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Hepatitis B virus genotypes A1 and A2 have distinct replication phenotypes due to polymorphisms in the HBx gene

Hepatitis B virus genotypes A1 and A2 have distinct replication phenotypes due to polymorphisms in the HBx gene

2025/05/08

Zhang, M. Mouzannar, K. Zhang, Z. Teraoka, Y. Piotrowski, J. Ishida, Y. Tateno-Mukaidani, C. Saito, T.Abe-Chayama, H. Chayama, K.Liang, T. J.
PLoS Pathog. 2025 Jan 9;21(1):e1012803. doi: 10.1371/journal.ppat.1012803.

Theoretical modeling of hepatitis C acute infection in liver-humanized mice support pre-clinical assessment of candidate viruses for controlled-human-infection studies

2025/05/08

Shi, Z. Mhlanga, A. Ishida, Y. Josephson, A. Collier, N. T. Abe-Chayama, H. Tateno-Mukaidani, C. Cotler, S. J. Ozik, J. Major, M. Feld, J. J. Chayama, K. Dahari, H.
Sci Rep. 2024 Dec 30;14(1):31826. doi: 10.1038/s41598-024-83104-0.

Alteration of Gene Expression After Entecavir and Pegylated Interferon Therapy in HBV-Infected Chimeric Mouse Liver

2025/05/08

Bao, H. Murakami, S. Tsuge, M. Uchida, T. Uchikawa, S. Fujino, H. Ono, A. Murakami, E. Kawaoka, T. Miki, D. Hayes, C. N. Oka, S.
Viruses. 2024 Nov 6;16(11):1743. doi: 10.3390/v16111743.

Modelling of hepatitis B virus kinetics and accumulation of cccDNA in primary human hepatocytes

2025/05/08

Louis Shekhtman, Yuji Ishida, Masataka Tsuge, Vladimir Reinharz, Mikaru Yamao, Masaki Takahashi, Chise Tateno, Susan L. Uprichard, Harel Dahari, Kazuaki Chayama
JHEP Reports https://doi.org/10.1016/j.jhepr.2024.101311.

第7回医薬品毒性機序研究会でのランチョンセミナー開催のご案内

2024/12/06

2025年1月8日(水)~9日(木)にグランシップ(静岡県コンベンションアーツセンター)で開催されます第7回医薬品毒性機序研究会にて、ランチョンセミナーを開催致しますのでご案内申し上げます。

An atlas of the human liver diurnal transcriptome and its perturbation by hepatitis C virus infection

2024/11/06

Mukherji, A. Jühling, F. Simanjuntak, Y. Crouchet, E. Del Zompo, F. Teraoka, Y. Haller, A. Baltzinger, P. Paritala, S. Rasha, F. Fujiwara, N. Gadenne, C. Slovic, N. Oudot, M. A. Durand, S. C.
Nat Commun. 2024 Aug 29;15(1):7486. doi: 10.1038/s41467-024-51698-8.

Plasma and urinary CP I and CP III concentrations in chimeric mice with human hepatocytes after rifampicin administration

2024/11/06

Shishido, Y. Yoshida, T. Oshida, K. Uchida, M.
Pharmacol Res Perspect. 2024 Oct;12(5):e70017. doi: 10.1002/prp2.70017.

Infectivity of Hepatitis B Virus Surface Antigen-Positive Plasma With Undetectable HBV-DNA: Can HBsAg Screening Be Discontinued in Egyptian Blood Donors?

2024/11/06

El Ekiaby, M. Tanaka, J. van Drimmelen, H. Allain, J. P. Lelie, N.
J Viral Hepat. 2024 Aug 10. doi: 10.1111/jvh.13990.

Interferon alpha induces a stronger antiviral effect than interferon lambda in HBV/HDV infected humanized mice

2024/11/06

Duehren, S. Uchida, T. Tsuge, M. Hiraga, N. Uprichard, S. L. Etzion, O. Glenn, J. Koh, C. Heller, T. Cotler, S. J. Oka, S. Chayama, K. Dahari, H.
Virus Res. 2024 Aug 26;349:199451. doi: 10.1016/j.virusres.2024.199451.

The Evaluation of Lipid Analysis for PXB-Cells LA as a Human Non-Alcoholic Fatty Liver Disease Model

2024/11/06

Takahashi, Masaki Tomatsu, Sayaka Inamatsu, Mutsumi, Yoshikawa, Nami, Hata, Keishi, Kakuni, Masakazu
BPB Reports (2024) 7(4):147-156

Lipid nanoparticle-encapsulated DOCK11-siRNA efficiently reduces hepatitis B virus cccDNA level in infected mice

2024/11/06

Okada, H. Sakamoto, T. Nio, K. Li, Y. Kuroki, K. Sugimoto, S. Shimakami, T. Doi, N. Honda, M. Seiki, M. Kaneko, S. Yamashita, T.
Mol Ther Methods Clin Dev. 2024 Jun 24;32(3):101289. doi: 10.1016/j.omtm.2024.101289.

Human Hepatocytes Can Give Rise to Intrahepatic Cholangiocarcinomas

2024/11/06

Hsu, Bernadette Y. Driscoll, Julia. Tateno, Chise. Mattis, Aras N. Kelley, Robin K. Willenbring, Holger
Gastroenterology. 2024 Oct;167(5):1029-1032.e7. doi: 10.1053/j.gastro.2024.05.033.

Utility of Chimeric Mice with Humanized Livers for Predicting Hepatic Organic Anion – Transporting Polypeptide 1B (OATP1B) – Mediated Clinical Drug-Drug Interactions

2024/11/06

Feng, B. Liang, G. Zetterberg, C. Li, S. Huang, H. Williams, J.Gao, H. Morikawa, Y. Kumar, S.
Drug Metab Dispos. 2024 Aug 5:DMD-AR-2024-001792. doi: 10.1124/dmd.124.001792.

Selective depletion of HBV-infected hepatocytes by class A capsid assembly modulators requires high levels of intrahepatic HBV core protein

2024/11/06

Kornyeyev, D. Song, Z. Eng, S. Soulette, C. Ramirez, R. Tang, J. Yue, Q. Subramanian, R. Zaboli, S. Moon, C. Tam, J. Brodbeck, J. Aggarwal, A. Diehl, L. Fletcher, S. P. Hyrina, A. Holdorf, M. M. Burdette, D.
Antimicrob Agents Chemother. 2024 Jul 9;68(7):e0042024. doi: 10.1128/aac.00420-24.

Antiviral effect of peptoids on hepatitis B virus infection in cell culture

2024/11/06

Murayama, A. Igarashi, H. Yamada, N. Aly, H. H. Molchanova, N. Lin, J. S. Nishitsuji, H. Shimotohno, K. Muramatsu, M. Barron, A. E. Kato, T.
Antiviral Res. 2024 Mar;223:105821. doi: 10.1016/j.antiviral.2024.105821.

The mitochondrial TSPO ligand Atriol mitigates metabolic-associated steatohepatitis by downregulating CXCL1

2024/11/06

Li, Y. Chen, L.b. Sottas, C. Raul, M. C. Patel, N. D. Bijja, J. R. Ahmed, S. K. Kapelanski-Lamoureux, A. Lazaris, A. Metrakos, P. Zambidis, A. Chopra, S. Li, M. Sugahara, G. Saito, T.
Metabolism. 2024 Jun 11:155942. doi: 10.1016/j.metabol.2024.155942

An allosteric inhibitor of sirtuin 2 blocks hepatitis B virus covalently closed circular DNA establishment and its transcriptional activity

2024/11/06

Tang, L. Remiszewski, S. Snedeker, A. Chiang, L. W. Shenk, T.
Antiviral Res. 2024 Jun;226:105888. doi: 10.1016/j.antiviral.2024.105888.

A Novel Approach to Orthotopic Hepatocyte Transplantation Engineered With Liver Hydrogel for Fibrotic Livers, Enhancing Cell-Cell Interaction and Angiogenesis

Udagawa, D. Nagata, S. Yagi, H. Nishi, K. Morisaku, T. Adachi, S. Nakano, Y. Tanaka, M. Hori, S. Hasegawa, Y.. Abe, Y. Kitago, M. Kitagawa, Y.
FEBS Lett. 2024 Jun;598(11):1354-1365. doi: 10.1002/1873-3468.14842.

ヒト脂肪肝モデル細胞に関する論文のご案内

2024/09/18

弊社研究員の高橋より、ヒト脂肪肝モデル細胞(PXB-cells LA)に関する論文が発表されましたので、ご案内いたします。

AAPS 2024 PharmSci 360におけるPXBマウス関連発表のBest Abstract Award受賞のご案内(中外製薬株式会社 三宅 泰司様)

2024/08/21

米国・ソルトレークシティーで2024年10月に開催されるAAPS 2024 PharmSci 360において、
中外製薬株式会社 三宅 泰司様のPXBマウスを用いたUGT基質のクリアランス予測に関するポスター発表が
Best Abstract Awardに選ばれました!
発表ならびに学会に関する概要は以下の通りです。