Phoenix Bio

第6回広島肝臓プロジェクト研究センターシンポジウム 

第6回広島肝臓プロジェクト研究センターシンポジウム 

2010/06/04

Activation of Morphine Glucuronidation by Fatty Acyl-CoAs and Its Plasticity: A Comparative Study in Humans and Rodents Including Chimeric Mice Carrying Human Liver.

2010/05/01

Nurrochmad A, Ishii Y, Nakanoh H, Inoue T, Horie T, Sugihara K, Ohta S, Taketomi A, Maehara Y, Yamada H.
Drug Metab Pharmacokinet. in press.

日本薬学会第130年会 

2010/03/28

ヒト型肝臓を持つキメラマウスから分離したヒト肝細胞のCYPおよびUGT活性の評価

2010/02/10

Yamasaki, C., et al

DMPK. 2010; 6:45

ヒト肝細胞キメラマウスを用いた治療抵抗性の肝炎に関する研究

2010/01/02

茶山一彰

研究班会議

ヒト肝細胞キメラマウス

2010/01/02

立野知世

総合臨床 2010; 59(2): 297-298

Approach for in vivo protein binding of 5-n-butyl-pyrazolo[1,5-a]pyrimidine bioactivated in chimeric mice with humanized liver by two-dimensional electrophoresis with accelerator mass spectrometry.

2010/01/01

Yamazaki H, Kuribayashi S, Inoue T, Tateno C, Nishikura Y, Oofusa K, Harada D, Naito S, Horie T, Ohta S.
Chem Res Toxicol. 2010 Jan;23(1):152-8.

In vivo modeling of human liver for pharmacological study using humanized mouse.

2009/12/12

Yoshizato K, Tateno C.

Expert Opin Drug Metab Toxicol. 2009 Nov;5(11):1435-46.

第57回 日本ウイルス学会学術年会

2009/10/25

Absence of viral interference and different susceptibility to interferon between hepatitis B virus and hepatitis C virus in human hepatocyte chimeric mice.

2009/09/23

Hiraga N, Imamura M, Hatakeyama T, Kitamura S, Mitsui F, Tanaka S, Tsuge M, Takahashi S, Abe H, Maekawa T, Ochi H, Tateno C, Yoshizato K, Wakita T, Chayama K.
J Hepatol. 2009 Dec;51(6):1046-54. Epub 2009 Sep 23.

A human hepatocyte-bearing mouse: an animal model to predict drug metabolism and effectiveness in humans.

2009/08/12

Yoshizato K, Tateno C.

PPAR Res.2009:476217. Epub 2009 Oct 26.

Amphipathic DNA polymers inhibit hepatitis C virus infection by blocking viral entry.

2009/08/01

Matsumura T, Hu Z, Kato T, Dreux M, Zhang YY, Imamura M, Hiraga N, Juteau JM, Cosset FL, Chayama K, Vaillant A, Liang TJ.
Gastroenterology. 2009 Aug;137(2):673-81

Adoptive immunotherapy with liver allograft-derived lymphocytes induces anti-HCV activity after liver transplantation in humans and humanized mice.

2009/08/01

Ohira M, Ishiyama K, Tanaka Y, Doskali M, Igarashi Y, Tashiro H, Hiraga N, Imamura M, Sakamoto N, Asahara T, Chayama K, Ohdan H.

J Clin Invest. 2009 Nov;119(11):3226-35.

A genetic variant of hepatitis B virus divergent from known human and ape genotypes isolated from a Japanese patient and provisionally assigned to new genotype J.

2009/08/01

Tatematsu K, Tanaka Y, Kurbanov F, Sugauchi F, Mano S, Maeshiro T, Nakayoshi T, Wakuta M, Miyakawa Y, Mizokami M.

J Virol. 2009 Oct;83(20):10538-47.

CYP1A1 and CYP1A2 expression: comparing ‘humanized’ mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines.

2009/05/01

Uno S, Endo K, Ishida Y, Tateno C, Makishima M, Yoshizato K, Nebert DW.
Toxicol Appl Pharmacol. 2009 May 15;237(1):119-26.

Direct cytopathic effects of particular hepatitis B virus genotypes in severe combined immunodeficiency transgenic with urokinase-type plasminogen activator mouse with human hepatocytes.

2009/02/01

Sugiyama M, Tanaka Y, Kurbanov F, Maruyama I, Shimada T, Takahashi S, Shirai T, Hino K, Sakaida I, Mizokami M.
Gastroenterology. 2009 Feb;136(2):652-62

ヒト肝キメラマウスの特性

2009/01/02

特免編集部

シリーズIII: 継続・肝炎ウイルス十話_第一話

Prediction of Human Disposition toward S-3H-Warfarin using Chimeric Mice with Humanized Liver

2009/01/01

Tae INOUE, Kazumi SUGIHARA, Hiroki OHSHITA, Toru HORIE, Shigeyuki KITAMURA and Shigeru OHTA
Drug Metabolism and Pharmacokinetics Vol. 24 (2009) , No. 2 pp.153-160

Titration of hepatitis B virus infectivity in the sera of pre-acute and late acute phases of HBV infection: transmission experiments to chimeric mice with human liver repopulated hepatocytes.

2008/12/01

Tabuchi A, Tanaka J, Katayama K, Mizui M, Matsukura H, Yugi H, Shimada T, Miyakawa Y, Yoshizawa H.
J Med Virol. 2008 Dec;80(12):2064-8.

CYP2C9-Catalyzed Metabolism of S-Warfarin to 7-Hydroxywarfarin in Vivo and in Vitro in Chimeric Mice with Humanized Liver.

2008/12/01

Inoue T, Nitta K, Sugihara K, Horie T, Kitamura S, Ohta S.
Drug Metab Dispos. 2008 Dec;36(12):2429-2433