Phoenix Bio

研究発表

研究発表

Endogenous and xenobiotic metabolite profiling of liver extracts from SCID and chimeric humanized mice following repeated oral administration of troglitazone

    Barnes, A. J. Baker, D. R. Hobby, K. Ashton, S. Michopoulos, F. Spagou, K. Loftus, N. J. Wilson, I. D.
    Xenobiotica. 2014 Jan; 44(2): 174-85.

    Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers.

      Schulz-Utermoehl T, Sarda S, Foster JR, Jacobsen M, Kenna JG, Morikawa Y, Salmu J, Gross G, Wilson ID.
      Xenobiotica. 2012 Jun;42(6):503-17.

      Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury

        Masakazu Kakuni, Mayu Morita, Kentaro Matsuo, Yumiko Katoh, Miki Nakajima,Chise Tateno, Tsuyoshi Yokoi
        Toxicology Letters 214 (2012) 9-18

        Differential Effect of Troglitazone on the Human Bile Acid Transporters, MRP2 and BSEP, in the PXB Hepatic Chimeric Mouse

          Foster JR, Jacobsen M, Kenna G, Schulz-Utermoehl T, Morikawa Y, Salmu J, Wilson ID.
          Toxicologic Pathology, 2012 Dec;40(8):1106-16.

          Approach for in vivo protein binding of 5-n-butyl-pyrazolo[1,5-a]pyrimidine bioactivated in chimeric mice with humanized liver by two-dimensional electrophoresis with accelerator mass spectrometry.

            Yamazaki H, Kuribayashi S, Inoue T, Tateno C, Nishikura Y, Oofusa K, Harada D, Naito S, Horie T, Ohta S.
            Chem Res Toxicol. 2010 Jan;23(1):152-8.

            Evaluation of human hepatocyte chimeric mice as a model for toxicological investigation using panomic approaches–effect of acetaminophen on the expression profiles of proteins and endogenous metabolites in liver, plasma and urine

              Yamamoto T, Tomizawa K, Fujikawa M, Sato Y, Yamada H, Horii I.
              J Toxicol Sci. 2007 Aug;32(3):205-15.