metabolism , Presentations , Publications
Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: Integration with hepatic drug metabolism
Sanoh, S. Naritomi, Y. Kitamura, S. Shinagawa, A. Kakuni, M. Tateno, C. Ohta, S.
Xenobiotica. 2020 Jun 5:1-10. doi: 10.1080/00498254.2020.1769229.
Species differences in liver accumulation and metabolism of nucleotide prodrug sofosbuvir
Wang, T. Babusis, D. Park, Y. Niu, C. Kim, C. Zhao, X. Lu, B. Ma, B. Muench, R. C. Sperger, D. Ray, A. S. Murakami, E.
Drug Metab Pharmacokinet. 2020 Jun;35(3):334-340. doi: 10.1016/j.dmpk.2020.04.333. Epub 2020 Apr 16.
Lipoprotein profile and lipid metabolism of PXB-cells((R)), human primary hepatocytes from liver-humanized mice: proposal of novel in vitro system for screening anti-lipidemic drugs
Hata, K. Sayaka, T. Takahashi, M. Sasaki, A. Umekawa, Y. Miyashita, K. Ogura, K. Toshima, G. Maeda, M. Takahashi, J. Kakuni, M.
Biomed Res. 2020;41(1):33-42. doi: 10.2220/biomedres.41.33.
Study of the Metabolism of New Drugs of Abuse
Kanamori, T.
Yakugaku Zasshi. 2019;139(5):699-704. doi: 10.1248/yakushi.18-00166-3.
Metabolism of Butyrylfentanyl in Fresh Human Hepatocytes: Chemical Synthesis of Authentic Metabolite Standards for Definitive Identification
Kanamori, T. Iwata, Y. T. Segawa, H. Yamamuro, T. Kuwayama, K. Tsujikawa, K. Inoue, H.
Biol Pharm Bull. 2019;42(4):623-630. doi: 10.1248/bpb.b18-00765.
Lack of human relevance for procymidone’s developmental toxicity attributable to species difference in its kinetics and metabolism
Tomigahara, Y. Tarui, H. Matsui, M. Kurosawa, M. Kawamura, S. Isobe, N.
J Pestic Sci. 2018 May 20;43(2):114-123. doi: 10.1584/jpestics.D17-085.
Results from Studies using PXB-Mouse and PXB-cells being presented at AASLD 2018
There will be poster presentations featuring PXB-Mouse and PXB-cells at The Liver Meeting 2018.
The Meeting will be held at Moscone North and South Convention Center (San Francisco, U.S.A) from Nov. 9 to Nov. 13, 2018.
Use of hepatocytes isolated from a liver-humanized mouse for studies on the metabolism of drugs: application to the metabolism of fentanyl and acetylfentanyl
Kanamori, T. Togawa-Iwata, Y. Segawa, H. Yamamuro, T. Kuwayama, K. Tsujikawa, K. Inoue, H.
Forensic Toxicol. 2018;36(2):467-475.
Chimeric mice with humanized liver: Application in drug metabolism and pharmacokinetics studies for drug discovery
Naritomi, Y. Sanoh, S. Ohta, S.
Drug Metab Pharmacokinet. 2017 Nov 9. pii: S1347-4367(17)30150-7. doi: 10.1016/j.dmpk.2017.11.001.
Significance of aldehyde oxidase during drug development: Effects on drug metabolism, pharmacokinetics, toxicity, and efficacy
Sanoh, S. Tayama, Y. Sugihara, K. Kitamura, S. Ohta, S.
Drug Metab Pharmacokinet. 2015 Feb;30(1):52-63.