Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus

Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus

2023/02/21

Pub Med URL https://pubmed.ncbi.nlm.nih.gov/36477212/

Gilmore, S. A. Tam, D. Cheung, T. L. Snyder, C. Farand, J. Dick, R.Matles, M. Feng, J. Y.Ramirez, R.Li, L. Yu, H. Xu, Y.Barnes, D. Czerwieniec, G. Brendza, K. M. Appleby, T. C. Birkus, G. Willkom, M. Kobayashi, T. Paoli, E. Labelle, M. Boesen, T.Tay, C. H. Delaney, W. E. thNotte, G. T. Schmitz, U. Feierbach, B.
PLoS One. 2022 Dec 7;17(12):e0271145. doi: 10.1371/journal.pone.0271145. eCollection 2022.

Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA2

2023/02/21

Pub Med URL https://pubmed.ncbi.nlm.nih.gov/36366568/

Nakanishi, A. Okumura, H. Hashita, T. Yamashita, A. Nishimura, Y. Watanabe, C. Kamimura, S. Hayashi, S. Murakami, S. Ito, K. Iwao, T. Ikeda, A. Hirose, T. Sunazuka, T. Tanaka, Y. Matsunaga, T.
Viruses. 2022 Nov 8;14(11):2468. doi: 10.3390/v14112468.

Physiologically based pharmacokinetic modeling for quantitative prediction of exposure to a human disproportionate metabolite of the selective Na(v)1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase, using chimeric mice with humanized liver

2023/02/21

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/36273823

Asano, D. Nakamura, K. Nishiya, Y. Shiozawa, H. Takakusa, H. Shibayama, T. Inoue, S. I. Shinozuka, T. Hamada, T. Yahara, C. Watanabe, N. Yoshinari, K.
Drug Metab Dispos. 2023 Jan;51(1):67-80. doi: 10.1124/dmd.122.001000. Epub 2022 Oct 23.

コラーゲンビトリゲルを用いた新規肝細胞培養系における薬物動態研究

2022/12/01

渡　隆爾
関東化学発行誌

Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions

2022/12/01

Pub Med URL https://pubmed.ncbi.nlm.nih.gov/36344661/

Sakai, K. Sugano-Nakamura, N. Mihara, E. Rojas-Chaverra, N. M. Watanabe, S. Sato, H. Imamura, R. Voon, D. C. Sakai, I. Yamasaki, C. Tateno, C. Shibata, M. Suga, H. Takagi, J. Matsumoto, K.
Nat Biomed Eng. 2022 Nov 7. doi: 10.1038/s41551-022-00955-6.

Evaluation of the mode of action and human relevance of liver tumors in male mice treated with epyrifenacil

2022/12/01

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/36210011

Fukunaga, S. Ogata, K. Eguchi, A. Matsunaga, K. Sakurai, K. Abe, J. Cohen, S. M. Asano, H.
Regul Toxicol Pharmacol. 2022 Oct 6;136:105268. doi: 10.1016/j.yrtph.2022.105268.

Fungal Secondary Metabolite Exophillic Acid Selectively Inhibits the Entry of Hepatitis B and D Viruses

2022/12/01

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/35458494

Kobayashi, C. Watanabe, Y. Oshima, M. Hirose, T. Yamasaki, M. Iwamoto, M. Iwatsuki, M. Asami, Y. Kuramochi, K. Wakae, K. Aizaki, H. Muramatsu, M. Sureau, C. Sunazuka, T. Watashi, K.
Viruses. 2022 Apr 6;14(4). pii: v14040764. doi: 10.339/v14040764.

Involvement of SLC16A1/MCT1 and SLC16A3/MCT4 in l-lactate transport in the hepatocellular carcinoma cell line

2022/12/01

Pub Med URL https://pubmed.ncbi.nlm.nih.gov/36104287/

Mukai, Y. Yamaguchi, A. Sakuma, T. Nadai, T. Furugen, A. Narumi, K. Kobayashi, M.
Biopharm Drug Dispos. 2022 Oct;43(5):183-191. doi: 10.1002/bdd.2329. Epub 2022 Sep 22.

Hepatitis B virus utilizes a retrograde trafficking route via the trans-Golgi network to avoid lysosomal degradation

2022/12/01

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/36270602

Li, Y. Y. Kuroki, K. Shimakami, T. Murai, K. Kawaguchi, K. Shirasaki, T. Nio, K. Sugimoto, S. Nishikawa, T. Okada, H. Orita, N. Takayama, H. Wang, Y. Thi Bich, P. D. Ishida, A. Iwabuchi, S.
Cell Mol Gastroenterol Hepatol. 2022 Oct 19. pii: S2352-345X(22)00219-3. doi: 10.1016/j.jcmgh.2022.10.008.

Letrozole ameliorates liver fibrosis through the inhibition of the CTGF pathway and 17β-hydroxysteroid dehydrogenase 13 expression

2022/12/01

Pub Med URL https://pubmed.ncbi.nlm.nih.gov/36301364/

Sakai, N. Kamimura, K. Miyamoto, H. Ko, M. Nagoya, T. Setsu, T. Sakamaki, A. Yokoo, T. Kamimura, H. Soki, H. Tokunaga, A. Inamine, T. Nakashima, M. Enomoto, H. Kousaka, K. Tachiki, H.
J Gastroenterol. 2022 Oct 27. doi: 10.1007/s00535-022-01929-w.

日本薬物動態学会37回年会でのランチョンセミナー開催のご案内

2022/10/17

2022年11月7日(月)～11月10日(木)に開催されます日本薬物動態学会37回年会にて、ランチョンセミナー及び
ブース展示を行います。

Targeting lipid biosynthesis pathways for hepatitis B virus cure

2022/09/22

Pub Med URL https://pubmed.ncbi.nlm.nih.gov/35925919/

Hyrina, A. Burdette, D. Song, Z. Ramirez, R. Okesli-Armlovich, A. Vijayakumar, A. Bates, J. Trevaskis, J. L. Fletcher, S. P. Lee, W. A. Holdorf, M. M.
PLoS One. 2022 Aug 4;17(8):e0270273. doi: 10.1371/journal.pone.0270273. eCollection 2022.

Downregulation of CYP17A1 by 20-hydroxyecdysone: plasma progesterone and its vasodilatory properties

2022/09/22

Pub Med URL https://pubmed.ncbi.nlm.nih.gov/35909994/

Aljaber, M. Y. Orie, N. N. Raees, A. Kraiem, S. Al-Jaber, M. Samsam, W. Hamza, M. M. Abraham, D. Kneteman, N. M. Beotra, A. Mohamed-Ali, V. Almaadheed, M.
Future Sci OA. 2022 Jul 7;8(6):FSO805. doi: 10.2144/fsoa-2022-0006. eCollection 2022 Jul.

Signature of chronic hepatitis B virus infection in nails and hair

2022/09/22

Pub Med URL https://pubmed.ncbi.nlm.nih.gov/35509029/

Komatsu, H. Inui, A. Odmaa, E. Ito, Y. Hoshino, H. Umetsu, S. Tsunoda, T. Fujisawa, T.
BMC Infect Dis. 2022 May 4;22(1):431. doi: 10.1186/s12879-022-07400-8.

Assessment of metabolic activation of felbamate in chimeric mice with humanized liver in combination with in vitro metabolic assays

2022/09/22

Pub Med URL https://pubmed.ncbi.nlm.nih.gov/35786679/

Sato, K. Sanoh, S. Ishida, Y. Tateno, C. Ohta, S. Kotake, Y.
J Toxicol Sci. 2022;47(7):277-288. doi: 10.2131/jts.47.277.

IL-31 Levels Correlate with Pruritus in Patients with Cholestatic and Metabolic Liver Diseases and is FXR Responsive in NASH

2022/09/22

Pub Med URL https://pubmed.ncbi.nlm.nih.gov/35686937/

Xu, J. Wang, Y. Khoshdeli, M. Peach, M. Chuang, J. C. Lin, J. Tsai, W. W. Mahadevan, S. Minto, W. Diehl, L. Gupta, R. Trauner, M. Patel, K. Noureddin, M. Kowdley, K. V. Gulamhusein, A. Bowlus, C. L. Huss, R. S. Myers, R. P. Chung, C. Billin, A. N.
Hepatology. 2022 Jun 10. doi: 10.1002/hep.32599.

The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro

2022/09/22

Pub Med URL https://pubmed.ncbi.nlm.nih.gov/35312737/

Gad, S. A. Sugiyama, M. Tsuge, M. Wakae, K. Fukano, K. Oshima, M. Sureau, C. Watanabe, N. Kato, T. Murayama, A. Li, Y. Shoji, I. Shimotohno, K. Chayama, K. Muramatsu, M. Wakita, T. Nozaki, T. Aly, H. H.
PLoS Pathog. 2022 Mar 21;18(3):e1009983. doi: 10.1371/journal.ppat.1009983. eCollection 2022 Mar.

A single hepatitis B virus genome with a reporter allows the entire viral life cycle to be monitored in primary human hepatocytes

2022/09/22

Pub Med URL https://pubmed.ncbi.nlm.nih.gov/35691027/

Sumiyadorj, A. Murai, K. Shimakami, T. Kukroki, K. Nishikawa, T. Kakuya, M. Yamada, A. Wang, Y. Ishida, A. Shirasaki, T. Kawase, S. Li, Y. Y. Okada, H. Nio, K. Kawaguchi, K. Yamashita, T. Sakai, Y. Duger, D. Mizukoshi, E. Honda, M. Kaneko, S.
Hepatol Commun. 2022 Jun 12. doi: 10.1002/hep4.2018.

Freshly Isolated Hepatocytes from Chimeric Humanized Liver Mice for the In Vitro Assessment of Drug Metabolism, Inhibition/Induction, and Safety Studies

2022/06/29

Pub Med URL https://pubmed.ncbi.nlm.nih.gov/35598301/

Kakuni, M
Curr Protoc. 2022 May;2(5):e429. doi: 10.1002/cpz1.429.

Insights from a high-fat diet fed mouse model with a humanized liver

2022/06/29

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/35533183

Saxena, R. Nassiri, M. Yin, X. M. Morral, N.
PLoS One. 2022 May 9;17(5):e0268260. doi: 10.1371/journal.pone.0268260. eCollection 2022.