Phoenix Bio

Development of Murine Cyp3a Knockout Chimeric Mice with Humanized Liver

Development of Murine Cyp3a Knockout Chimeric Mice with Humanized Liver

2015/08/11

Kato, K. Ohbuchi, M. Hamamura, S. Ohshita, H. Kazuki, Y. Oshimura, M. Sato, K. Nakada, N. Kawamura, A. Usui, T. Kamimura, H. Tateno, C.

Drug Metab Dispos. 2015 Aug;43(8):1208-17.

 

Prevention of hepatitis C virus infection and spread in human liver chimeric mice by an anti-CD81 monoclonal antibody

2015/08/11

Ji, C. Liu, Y. Pamulapati, C. Bohini, S. Fertig, G. Schraeml, M. Rubas, W. Brandt, M. Ries, S. Ma, H. Klumpp, K.

Hepatology. 2015 Apr;61(4):1136-44.

Identification and characterization of metabolites of ASP015K, a novel oral Janus kinase inhibitor, in rats, chimeric mice with humanized liver, and humans

2015/08/11

Nakada, N. Oda, K.

Xenobiotica. 2015 Apr 14:1-9.

Monoclonal Antibodies against Extracellular Domains of Claudin-1 Block Hepatitis C Virus Infection in a Mouse Model

2015/08/11

Fukasawa, M. Nagase, S. Shirasago, Y. Iida, M. Yamashita, M. Endo, K. Yagi, K. Suzuki, T. Wakita, T. Hanada, K. Kuniyasu, H. Kondoh, M.

J Virol. 2015 May 1;89(9):4866-79.

Postexposure Prophylactic Effect of Hepatitis B Virus (HBV)-Active Antiretroviral Therapy against HBV Infection

2015/08/11

Watanabe, T. Hamada-Tsutsumi, S. Yokomaku, Y. Imamura, J. Sugiura, W. Tanaka, Y.

Antimicrob Agents Chemother. 2015 Feb;59(2):1292-8.

Discovering novel direct acting antiviral agents for HBV using in silico screening

2015/08/11

Murakami, Y. Hayakawa, M. Yano, Y. Tanahashi, T. Enomoto, M. Tamori, A. Kawada, N. Iwadate, M. Umeyama, H.

Biochem Biophys Res Commun. 2015 Jan 2;456(1):20-8.

Novel robust in vitro hepatitis B virus infection model using fresh human hepatocytes isolated from humanized mice

2015/08/11

Ishida Y, Yamasaki C, Yanagi A, Yoshizane Y, Fujikawa K, Watashi K, Abe H, Wakita T, Hayes CN, Chayama K, Tateno C

Am J Pathol. 2015 May;185(5):1275-85. doi: 10.1016/j.ajpath.2015.01.028. Epub 2015 Mar 17.

Predictability of plasma concentration-time curves in humans using single-species allometric scaling of chimeric mice with humanized liver

2015/08/11

Sanoh, S. Naritomi, Y. Fujimoto, M. Sato, K. Kawamura, A. Horiguchi, A.Sugihara, K. Kotake, Y. Ohshita, H. Tateno, C. Horie, T. Kitamura, S. Ohta, S.

Xenobiotica. 2015 Mar 3:1-10.

The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus

2015/08/11

Sato, S. Li, K. Kameyama, T. Hayashi, T. Ishida, Y. Murakami, S. Watanabe, T. Iijima, S. Sakurai, Y. Watashi, K. Tsutsumi, S. Sato, Y. Akita, H. Wakita, T. Rice, C. M. Harashima, H. Kohara, M.Tanaka, Y.Takaoka, A.

Immunity. 2015 Jan 20;42(1):123-32.

Validation of cross-genotype neutralization by hepatitis B virus-specific monoclonal antibodies by in vitro and in vivo infection

2015/08/11

Hamada-Tsutsumi, S. Iio, E. Watanabe, T. Murakami, S. Isogawa, M. Iijima, S. Inoue, T. Matsunami, K. Tajiri, K. Ozawa, T. Kishi, H. Muraguchi, A. Joh, T. Tanaka, Y.

PLoS One. 2015 Feb 18;10(2):e0118062.

Hepatitis C Virus Core Protein Suppresses Mitophagy by Interacting with Parkin in the Context of Mitochondrial Depolarization

2015/08/11

Hara, Y. Yanatori, I. Ikeda, M. Kiyokage, E. Nishina, S. Tomiyama, Y. Toida, K. Kishi, F. Kato, N. Imamura, M. Chayama, K. Hino, K.

Am J Pathol. 2014 Sep 19. pii: S0002-9440(14)00483-0. doi: 10.1016/j.ajpath.2014.07.024.

In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus

2015/08/11

Watanabe, T. Hatakeyama, H. Matsuda-Yasui, C. Sato, Y. Sudoh, M. Takagi, A. Hirata, Y. Ohtsuki, T. Arai, M. Inoue, K. Harashima, H. Kohara, M.

Sci Rep. 2014 Apr 23;4:4750. doi: 10.1038/srep04750.

 

 

Human microRNA hsa-miR-1231 suppresses hepatitis B virus replication by targeting core mRNA

2015/08/11

Kohno, T. Tsuge, M. Murakami, E. Hiraga, N. Abe, H. Miki, D. Imamura, M. Ochi,

H. Hayes, C. N. Chayama, K.

J Viral Hepat. 2014 Sep;21(9):e89-97. doi: 10.1111/jvh.12240. Epub 2014 May 16.

Zone analysis by two-dimensional electrophoresis with accelerator mass spectrometry of in vivo protein bindings of idiosyncratic hepatotoxicants troglitazone and flutamide bioactivated in chimeric mice with humanized liver

2015/08/11

Yamazaki, H. Kuribayashi, S. Inoue, T. Honda,T. Tateno, C. Oofusa, K. Ninomiya, S.Ikedag , T. Izumi, T and Horie, T

Toxicology Research

Human Hepatocytes Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogen Sodium Phenobarbital in an in vivo Study Using a Chimeric Mouse with Humanized Liver

2015/08/10

Yamada, T. Okuda, Y. Kushida, M. Sumida, K. Takeuchi, H. Nagahori, H. Fukuda, T. Lake, B. G. Cohen, S. M. Kawamura, S.

Toxicol Sci. 2014 Aug 21. pii: kfu173.

第11回広島肝臓プロジェクト研究センター シンポジウムでのPXBマウス関連研究発表のご案内

2015/06/26

2015年 7月4日(土) にホテルグランヴィア広島にて開催されます第11回広島肝臓プロジェクト研究センターのシンポジウムにてPXBマウス関連研究発表がありますので、ご案内申し上げます。

 

第42回日本毒性学会学術年会でのPXBマウス関連研究発表、ブース展示及びランチョンセミナーのご案内

2015/06/23

2015年6月29日(月)〜 7月1日(水)に石川県金沢市で開催されます第42回日本毒性学会学術年会にてPXBマウス・PXB-cells関連研究発表があります。ブース展示及びランチョンセミナーも行いますので是非お立ち寄りください。

Restorative effect of hair follicular dermal cells on injured human hair follicles in a mouse model

2015/06/03

Yamao, M. Inamatsu, M. Okada, T. Ogawa, Y. Ishida, Y. Tateno, C. Yoshizato, K.

Exp Dermatol. 2015 Mar;24(3):225-7.

Enhanced restoration of in situ-damaged hairs by intradermal transplantation of trichogenous dermal cells

2015/06/01

Yamao, M. Inamatsu, M. Okada, T. Ogawa, Y. Tateno, C. Yoshizato, K.

J Tissue Eng Regen Med. 2015 Feb 17. doi: 10.1002/term.1997.

第51回日本肝臓学会総会(2015年5月21, 22日)でのPXBマウス・PXB-cells関連研究発表のご案内

2015/05/20

2015年5月21日(木), 22日(金)に熊本市中央区で開催されます第51回日本肝臓学会総会にてPXBマウス・PXB-cells関連研究発表があります