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論文一覧

論文一覧

論文一覧

ヒト肝細胞キメラマウスを利用したB型 肝炎ウイルス/D型肝炎ウイルス共感染モデル

加国 雅和
Medical Science Digest(MSD) 2021;47(14):26-27

Variation in Expression of Cytochrome P450 3A Isoforms and Toxicological Effects: Endo- and Exogenous Substances as Regulatory Factors and Substrates

    Fujino, C. Sanoh, S. Katsura, T.
    Biol Pharm Bull. 2021;44(11):1617-1634. doi: 10.1248/bpb.b21-00332.

    Are Humanized Mouse Models Useful for Basic Research of Hepatocarcinogenesis through Chronic Hepatitis B Virus Infection?

      Masataka Tsuge
      Viruses. 2021 Sep 24;13(10). pii: v13101920. doi: 10.3390/v13101920.

      High-throughput screening of anti-lipidemic agents using PXB-cells®, human primary hepatocytes from humanized mice livers: Assessment of lipoproteins by an enzyme-linked immunosolvent assay on apolipoproteins Apolipoprotein assay for assessing lipoprotein in hepatocyte

        Sayaka Tomatsu , Masaki Takahashi, Gen Toshima, Shiho Nakagawa, Junichiro Takahashi, Kazuya Miyashita, Kazumi Ogura, Masakazu Kakuni, Keishi Hata
        Journal of Biological Macromol …/2021; 21(2): 89-92

        Elucidation of the species differences of epyrifenacil-induced hepatotoxicity between mice and humans by mass spectrometry imaging analysis in chimeric mice with humanized liver

          Matsunaga, K. Abe, J. Ogata, K. Fukunaga, S. Kitamoto, S.
          J Toxicol Sci. 2021;46(12):601-609. doi: 10.2131/jts.46.601.

          Estimating Drug Efficacy with a Diet-Induced NASH Model in Chimeric Mice with Humanized Livers

            Kisoh, K. Sugahara, G. Ogawa, Y. Furukawa, S. Ishida, Y. Okanoue, T. Kohara, M. Tateno, C.
            Biomedicines. 2021 Nov 9;9(11):1647. doi: 10.3390/biomedicines9111647.

            Utility of Gottingen minipigs for the prediction of human pharmacokinetic profiles after intravenous drug administration

              Ding, N. Yamamoto, S. Chisaki, I. Nakayama, M. Matsumoto, S. I. Hirabayashi, H.
              Drug Metab Pharmacokinet. 2021 Dec;41:100408. doi: 10.1016/j.dmpk.2021.100408. Epub 2021 Jun 9.

              Lipoprotein Z, A novel hepatotoxic lipoprotein, predicts outcome in alcoholic hepatitis

                Hu, K. Camila Perez-Matos, M. Argemi, J. Vilar, E. Shalaurova, I. Bullitt, E. Landeen, L. Sugahara, G. Deng, H. Mathur, K. Tran, S. Cai, H. He, H. Yalcin, Y. Vieira Barbosa, J. Ventura-Cots, M. Marx, K. Gad, A. P. Niezen, S. Izunza Barba, S. Lay-Hong, A. Popov, Y. V. Fricker, Z. Lai, M. Curry, M. Afdhal, N. Szabo, G. Mukamal, K. J. Sanyal, A. J. Otvos, J. D. Malik, R.
                Hepatology. 2021 Oct 18. doi: 10.1002/hep.32203.

                A Kinetic Pump Integrated Microfluidic Plate (KIM-Plate) with High Usability for Cell Culture-Based Multiorgan Microphysiological Systems

                  Shinha, K. Nihei, W. Nakamura, H. Goto, T. Kawanishi, T. Ishida, N. Yamazaki, N. Imakura, Y. Mima, S. Inamura, K. Arakawa, H. Nishikawa, M. Kato, Y. Sakai, Y. Kimura, H.
                  Micromachines (Basel). 2021 Aug 24;12(9):1007. doi: 10.3390/mi12091007.

                  Hexa Histidine-Tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species

                    Dat, N. Q. Thuy, L. T. T. Hieu, V. N. Hai, H. Hoang, D. V. Thi Thanh Hai, N. Thuy, T. T. V. Komiya, T. Rombouts, K. Dong, M. P. Hanh, N. V. Hoang, T. H. Sato-Matsubara, M. Daikoku, A. Kadono, C. Oikawa, D. Yoshizato, K. Tokunaga, F. Pinzani, M. Kawada, N.
                    Hepatology. 2021 Jun;73(6):2527-2545. doi: 10.1002/hep.31752. Epub 2021 May 22.

                    Transduction Properties of an Adenovirus Vector Containing Sequences Complementary to a Liver-Specific microRNA, miR-122a, in the 3′-Untranslated Region of the E4 Gene in Human Hepatocytes from Chimeric Mice with Humanized Liver

                      Sakurai, F. Tsukamoto, T. Ono, R. Nishimae, F. Shiota, A. Iizuka, S.Shimizu, K. Sakai, E. Ishida, Y. Tateno, C. Chayama, K. Mizuguchi, H.
                      Biol Pharm Bull. 2021;44(10):1506-1513. doi: 10.1248/bpb.b21-00394.

                      Functional changes of cocultured hepatocyte sheets subjected to continuous liver regeneration stimulation in cDNA-uPA/SCID mouse: Differences in transplantation sites

                        Miyamoto, D. Sakai, Y. Huang, Y. Yamasaki, C. Tateno, C. Hasegawa, H. Murai, T. Hara, T. Adachi, T. Soyama, A. Hidaka, M.Ito, S. Kanetaka, K. Eguchi, S.
                        Regen Ther. 2021 Mar 18;18:7-11. doi: 10.1016/j.reth.2021.02.004. eCollection 2021 Dec.

                        Inhibition of HBV Transcription From cccDNA With Nitazoxanide by Targeting the HBx-DDB1 Interaction

                          Sekiba, K. Otsuka, M. Ohno, M. Yamagami, M. Kishikawa, T. Suzuki, T. Ishibashi, R. Seimiya, T. Tanaka, E. Koike, K.
                          Cell Mol Gastroenterol Hepatol. 2019;7(2):297-312. doi: 10.1016/j.jcmgh.2018.10.010.

                          Bile acid dysmetabolism in the gut-microbiota-liver axis under hepatitis C virus infection

                            Inoue, T. Funatsu, Y. Ohnishi, M. Isogawa, M. Kawashima, K. Tanaka, M. Moriya, K. Kawaratani, H. Momoda, R. Iio, E. Nakagawa, H. Suzuki, Y. Matsuura, K. Fujiwara, K. Nakajima, A. Yoshiji, H. Nakayama, J. Tanaka, Y.

                            Liver Int. 2021 Aug 19. doi: 10.1111/liv.15041.

                            HBx-induced degradation of Smc5/6 complex impairs homologous recombination-mediated repair of damaged DNA

                              Sekiba, K. Otsuka, M. Funato, K. Miyakawa, Y. Tanaka, E. Seimiya, T. Yamagami, M. Tsutsumi, T. Okushin, K. Miyakawa, K. Ryo, A. Koike, K.

                              J Hepatol. 2021 Aug 25. pii: S0168-8278(21)02005-5. doi: 10.1016/j.jhep.2021.08.010.

                              Infection courses, virological features and IFN-alpha responses of HBV genotypes in cell culture and animal models

                                Zhang, M. Zhang, Z. Imamura, M. Osawa, M. Teraoka, Y. Piotrowski, J. Ishida, Y. Sozzi, V. Revill, P. A. Saito, T. Chayama, K. Liang, T. J.

                                J Hepatol. 2021 Aug 4. pii: S0168-8278(21)01960-7. doi: 10.1016/j.jhep.2021.07.030.

                                Chimeric Mouse With Humanized Liver Is an Appropriate Animal Model to Investigate Mode of Action for Porphyria-Mediated Hepatocytotoxicity

                                  Toxicol Pathol. 2021 Jul 9:1926233211027474. doi: 10.1177/01926233211027474.

                                  Eguchi, A. Fukunaga, S. Ogata, K. Kushida, M. Asano, H. Cohen, S. M. Sukata, T.

                                  Application of humanized mice to toxicology studies: Evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)

                                    Journal Toxicologic Pathology 2021; 34(4): 283-297. doi: https://doi.org/10.1293/tox.2021-0027

                                    Tomoya Yamada

                                     

                                    Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)

                                      Yamada, T. Cohen, S. M. Lake, B. G.

                                      Crit Rev Toxicol. 2021;51(5):373-394. doi:10.1080/10408444.2021.1939654. Epub 2021 Jul 15.

                                      Epidermal growth factor receptor is a host-entry cofactor triggering hepatitis B virus internalization

                                        Iwamoto, M. Saso, W. Sugiyama, R. Ishii, K. Ohki, M. Nagamori, S. Suzuki, R. Aizaki, H. Ryo, A. Yun, J. H. Park, S. Y. Ohtani, N. Muramatsu, M. Iwami, S. Tanaka, Y. Sureau, C. Wakita, T. Watashi, K.
                                        Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8487-8492. doi: 10.1073/pnas.1811064116. Epub 2019 Apr 5.