Phoenix Bio

研究発表

研究発表

RXR agonist S169 inhibits HBV/HDV entry in vitro by disrupting KIF4-dependent NTCP trafficking

    Gad, S. A. Abo Elwafa, D. A. Hussein, S. A. Fukano, K. Kato, T. Shoji, I. Chayama, K. Muramatsu, M. Isogawa, M. Wakita, T. Merk, D. Aly, H. H.
    Antiviral Res. 2025 Aug;240:106214. doi: 10.1016/j.antiviral.2025.106214.

    A novel synthetic bile acid derivative inhibits hepatitis B virus infection at entry step by interfering with the oligomerization of sodium taurocholate co-transporting polypeptide

      Rsi Suwardana, G. N. Abe, T. Deng, L. Matsui, C. Okitsu, T. Yamada, T. Hatano, M. Wiriyasermkul, P. Nagamori, S. Gad, S. A. Aly, H. H. Nishitsuji, H. Shimotohno, K. Shoji, I.
      Antiviral Res. 2025 Aug 30;243:106267. doi: 10.1016/j.antiviral.2025.106267.

      Therapy with murinized tobevibart and elebsiran is efficacious in a liver-chimeric mouse model of HDV infection

        Zhou, J. Kaiser, H. Rocha, E. Terrell, A. N. Corti, D. Purcell, L. A. Lempp, F. A. Puschnik, A. S.
        JHEP Rep. 2025 Mar 22;7(6):101400. doi: 10.1016/j.jhepr.2025.101400. eCollection

        Interferon alpha induces a stronger antiviral effect than interferon lambda in HBV/HDV infected humanized mice

          Duehren, S. Uchida, T. Tsuge, M. Hiraga, N. Uprichard, S. L. Etzion, O. Glenn, J. Koh, C. Heller, T. Cotler, S. J. Oka, S. Chayama, K. Dahari, H.
          Virus Res. 2024 Aug 26;349:199451. doi: 10.1016/j.virusres.2024.199451.

          Persistent hepatic IFN system activation in HBV-HDV infection determines viral replication dynamics and therapeutic response

            Chida, T. Ishida, Y. Morioka, S. Sugahara, G. Han, C. Lam, B. Yamasaki, C. Sugahara, R. Li, M. Tanaka, Y. Liang, T. J. Tateno, C. Saito, T.
            JCI Insight. 2023 May 8;8(9):e162404. doi: 10.1172/jci.insight.162404.

            Fungal Secondary Metabolite Exophillic Acid Selectively Inhibits the Entry of Hepatitis B and D Viruses

              Kobayashi, C. Watanabe, Y. Oshima, M. Hirose, T. Yamasaki, M. Iwamoto, M. Iwatsuki, M. Asami, Y. Kuramochi, K. Wakae, K. Aizaki, H. Muramatsu, M. Sureau, C. Sunazuka, T. Watashi, K.
              Viruses. 2022 Apr 6;14(4). pii: v14040764. doi: 10.339/v14040764.

              Hepatitis B Virus Therapeutic Agent ARB-1740 Has Inhibitory Effect on Hepatitis Delta Virus in a New Dually-Infected Humanized Mouse Model

                Ye, X. Tateno, C. Thi, E. P. Kakuni, M. Snead, N. M. Ishida, Y. Barnard, T. R. Sofia, M. Shimada, T. Lee, A. C. H.

                ACS Infect Dis. 2018 Nov 8. doi: 10.1021/acsinfecdis.8b00192.

                A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide

                  Kaneko, M. Watashi, K. Kamisuki, S. Matsunaga, H. Iwamoto, M. Kawai, F. Ohashi, H. Tsukuda, S. Shimura, S. Suzuki, R. Aizaki, H. Sugiyama, M. Park, S. Y. Ito, T. Ohtani, N. Sugawara, F. Tanaka, Y. Mizokami, M. Sureau, C. Wakita, T.

                  J Virol. 2015 Dec;89(23):11945-53. doi: 10.1128/JVI.01855-15.