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論文一覧

論文一覧

論文一覧

Chimeric mouse with humanized liver, an emerging tool for the drug development「創薬ツールとしてのヒト肝細胞キメラマウス」

    Shimada, T.
    Nihon Yakurigaku Zasshi. 2023;158(6):483-489. doi: 10.1254/fpj.23038.

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    A small molecule iCDM-34 identified by in silico screening suppresses HBV DNA through activation of aryl hydrocarbon receptor

      Furutani, Y. Hirano, Y. Toguchi, M. Higuchi, S. Qin, X. Y. Yanaka, K. Sato-Shiozaki, Y. Takahashi, N. Sakai, M. Kongpracha, P. Suzuki, T. Dohmae, N. Kukimoto-Niino, M. Shirouzu, M. Nagamori, S. Suzuki, H. Kobayashi, K. Masaki, T. Koyama, H. Sekiba, K. Otsuka, M. Koike, K. Kohara, M. Kojima, S. Kakeya, H. Matsuura, T.
      Cell Death Discov. 2023 Dec 22;9(1):467. doi: 10.1038/s41420-023-01755-w.

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      Induction of open-form bile canaliculus formation by hepatocytes for evaluation of biliary drug excretion

        Arakawa, H. Nakazono, Y. Matsuoka, N. Hayashi, M. Shirasaka, Y. Hirao, A. Tamai, I.
        Commun Biol. 2023 Aug 22;6(1):866. doi: 10.1038/s42003-023-05216-z.

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        Hepatocyte-targeted siTAZ therapy lowers liver fibrosis in NASH diet-fed chimeric mice with hepatocyte-humanized livers

          Wang, X. Moore, M. P. Shi, H. Miyata, Y. Donnelly, S. K. Radiloff, D. R. Tabas, I.
          Mol Ther Methods Clin Dev. 2023 Nov 23;31:101165. doi: 10.1016/j.omtm.2023.101165. eCollection 2023 Dec 14.

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          SRPKIN-1 as an inhibitor against hepatitis B virus blocking the viral particle formation and the early step of the viral infection

            Li, X. Nakashima, K. Ito, M. Matsuda, M. Chida, T. Sekihara, K. Takahashi, H. Kato, T. Sawasaki, T. Suzuki, T.
            Antiviral Res. 2023 Dec;220:105756. doi: 10.1016/j.antiviral.2023.105756. Epub 2023 Nov 20.

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            A versatile method to profile hepatitis B virus DNA integration

              Fukano, K. Wakae, K. Nao, N. Saito, M. Tsubota, A. Toyoshima, T. Aizaki, H. Iijima, H. Matsudaira, T. Kimura, M. Watashi, K. Sugiura, W. Muramatsu, M.
              Hepatol Commun. 2023 Dec 1;7(12):e0328. doi: 10.1097/HC9.0000000000000328. eCollection 2023 Dec 1.

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              Quantitative prediction of CYP3A-mediated drug-drug interactions by correctly estimating fraction metabolized using human liver chimeric mice

                Miyake, T. Mochizuki, T. Nakagawa, T. Nakamura, M. Emoto, C. Komiyama, N. Hirabayashi, M. Tsuruta, S. Shimojo, T. Terao, K. Tachibana, T.
                Br J Pharmacol. 2023 Oct 23. doi: 10.1111/bph.16270.

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                Development and characterization of secondary standards for nucleic acid amplification technology (NAAT) assays for detection of hepatitis E virus

                  Fares-Gusmao, R. Jiang, Z. Subramaniam, S. Visser, B. J. Scott, A. Ishida, Y. Saito, T. Baylis, S. A. McGivern, D. R. H. E. V. Standard Calibration Study Group
                  J Clin Virol. 2022 Dec;157:105325. doi: 10.1016/j.jcv.2022.105325.

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                  Functional involvement of endothelial lipase in hepatitis B virus infection

                    Shirasaki, T. Murai, K. Ishida, A. Kuroki, K. Kawaguchi, K. Wang, Y. Yamanaka, S. Yasukawa, R. Kawasaki, N. Li, Y. Y. Shimakami, T. Sumiyadorj, A. Nio, K. Sugimoto, S. Orita, N. Takayama, H. Okada, H. Thi Bich, P. D. Iwabuchi, S. Hashimoto, S. Ide, M. Tabata, N. Ito, S. Matsushima, K. Yanagawa, H. Yamashita, T. Kaneko, S. Honda, M.
                    Hepatol Commun. 2023 Aug 31;7(9):e0206.

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                    Function of hepatocyte spheroids in bioactive microcapsules is enhanced by endogenous and exogenous hepatocyte growth factor

                      Gwon, K. Choi, D. de Hoyos-Vega, J. M. Baskaran, H. Gonzalez-Suarez, A. M. Lee, S. Hong, H. J. Nguyen, K. M.n Dharmesh, E. Sugahara, G. Ishida, Y. Saito, T. Stybayeva, G. Revzin, A.
                      Bioact Mater. 2023 May 24;28:183-195. doi: 10.1016/j.bioactmat.2023.05.009.

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                      Guiding Hepatic Differentiation of Pluripotent Stem Cells Using 3D Microfluidic Co-Cultures with Human Hepatocytes

                        Fattahi, P. de Hoyos-Vega, J. M. Choi, J. H. Duffy, C. D. Gonzalez-Suarez, A. M. Ishida, Y. Nguyen, K. M. Gwon, K. Peterson, Q. P. Saito, T. Stybayeva, G. Revzin, A.
                        Cells. 2023 Aug 1;12(15):1982. doi: 10.3390/cells12151982.

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                        Efficient gene transduction in pigs and macaques with the engineered AAV vector AAV.GT5 for hemophilia B gene therapy

                          Kashiwakura, Y. Endo, K. Ugajin, A. Kikuchi, T. Hishikawa, S. Nakamura, H. Katakai, Y. Baatartsogt, N. Hiramoto, T. Hayakawa, M. Kamoshita, N. Yamazaki, S. Kume, A. Mori, H. Sata, N. Sakata, Y. Muramatsu, S. I. Ohmori, T.
                          Mol Ther Methods Clin Dev. 2023 Aug 22;30:502-514. doi: 10.1016/j.omtm.2023.08.016.

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                          Modeling suggests that virion production cycles within individual cells is key to understanding acute hepatitis B virus infection kinetics

                            Hailegiorgis, A. Ishida, Y. Collier, N. Imamura, M. Shi, Z. Reinharz, V. Tsuge, M. Barash, D. Hiraga, N. Yokomichi, H. Tateno, C. Ozik, J. Uprichard, S. L. Chayama, K. Dahari, H.
                            PLoS Comput Biol. 2023 Aug 3;19(8):e1011309. doi: 10.1371/journal.pcbi.1011309.

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                            Evaluation of RNAi Therapeutics VIR-2218 and ALN-HBV for Chronic Hepatitis B: Results From Randomized Clinical Trials

                              Gane, E. Lim, Y. S. Kim, J. B. Jadhav, V. Shen, L. Bakardjiev, A. I. Huang, S. A. Cathcart, A. L. Lempp, F. A. Janas, M. M. Cloutier, D. J. Kaittanis, C. Sepp-Lorenzino, L, Hinkle, G. Taubel, J. Haslett, P. Milstein, S. Anglero-Rodriguez, Y. I. Hebner, C. M. Pang, P. S. Yuen, M. F.
                              J Hepatol. 2023 Jun 6:S0168-8278(23)00352-5. doi: 10.1016/j.jhep.2023.05.023.

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                              Super-Resolution Microscopy Analysis of Hepatitis B Viral cccDNA and Host Factors

                                Doan, P. T. B. Nio, K. Shimakami, T. Kuroki, K. Li, Y. Y. Sugimoto, S. Takayama, H. Okada, H. Kaneko, S. Honda, M. Yamashita, T.
                                Viruses. 2023 May 16;15(5):1178. doi: 10.3390/v15051178.

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                                Persistent hepatic IFN system activation in HBV-HDV infection determines viral replication dynamics and therapeutic response

                                  Chida, T. Ishida, Y. Morioka, S. Sugahara, G. Han, C. Lam, B. Yamasaki, C. Sugahara, R. Li, M. Tanaka, Y. Liang, T. J. Tateno, C. Saito, T.
                                  JCI Insight. 2023 May 8;8(9):e162404. doi: 10.1172/jci.insight.162404.

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                                  Amentoflavone inhibits hepatitis B virus infection via the suppression of preS1 binding to host cells

                                    Aoki-Utsubo, C. Indrasetiawan, P. Fukano, K. Muramatsu, M. Artanti, N. Hanafi, M. Hotta, H. Kameoka, M.
                                    Microbiol Immunol. 2023 Mar 16. doi: 10.1111/1348-0421.13064.

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                                    Characterization of a Novel Capsid Assembly Modulator for the Treatment of Chronic Hepatitis B Virus Infection

                                      Burdette, D. Hyrina, A. Song, Z. Beran, R. K. Cheung, T. Gilmore, S. Kobayashi, T. Li, L. Liu, Y. Niedziela-Majka, A. Medley, J. Mehra, U. Morganelli, P. Novikov, N. Niu, C. Tam, D. Tang, J. Wang, J. Yue, Q. Fletcher, S. P. Holdorf, M. M. Delaney, W. E. th Feierbach, B. Lazerwith, S.
                                      Antimicrob Agents Chemother. 2023 Jan 24;67(1):e0134822. doi: 10.1128/aac.01348-22.

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                                      Downregulation of SOCS1 increases interferon-induced ISGylation during differentiation of induced-pluripotent stem cells to hepatocytes

                                        Edwards, J. S. Delabat, S. A. Badilla, A. D. DiCaprio, R. C. Hyun, J. Burgess, R. A. Silva, T. Dykxhoorn, D. M. Chen, S. X. Wang, L. Ishida, Y. Saito, T. Thomas, E.
                                        JHEP Rep. 2022 Sep 23;4(12):100592. doi: 10.1016/j.jhepr.2022.100592. eCollection 2022 Dec.

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                                        The Gut-Organ-Axis Concept: Advances the Application of Gut-on-Chip Technology

                                          Guo, Y. Chen, X. Gong, P.Li, G. Yao, W. Yang, W.
                                          Int J Mol Sci. 2023 Feb 17;24(4):4089. doi: 10.3390/ijms24044089.

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