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Evaluation of the mode of action and human relevance of liver tumors in male mice treated with epyrifenacil

Fukunaga, S. Ogata, K. Eguchi, A. Matsunaga, K. Sakurai, K. Abe, J. Cohen, S. M. Asano, H.
Regul Toxicol Pharmacol. 2022 Oct 6;136:105268. doi: 10.1016/j.yrtph.2022.105268.

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Fungal Secondary Metabolite Exophillic Acid Selectively Inhibits the Entry of Hepatitis B and D Viruses

Kobayashi, C. Watanabe, Y. Oshima, M. Hirose, T. Yamasaki, M. Iwamoto, M. Iwatsuki, M. Asami, Y. Kuramochi, K. Wakae, K. Aizaki, H. Muramatsu, M. Sureau, C. Sunazuka, T. Watashi, K.
Viruses. 2022 Apr 6;14(4). pii: v14040764. doi: 10.339/v14040764.

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Involvement of SLC16A1/MCT1 and SLC16A3/MCT4 in l-lactate transport in the hepatocellular carcinoma cell line

Mukai, Y. Yamaguchi, A. Sakuma, T. Nadai, T. Furugen, A. Narumi, K. Kobayashi, M.
Biopharm Drug Dispos. 2022 Oct;43(5):183-191. doi: 10.1002/bdd.2329. Epub 2022 Sep 22.

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Hepatitis B virus utilizes a retrograde trafficking route via the trans-Golgi network to avoid lysosomal degradation

Li, Y. Y. Kuroki, K. Shimakami, T. Murai, K. Kawaguchi, K. Shirasaki, T. Nio, K. Sugimoto, S. Nishikawa, T. Okada, H. Orita, N. Takayama, H. Wang, Y. Thi Bich, P. D. Ishida, A. Iwabuchi, S.
Cell Mol Gastroenterol Hepatol. 2022 Oct 19. pii: S2352-345X(22)00219-3. doi: 10.1016/j.jcmgh.2022.10.008.

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Letrozole ameliorates liver fibrosis through the inhibition of the CTGF pathway and 17β-hydroxysteroid dehydrogenase 13 expression

Sakai, N. Kamimura, K. Miyamoto, H. Ko, M. Nagoya, T. Setsu, T. Sakamaki, A. Yokoo, T. Kamimura, H. Soki, H. Tokunaga, A. Inamine, T. Nakashima, M. Enomoto, H. Kousaka, K. Tachiki, H.
J Gastroenterol. 2022 Oct 27. doi: 10.1007/s00535-022-01929-w.

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Targeting lipid biosynthesis pathways for hepatitis B virus cure

Hyrina, A. Burdette, D. Song, Z. Ramirez, R. Okesli-Armlovich, A. Vijayakumar, A. Bates, J. Trevaskis, J. L. Fletcher, S. P. Lee, W. A. Holdorf, M. M.
PLoS One. 2022 Aug 4;17(8):e0270273. doi: 10.1371/journal.pone.0270273. eCollection 2022.

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Downregulation of CYP17A1 by 20-hydroxyecdysone: plasma progesterone and its vasodilatory properties

Aljaber, M. Y. Orie, N. N. Raees, A. Kraiem, S. Al-Jaber, M. Samsam, W. Hamza, M. M. Abraham, D. Kneteman, N. M. Beotra, A. Mohamed-Ali, V. Almaadheed, M.
Future Sci OA. 2022 Jul 7;8(6):FSO805. doi: 10.2144/fsoa-2022-0006. eCollection 2022 Jul.

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Signature of chronic hepatitis B virus infection in nails and hair

Komatsu, H. Inui, A. Odmaa, E. Ito, Y. Hoshino, H. Umetsu, S. Tsunoda, T. Fujisawa, T.
BMC Infect Dis. 2022 May 4;22(1):431. doi: 10.1186/s12879-022-07400-8.

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Assessment of metabolic activation of felbamate in chimeric mice with humanized liver in combination with in vitro metabolic assays

Sato, K. Sanoh, S. Ishida, Y. Tateno, C. Ohta, S. Kotake, Y.
J Toxicol Sci. 2022;47(7):277-288. doi: 10.2131/jts.47.277.

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IL-31 Levels Correlate with Pruritus in Patients with Cholestatic and Metabolic Liver Diseases and is FXR Responsive in NASH

Xu, J. Wang, Y. Khoshdeli, M. Peach, M. Chuang, J. C. Lin, J. Tsai, W. W. Mahadevan, S. Minto, W. Diehl, L. Gupta, R. Trauner, M. Patel, K. Noureddin, M. Kowdley, K. V. Gulamhusein, A. Bowlus, C. L. Huss, R. S. Myers, R. P. Chung, C. Billin, A. N.
Hepatology. 2022 Jun 10. doi: 10.1002/hep.32599.

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The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro

Gad, S. A. Sugiyama, M. Tsuge, M. Wakae, K. Fukano, K. Oshima, M. Sureau, C. Watanabe, N. Kato, T. Murayama, A. Li, Y. Shoji, I. Shimotohno, K. Chayama, K. Muramatsu, M. Wakita, T. Nozaki, T. Aly, H. H.
PLoS Pathog. 2022 Mar 21;18(3):e1009983. doi: 10.1371/journal.ppat.1009983. eCollection 2022 Mar.

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A single hepatitis B virus genome with a reporter allows the entire viral life cycle to be monitored in primary human hepatocytes

Sumiyadorj, A. Murai, K. Shimakami, T. Kukroki, K. Nishikawa, T. Kakuya, M. Yamada, A. Wang, Y. Ishida, A. Shirasaki, T. Kawase, S. Li, Y. Y. Okada, H. Nio, K. Kawaguchi, K. Yamashita, T. Sakai, Y. Duger, D. Mizukoshi, E. Honda, M. Kaneko, S.
Hepatol Commun. 2022 Jun 12. doi: 10.1002/hep4.2018.

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Freshly Isolated Hepatocytes from Chimeric Humanized Liver Mice for the In Vitro Assessment of Drug Metabolism, Inhibition/Induction, and Safety Studies

Kakuni, M
Curr Protoc. 2022 May;2(5):e429. doi: 10.1002/cpz1.429.

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Insights from a high-fat diet fed mouse model with a humanized liver

Saxena, R. Nassiri, M. Yin, X. M. Morral, N.
PLoS One. 2022 May 9;17(5):e0268260. doi: 10.1371/journal.pone.0268260. eCollection 2022.

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Loss of mitochondrial ATPase ATAD3A contributes to non-alcoholic fatty liver disease through accumulation of lipids and damaged mitochondria

Chen, L. Li, Y. Sottas, C. Lazaris, A. Petrillo, S. K. Metrakos, P. Li, L. Ishida, Y. Saito, T. Garza, S, Papadopoulos, V.
J Biol Chem. 2022 May 2;298(6):102008. doi: 10.1016/j.jbc.2022.102008.

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Ongoing viral replication and production of infectious virus in patients with chronic hepatitis B virus suppressed below the limit of quantitation on long-term nucleos(t)ide therapy

Burdette, D. L. Lazerwith, S. Yang, J. Chan, H. L. Y. Delaney Iv, W. E. Fletcher, S. P. Cihlar, T. Feierbach, B.
PLoS One. 2022 Apr 1;17(4):e0262516. doi: 10.1371/journal.pone.0262516.

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Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1beta to downregulate PPARalpha and FOXO3

Li, Y. Zhu, Y. Feng, S. Ishida, Y. Chiu, T. P. Saito, T. Wang, S. Ann, D. K. Ou, J. J.
Cell Rep. 2022 Jan 25;38(4):110284. doi: 10.1016/j.celrep.2021.110284.

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HBV upregulates TRAIL-R3 expression in hepatocytes for escaping both cell apoptosis and suppression of their replication by TRAIL

Suehiro, Y. Tsuge, M. Kurihara, M. Uchida, T. Fujino, H. Ono, A. Yamauchi, M. Makokha, G. N. Nakahara, T. Murakami, E. Abe-Chayama, H. Kawaoka, T. Miki, D. Imamura, M. Aikata, H. Hayes, C. N. Fujita, T. Chayama, K.
J Infect Dis. 2022 Feb 28. pii: 6534478. doi: 10.1093/infdis/jiac044.

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Droplet digital PCR assay provides intrahepatic HBV cccDNA quantification tool for clinical application

Hayashi, S. Isogawa, M. Kawashima, K. Ito, K. Chuaypen, N. Morine, Y. Shimada, M. Higashi-Kuwata, N. Watanabe, T. Tangkijvanich, P. Mitsuya, H. Tanaka, Y.
Sci Rep. 2022 Feb 8;12(1):2133. doi: 10.1038/s41598-022-05882-9.

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Simultaneous Measurement of Mouse and Human Albumin in Chimeric Mice with Humanized Livers

France Landry1, Hong Shen2, Yueping Zhang2, Asako Uchiyama3, Yoshinari Miyata4, Yoshio Morikawa4, Beth Joshi2, and Petia Shipkova1
Bioanalysis. 2022 Mar;14(5):267-278. doi: 10.4155/bio-2021-0250. Epub 2022 Feb 23.

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