学術論文が発表されましたのでご紹介申し上げます。

                        【詳細】

                        掲載雑誌名:Xenobiotica. 2020 Aug 25; 1-10.  doi:10.1080/00498254.2020.1808735

                        掲載日:2020年8月25日

                        論文名:Characterization of plasma protein binding in two mouse models of humanized liver, PXB mouse and humanized

                        TK-NOG mouse.

                        著者:Maki Miyamoto, et. al.(武田薬品工業株式会社)

                        概要:ヒトPK予測の重要な指標となる血漿中タンパク結合率について、2種類のヒト肝細胞キメラマウスである “PXBマ

                        ウス” と “Hu-Liver TK-NOGマウス” を用 いて、ヒト予測精度を比較した。
                        臨床データとの相関性は、PXBマウスは39化合物中34化合物(87.2%)、 Hu- Liver TK-NOGマウスは24化合物中15化合物(62.5%)であり、PXBマウスの方が高い予測精度を示した。

                        Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation

                          Steeneck, C. Kinzel, O. Anderhub, S. Hornberger, M. Pinto, S. Morschhaeuser, B. Braun, F. Kleymann, G. Hoffmann, T.

                          ACS Med Chem Lett. 2020 Jan 27;11(2):179-187. doi: 10.1021/acsmedchemlett.9b00572. eCollection 2020 Feb 13.

                          Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: Integration with hepatic drug metabolism

                            Sanoh, S. Naritomi, Y. Kitamura, S. Shinagawa, A. Kakuni, M. Tateno, C. Ohta, S.

                            Xenobiotica. 2020 Jun 5:1-10. doi: 10.1080/00498254.2020.1769229.

                            High-throughput screening to evaluate inhibition of bile acid transporters using human hepatocytes isolated from chimeric mice

                              Kohara, H. Bajaj, P. Yamanaka, K. Miyawaki, A. Harada, K. Miyamoto, K. Matsui, T. Okai, Y. Wagoner, M. Shinozawa, T.

                              Toxicol Sci. 2019 Nov 13. pii: 5625164. doi: 10.1093/toxsci/kfz229.

                              Application of a Novel Mass Spectral Data Acquisition Approach to Lipidomic Analysis of Liver Extracts from Sitaxentan-treated Liver-Humanized PXB Mice

                                King, A. Baginski, M. Morikawa, Y. Rainville, P. D. Gethings, L. A. Wilson, I. D. Plumb, R. S.

                                J Proteome Res. 2019 Oct 8. doi: 10.1021/acs.jproteome.9b00334..

                                Effect of Rifampicin on the Plasma Concentrations of Bile Acid-O-Sulfates in Monkeys and Human Liver-Transplanted Chimeric Mice With or Without Bile Flow Diversion

                                  Takehara, I. Watanabe, N. Mori, D. Ando, O. Kusuhara, H.

                                  J Pharm Sci. 2019 Mar 21.

                                  Utility of Chimeric Mice with Humanized Liver for Predicting Human Pharmacokinetics in Drug Discovery: Comparison with in Vitro-in Vivo Extrapolation and Allometric Scaling

                                    Naritomi, Y. Sanoh, S. Ohta, S.

                                    Biol Pharm Bull. 2019;42(3):327-336. doi: 10.1248/bpb.b18-00754.

                                    Study of the Metabolism of New Drugs of Abuse

                                      Kanamori, T.

                                      Yakugaku Zasshi. 2019;139(5):699-704. doi: 10.1248/yakushi.18-00166-3.

                                      Changes in Bile Acid Concentrations after Administration of Ketoconazole or Rifampicin to Chimeric Mice with Humanized Liver

                                      Seigo Sanoh*,a, Yuka Tamuraa, Chieri Fujinoa, Go Sugaharab, Yasumi Yoshizaneb, Ami Yanagib, Keishi Kisohb, Yuji Ishidab,c, Chise Tatenob,c, Shigeru Ohtaa,d, and Yaichiro Kotakea.

                                      BPB Reports

                                      Changes in Bile Acid Concentrations in Chimeric Mice Transplanted with Different Replacement Indexes of Human Hepatocytes

                                        Chieri Fujino,a Seigo Sanoh,*,a Yuka Tamura,a Yuji Ishida,b,c Chise Tateno,b,c Shigeru Ohta,a,d and Yaichiro Kotakea.

                                        BPB Reports 2, 29-34 (2019)