論文一覧

論文一覧

論文一覧

A single hepatitis B virus genome with a reporter allows the entire viral life cycle to be monitored in primary human hepatocytes

Sumiyadorj, A. Murai, K. Shimakami, T. Kukroki, K. Nishikawa, T. Kakuya, M. Yamada, A. Wang, Y. Ishida, A. Shirasaki, T. Kawase, S. Li, Y. Y. Okada, H. Nio, K. Kawaguchi, K. Yamashita, T. Sakai, Y. Duger, D. Mizukoshi, E. Honda, M. Kaneko, S.
Hepatol Commun. 2022 Jun 12. doi: 10.1002/hep4.2018.

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Freshly Isolated Hepatocytes from Chimeric Humanized Liver Mice for the In Vitro Assessment of Drug Metabolism, Inhibition/Induction, and Safety Studies

Kakuni, M
Curr Protoc. 2022 May;2(5):e429. doi: 10.1002/cpz1.429.

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Insights from a high-fat diet fed mouse model with a humanized liver

Saxena, R. Nassiri, M. Yin, X. M. Morral, N.
PLoS One. 2022 May 9;17(5):e0268260. doi: 10.1371/journal.pone.0268260. eCollection 2022.

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Loss of mitochondrial ATPase ATAD3A contributes to non-alcoholic fatty liver disease through accumulation of lipids and damaged mitochondria

Chen, L. Li, Y. Sottas, C. Lazaris, A. Petrillo, S. K. Metrakos, P. Li, L. Ishida, Y. Saito, T. Garza, S, Papadopoulos, V.
J Biol Chem. 2022 May 2;298(6):102008. doi: 10.1016/j.jbc.2022.102008.

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Ongoing viral replication and production of infectious virus in patients with chronic hepatitis B virus suppressed below the limit of quantitation on long-term nucleos(t)ide therapy

Burdette, D. L. Lazerwith, S. Yang, J. Chan, H. L. Y. Delaney Iv, W. E. Fletcher, S. P. Cihlar, T. Feierbach, B.
PLoS One. 2022 Apr 1;17(4):e0262516. doi: 10.1371/journal.pone.0262516.

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Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1beta to downregulate PPARalpha and FOXO3

Li, Y. Zhu, Y. Feng, S. Ishida, Y. Chiu, T. P. Saito, T. Wang, S. Ann, D. K. Ou, J. J.
Cell Rep. 2022 Jan 25;38(4):110284. doi: 10.1016/j.celrep.2021.110284.

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HBV upregulates TRAIL-R3 expression in hepatocytes for escaping both cell apoptosis and suppression of their replication by TRAIL

Suehiro, Y. Tsuge, M. Kurihara, M. Uchida, T. Fujino, H. Ono, A. Yamauchi, M. Makokha, G. N. Nakahara, T. Murakami, E. Abe-Chayama, H. Kawaoka, T. Miki, D. Imamura, M. Aikata, H. Hayes, C. N. Fujita, T. Chayama, K.
J Infect Dis. 2022 Feb 28. pii: 6534478. doi: 10.1093/infdis/jiac044.

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Droplet digital PCR assay provides intrahepatic HBV cccDNA quantification tool for clinical application

Hayashi, S. Isogawa, M. Kawashima, K. Ito, K. Chuaypen, N. Morine, Y. Shimada, M. Higashi-Kuwata, N. Watanabe, T. Tangkijvanich, P. Mitsuya, H. Tanaka, Y.
Sci Rep. 2022 Feb 8;12(1):2133. doi: 10.1038/s41598-022-05882-9.

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Simultaneous Measurement of Mouse and Human Albumin in Chimeric Mice with Humanized Livers

France Landry1, Hong Shen2, Yueping Zhang2, Asako Uchiyama3, Yoshinari Miyata4, Yoshio Morikawa4, Beth Joshi2, and Petia Shipkova1
Bioanalysis. 2022 Mar;14(5):267-278. doi: 10.4155/bio-2021-0250. Epub 2022 Feb 23.

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ヒト肝細胞キメラマウスを利用したB型肝炎ウイルス/D型肝炎ウイルス共感染モデル

加国雅和
Medical Science Digest（MSD)　2021；47（14）：26－27

Variation in Expression of Cytochrome P450 3A Isoforms and Toxicological Effects: Endo- and Exogenous Substances as Regulatory Factors and Substrates

Fujino, C. Sanoh, S. Katsura, T.
Biol Pharm Bull. 2021;44(11):1617-1634. doi: 10.1248/bpb.b21-00332.

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Are Humanized Mouse Models Useful for Basic Research of Hepatocarcinogenesis through Chronic Hepatitis B Virus Infection?

Masataka Tsuge
Viruses. 2021 Sep 24;13(10). pii: v13101920. doi: 10.3390/v13101920.

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High-throughput screening of anti-lipidemic agents using PXB-cells®, human primary hepatocytes from humanized mice livers: Assessment of lipoproteins by an enzyme-linked immunosolvent assay on apolipoproteins Apolipoprotein assay for assessing lipoprotein in hepatocyte

Sayaka Tomatsu , Masaki Takahashi, Gen Toshima, Shiho Nakagawa, Junichiro Takahashi, Kazuya Miyashita, Kazumi Ogura, Masakazu Kakuni, Keishi Hata
Journal of Biological Macromol …/2021; 21(2): 89-92

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Elucidation of the species differences of epyrifenacil-induced hepatotoxicity between mice and humans by mass spectrometry imaging analysis in chimeric mice with humanized liver

Matsunaga, K. Abe, J. Ogata, K. Fukunaga, S. Kitamoto, S.
J Toxicol Sci. 2021;46(12):601-609. doi: 10.2131/jts.46.601.

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Estimating Drug Efficacy with a Diet-Induced NASH Model in Chimeric Mice with Humanized Livers

Kisoh, K. Sugahara, G. Ogawa, Y. Furukawa, S. Ishida, Y. Okanoue, T. Kohara, M. Tateno, C.
Biomedicines. 2021 Nov 9;9(11):1647. doi: 10.3390/biomedicines9111647.

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Utility of Gottingen minipigs for the prediction of human pharmacokinetic profiles after intravenous drug administration

Ding, N. Yamamoto, S. Chisaki, I. Nakayama, M. Matsumoto, S. I. Hirabayashi, H.
Drug Metab Pharmacokinet. 2021 Dec;41:100408. doi: 10.1016/j.dmpk.2021.100408. Epub 2021 Jun 9.

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Lipoprotein Z, A novel hepatotoxic lipoprotein, predicts outcome in alcoholic hepatitis

Hu, K. Camila Perez-Matos, M. Argemi, J. Vilar, E. Shalaurova, I. Bullitt, E. Landeen, L. Sugahara, G. Deng, H. Mathur, K. Tran, S. Cai, H. He, H. Yalcin, Y. Vieira Barbosa, J. Ventura-Cots, M. Marx, K. Gad, A. P. Niezen, S. Izunza Barba, S. Lay-Hong, A. Popov, Y. V. Fricker, Z. Lai, M. Curry, M. Afdhal, N. Szabo, G. Mukamal, K. J. Sanyal, A. J. Otvos, J. D. Malik, R.
Hepatology. 2021 Oct 18. doi: 10.1002/hep.32203.

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A Kinetic Pump Integrated Microfluidic Plate (KIM-Plate) with High Usability for Cell Culture-Based Multiorgan Microphysiological Systems

Shinha, K. Nihei, W. Nakamura, H. Goto, T. Kawanishi, T. Ishida, N. Yamazaki, N. Imakura, Y. Mima, S. Inamura, K. Arakawa, H. Nishikawa, M. Kato, Y. Sakai, Y. Kimura, H.
Micromachines (Basel). 2021 Aug 24;12(9):1007. doi: 10.3390/mi12091007.

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Hexa Histidine-Tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species

Dat, N. Q. Thuy, L. T. T. Hieu, V. N. Hai, H. Hoang, D. V. Thi Thanh Hai, N. Thuy, T. T. V. Komiya, T. Rombouts, K. Dong, M. P. Hanh, N. V. Hoang, T. H. Sato-Matsubara, M. Daikoku, A. Kadono, C. Oikawa, D. Yoshizato, K. Tokunaga, F. Pinzani, M. Kawada, N.
Hepatology. 2021 Jun;73(6):2527-2545. doi: 10.1002/hep.31752. Epub 2021 May 22.

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Transduction Properties of an Adenovirus Vector Containing Sequences Complementary to a Liver-Specific microRNA, miR-122a, in the 3′-Untranslated Region of the E4 Gene in Human Hepatocytes from Chimeric Mice with Humanized Liver

Sakurai, F. Tsukamoto, T. Ono, R. Nishimae, F. Shiota, A. Iizuka, S.Shimizu, K. Sakai, E. Ishida, Y. Tateno, C. Chayama, K. Mizuguchi, H.
Biol Pharm Bull. 2021;44(10):1506-1513. doi: 10.1248/bpb.b21-00394.

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