研究発表

研究発表

Selective depletion of HBV-infected hepatocytes by class A capsid assembly modulators requires high levels of intrahepatic HBV core protein

Kornyeyev, D. Song, Z. Eng, S. Soulette, C. Ramirez, R. Tang, J. Yue, Q. Subramanian, R. Zaboli, S. Moon, C. Tam, J. Brodbeck, J. Aggarwal, A. Diehl, L. Fletcher, S. P. Hyrina, A. Holdorf, M. M. Burdette, D.
Antimicrob Agents Chemother. 2024 Jul 9;68(7):e0042024. doi: 10.1128/aac.00420-24.

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Antiviral effect of peptoids on hepatitis B virus infection in cell culture

Murayama, A. Igarashi, H. Yamada, N. Aly, H. H. Molchanova, N. Lin, J. S. Nishitsuji, H. Shimotohno, K. Muramatsu, M. Barron, A. E. Kato, T.
Antiviral Res. 2024 Mar;223:105821. doi: 10.1016/j.antiviral.2024.105821.

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An allosteric inhibitor of sirtuin 2 blocks hepatitis B virus covalently closed circular DNA establishment and its transcriptional activity

Tang, L. Remiszewski, S. Snedeker, A. Chiang, L. W. Shenk, T.
Antiviral Res. 2024 Jun;226:105888. doi: 10.1016/j.antiviral.2024.105888.

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A novel, small anti-HBV compound reduces HBsAg and HBV-DNA by destabilizing HBV-RNA

Watanabe, T. Hayashi, S. Zhaoyu, Y. Inada, H. Nagaoka, K. Tateyama, M. Tanaka, Y.
J Gastroenterol. 2024 Apr;59(4):315-328. doi: 10.1007/s00535-023-02070-y. Epub 2024 Feb 5.

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Nucleos(t)ide analogs for hepatitis B virus infection differentially regulate the growth factor signaling in hepatocytes

Shimizu, R. Murai, K. Tanaka, K. Sato, Y. Takeda, N. Nakasyo, S. Shirasaki, T. Kawaguchi, K. Shimakami, T. Nio, K. Nakaya, Y. Kagiwada, H. Horimoto, K. Mizokami, M. Kaneko, S. Murata, K. Yamashita, T. Honda, M.
Hepatol Commun. 2024 Jan 5;8(1):e0351. doi: 10.1097/HC9.0000000000000351. eCollection 2024 Jan 1.

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Hepatitis B virus evades the immune system by suppressing the NF-kappaB signaling pathway with DENND2A

Ide, M. Tabata, N. Yonemura, Y. Murai, K. Wang, Y. Ishida, A. Honda, M. Kaneko, S. Ito, S. Yanagawa, H.
Microbiol Spectr. 2024 Jan 19:e0378523. doi: 10.1128/spectrum.03785-23.

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A small molecule iCDM-34 identified by in silico screening suppresses HBV DNA through activation of aryl hydrocarbon receptor

Furutani, Y. Hirano, Y. Toguchi, M. Higuchi, S. Qin, X. Y. Yanaka, K. Sato-Shiozaki, Y. Takahashi, N. Sakai, M. Kongpracha, P. Suzuki, T. Dohmae, N. Kukimoto-Niino, M. Shirouzu, M. Nagamori, S. Suzuki, H. Kobayashi, K. Masaki, T. Koyama, H. Sekiba, K. Otsuka, M. Koike, K. Kohara, M. Kojima, S. Kakeya, H. Matsuura, T.
Cell Death Discov. 2023 Dec 22;9(1):467. doi: 10.1038/s41420-023-01755-w.

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SRPKIN-1 as an inhibitor against hepatitis B virus blocking the viral particle formation and the early step of the viral infection

Li, X. Nakashima, K. Ito, M. Matsuda, M. Chida, T. Sekihara, K. Takahashi, H. Kato, T. Sawasaki, T. Suzuki, T.
Antiviral Res. 2023 Dec;220:105756. doi: 10.1016/j.antiviral.2023.105756. Epub 2023 Nov 20.

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A versatile method to profile hepatitis B virus DNA integration

Fukano, K. Wakae, K. Nao, N. Saito, M. Tsubota, A. Toyoshima, T. Aizaki, H. Iijima, H. Matsudaira, T. Kimura, M. Watashi, K. Sugiura, W. Muramatsu, M.
Hepatol Commun. 2023 Dec 1;7(12):e0328. doi: 10.1097/HC9.0000000000000328. eCollection 2023 Dec 1.

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Functional involvement of endothelial lipase in hepatitis B virus infection

Shirasaki, T. Murai, K. Ishida, A. Kuroki, K. Kawaguchi, K. Wang, Y. Yamanaka, S. Yasukawa, R. Kawasaki, N. Li, Y. Y. Shimakami, T. Sumiyadorj, A. Nio, K. Sugimoto, S. Orita, N. Takayama, H. Okada, H. Thi Bich, P. D. Iwabuchi, S. Hashimoto, S. Ide, M. Tabata, N. Ito, S. Matsushima, K. Yanagawa, H. Yamashita, T. Kaneko, S. Honda, M.
Hepatol Commun. 2023 Aug 31;7(9):e0206.

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Modeling suggests that virion production cycles within individual cells is key to understanding acute hepatitis B virus infection kinetics

Hailegiorgis, A. Ishida, Y. Collier, N. Imamura, M. Shi, Z. Reinharz, V. Tsuge, M. Barash, D. Hiraga, N. Yokomichi, H. Tateno, C. Ozik, J. Uprichard, S. L. Chayama, K. Dahari, H.
PLoS Comput Biol. 2023 Aug 3;19(8):e1011309. doi: 10.1371/journal.pcbi.1011309.

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Evaluation of RNAi Therapeutics VIR-2218 and ALN-HBV for Chronic Hepatitis B: Results From Randomized Clinical Trials

Gane, E. Lim, Y. S. Kim, J. B. Jadhav, V. Shen, L. Bakardjiev, A. I. Huang, S. A. Cathcart, A. L. Lempp, F. A. Janas, M. M. Cloutier, D. J. Kaittanis, C. Sepp-Lorenzino, L, Hinkle, G. Taubel, J. Haslett, P. Milstein, S. Anglero-Rodriguez, Y. I. Hebner, C. M. Pang, P. S. Yuen, M. F.
J Hepatol. 2023 Jun 6:S0168-8278(23)00352-5. doi: 10.1016/j.jhep.2023.05.023.

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Super-Resolution Microscopy Analysis of Hepatitis B Viral cccDNA and Host Factors

Doan, P. T. B. Nio, K. Shimakami, T. Kuroki, K. Li, Y. Y. Sugimoto, S. Takayama, H. Okada, H. Kaneko, S. Honda, M. Yamashita, T.
Viruses. 2023 May 16;15(5):1178. doi: 10.3390/v15051178.

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Persistent hepatic IFN system activation in HBV-HDV infection determines viral replication dynamics and therapeutic response

Chida, T. Ishida, Y. Morioka, S. Sugahara, G. Han, C. Lam, B. Yamasaki, C. Sugahara, R. Li, M. Tanaka, Y. Liang, T. J. Tateno, C. Saito, T.
JCI Insight. 2023 May 8;8(9):e162404. doi: 10.1172/jci.insight.162404.

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Amentoflavone inhibits hepatitis B virus infection via the suppression of preS1 binding to host cells

Aoki-Utsubo, C. Indrasetiawan, P. Fukano, K. Muramatsu, M. Artanti, N. Hanafi, M. Hotta, H. Kameoka, M.
Microbiol Immunol. 2023 Mar 16. doi: 10.1111/1348-0421.13064.

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Characterization of a Novel Capsid Assembly Modulator for the Treatment of Chronic Hepatitis B Virus Infection

Burdette, D. Hyrina, A. Song, Z. Beran, R. K. Cheung, T. Gilmore, S. Kobayashi, T. Li, L. Liu, Y. Niedziela-Majka, A. Medley, J. Mehra, U. Morganelli, P. Novikov, N. Niu, C. Tam, D. Tang, J. Wang, J. Yue, Q. Fletcher, S. P. Holdorf, M. M. Delaney, W. E. th Feierbach, B. Lazerwith, S.
Antimicrob Agents Chemother. 2023 Jan 24;67(1):e0134822. doi: 10.1128/aac.01348-22.

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Novel Neplanocin A Derivatives as Selective Inhibitors of Hepatitis B Virus with a Unique Mechanism of Action

Toyama, M. Watashi, K. Ikeda, M. Yamashita, A. Okamoto, M. Moriishi, K. Muramatsu, M. Wakita, T. Sharon, A. Baba, M.
Antimicrob Agents Chemother. 2022 Jun 21;66(6):e0207321. doi: 10.1128/aac.02073-21. Epub 2022 May 23.

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Hepatitis B virus X protein counteracts high mobility group box 1 protein-mediated epigenetic silencing of covalently closed circular DNA

Kim, E. S. Zhou, J. Zhang, H. Marchetti, A. van de Klundert, M. Cai, D.Yu, X. Mitra, B. Liu, Y. Wang, M. Protzer, U. Guo, H.
PLoS Pathog. 2022 Jun 9;18(6):e1010576. doi: 10.1371/journal.ppat.1010576.

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Autophagic membranes participate in hepatitis B virus nucleocapsid assembly, precore and core protein trafficking, and viral release

Chu, J. Y. K. Chuang, Y. C. Tsai, K. N. Pantuso, J. Ishida, Y. Saito, T. Ou, J. J.

Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2201927119. doi: 10.1073/pnas.2201927119. Epub 2022 Jul 18.

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Guanine nucleotide exchange factor DOCK11-binding peptide fused with a single chain antibody inhibits hepatitis B virus infection and replication

Ide, M. Tabata, N. Yonemura, Y. Shirasaki, T. Murai, K. Wang, Y. Ishida, A. Okada, H. Honda, M. Kaneko, S. Doi, N. Ito, S. Yanagawa, H.
J Biol Chem. 2022 Jul;298(7):102097. doi: 10.1016/j.jbc.2022.102097. Epub 2022 Jun 2.

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