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metabolism , Presentations , Publications

June 17, 2020

Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: Integration with hepatic drug metabolism

    Sanoh, S. Naritomi, Y. Kitamura, S. Shinagawa, A. Kakuni, M. Tateno, C. Ohta, S. Xenobiotica. 2020 Jun 5:1-10. doi: 10.1080/00498254.2020.1769229.
    June 17, 2020

    Species differences in liver accumulation and metabolism of nucleotide prodrug sofosbuvir

      Wang, T. Babusis, D. Park, Y. Niu, C. Kim, C. Zhao, X. Lu, B. Ma, B. Muench, R. C. Sperger, D. Ray, A. S. Murakami, E. Drug Metab Pharmacokinet. 2020 Jun;35(3):334-340. doi: 10.1016/j.dmpk.2020.04.333. Epub 2020 Apr 16.
      April 14, 2020

      Lipoprotein profile and lipid metabolism of PXB-cells((R)), human primary hepatocytes from liver-humanized mice: proposal of novel in vitro system for screening anti-lipidemic drugs

        Hata, K. Sayaka, T. Takahashi, M. Sasaki, A. Umekawa, Y. Miyashita, K. Ogura, K. Toshima, G. Maeda, M. Takahashi, J. Kakuni, M. Biomed Res. 2020;41(1):33-42. doi: 10.2220/biomedres.41.33.
        June 26, 2019

        Study of the Metabolism of New Drugs of Abuse

          Kanamori, T. Yakugaku Zasshi. 2019;139(5):699-704. doi: 10.1248/yakushi.18-00166-3.
          June 26, 2019

          Metabolism of Butyrylfentanyl in Fresh Human Hepatocytes: Chemical Synthesis of Authentic Metabolite Standards for Definitive Identification

            Kanamori, T. Iwata, Y. T. Segawa, H. Yamamuro, T. Kuwayama, K. Tsujikawa, K. Inoue, H. Biol Pharm Bull. 2019;42(4):623-630. doi: 10.1248/bpb.b18-00765.
            March 20, 2019

            Lack of human relevance for procymidone’s developmental toxicity attributable to species difference in its kinetics and metabolism

              Tomigahara, Y. Tarui, H. Matsui, M. Kurosawa, M. Kawamura, S. Isobe, N. J Pestic Sci. 2018 May 20;43(2):114-123. doi: 10.1584/jpestics.D17-085.
              November 08, 2018

              Results from Studies using PXB-Mouse and PXB-cells being presented at AASLD 2018

              There will be poster presentations featuring PXB-Mouse and PXB-cells at The Liver Meeting 2018.

              The Meeting will be held at Moscone North and South Convention Center (San Francisco, U.S.A) from Nov. 9 to Nov. 13, 2018.

              August 14, 2018

              Use of hepatocytes isolated from a liver-humanized mouse for studies on the metabolism of drugs: application to the metabolism of fentanyl and acetylfentanyl

                Kanamori, T. Togawa-Iwata, Y. Segawa, H. Yamamuro, T. Kuwayama, K. Tsujikawa, K. Inoue, H. Forensic Toxicol. 2018;36(2):467-475.
                May 22, 2018

                Chimeric mice with humanized liver: Application in drug metabolism and pharmacokinetics studies for drug discovery

                  Naritomi, Y. Sanoh, S. Ohta, S. Drug Metab Pharmacokinet. 2017 Nov 9. pii: S1347-4367(17)30150-7. doi: 10.1016/j.dmpk.2017.11.001.
                  March 12, 2018

                  Significance of aldehyde oxidase during drug development: Effects on drug metabolism, pharmacokinetics, toxicity, and efficacy

                    Sanoh, S. Tayama, Y. Sugihara, K. Kitamura, S. Ohta, S. Drug Metab Pharmacokinet. 2015 Feb;30(1):52-63.