Phoenix Bio

論文一覧

論文一覧

論文一覧

N6-methyladenosine Modification of Hepatitis B Virus RNA in the Coding Region of HBx

    Murata, T. Iwahori, S. Okuno, Y. Nishitsuji, H. Yanagi, Y. Watashi, K. Wakita, T. Kimura, H. Shimotohno, K.
    Int J Mol Sci. 2023 Jan 23;24(3):2265. doi: 10.3390/ijms24032265.

    Novel approach for verification of a human PBPK modeling strategy using chimeric mice in the health risk assessment of epyrifenacil

      Hirasawa, K. Abe, J. Nagahori, H. Kitamoto, S
      Toxicol Appl Pharmacol. 2023 Apr 15;465:116439. doi: 10.1016/j.taap.2023.116439. Epub 2023 Feb 27.

      A Novel Anti-HBV Agent, E-CFCP, restores Hepatitis B virus (HBV)-induced Senescence-associated Cellular Markers Perturbation in Human Hepatocytes

        Takamatsu, Y. Hayashi, S. Kumamoto, H. Imoto, S. Tanaka, Y. Mitsuya, H. Higashi-Kuwata, N.
        Virus Res. 2023 Mar 23;329:199094. doi: 10.1016/j.virusres.2023.199094.

        HBV with precore and basal core promoter mutations exhibits a high replication phenotype and causes ER stress-mediated cell death in humanized liver chimeric mice

          Uchida, T. Imamura, M. Hayes, C. N. Suehiro, Y. Teraoka, Y. Ohya, K. Aikata, H. Abe-Chayama, H. Ishida, Y. Tateno, C. Hara, Y. Hino, K. Okamoto, T. Matsuura, Y. Aizaki, H. Wake, K. Kohara, M. Liang, T. J. Oka, S. Chayama, K.
          Hepatology. 2023 Mar 13. doi: 10.1097/HEP.0000000000000335.

          Identification of SARS-CoV-2 M(pro) inhibitors containing P1′ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2

            Higashi-Kuwata, N. Tsuji, K. Hayashi, H. Bulut, H. Kiso, M. Imai, M. Ogata-Aoki, H. .Ishii, T. Kobayakawa, T. Nakano, K. Takamune, N. Kishimoto, N. Hattori, S. I. Das, D. Uemura, Y. Shimizu, Y. Aoki, M. Hasegawa, K. Suzuki, S. Nishiyama, A. Saruwatari, J. Shimizu, Y. Sukenaga, Y. Takamatsu, Y. Tsuchiya, K. Maeda, K. Yoshimura, K. Iida, S. Ozono, S. Suzuki, T. Okamura, T. Misumi, S. Kawaoka, Y. Tamamura, H. Mitsuya, H.
            Nat Commun. 2023 Feb 25;14(1):1076. doi: 10.1038/s41467-023-36729-0.

            Establishment of hyperoxic cell culture system for predicting drug-induced liver injury: reducing accumulated lipids in hepatocytes derived from chimeric mice with humanized liver

              Ohtsuki, Y. Sanoh, S. Yamao, M. Kojima, Y. Kotake, Y. Tateno, C.
              J Toxicol Sci. 2023;48(2):99-108. doi: 10.2131/jts.48.99.

              Patient-derived monoclonal antibody neutralizes HCV infection in vitro and vivo without generating escape mutants

                Yokokawa, H. Shinohara, M. Teraoka, Y. Imamura, M. Nakamura, N. Watanabe, N. Date, T. Aizaki, H. Iwamura, T. Narumi, H. Chayama, K. Wakita, T.
                PLoS One. 2022 Sep 22;17(9):e0274283. doi: 10.1371/journal.pone.0274283. eCollection 2022.

                Prediction of the human pharmacokinetics of epyrifenacil and its major metabolite, S-3100-CA, by a physiologically based pharmacokinetic modeling using chimeric mice with humanized liver

                  Hirasawa, K. Abe, J. Nagahori, H. Kitamoto, S.
                  Toxicol Appl Pharmacol. 2022 Mar 15;439:115912. doi: 10.1016/j.taap.2022.115912.

                  Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases

                    Yarnall, M. T. N. Ioannidi, E. I. Schmitt-Ulms, C. Krajeski, R. N. Lim, J. Villiger, L. Zhou, W. Jiang, K. Garushyants, S. K. Roberts, N. Zhang, L. Vakulskas, C. A. Walker, J. A., 2nd. Kadina, A. P. Zepeda, A. E. Holden, K. Ma, H. Xie, J. Gao, G. Foquet, L. Bial, G. Donnelly, S. K. Miyata, Y. Radiloff, D. R. Henderson, J. M. Ujita, A. Abudayyeh, O. O. Gootenberg, J. S.
                    Nat Biotechnol. 2022 Nov 24. doi: 10.1038/s41587-022-01527-4.

                    Discovery of a first-in-class orally available HBV cccDNA inhibitor

                      Wang, L. Zhu, Q. Zhang, J. D. Zhang, Y. Ni, X. Xiang, K. Jiang, J. Li, B. Yu, Y. Hu, H. Zhang, M. Wu, W. Zeng, J. Yan, Z. Dai, J. Sun, K. Zhang, X. Chen, D. Feng, S. Sach Peltason, L. Young, J. A. T. Gao, L.
                      J Hepatol. 2022 Dec 29:S0168-8278(22)03466-3. doi: 10.1016/j.jhep.2022.12.014.

                      Consideration of Commercially Available Hepatocytes as Cell Sources for Liver-Microphysiological Systems by Comparing Liver Characteristics

                        Horiuchi, S. Kuroda, Y. Komizu, Y. Ishida, S.
                        Pharmaceutics. 2022 Dec 24;15(1):55. doi: 10.3390/pharmaceutics15010055.

                        Long-term cell fate and functional maintenance of human hepatocyte through stepwise culture configuration

                          Sugahara, G. Ishida, Y. Lee, J. J. Li, M. Tanaka, Y. Eoh, H. Higuchi, Y. Saito, T.
                          FASEB J. 2023 Feb;37(2):e22750. doi: 10.1096/fj.202201292RR.

                          A novel cDNA-uPA/SCID/Rag2(-/-) /Jak3(-/-) mouse model for hepatitis virus infection and reconstruction of human immune system

                            Uchida, T. Yuji, T. Imamura, M. Abe-Chayama, H. Makokha, G. N. Hayes, C. N. Aikata, H. Hamamura, S. Ishida, Y. Tateno, C. Shirouzu, T. Kawai, S. Tanaka, Y. Ohdan, H. Okada, S. Chayama, K.
                            J Viral Hepat. 2022 Dec 27. doi: 10.1111/jvh.13793. https://www.ncbi.nlm.nih.gov/pubmed/36575861

                            Characterization and Prevention of Hypovitaminosis C in Chimeric Mice with Humanized Livers

                              Touchette, Erin K. Bates, Maria C. Johnson, Mitch C. O’Brien, Tracy C. Melton, Roger J. Long, Kelly R. Kakuni, Masakazu, Baginski, Matthew, Radiloff, Daniel R. Sagartz, John E.
                              Comparative Medicine 2022, 72(6): 355-363.

                              Pegylated interferon therapy-related microRNA-6126 downregulates sodium taurocholate cotransporting polypeptide expression in hepatocytes

                                Fujita, K. Nishitsuji, H. Iwama, H. Tadokoro, T. Morishita, A. Mimura, S. Ono, M. Himoto, T. Shimotohno, K. Masaki, T.
                                Gene. 2022 Nov 24;853:147068. doi: 10.1016/j.gene.2022.147068.

                                Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus

                                  Gilmore, S. A. Tam, D. Cheung, T. L. Snyder, C. Farand, J. Dick, R.Matles, M. Feng, J. Y.Ramirez, R.Li, L. Yu, H. Xu, Y.Barnes, D. Czerwieniec, G. Brendza, K. M. Appleby, T. C. Birkus, G. Willkom, M. Kobayashi, T. Paoli, E. Labelle, M. Boesen, T.Tay, C. H. Delaney, W. E. thNotte, G. T. Schmitz, U. Feierbach, B.
                                  PLoS One. 2022 Dec 7;17(12):e0271145. doi: 10.1371/journal.pone.0271145. eCollection 2022.

                                  Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA2

                                    Nakanishi, A. Okumura, H. Hashita, T. Yamashita, A. Nishimura, Y. Watanabe, C. Kamimura, S. Hayashi, S. Murakami, S. Ito, K. Iwao, T. Ikeda, A. Hirose, T. Sunazuka, T. Tanaka, Y. Matsunaga, T.
                                    Viruses. 2022 Nov 8;14(11):2468. doi: 10.3390/v14112468.

                                    Physiologically based pharmacokinetic modeling for quantitative prediction of exposure to a human disproportionate metabolite of the selective Na(v)1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase, using chimeric mice with humanized liver

                                      Asano, D. Nakamura, K. Nishiya, Y. Shiozawa, H. Takakusa, H. Shibayama, T. Inoue, S. I. Shinozuka, T. Hamada, T. Yahara, C. Watanabe, N. Yoshinari, K.
                                      Drug Metab Dispos. 2023 Jan;51(1):67-80. doi: 10.1124/dmd.122.001000. Epub 2022 Oct 23.

                                      コラーゲンビトリゲルを用いた新規肝細胞培養系における薬物動態研究

                                      渡 隆爾
                                      関東化学発行誌

                                      Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions

                                        Sakai, K. Sugano-Nakamura, N. Mihara, E. Rojas-Chaverra, N. M. Watanabe, S. Sato, H. Imamura, R. Voon, D. C. Sakai, I. Yamasaki, C. Tateno, C. Shibata, M. Suga, H. Takagi, J. Matsumoto, K.
                                        Nat Biomed Eng. 2022 Nov 7. doi: 10.1038/s41551-022-00955-6.