• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/34363922

Zhang, M. Zhang, Z. Imamura, M. Osawa, M. Teraoka, Y. Piotrowski, J. Ishida, Y. Sozzi, V. Revill, P. A. Saito, T. Chayama, K. Liang, T. J.

J Hepatol. 2021 Aug 4. pii: S0168-8278(21)01960-7. doi: 10.1016/j.jhep.2021.07.030.

• Pub Med URL https://pubmed.ncbi.nlm.nih.gov/34238059/

Toxicol Pathol. 2021 Jul 9:1926233211027474. doi: 10.1177/01926233211027474.

Eguchi, A. Fukunaga, S. Ogata, K. Kushida, M. Asano, H. Cohen, S. M. Sukata, T.

• Pub Med URL https://doi.org/10.1293/tox.2021-0027

Journal Toxicologic Pathology 2021; 34(4): 283-297. doi: https://doi.org/10.1293/tox.2021-0027

Tomoya Yamada

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/34264181

Yamada, T. Cohen, S. M. Lake, B. G.

Crit Rev Toxicol. 2021;51(5):373-394. doi:10.1080/10408444.2021.1939654. Epub 2021 Jul 15.

• Pub Med URL https://pubmed.ncbi.nlm.nih.gov/30952782/

Iwamoto, M. Saso, W. Sugiyama, R. Ishii, K. Ohki, M. Nagamori, S. Suzuki, R. Aizaki, H. Ryo, A. Yun, J. H. Park, S. Y. Ohtani, N. Muramatsu, M. Iwami, S. Tanaka, Y. Sureau, C. Wakita, T. Watashi, K.
Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8487-8492. doi: 10.1073/pnas.1811064116. Epub 2019 Apr 5.

住友化学様より、PXBマウス・PXB-cells関連の学術論文(3報)が発表されましたのでご紹介申し上げます。

【 1 】
掲載雑誌名：Journal of Toxicological Pathology
論文名：Review / Featured Article Application of humanized mice to toxicology studies: evaluation of the human relevance

著者：Dr. Tomoya Yamada（住友化学株式会社）
URL：https://www.jstage.jst.go.jp/article/tox/advpub/0/advpub_2021-0027/_article/-char/en

【 2 】
掲載雑誌名：Toxicologic Pathology
論文名：Chimeric Mouse With Humanized Liver Is an Appropriate Animal Model to Investigate Mode of Action for

著者：Dr. Ayumi Eguchi（住友化学株式会社）
URL：https://journals.sagepub.com/eprint/F3WIGCATIMNKMI35FEPH/full

【 3 】
掲載雑誌名：Critical Reviews of Toxicology
論文名：Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of

著者：Dr. Tomoya Yamada（住友化学株式会社）
URL：https://www.tandfonline.com/doi/full/10.1080/10408444.2021.1939654

• Pub Med URL https://pubmed.ncbi.nlm.nih.gov/33980595/

Marwa K. Ibrahim, Tawfeek H. Abdelhafez, Junko S. Takeuchi, Kosho Wakae, Masaya Sugiyama, Masataka Tsuge, Masahiko Ito, Koichi Watashi, Mohamed El. Kassas, Takanobu Kato, Asako Murayama, Tetsuro Suzuki, Kazuaki Chayama, Kunitada Shimotohno, Masamichi Muramatsu, Hussein H. Aly, Takaji Wakita

J Virol. 2021 Jul 12;95(15):　e0076721. doi: 10.1128/JVI.00767-21. Epub 2021 Jul 12.

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/34013171

Li, Y. Chen, L. Li, L. Sottas, C. Petrillo, S. K. Lazaris, A. Metrakos, P. Wu, H. Ishida, Y. Saito, T. Golden-Mason, L. Rosen, H. R. Wolff, J. J. Silvescu, C. I. Garza, S. Cheung, G. Huang, T. Fan, J. Culty, M. Stiles, B. Asahina, K. Papadopoulos, V.

iScience. 2021 May 1;24(5):102457. doi: 10.1016/j.isci.2021.102457.

• Pub Med URL https://pubmed.ncbi.nlm.nih.gov/34147666/

Lua, I. Balog, S. Yanagi, A. Tateno, C. Asahina, K.

Prostaglandins Other Lipid Mediat. 2021 Jun 17:106577. doi: 10.1016/j.prostaglandins.2021.106577.

• Pub Med URL https://pubmed.ncbi.nlm.nih.gov/33932902/

Ohya, K. Imamura, M. Teraoka, Y. Uchida, T. Fujino, H. Nakahara, T. Ono, A. Murakami, E. Yamauchi, M. Kawaoka, T. Miki, D. Tsuge, M. Abe-Chayama, H. Hayes, C. N. Aikata, H. Ishida, Y. Tateno, C. Song, H. Miyayama, Y. Hijikata, M. Chayama, K.

Biochem Biophys Res Commun. 2021 Jun 25;559:78-83. doi: 10.1016/j.bbrc.2021.04.062. Epub 2021 Apr 29.

• Pub Med URL https://pubmed.ncbi.nlm.nih.gov/34080287/

Yoshida, K. Doi, Y. Iwazaki, N. Yasuhara, H. Ikenaga, Y. Shimizu, H. Nakada, T. Watanabe, T. Tateno, C. Sanoh, S.Kotake, Y.

Clin Transl Sci. 2021 Jun 3. doi: 10.1111/cts.13070.

2021年4月～6月に開催されました以下学会にて、PXBマウス及びPXB-cells関連の「15演題」の研究発表が
ありましたのでご紹介申し上げます。

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/33686099

Shinohara, M. Arakawa, H. Oda, Y. Shiraki, N. Sugiura, S. Nishiuchi, T. Satoh, T. Iino, K. Leo, S. Kato, Y. Araya, K. Kawanishi, T. Nakatsuji, T. Mitsuta, M. Inamura, K. Goto, T. Shinha, K. Nihei, W.
Sci Rep. 2021 Mar 8;11(1):5437. doi: 10.1038/s41598-021-84861-y.

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/33393671

Haraguchi, M. Miuma, S. Yamamoto, K. Nakao, Y. Ichikawa, T. Kanda, Y. Sasaki, R. Fukushima, M. Akazawa, Y. Miyaaki, H. Nakao, K.
J Gastroenterol Hepatol. 2021 Jan 4. doi: 10.1111/jgh.15394.

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/33823239

Harada, K. Kohara, H. Yukawa, T. Matsumiya, K. Shinozawa, T.
Toxicol In Vitro. 2021 Aug;74:105159. doi: 10.1016/j.tiv.2021.105159. Epub 2021 Apr 3.

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/32861832

Dent, M. Hamorsky, K. Vausselin, T. Dubuisson, J. Miyata, Y. Morikawa, Y. Matoba, N.
Cell Mol Gastroenterol Hepatol. 2021;11(1):185-198. doi: 10.1016/j.jcmgh.2020.08.009. Epub 2020 Aug 27.

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/33979382

Baudi, I. Isogawa, M. Moalli, F. Onishi, M. Kawashima, K. Ishida, Y. Tateno, C. Sato, Y. Harashima, H. Ito, H. Ishikawa, T. Wakita, T. Iannacone, M. Tanaka, Y.
PLoS Pathog. 2021 May 12;17(5):e1009228. doi: 10.1371/journal.ppat.1009228.

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/33910953

Reinharz, V. Ishida, Y. Tsuge, M. Durso-Cain, K. Chung, T. L. Tateno, C. Perelson, A. S. Uprichard, S. L. Chayama, K. Dahari, H.
J Virol. 2021 Apr 28. pii: JVI.00492-20. doi: 10.1128/JVI.00492-20.

• Pub Med URL https://www.ncbi.nlm.nih.gov/pubmed/33927271

Ito, M. Takino, N. Nomura, T. Kan, A. Muramatsu, S. I.
Sci Rep. 2021 Apr 29;11(1):9322. doi: 10.1038/s41598-021-88614-9.

• Pub Med URL https://pubmed.ncbi.nlm.nih.gov/33333207/

Higashi-Kuwata, N. Hayashi, S. Kumamoto, H. Ogata-Aoki, H. Das, D. Venzon, D. Hattori, S. I. Bulut, H. Hashimoto, M. Otagiri, M. Takamune, N. Kishimoto, N. Davis, D. A. Misumi, S. Kakuni, M.
J Hepatol. 2020 Dec 15. pii: S0168-8278(20)33843-5. doi: 10.1016/j.jhep.2020.12.006.