Phoenix Bio

研究発表

研究発表

Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers.

    Schulz-Utermoehl T, Sarda S, Foster JR, Jacobsen M, Kenna JG, Morikawa Y, Salmu J, Gross G, Wilson ID.
    Xenobiotica. 2012 Jun;42(6):503-17.

    Predictability of metabolism of ibuprofen and naproxen using chimeric mice with human hepatocytes.

      Sanoh S, Horiguchi A, Sugihara K, Kotake Y, Tayama Y, Uramaru N, Ohshita H, Tateno C, Horie T, Kitamura S, Ohta S.
      Drug Metab Dispos. 2012 Dec;40(12):2267-72.

      Pharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers

        Samuelsson K, Pickup K, Sarda S, Swales JG, Morikawa Y, Schulz-Utermoehl T, Hutchison M, Wilson ID.
        Xenobiotica. 2012 Nov;42(11):1128-37.

        Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton’s tyrosine kinase inhibitor.

          Liu L, Halladay JS, Shin Y, Wong S, Coraggio M, La H, Baumgardner M, Le H, Gopaul S, Boggs J, Kuebler P, Davis JC Jr, Liao XC, Lubach JW, Deese A, Sowell CG, Currie KS, Young WB, Khojasteh SC, Hop CE, Wong H.
          Drug Metab Dispos. 2011 Oct;39(10):1840-9.

          Evaluation of a chimeric (uPA+/+)/SCID mouse model with a humanized liver for prediction of human metabolism.

            De Serres M, Bowers G, Boyle G, Beaumont C, Castellino S, Sigafoos J, Dave M, Roberts A, Shah V, Olson K, Patel D, Wagner D, Yeager R, Serabjit-Singh C.
            Xenobiotica. 2011 Jun;41(6):464-75.

            In vitro evaluation of cytochrome p450 and glucuronidation activities in hepatocytes isolated from liver-humanized mice.

              Yamasaki C, Kataoka M, Kato Y, Kakuni M, Usuda S, Ohzone Y, Matsuda S, Adachi Y, Ninomiya S, Itamoto T, Asahara T, Yoshizato K, Tateno C.
              Drug Metab Pharmacokinet. 2011 Jan 14;25(6):539-50

              Activation of Morphine Glucuronidation by Fatty Acyl-CoAs and Its Plasticity: A Comparative Study in Humans and Rodents Including Chimeric Mice Carrying Human Liver.

              Nurrochmad A, Ishii Y, Nakanoh H, Inoue T, Horie T, Sugihara K, Ohta S, Taketomi A, Maehara Y, Yamada H.
              Drug Metab Pharmacokinet. in press.

              Approach for in vivo protein binding of 5-n-butyl-pyrazolo[1,5-a]pyrimidine bioactivated in chimeric mice with humanized liver by two-dimensional electrophoresis with accelerator mass spectrometry.

                Yamazaki H, Kuribayashi S, Inoue T, Tateno C, Nishikura Y, Oofusa K, Harada D, Naito S, Horie T, Ohta S.
                Chem Res Toxicol. 2010 Jan;23(1):152-8.

                CYP1A1 and CYP1A2 expression: comparing ‘humanized’ mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines.

                  Uno S, Endo K, Ishida Y, Tateno C, Makishima M, Yoshizato K, Nebert DW.
                  Toxicol Appl Pharmacol. 2009 May 15;237(1):119-26.

                  Prediction of Human Disposition toward S-3H-Warfarin using Chimeric Mice with Humanized Liver

                    Tae INOUE, Kazumi SUGIHARA, Hiroki OHSHITA, Toru HORIE, Shigeyuki KITAMURA and Shigeru OHTA
                    Drug Metabolism and Pharmacokinetics Vol. 24 (2009) , No. 2 pp.153-160

                    CYP2C9-Catalyzed Metabolism of S-Warfarin to 7-Hydroxywarfarin in Vivo and in Vitro in Chimeric Mice with Humanized Liver.

                      Inoue T, Nitta K, Sugihara K, Horie T, Kitamura S, Ohta S.
                      Drug Metab Dispos. 2008 Dec;36(12):2429-2433

                      Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice.

                        Okada K, Shoda J, Taguchi K, Maher JM, Ishizaki K, Inoue Y, Ohtsuki M, Goto N, Takeda K, Utsunomiya H, Oda K, Warabi E, Ishii T, Osaka K, Hyodo I, Yamamoto M.
                        Am J Physiol Gastrointest Liver Physiol. 2008 Oct;295(4):G735-47. Epub 2008 Aug 7.

                        Aldehyde oxidase-catalyzed metabolism of N1-methylnicotinamide in vivo and in vitro in chimeric mice with humanized liver.

                          Kitamura S, Nitta K, Tayama Y, Tanoue C, Sugihara K, Inoue T, Horie T, Ohta S.
                          Drug Metab Dispos. 2008 Jul;36(7):1202-5

                          Human hepatocytes can repopulate mouse liver: histopathology of the liver in human hepatocyte-transplanted chimeric mice and toxicologic responses to acetaminophen.

                            Sato Y, Yamada H, Iwasaki K, Tateno C, Yokoi T, Yoshizato K, Horii I.
                            Toxicol Pathol. 2008;36(4):581-91.

                            Non-invasive method to detect induction of CYP3A4 in chimeric mice with a humanized liver

                              Emoto C, Yamato Y, Sato Y, Ohshita H, Katoh M, Tateno C, Yokoi T, Yoshizato K, Iwasaki K.
                              Xenobiotica. 2008 Mar;38(3):239-48.

                              Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers.

                                Okada K, Shoda J, Kano M, Suzuki S, Ohtake N, Yamamoto M, Takahashi H, Utsunomiya H, Oda K, Sato K, Watanabe A, Ishii T, Itoh K, Yamamoto M, Yokoi T, Yoshizato K, Sugiyama Y, Suzuki H.

                                Am J Physiol Gastrointest Liver Physiol. 2007 May;292(5):G1450-1463.

                                In Vivo Drug Metabolism Model for Human Cytochrome P450 Enzyme Using Chimeric Mice with Humanized Liver

                                  Katoh M, Sawada T, Soeno Y, Nakajima M, Tateno C, Yoshizato K, Yokoi T.

                                  J Pharm Sci. 2007 Feb;96(2):428-437.

                                  Evaluation of human hepatocyte chimeric mice as a model for toxicological investigation using panomic approaches–effect of acetaminophen on the expression profiles of proteins and endogenous metabolites in liver, plasma and urine

                                    Yamamoto T, Tomizawa K, Fujikawa M, Sato Y, Yamada H, Horii I.
                                    J Toxicol Sci. 2007 Aug;32(3):205-15.

                                    Bezafibrate induces multidrug-resistance P-Glycoprotein 3 expression in cultured human hepatocytes and humanized livers of chimeric mice.

                                      Shoda J, Okada K, Inada Y, Kusama H, Utsunomiya H, Oda K, Yokoi T, Yoshizato K, Suzuki H.
                                      Hepatol Res. 2007 Jul;37(7):548-56.

                                      Humanization of Excretory Pathway in Chimeric Mice with Humanized Liver

                                        Okumura H, Katoh M, Sawada T, Nakajima M, Soeno Y, Yabuuchi H, Ikeda T, Tateno C, Yoshizato K, Yokoi T.
                                        Toxicol Sci. 2007 Jun;97(2):533-8. Epub 2007 Mar 6.