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Persistent hepatic IFN system activation in HBV-HDV infection determines viral replication dynamics and therapeutic response

Persistent hepatic IFN system activation in HBV-HDV infection determines viral replication dynamics and therapeutic response

2023/08/15

Chida, T. Ishida, Y. Morioka, S. Sugahara, G. Han, C. Lam, B. Yamasaki, C. Sugahara, R. Li, M. Tanaka, Y. Liang, T. J. Tateno, C. Saito, T.
JCI Insight. 2023 May 8;8(9):e162404. doi: 10.1172/jci.insight.162404.

Amentoflavone inhibits hepatitis B virus infection via the suppression of preS1 binding to host cells

2023/08/15

Aoki-Utsubo, C. Indrasetiawan, P. Fukano, K. Muramatsu, M. Artanti, N. Hanafi, M. Hotta, H. Kameoka, M.
Microbiol Immunol. 2023 Mar 16. doi: 10.1111/1348-0421.13064.

Characterization of a Novel Capsid Assembly Modulator for the Treatment of Chronic Hepatitis B Virus Infection

2023/08/15

Burdette, D. Hyrina, A. Song, Z. Beran, R. K. Cheung, T. Gilmore, S. Kobayashi, T. Li, L. Liu, Y. Niedziela-Majka, A. Medley, J. Mehra, U. Morganelli, P. Novikov, N. Niu, C. Tam, D. Tang, J. Wang, J. Yue, Q. Fletcher, S. P. Holdorf, M. M. Delaney, W. E. th Feierbach, B. Lazerwith, S.
Antimicrob Agents Chemother. 2023 Jan 24;67(1):e0134822. doi: 10.1128/aac.01348-22.

日本薬物動態学会第 16回ショートコースでのランチョンセミナー開催のご案内

2023/08/08

2023年9月25日(月)に開催されます日本薬物動態学会 第16回ショートコースにて、
ランチョンセミナーの開催が決定しましたのでご案内します。

第50回日本毒性学会学術年会での企業展示及びランチョンセミナー開催のご案内

2023/06/06

2023年6月19日(月)~21日(水)にパシフィコ横浜で開催されます第50回日本毒性学会学術年会にて、
企業展示を行います。

ランチョンセミナーも開催致しますので、ご来場の方はぜひお立ち寄りください。

第50回日本毒性学会学術年会でのランチョンセミナー開催のご案内

2023/05/01

2023年6月19日(月)~21日(水)に開催される第50回日本毒性学会学術年会にて、
ランチョンセミナーの開催が決定しましたのでご案内します。

Downregulation of SOCS1 increases interferon-induced ISGylation during differentiation of induced-pluripotent stem cells to hepatocytes

2023/04/13

Edwards, J. S. Delabat, S. A. Badilla, A. D. DiCaprio, R. C. Hyun, J. Burgess, R. A. Silva, T. Dykxhoorn, D. M. Chen, S. X. Wang, L. Ishida, Y. Saito, T. Thomas, E.
JHEP Rep. 2022 Sep 23;4(12):100592. doi: 10.1016/j.jhepr.2022.100592. eCollection 2022 Dec.

The Gut-Organ-Axis Concept: Advances the Application of Gut-on-Chip Technology

2023/04/13

Guo, Y. Chen, X. Gong, P.Li, G. Yao, W. Yang, W.
Int J Mol Sci. 2023 Feb 17;24(4):4089. doi: 10.3390/ijms24044089.

Novel AAV-mediated genome editing therapy improves health and survival in a mouse model of methylmalonic acidemia

2023/04/13

Zhang, S. Bastille, A. Gordo, S. Ramesh, N. Vora, J. McCarthy, E.Zhang, X. Frank, D. Ko, C. W. Wu, C. Walsh, N. Amarwani, S. Liao, J. Xiong, Q. Drouin, L. Hebben, M. Chiang, K. Chau, B. N.
PLoS One. 2022 Sep 20;17(9):e0274774. doi: 10.1371/journal.pone.0274774.

The Synthesis and Anti-Cytomegalovirus Activity of Piperidine-4-Carboxamides

2023/04/13

Guo, X Ghosh, A. K. Keyes, R. F. Peterson, F. Forman, M. Meyers, D. J. Arav-Boger, R.
Viruses. 2022 Jan 25;14(2):234. doi: 10.3390/v14020234.

Development of Recombinant Infectious Hepatitis E Virus Harboring the nanoKAZ Gene and Its Application in Drug Screening

2023/04/13

Primadharsini, P. P. Nagashima, S. Nishiyama, T. Takahashi, M. Murata, K. Okamoto, H.
J Virol. 2022 Mar 23;96(6):e0190621. doi: 10.1128/jvi.01906-21. Epub 2022 Feb 2.

Novel Neplanocin A Derivatives as Selective Inhibitors of Hepatitis B Virus with a Unique Mechanism of Action

2023/04/13

Toyama, M. Watashi, K. Ikeda, M. Yamashita, A. Okamoto, M. Moriishi, K. Muramatsu, M. Wakita, T. Sharon, A. Baba, M.
Antimicrob Agents Chemother. 2022 Jun 21;66(6):e0207321. doi: 10.1128/aac.02073-21. Epub 2022 May 23.

Hepatitis B virus X protein counteracts high mobility group box 1 protein-mediated epigenetic silencing of covalently closed circular DNA

2023/04/13

Kim, E. S. Zhou, J. Zhang, H. Marchetti, A. van de Klundert, M. Cai, D.Yu, X. Mitra, B. Liu, Y. Wang, M. Protzer, U. Guo, H.
PLoS Pathog. 2022 Jun 9;18(6):e1010576. doi: 10.1371/journal.ppat.1010576.

Autophagic membranes participate in hepatitis B virus nucleocapsid assembly, precore and core protein trafficking, and viral release

2023/04/13

Chu, J. Y. K. Chuang, Y. C. Tsai, K. N. Pantuso, J. Ishida, Y. Saito, T. Ou, J. J.

Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2201927119. doi: 10.1073/pnas.2201927119. Epub 2022 Jul 18.

Guanine nucleotide exchange factor DOCK11-binding peptide fused with a single chain antibody inhibits hepatitis B virus infection and replication

2023/04/13

Ide, M. Tabata, N. Yonemura, Y. Shirasaki, T. Murai, K. Wang, Y. Ishida, A. Okada, H. Honda, M. Kaneko, S. Doi, N. Ito, S. Yanagawa, H.
J Biol Chem. 2022 Jul;298(7):102097. doi: 10.1016/j.jbc.2022.102097. Epub 2022 Jun 2.

Establishment of a Monoclonal Antibody against Human NTCP That Blocks Hepatitis B Virus Infection

2023/04/13

Takemori, T. Sugimoto-Ishige, A. Nishitsuji, H. Futamura, Y. Harada, M. Kimura-Someya, T. Matsumoto, T. Honma, T. Tanaka, M. Yaguchi, M. Isono, K. Koseki, H. Osada, H. Miki, D. Saito, T. Tanaka, T. Fukami, T. Goto, T. Shirouzu, M. Shimotohno, K. Chayama, K.
J Virol. 2022 Mar 9;96(5):e0168621. doi: 10.1128/JVI.01686-21. Epub 2022 Jan 5.

Antiviral Compounds Screening Targeting HBx Protein of the Hepatitis B Virus

2023/04/13

Ma, Y. Nakamoto, S. Ao, J. Qiang, N. Kogure, T. Ogawa, K. Nakagawa, M. Fujiwara, K. Iwanaga, T. Kojima, R. Kanzaki, H. Koroki, K. Kobayashi, K. Kanogawa, N. Kiyono, S. Nakamura, M. Kondo, T. Nakagawa, R. Ogasawara, S. Muroyama, R. Chiba, T. Kato, J. Kato, N.
Int J Mol Sci. 2022 Oct 10;23(19):12015. doi: 10.3390/ijms231912015.

N6-methyladenosine Modification of Hepatitis B Virus RNA in the Coding Region of HBx

2023/04/13

Murata, T. Iwahori, S. Okuno, Y. Nishitsuji, H. Yanagi, Y. Watashi, K. Wakita, T. Kimura, H. Shimotohno, K.
Int J Mol Sci. 2023 Jan 23;24(3):2265. doi: 10.3390/ijms24032265.

Novel approach for verification of a human PBPK modeling strategy using chimeric mice in the health risk assessment of epyrifenacil

2023/04/13

Hirasawa, K. Abe, J. Nagahori, H. Kitamoto, S
Toxicol Appl Pharmacol. 2023 Apr 15;465:116439. doi: 10.1016/j.taap.2023.116439. Epub 2023 Feb 27.

A Novel Anti-HBV Agent, E-CFCP, restores Hepatitis B virus (HBV)-induced Senescence-associated Cellular Markers Perturbation in Human Hepatocytes

2023/04/13

Takamatsu, Y. Hayashi, S. Kumamoto, H. Imoto, S. Tanaka, Y. Mitsuya, H. Higashi-Kuwata, N.
Virus Res. 2023 Mar 23;329:199094. doi: 10.1016/j.virusres.2023.199094.