Phoenix Bio

研究開発

研究開発

2020/09/11

PXBマウス関連の学術論文のご紹介:武田薬品工業株式会社

    武田薬品工業様より、PXBマウス関連の学術論文が発表されましたのでご紹介申し上げます。

    【詳細】

    掲載雑誌名:Xenobiotica. 2020 Aug 25; 1-10.  doi:10.1080/00498254.2020.1808735

    掲載日:2020年8月25日

    論文名:Characterization of plasma protein binding in two mouse models of humanized liver, PXB mouse and humanized

    TK-NOG mouse.

    著者:Maki Miyamoto, et. al.(武田薬品工業株式会社)

    概要:ヒトPK予測の重要な指標となる血漿中タンパク結合率について、2種類のヒト肝細胞キメラマウスである “PXBマ

    ウス” と “Hu-Liver TK-NOGマウス” を用 いて、ヒト予測精度を比較した。
    臨床データとの相関性は、PXBマウスは39化合物中34化合物(87.2%)、 Hu- Liver TK-NOGマウスは24化合物中15化合物(62.5%)であり、PXBマウスの方が高い予測精度を示した。

    Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation

      Steeneck, C. Kinzel, O. Anderhub, S. Hornberger, M. Pinto, S. Morschhaeuser, B. Braun, F. Kleymann, G. Hoffmann, T.

      ACS Med Chem Lett. 2020 Jan 27;11(2):179-187. doi: 10.1021/acsmedchemlett.9b00572. eCollection 2020 Feb 13.

      Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: Integration with hepatic drug metabolism

        Sanoh, S. Naritomi, Y. Kitamura, S. Shinagawa, A. Kakuni, M. Tateno, C. Ohta, S.

        Xenobiotica. 2020 Jun 5:1-10. doi: 10.1080/00498254.2020.1769229.

        High-throughput screening to evaluate inhibition of bile acid transporters using human hepatocytes isolated from chimeric mice

          Kohara, H. Bajaj, P. Yamanaka, K. Miyawaki, A. Harada, K. Miyamoto, K. Matsui, T. Okai, Y. Wagoner, M. Shinozawa, T.

          Toxicol Sci. 2019 Nov 13. pii: 5625164. doi: 10.1093/toxsci/kfz229.

          Application of a Novel Mass Spectral Data Acquisition Approach to Lipidomic Analysis of Liver Extracts from Sitaxentan-treated Liver-Humanized PXB Mice

            King, A. Baginski, M. Morikawa, Y. Rainville, P. D. Gethings, L. A. Wilson, I. D. Plumb, R. S.

            J Proteome Res. 2019 Oct 8. doi: 10.1021/acs.jproteome.9b00334..

            Effect of Rifampicin on the Plasma Concentrations of Bile Acid-O-Sulfates in Monkeys and Human Liver-Transplanted Chimeric Mice With or Without Bile Flow Diversion

              Takehara, I. Watanabe, N. Mori, D. Ando, O. Kusuhara, H.

              J Pharm Sci. 2019 Mar 21.

              Utility of Chimeric Mice with Humanized Liver for Predicting Human Pharmacokinetics in Drug Discovery: Comparison with in Vitro-in Vivo Extrapolation and Allometric Scaling

                Naritomi, Y. Sanoh, S. Ohta, S.

                Biol Pharm Bull. 2019;42(3):327-336. doi: 10.1248/bpb.b18-00754.

                Study of the Metabolism of New Drugs of Abuse

                  Kanamori, T.

                  Yakugaku Zasshi. 2019;139(5):699-704. doi: 10.1248/yakushi.18-00166-3.

                  Changes in Bile Acid Concentrations after Administration of Ketoconazole or Rifampicin to Chimeric Mice with Humanized Liver

                  Seigo Sanoh*,a, Yuka Tamuraa, Chieri Fujinoa, Go Sugaharab, Yasumi Yoshizaneb, Ami Yanagib, Keishi Kisohb, Yuji Ishidab,c, Chise Tatenob,c, Shigeru Ohtaa,d, and Yaichiro Kotakea.

                  BPB Reports

                  Changes in Bile Acid Concentrations in Chimeric Mice Transplanted with Different Replacement Indexes of Human Hepatocytes

                    Chieri Fujino,a Seigo Sanoh,*,a Yuka Tamura,a Yuji Ishida,b,c Chise Tateno,b,c Shigeru Ohta,a,d and Yaichiro Kotakea.

                    BPB Reports 2, 29-34 (2019)

                    Metabolism of Butyrylfentanyl in Fresh Human Hepatocytes: Chemical Synthesis of Authentic Metabolite Standards for Definitive Identification

                      Kanamori, T. Iwata, Y. T. Segawa, H. Yamamuro, T. Kuwayama, K. Tsujikawa, K. Inoue, H.

                      Biol Pharm Bull. 2019;42(4):623-630. doi: 10.1248/bpb.b18-00765.

                      Prediction of human pharmacokinetics of typical compounds by a physiologically based method using chimeric mice with humanized liver

                        Nakayama, K. Ito, S. Suzuki, M. Takubo, H. Yamazaki, H. Nomura, Y.

                        Xenobiotica. 2019 Apr; 49(4):404-414.  doi:10.1080/00498254.2018.1460516. Epub 2018 Apr 19.

                        Prediction of Human Hepatic Clearance for Cytochrome P450 Substrates via a New Culture Method Using the Collagen Vitrigel Membrane Chamber and Fresh Hepatocytes Isolated from Liver Humanized Mice

                          Watari, R. Kakiki, M. Yamasaki, C. Ishida, Y. Tateno, C. Kuroda, Y. Ishida, S. Kusano, K.

                          Biol Pharm Bull. 2019;42(3):348-353. doi: 10.1248/bpb.b18-00582.

                          Prediction of human pharmacokinetics of long half-life compounds using chimeric mice with humanised liver

                            Miyamoto, M. Iwasaki, S. Chisaki, I. Nakagawa, S. Amano, N. Kosugi, Y. Hirabayashi, H.

                            Xenobiotica. 2019 Feb 12:1-31. doi: 10.1080/00498254.2019.1579394.

                            MicroRNAs Enable mRNA Therapeutics to Selectively Program Cancer Cells to Self-Destruct

                              Jain, R. Frederick, J. P. Huang, E. Y. Burke, K. E. Mauger, D. M. Andrianova, E. A. Farlow, S. J.Siddiqui, S. Pimentel, J. Cheung-Ong, K. McKinney, K. M. Kohrer, C. Moore, M. J. Chakraborty, T.

                              Nucleic Acid Ther. 2018 Oct;28(5):285-296.

                              Lack of human relevance for procymidone’s developmental toxicity attributable to species difference in its kinetics and metabolism

                                Tomigahara, Y. Tarui, H. Matsui, M. Kurosawa, M. Kawamura, S. Isobe, N.

                                J Pestic Sci. 2018 May 20;43(2):114-123. doi: 10.1584/jpestics.D17-085.

                                Chimeric mice with humanized livers demonstrate human-specific hepatotoxicity caused by a therapeutic antibody against TRAIL-receptor 2/death receptor 5

                                  Nihira, K. Nan-Ya, K. I. Kakuni, M. Ono, Y. Yoshikawa, Y. Ota, T. Hiura, M. Yoshinari, K.

                                  Toxicol Sci. 2018 Sep 9. pii: 5093319. doi: 10.1093/toxsci/kfy228.

                                  The metabolic fate of fenclozic acid in chimeric mice with a humanized liver

                                    Ekdahl, A. Weidolf, L. Baginski, M. Morikawa, Y. Thompson, R. A. Wilson, I. D.

                                    Arch Toxicol. 2018 Sep;92(9):2819-2828.

                                    A long-term culture system based on a collagen vitrigel membrane chamber that supports liver-specific functions of hepatocytes isolated from mice with humanized livers

                                      Watari, R. Kakiki, M. Oshikata, A. Takezawa, T. Yamasaki, C. Ishida, Y. Tateno, C. Kuroda, Y. Ishida, S. Kusano, K.

                                      J Toxicol Sci. 2018;43(8):521-529.

                                      Contribution of chimeric mice with a humanized liver to the evaluation of pharmacology, toxicity, and pharmacokinetics in drug discovery and development

                                        Sanoh, S. Ohta, S.

                                        Nihon Yakurigaku Zasshi. 2018;151(5):213-220