| 株式会社フェニックスバイオ

Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP)

2014/04/07

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24375637

Watashi, K. Sluder, A. Daito, T. Matsunaga, S. Ryo, A. Nagamori, S. wamoto, M. Nakajima, S. Tsukuda, S. Borroto-Esoda, K. Sugiyama, M. Tanaka, Y. Kanai, Y. Kusuhara, H. Mizokami, M. Wakita, T.

Hepatology. 2014 May;59(5):1726-37.

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Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics

2014/04/07

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24114658

Sanoh, S. Ohta, S.
Biopharm Drug Dispos. 2014 Mar;35(2):71-86.

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Chimeric Mice with Humanized Livers: A Unique Tool for in Vivo and in Vitro Enzyme Induction Studies

2014/04/07

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24362577

Masakazu Kakuni, Chihiro Yamasaki, Asato Tachibana, Yasumi Yoshizane, Yuji Ishida and Chise Tateno
Int. J. Mol. Sci. 2014, 15, 58-74

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Hepatitis Virus Infection Affects DNA Methylation in Mice with Humanized Livers

2014/04/07

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24184133

Okamoto, Y. Shinjo, K., Shimizu, Y. Sano, T. Yamao, K. Gao, W. Fujii, M. Osada, H. Sekido, Y. Murakami, S. Tanaka, Y. Joh, T. Sato, S. Takahashi, S. Wakita, T. Zhu, J.Issa, J. P. Kondo, Y.
Gastroenterology. 2014 Feb;146(2):562-72.

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Long-Term Elimination of Hepatitis C Virus from Human Hepatocyte Chimeric Mice After Interferon-gamma Gene Transfer

2014/04/07

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24279674

Takahashi, Y. Ando, M. Nishikawa, M. Hiraga, N. Imamura, M. Chayama, K. Takakura, Y.

Hum Gene Ther Clin Dev. 2014 Mar;25(1):28-39.

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Formulated Minimal-Length Synthetic Small Hairpin RNAs are Potent Inhibitors of Hepatitis C Virus in Mice with Humanized Livers

2014/04/07

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24076507

Ma, H. Dallas, A. Ilves, H. Shorenstein, J. Maclachlan, I. Klumpp, K. Johnston, B. H.
Gastroenterology. 2014 Jan;146(1):63-6.

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In vitro and in vivo metabolism of a novel chymase inhibitor, SUN13834, and the predictability of human metabolism using mice with humanized liver

2014/04/06

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24304169

Igawa, Y. Fujitani, T. Shah, B. Oo, C. Kanai, Y.
Xenobiotica. 2014 Jan;44(2):154-63.

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Endogenous and xenobiotic metabolite profiling of liver extracts from SCID and chimeric humanized mice following repeated oral administration of troglitazone

2014/04/06

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24350779

Barnes, A. J. Baker, D. R. Hobby, K. Ashton, S. Michopoulos, F. Spagou, K. Loftus, N. J. Wilson, I. D.
Xenobiotica. 2014 Jan; 44(2): 174-85.

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Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver

2014/04/06

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24329499

Kitamura, S. Sugihara, K.
Xenobiotica. 2014 Jan; 44(2): 123-34.

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Isolation and characterization of highly replicable hepatitis C virus genotype 1a strain HCV-RMT

2014/04/05

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24358200

Arai M, Tokunaga Y, Takagi A, Tobita Y, Hirata Y, Ishida Y, TatenoC, Kohara M
PLoS One. 2013 Dec 16;8(12):e82527.

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SOT 53th Annual Meeting and ToxExpo2014でのPXBマウス関連研究発表、ブース展示のご案内

2014/03/19

2014年3月23日(日)〜27日(木)に米国アリゾナ州フェニックス（the Phoenix Convention Center in Phoenix, Arizona, U.S.A）にて開催されるSOT 53th Annual Meeting and ToxExpo2014にて、PXBマウス関連研究発表があります。
ブース展示も行いますので是非お立ち寄りください。

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HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-beta type I receptor

2013/11/22

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/24263861

Sakata, K. Hara, M. Terada, T. Watanabe, N. Takaya, D. Yaguchi, S. Matsumoto, T. Matsuura, T. Shirouzu, M. Yokoyama, S. Yamaguchi, T. Miyazawa, K. Aizaki, H. Suzuki, T. Wakita, T. Imoto, M. Kojima, S.
Sci Rep. 2013 Nov 22;3:3243. doi: 10.1038/srep03243.

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Transplantation of engineered chimeric liver with autologous hepatocytes and xenobiotic scaffold

2013/11/22

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/22691372

Hata T, Uemoto S, Fujimoto Y, Murakami T, Tateno C, Yoshizato K, Kobayashi E.
Ann Surg. 2013 Mar;257(3):542-7.

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Repopulation of the immunosuppressed retrorsine-treated infant rat liver with human hepatocytes.

2013/11/22

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/23683097

Tachibana A, Tateno C, Yoshizato K.
Xenotransplantation. 2013 Jul;20(4):227-38.

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Hepatitis C virus kinetics by administration of pegylated interferon-α in human and chimeric mice carrying human hepatocytes with variants of the IL28B gene.

2013/09/01

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/23135762

Watanabe T, Sugauchi F, Tanaka Y, Matsuura K, Yatsuhashi H, Murakami S, Iijima S, Iio E, Sugiyama M, Shimada T, Kakuni M, Kohara M, Mizokami M.
Gut. 2013 Sep;62(9):1340-6

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Targeted induction of interferon-λ in humanized chimeric mouse liver abrogates hepatotropic virus infection.

2013/09/01

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/23555725

Nakagawa S, Hirata Y, Kameyama T, Tokunaga Y, Nishito Y, Hirabayashi K, Yano J, Ochiya T, Tateno C, Tanaka Y, Mizokami M, Tsukiyama-Kohara K, Inoue K, Yoshiba M, Takaoka A, Kohara M.
PLoS One. 2013;8(3):e59611.

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Thromboxane A2 Synthase Inhibitors Prevent Production of Infectious Hepatitis C Virus in Mice with Humanized Livers.

2013/08/31

Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/23684750

Abe Y, Aly HH, Hiraga N, Imamura M, Wakita T, Shimotohno K, Chayama K, Hijikata M
Gastroenterology. 2013 Sep;145(3):658-67.e11.

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A serine palmitoyltransferase inhibitor blocks hepatitis C virus replication in human hepatocytes

2013/08/31

Pub Med URL https://pubmed.ncbi.nlm.nih.gov/23791700/

Katsume A, Tokunaga Y, Hirata Y, Munakata T, Saito M, Hayashi H, Okamoto K, Ohmori Y, Kusanagi I, Fujiwara S, Tsukuda T, Aoki Y, Klumpp K, Tsukiyama-Kohara K, El-Gohary A, Sudoh M, Kohara M.
Gastroenterology. 2013 Oct;145(4):865-73.

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Demonstration of hepatitis C virus RNA with in situ hybridization employing a locked nucleic Acid probe in humanized liver of infected chimeric mice and in needle-biopsied human liver.

2013/08/30

Pub Med URL https://pubmed.ncbi.nlm.nih.gov/23853723/

Shiogama K, Inada K, Kohara M, Teramoto H, Mizutani Y, Onouchi T, Tsutsumi Y.
Int J Hepatol. 2013;2013:249535. doi: 10.1155/2013/249535. Epub 2013 Jun 18.

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Combination therapies with NS5A, NS3 and NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice.

2013/08/30

Pub Med URL https://pubmed.ncbi.nlm.nih.gov/23322441/

Shi N, Hiraga N, Imamura M, Hayes CN, Zhang Y, Kosaka K, Okazaki A, Murakami E, Tsuge M, Abe H, Aikata H, Takahashi S, Ochi H, Tateno-Mukaidani C, Yoshizato K, Matsui H, Kanai A, Inaba T, McPhee F, Gao M, Chayama K.
Gut. 2013 Jul;62(7):1055-61

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