Phoenix Bio

研究発表

研究発表

Pegylated interferon therapy-related microRNA-6126 downregulates sodium taurocholate cotransporting polypeptide expression in hepatocytes

    Fujita, K. Nishitsuji, H. Iwama, H. Tadokoro, T. Morishita, A. Mimura, S. Ono, M. Himoto, T. Shimotohno, K. Masaki, T.
    Gene. 2022 Nov 24;853:147068. doi: 10.1016/j.gene.2022.147068.

    Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus

      Gilmore, S. A. Tam, D. Cheung, T. L. Snyder, C. Farand, J. Dick, R.Matles, M. Feng, J. Y.Ramirez, R.Li, L. Yu, H. Xu, Y.Barnes, D. Czerwieniec, G. Brendza, K. M. Appleby, T. C. Birkus, G. Willkom, M. Kobayashi, T. Paoli, E. Labelle, M. Boesen, T.Tay, C. H. Delaney, W. E. thNotte, G. T. Schmitz, U. Feierbach, B.
      PLoS One. 2022 Dec 7;17(12):e0271145. doi: 10.1371/journal.pone.0271145. eCollection 2022.

      Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA2

        Nakanishi, A. Okumura, H. Hashita, T. Yamashita, A. Nishimura, Y. Watanabe, C. Kamimura, S. Hayashi, S. Murakami, S. Ito, K. Iwao, T. Ikeda, A. Hirose, T. Sunazuka, T. Tanaka, Y. Matsunaga, T.
        Viruses. 2022 Nov 8;14(11):2468. doi: 10.3390/v14112468.

        Fungal Secondary Metabolite Exophillic Acid Selectively Inhibits the Entry of Hepatitis B and D Viruses

          Kobayashi, C. Watanabe, Y. Oshima, M. Hirose, T. Yamasaki, M. Iwamoto, M. Iwatsuki, M. Asami, Y. Kuramochi, K. Wakae, K. Aizaki, H. Muramatsu, M. Sureau, C. Sunazuka, T. Watashi, K.
          Viruses. 2022 Apr 6;14(4). pii: v14040764. doi: 10.339/v14040764.

          Hepatitis B virus utilizes a retrograde trafficking route via the trans-Golgi network to avoid lysosomal degradation

            Li, Y. Y. Kuroki, K. Shimakami, T. Murai, K. Kawaguchi, K. Shirasaki, T. Nio, K. Sugimoto, S. Nishikawa, T. Okada, H. Orita, N. Takayama, H. Wang, Y. Thi Bich, P. D. Ishida, A. Iwabuchi, S.
            Cell Mol Gastroenterol Hepatol. 2022 Oct 19. pii: S2352-345X(22)00219-3. doi: 10.1016/j.jcmgh.2022.10.008.

            Targeting lipid biosynthesis pathways for hepatitis B virus cure

              Hyrina, A. Burdette, D. Song, Z. Ramirez, R. Okesli-Armlovich, A. Vijayakumar, A. Bates, J. Trevaskis, J. L. Fletcher, S. P. Lee, W. A. Holdorf, M. M.
              PLoS One. 2022 Aug 4;17(8):e0270273. doi: 10.1371/journal.pone.0270273. eCollection 2022.

              Signature of chronic hepatitis B virus infection in nails and hair

                Komatsu, H. Inui, A. Odmaa, E. Ito, Y. Hoshino, H. Umetsu, S. Tsunoda, T. Fujisawa, T.
                BMC Infect Dis. 2022 May 4;22(1):431. doi: 10.1186/s12879-022-07400-8.

                The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro

                  Gad, S. A. Sugiyama, M. Tsuge, M. Wakae, K. Fukano, K. Oshima, M. Sureau, C. Watanabe, N. Kato, T. Murayama, A. Li, Y. Shoji, I. Shimotohno, K. Chayama, K. Muramatsu, M. Wakita, T. Nozaki, T. Aly, H. H.
                  PLoS Pathog. 2022 Mar 21;18(3):e1009983. doi: 10.1371/journal.ppat.1009983. eCollection 2022 Mar.

                  A single hepatitis B virus genome with a reporter allows the entire viral life cycle to be monitored in primary human hepatocytes

                    Sumiyadorj, A. Murai, K. Shimakami, T. Kukroki, K. Nishikawa, T. Kakuya, M. Yamada, A. Wang, Y. Ishida, A. Shirasaki, T. Kawase, S. Li, Y. Y. Okada, H. Nio, K. Kawaguchi, K. Yamashita, T. Sakai, Y. Duger, D. Mizukoshi, E. Honda, M. Kaneko, S.
                    Hepatol Commun. 2022 Jun 12. doi: 10.1002/hep4.2018.

                    Ongoing viral replication and production of infectious virus in patients with chronic hepatitis B virus suppressed below the limit of quantitation on long-term nucleos(t)ide therapy

                      Burdette, D. L. Lazerwith, S. Yang, J. Chan, H. L. Y. Delaney Iv, W. E. Fletcher, S. P. Cihlar, T. Feierbach, B.
                      PLoS One. 2022 Apr 1;17(4):e0262516. doi: 10.1371/journal.pone.0262516.

                      Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1beta to downregulate PPARalpha and FOXO3

                        Li, Y. Zhu, Y. Feng, S. Ishida, Y. Chiu, T. P. Saito, T. Wang, S. Ann, D. K. Ou, J. J.
                        Cell Rep. 2022 Jan 25;38(4):110284. doi: 10.1016/j.celrep.2021.110284.

                        HBV upregulates TRAIL-R3 expression in hepatocytes for escaping both cell apoptosis and suppression of their replication by TRAIL

                          Suehiro, Y. Tsuge, M. Kurihara, M. Uchida, T. Fujino, H. Ono, A. Yamauchi, M. Makokha, G. N. Nakahara, T. Murakami, E. Abe-Chayama, H. Kawaoka, T. Miki, D. Imamura, M. Aikata, H. Hayes, C. N. Fujita, T. Chayama, K.
                          J Infect Dis. 2022 Feb 28. pii: 6534478. doi: 10.1093/infdis/jiac044.

                          Droplet digital PCR assay provides intrahepatic HBV cccDNA quantification tool for clinical application

                            Hayashi, S. Isogawa, M. Kawashima, K. Ito, K. Chuaypen, N. Morine, Y. Shimada, M. Higashi-Kuwata, N. Watanabe, T. Tangkijvanich, P. Mitsuya, H. Tanaka, Y.
                            Sci Rep. 2022 Feb 8;12(1):2133. doi: 10.1038/s41598-022-05882-9.

                            ヒト肝細胞キメラマウスを利用したB型 肝炎ウイルス/D型肝炎ウイルス共感染モデル

                            加国 雅和
                            Medical Science Digest(MSD) 2021;47(14):26-27

                            Are Humanized Mouse Models Useful for Basic Research of Hepatocarcinogenesis through Chronic Hepatitis B Virus Infection?

                              Masataka Tsuge
                              Viruses. 2021 Sep 24;13(10). pii: v13101920. doi: 10.3390/v13101920.

                              HBx-induced degradation of Smc5/6 complex impairs homologous recombination-mediated repair of damaged DNA

                                Sekiba, K. Otsuka, M. Funato, K. Miyakawa, Y. Tanaka, E. Seimiya, T. Yamagami, M. Tsutsumi, T. Okushin, K. Miyakawa, K. Ryo, A. Koike, K.

                                J Hepatol. 2021 Aug 25. pii: S0168-8278(21)02005-5. doi: 10.1016/j.jhep.2021.08.010.

                                Infection courses, virological features and IFN-alpha responses of HBV genotypes in cell culture and animal models

                                  Zhang, M. Zhang, Z. Imamura, M. Osawa, M. Teraoka, Y. Piotrowski, J. Ishida, Y. Sozzi, V. Revill, P. A. Saito, T. Chayama, K. Liang, T. J.

                                  J Hepatol. 2021 Aug 4. pii: S0168-8278(21)01960-7. doi: 10.1016/j.jhep.2021.07.030.

                                  Epidermal growth factor receptor is a host-entry cofactor triggering hepatitis B virus internalization

                                    Iwamoto, M. Saso, W. Sugiyama, R. Ishii, K. Ohki, M. Nagamori, S. Suzuki, R. Aizaki, H. Ryo, A. Yun, J. H. Park, S. Y. Ohtani, N. Muramatsu, M. Iwami, S. Tanaka, Y. Sureau, C. Wakita, T. Watashi, K.
                                    Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8487-8492. doi: 10.1073/pnas.1811064116. Epub 2019 Apr 5.

                                    MafF is an antiviral host factor that suppresses transcription from Hepatitis B Virus core promoter

                                      Marwa K. Ibrahim, Tawfeek H. Abdelhafez, Junko S. Takeuchi, Kosho Wakae, Masaya Sugiyama, Masataka Tsuge, Masahiko Ito, Koichi Watashi, Mohamed El. Kassas, Takanobu Kato, Asako Murayama, Tetsuro Suzuki, Kazuaki Chayama, Kunitada Shimotohno, Masamichi Muramatsu, Hussein H. Aly, Takaji Wakita

                                      J Virol. 2021 Jul 12;95(15): e0076721. doi: 10.1128/JVI.00767-21. Epub 2021 Jul 12.

                                      Geranylgeranylacetone decreases the production of hepatitis B virus-related antigen by comprehensive downregulation of mRNA transcription activity

                                        Haraguchi, M. Miuma, S. Yamamoto, K. Nakao, Y. Ichikawa, T. Kanda, Y. Sasaki, R. Fukushima, M. Akazawa, Y. Miyaaki, H. Nakao, K.
                                        J Gastroenterol Hepatol. 2021 Jan 4. doi: 10.1111/jgh.15394.