下記の3学会で、PXBマウス・PXB-cells関連研究発表がありました。

– 2018 International HBV meeting（2018年10月3日～6日・Taormina, Italy）

– 第22回日本肝臓学会・JDDW2018（2018年11月１日～2日・兵庫県神戸市）

– The Liver Meeting 2018（2018年11月9日～13日・San Francisco, US）

番号：P-28
演題：Impact of gut microbes on liver fibrosis in chimeric mice model with human hepaotcytes persistently infected with hepatitis B virus
発表者：Dr. Masaya Sugiyama(National Center for Global Health and Medicine)

 

番号：O-65
演題：Development of a HBV cell culture model with efficient viral spread to support the entire HBV cycle
発表者：Dr. Robert Muench (Gilead)

 

番号：O-86
演題：A drug free effect by combo-treatment with entecavir and CDM-3008 against HBV reactivation in primary cultured human heptocytes
発表者：Dr. Yutaka Furutani (RIKEN)

 

番号：O-87
演題：Highly accurate quantification of intrahepatic Hepatitis B virus cccDNA by droplet digital PCR
発表者：Dr. Sanae Hayashi (Nagoya City Universitiy)

 

番号：O-101
演題：Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase binding
発表者：Dr. Yuta Tsukamoto (Kyoto University / University Hospital Bonn)

 

番号：O-118
演題：Effect of Interleukin 4 on HBV production in HBV-infected hepatocytes
発表者：Dr. Shingo Nakamoto (Chiba University)

 

番号：O-125
演題：A screening system for covalently closed circular (ccc) DNA
発表者：Dr. Fumihiko Takeuchi (Kyoto University)

 

番号：O-144
演題：Comparison of different in vitro cell models to test HBV inhibitors
発表者：Dr. Nele Vandervoort (Galapagos)

 

番号：O-145
演題：Identification of PAPD5/7 as novel dependency host factors for high-level HBV gene expression
発表者：Dr. Henrik Mueller (Roche)

 

番号：O-193
演題：Development of delivery system of CRISPR/Cas9 targeting hepatitis B virus
発表者：Dr. Mohammad Enamul Hoque Kayesh (Kagoshima University)

 

番号：O-203
演題：Efficacy of JNJ-61758320 (JNJ-8320), a capsid assembly modulator, in HBV-infected chimeric uPA/SCID mice with humanized liver
発表者：Dr. Jan Martin Berke (Janssen)

 

番号：O-219
演題：Enhancement of hepatitis B virus replication by a microRNA targeting pregenomic RNA
発表者：Dr. Tsubasa Munakata (Tokyo Metropolitan Institute of Medical Science)

 

番号：O-261
演題：Preliminary analysis of HBV and HDV dynamics during acute co-infection in uPA/SCID chimeric mice using an agent-based modeling approach
発表者：Dr. Harel Dahari (Loyola University Medical Center)

番号：特別講演
演題：HIV感染症とHBV感染症に対する治療薬のデザイン・開発　－構造生物学と臨床薬理学に導かれて－
発表者：満屋 裕明 先生（国立国際医療研究センター研究所）

 

番号：肝S1-1
演題：HCV感染マウスを用いたNS5A-P32delに対するDAA治療効果
発表者：今村 道雄 先生（広島大学　消化器・代謝内科）

 

番号：肝W7-10
演題：HBV in vitro 感染モデルを用いた抗cccDNA肝細胞シグナル分子の検討
発表者：野阪 拓人 先生（福井大学　2内科）

 

番号：肝W7-13
演題：スタチンならびに新規ウイルス増殖因子抑制物質, 既存の抗ウイルス薬2剤の4種併用療法によるcccDNAを含む

抗HBV療法の探索
発表者：藤永 秀剛 先生（東京大学　消化器内科）

 

番号：肝P-3
演題：B型肝炎ウイルス感染に対する爪と毛髪を用いた新しい診断アプローチ
発表者：小松 陽樹 先生（東邦大学　小児科）

 

番号：肝P-227
演題：マウス肝線維化進展予防薬の探索及び効果の検証
発表者：酒井 規裕 先生（新潟大学　消化器内科）

番号：0078
演題：Potent and Durable RNAi-Mediated Suppression of Hepatitis B Virus  Infection in a Mouse Model By a Non-Viral Closed-Ended Linear Duplex(CELiD)DNA Vector
発表者：Dr. Badriprasad Ananthanarayanan(Benitec Biopharma)

番号：0246

演題：Discovery of a Novel Therapeutic Agent Targeting HBx-DDB1 Interaction for HBV Cure
発表者：Dr. Kazuma Sekiba (The University of Tokyo)

番号：409

演題：Novel Candidate Drugs That Target Cccdna of HBV

発表者：Dr. Yoshiki Murakami (Osaka City University)

番号：414

演題：Promising Antiviral Combination Therapy Targeting HBV Eradication with Nucleoside Analogue, Interferon, Statin, and a Novel Compound Derived from Spice
発表者：Dr. Kazuya Okushin (The University of Tokyo)

番号：528

演題：Regulation of the Hepatitis B Virus Gene Expression and Replication By the Multi-Functional Protein Tardbp
発表者：Dr. Grace Naswa Makokha (Hiroshima University)

番号：529

演題：Liver Fibrosis Induced By Gut Microbes in Chimeric Mice Model with Human Hepatocytes Persistently Infected with Hepatitis B Virus

発表者：Dr. Masaya Sugiyama (National Center for Global Health and Medicine)

番号：645

演題：Prevalence of NS5A Resistance Associated Variants in NS5A Inhibitor Treatment Failures and an Effective Treatment for NS5A-P32 Deleted Hepatitis C Virus in Humanized Mice
発表者：Dr. Yuji Teraoka (Hiroshima University)

番号：693

演題：Efficacy of Glecaprevir and Pibrentasvir Treatment for Hepatitis C Virus Drug Resistance-Associated Variants in Humanized Mice
発表者：Dr. Mitsutaka Osawa (Hiroshima University)

番号：1006

演題：A Novel Jak3KORag2KO Chimeric Mouse Model for the Study of Hepatitis Virus Virology
発表者：Dr. Takuro Uchida (Hiroshima University)

番号：1121

演題：Screening of Pharmaceuticals for Their Effectiveness in Preventing Liver Fibrosis Using Mice with Humanized Livers, with an Assessment of the Therapeutic Effect Using Mouse Liver Fibrosis Models
発表者：Dr. Norihiro Sakai (Niigata University)

番号：1848

演題：Development of Human Ornithine Transcabamylase Deficiency Model Using cDNA-uPA/SCID Chimeric Mice with Patient Hepatocytes
発表者：Chise Tateno (Phoenixbio Co., Ltd.)

番号：2001

演題：The Role of TLL1 in Hepatic Fibrogenesis and Carcinogenesis
発表者：Dr. Kentaro Matsuura (Nagoya City University Graduate School of Medical Sciences)