株式会社フェニックスバイオ

Hepatitis B virus X protein counteracts high mobility group box 1 protein-mediated epigenetic silencing of covalently closed circular DNA

Kim, E. S. Zhou, J. Zhang, H. Marchetti, A. van de Klundert, M. Cai, D.Yu, X. Mitra, B. Liu, Y. Wang, M. Protzer, U. Guo, H.
PLoS Pathog. 2022 Jun 9;18(6):e1010576. doi: 10.1371/journal.ppat.1010576.

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Autophagic membranes participate in hepatitis B virus nucleocapsid assembly, precore and core protein trafficking, and viral release

Chu, J. Y. K. Chuang, Y. C. Tsai, K. N. Pantuso, J. Ishida, Y. Saito, T. Ou, J. J.

Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2201927119. doi: 10.1073/pnas.2201927119. Epub 2022 Jul 18.

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Guanine nucleotide exchange factor DOCK11-binding peptide fused with a single chain antibody inhibits hepatitis B virus infection and replication

Ide, M. Tabata, N. Yonemura, Y. Shirasaki, T. Murai, K. Wang, Y. Ishida, A. Okada, H. Honda, M. Kaneko, S. Doi, N. Ito, S. Yanagawa, H.
J Biol Chem. 2022 Jul;298(7):102097. doi: 10.1016/j.jbc.2022.102097. Epub 2022 Jun 2.

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Establishment of a Monoclonal Antibody against Human NTCP That Blocks Hepatitis B Virus Infection

Takemori, T. Sugimoto-Ishige, A. Nishitsuji, H. Futamura, Y. Harada, M. Kimura-Someya, T. Matsumoto, T. Honma, T. Tanaka, M. Yaguchi, M. Isono, K. Koseki, H. Osada, H. Miki, D. Saito, T. Tanaka, T. Fukami, T. Goto, T. Shirouzu, M. Shimotohno, K. Chayama, K.
J Virol. 2022 Mar 9;96(5):e0168621. doi: 10.1128/JVI.01686-21. Epub 2022 Jan 5.

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Antiviral Compounds Screening Targeting HBx Protein of the Hepatitis B Virus

Ma, Y. Nakamoto, S. Ao, J. Qiang, N. Kogure, T. Ogawa, K. Nakagawa, M. Fujiwara, K. Iwanaga, T. Kojima, R. Kanzaki, H. Koroki, K. Kobayashi, K. Kanogawa, N. Kiyono, S. Nakamura, M. Kondo, T. Nakagawa, R. Ogasawara, S. Muroyama, R. Chiba, T. Kato, J. Kato, N.
Int J Mol Sci. 2022 Oct 10;23(19):12015. doi: 10.3390/ijms231912015.

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N6-methyladenosine Modification of Hepatitis B Virus RNA in the Coding Region of HBx

Murata, T. Iwahori, S. Okuno, Y. Nishitsuji, H. Yanagi, Y. Watashi, K. Wakita, T. Kimura, H. Shimotohno, K.
Int J Mol Sci. 2023 Jan 23;24(3):2265. doi: 10.3390/ijms24032265.

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A Novel Anti-HBV Agent, E-CFCP, restores Hepatitis B virus (HBV)-induced Senescence-associated Cellular Markers Perturbation in Human Hepatocytes

Takamatsu, Y. Hayashi, S. Kumamoto, H. Imoto, S. Tanaka, Y. Mitsuya, H. Higashi-Kuwata, N.
Virus Res. 2023 Mar 23;329:199094. doi: 10.1016/j.virusres.2023.199094.

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HBV with precore and basal core promoter mutations exhibits a high replication phenotype and causes ER stress-mediated cell death in humanized liver chimeric mice

Uchida, T. Imamura, M. Hayes, C. N. Suehiro, Y. Teraoka, Y. Ohya, K. Aikata, H. Abe-Chayama, H. Ishida, Y. Tateno, C. Hara, Y. Hino, K. Okamoto, T. Matsuura, Y. Aizaki, H. Wake, K. Kohara, M. Liang, T. J. Oka, S. Chayama, K.
Hepatology. 2023 Mar 13. doi: 10.1097/HEP.0000000000000335.

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Discovery of a first-in-class orally available HBV cccDNA inhibitor

Wang, L. Zhu, Q. Zhang, J. D. Zhang, Y. Ni, X. Xiang, K. Jiang, J. Li, B. Yu, Y. Hu, H. Zhang, M. Wu, W. Zeng, J. Yan, Z. Dai, J. Sun, K. Zhang, X. Chen, D. Feng, S. Sach Peltason, L. Young, J. A. T. Gao, L.
J Hepatol. 2022 Dec 29:S0168-8278(22)03466-3. doi: 10.1016/j.jhep.2022.12.014.

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Pegylated interferon therapy-related microRNA-6126 downregulates sodium taurocholate cotransporting polypeptide expression in hepatocytes

Fujita, K. Nishitsuji, H. Iwama, H. Tadokoro, T. Morishita, A. Mimura, S. Ono, M. Himoto, T. Shimotohno, K. Masaki, T.
Gene. 2022 Nov 24;853:147068. doi: 10.1016/j.gene.2022.147068.

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Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus

Gilmore, S. A. Tam, D. Cheung, T. L. Snyder, C. Farand, J. Dick, R.Matles, M. Feng, J. Y.Ramirez, R.Li, L. Yu, H. Xu, Y.Barnes, D. Czerwieniec, G. Brendza, K. M. Appleby, T. C. Birkus, G. Willkom, M. Kobayashi, T. Paoli, E. Labelle, M. Boesen, T.Tay, C. H. Delaney, W. E. thNotte, G. T. Schmitz, U. Feierbach, B.
PLoS One. 2022 Dec 7;17(12):e0271145. doi: 10.1371/journal.pone.0271145. eCollection 2022.

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Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA2

Nakanishi, A. Okumura, H. Hashita, T. Yamashita, A. Nishimura, Y. Watanabe, C. Kamimura, S. Hayashi, S. Murakami, S. Ito, K. Iwao, T. Ikeda, A. Hirose, T. Sunazuka, T. Tanaka, Y. Matsunaga, T.
Viruses. 2022 Nov 8;14(11):2468. doi: 10.3390/v14112468.

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Fungal Secondary Metabolite Exophillic Acid Selectively Inhibits the Entry of Hepatitis B and D Viruses

Kobayashi, C. Watanabe, Y. Oshima, M. Hirose, T. Yamasaki, M. Iwamoto, M. Iwatsuki, M. Asami, Y. Kuramochi, K. Wakae, K. Aizaki, H. Muramatsu, M. Sureau, C. Sunazuka, T. Watashi, K.
Viruses. 2022 Apr 6;14(4). pii: v14040764. doi: 10.339/v14040764.

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Hepatitis B virus utilizes a retrograde trafficking route via the trans-Golgi network to avoid lysosomal degradation

Li, Y. Y. Kuroki, K. Shimakami, T. Murai, K. Kawaguchi, K. Shirasaki, T. Nio, K. Sugimoto, S. Nishikawa, T. Okada, H. Orita, N. Takayama, H. Wang, Y. Thi Bich, P. D. Ishida, A. Iwabuchi, S.
Cell Mol Gastroenterol Hepatol. 2022 Oct 19. pii: S2352-345X(22)00219-3. doi: 10.1016/j.jcmgh.2022.10.008.

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Targeting lipid biosynthesis pathways for hepatitis B virus cure

Hyrina, A. Burdette, D. Song, Z. Ramirez, R. Okesli-Armlovich, A. Vijayakumar, A. Bates, J. Trevaskis, J. L. Fletcher, S. P. Lee, W. A. Holdorf, M. M.
PLoS One. 2022 Aug 4;17(8):e0270273. doi: 10.1371/journal.pone.0270273. eCollection 2022.

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Signature of chronic hepatitis B virus infection in nails and hair

Komatsu, H. Inui, A. Odmaa, E. Ito, Y. Hoshino, H. Umetsu, S. Tsunoda, T. Fujisawa, T.
BMC Infect Dis. 2022 May 4;22(1):431. doi: 10.1186/s12879-022-07400-8.

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The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro

Gad, S. A. Sugiyama, M. Tsuge, M. Wakae, K. Fukano, K. Oshima, M. Sureau, C. Watanabe, N. Kato, T. Murayama, A. Li, Y. Shoji, I. Shimotohno, K. Chayama, K. Muramatsu, M. Wakita, T. Nozaki, T. Aly, H. H.
PLoS Pathog. 2022 Mar 21;18(3):e1009983. doi: 10.1371/journal.ppat.1009983. eCollection 2022 Mar.

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A single hepatitis B virus genome with a reporter allows the entire viral life cycle to be monitored in primary human hepatocytes

Sumiyadorj, A. Murai, K. Shimakami, T. Kukroki, K. Nishikawa, T. Kakuya, M. Yamada, A. Wang, Y. Ishida, A. Shirasaki, T. Kawase, S. Li, Y. Y. Okada, H. Nio, K. Kawaguchi, K. Yamashita, T. Sakai, Y. Duger, D. Mizukoshi, E. Honda, M. Kaneko, S.
Hepatol Commun. 2022 Jun 12. doi: 10.1002/hep4.2018.

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Ongoing viral replication and production of infectious virus in patients with chronic hepatitis B virus suppressed below the limit of quantitation on long-term nucleos(t)ide therapy

Burdette, D. L. Lazerwith, S. Yang, J. Chan, H. L. Y. Delaney Iv, W. E. Fletcher, S. P. Cihlar, T. Feierbach, B.
PLoS One. 2022 Apr 1;17(4):e0262516. doi: 10.1371/journal.pone.0262516.

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Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1beta to downregulate PPARalpha and FOXO3

Li, Y. Zhu, Y. Feng, S. Ishida, Y. Chiu, T. P. Saito, T. Wang, S. Ann, D. K. Ou, J. J.
Cell Rep. 2022 Jan 25;38(4):110284. doi: 10.1016/j.celrep.2021.110284.

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研究発表

Hepatitis B virus X protein counteracts high mobility group box 1 protein-mediated epigenetic silencing of covalently closed circular DNA

Autophagic membranes participate in hepatitis B virus nucleocapsid assembly, precore and core protein trafficking, and viral release

Guanine nucleotide exchange factor DOCK11-binding peptide fused with a single chain antibody inhibits hepatitis B virus infection and replication

Establishment of a Monoclonal Antibody against Human NTCP That Blocks Hepatitis B Virus Infection

Antiviral Compounds Screening Targeting HBx Protein of the Hepatitis B Virus

N6-methyladenosine Modification of Hepatitis B Virus RNA in the Coding Region of HBx

A Novel Anti-HBV Agent, E-CFCP, restores Hepatitis B virus (HBV)-induced Senescence-associated Cellular Markers Perturbation in Human Hepatocytes

HBV with precore and basal core promoter mutations exhibits a high replication phenotype and causes ER stress-mediated cell death in humanized liver chimeric mice

Discovery of a first-in-class orally available HBV cccDNA inhibitor

Pegylated interferon therapy-related microRNA-6126 downregulates sodium taurocholate cotransporting polypeptide expression in hepatocytes

Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus

Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA2

Fungal Secondary Metabolite Exophillic Acid Selectively Inhibits the Entry of Hepatitis B and D Viruses

Hepatitis B virus utilizes a retrograde trafficking route via the trans-Golgi network to avoid lysosomal degradation

Targeting lipid biosynthesis pathways for hepatitis B virus cure

Signature of chronic hepatitis B virus infection in nails and hair

The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro

A single hepatitis B virus genome with a reporter allows the entire viral life cycle to be monitored in primary human hepatocytes

Ongoing viral replication and production of infectious virus in patients with chronic hepatitis B virus suppressed below the limit of quantitation on long-term nucleos(t)ide therapy

Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1beta to downregulate PPARalpha and FOXO3