Phoenix Bio

Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation

Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation

2020/06/17

Steeneck, C. Kinzel, O. Anderhub, S. Hornberger, M. Pinto, S. Morschhaeuser, B. Braun, F. Kleymann, G. Hoffmann, T.

ACS Med Chem Lett. 2020 Jan 27;11(2):179-187. doi: 10.1021/acsmedchemlett.9b00572. eCollection 2020 Feb 13.

Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: Integration with hepatic drug metabolism

2020/06/17

Sanoh, S. Naritomi, Y. Kitamura, S. Shinagawa, A. Kakuni, M. Tateno, C. Ohta, S.

Xenobiotica. 2020 Jun 5:1-10. doi: 10.1080/00498254.2020.1769229.

A novel evaluation method for determining drug-induced hepatotoxicity using 3D bio-printed human liver tissue

2020/06/17

Ide, I. Nagao, E. Kajiyama, S. Mizoguchi, N.

Toxicol Mech Methods. 2020 Mar;30(3):189-196. doi: 10.1080/15376516.2019.1686795. Epub 2019 Nov 21.

Engineering Cellular Biosensors with Customizable Antiviral Responses Targeting Hepatitis B Virus

2020/06/17

Matsunaga, S. Jeremiah, S. S. Miyakawa, K. Kurotaki, D. Shizukuishi, S. Watashi, K. Nishitsuji, H. Kimura, H. Tamura, T. Yamamoto, N. Shimotohno, K. Wakita, T. Ryo, A.

iScience. 2020 Mar 27;23(3):100867. doi: 10.1016/j.isci.2020.100867. Epub 2020 Feb 26.

Species differences in liver accumulation and metabolism of nucleotide prodrug sofosbuvir

2020/06/17

Wang, T. Babusis, D. Park, Y. Niu, C. Kim, C. Zhao, X. Lu, B. Ma, B. Muench, R. C. Sperger, D. Ray, A. S. Murakami, E.

Drug Metab Pharmacokinet. 2020 Jun;35(3):334-340. doi: 10.1016/j.dmpk.2020.04.333. Epub 2020 Apr 16.

Art of Making Artificial Liver: Depicting Human Liver Biology and Diseases in Mice

2020/04/14

Sugahara, G. Ishida, Y. Sun, J. Tateno, C. Saito, T.

Semin Liver Dis. 2020 Feb 19. doi: 10.1055/s-0040-1701444.

Characterization and applications of chimeric mice with humanized livers for preclinical drug development

2020/04/14

Tateno, Chise;   Kojima, Yuha

Laboratory Animal Research volume 36, Article number: 2 (2020)

Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection

2020/04/14

Cheng, X. Uchida, T. Xia, Y. Umarova, R. Liu, C. J. Chen, P. J. Gaggar, A. Suri, V. Mucke, M. M. Vermehren, J. Zeuzem, S. Teraoka, Y. Osawa, M. Aikata, H. Tsuji, K. Mori, N. Hige, S. Karino, Y. Imamura, M. Chayama, K. Liang, T. J.

J Clin Invest. 2020 Mar 12. pii: 135616. doi: 10.1172/JCI135616.

Lipoprotein profile and lipid metabolism of PXB-cells((R)), human primary hepatocytes from liver-humanized mice: proposal of novel in vitro system for screening anti-lipidemic drugs

2020/04/14

Hata, K. Sayaka, T. Takahashi, M. Sasaki, A. Umekawa, Y. Miyashita, K. Ogura, K. Toshima, G. Maeda, M. Takahashi, J. Kakuni, M.

Biomed Res. 2020;41(1):33-42. doi: 10.2220/biomedres.41.33.

Successful energy shift from glycolysis to mitochondrial oxidative phosphorylation in freshly isolated hepatocytes from humanized mice liver

2020/04/14

Ikeyama, Y. Sato, T. Takemura, A. Sekine, S. Ito, K.

Toxicol In Vitro. 2020 Jan 25:104785. doi: 10.1016/j.tiv.2020.104785.

SOT 59th Annual Meeting and ToxExpo 2020開催中止にともなうPXBマウス・PXB-cells関連研究発表およびブース展示に関して

2020/03/12

3月15日(日)~19日(水)にAnaheim Convention Center(米国・アナハイム)で開催されますSOT 59th Annual Meeting and

ToxExpo 2020について、大会事務局より3月9日付でCOVID-19の影響により学会開催の中止に関するアナウンスが

ございました。
当学会の中止に伴い、予定しておりましたPXBマウス・PXB-cells関連研究発表およびブース展示は行われないことを

ご報告申し上げます。

日本薬物動態学会でのPXBマウス・PXB-cells関連研究発表及びショートコースでのランチョンセミナー開催のご案内

2019/12/04

2019年12月10日(火)~12月12日(木)に開催されます日本薬物動態学会  第34回年会にてPXBマウス及びPXB-cells関連の研究発表及びブース展示があります。
又、12月9日(月)に日本薬物動態学会 第13回ショートコースにてランチョンセミナーを開催致しますので、重ねてご案内申し上げます。

High-throughput screening to evaluate inhibition of bile acid transporters using human hepatocytes isolated from chimeric mice

2019/11/28

Kohara, H. Bajaj, P. Yamanaka, K. Miyawaki, A. Harada, K. Miyamoto, K. Matsui, T. Okai, Y. Wagoner, M. Shinozawa, T.

Toxicol Sci. 2019 Nov 13. pii: 5625164. doi: 10.1093/toxsci/kfz229.

Application of a Novel Mass Spectral Data Acquisition Approach to Lipidomic Analysis of Liver Extracts from Sitaxentan-treated Liver-Humanized PXB Mice

2019/11/28

King, A. Baginski, M. Morikawa, Y. Rainville, P. D. Gethings, L. A. Wilson, I. D. Plumb, R. S.

J Proteome Res. 2019 Oct 8. doi: 10.1021/acs.jproteome.9b00334..

Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

2019/11/28

Katsuda, T. Matsuzaki, J. Yamaguchi, T. Yamada, Y. Prieto-Vila, M. Hosaka, K. Takeuchi, A. Saito, Y. Ochiya, T.

Elife. 2019 Aug 8;8. pii: 47313. doi: 10.7554/eLife.47313.

Efficacy of glecaprevir and pibrentasvir treatment for genotype 1b hepatitis C virus drug resistance-associated variants in humanized mice

2019/11/28

Osawa, M. Uchida, T. Imamura, M. Teraoka, Y. Fujino, H. Nakahara, T. Ono, A. Murakami, E. Kawaoka, T. Miki, D. Tsuge, M. Hiramatsu, A. Abe-Chayama, H. Hayes, C. N.

J Gen Virol. 2019 Jul;100(7):1123-1131.

Effect of Rifampicin on the Plasma Concentrations of Bile Acid-O-Sulfates in Monkeys and Human Liver-Transplanted Chimeric Mice With or Without Bile Flow Diversion

2019/11/28

Takehara, I. Watanabe, N. Mori, D. Ando, O. Kusuhara, H.

J Pharm Sci. 2019 Mar 21.

Anti-HBV activity of retinoid drugs in vitro versus in vivo

2019/11/28

Birkus, G. Snyder, C. Jordan, R. Kobayashi, T. Dick, R. Puscau, V. Li, L. Ramirez, R. Willkom, M. Morikawa, Y. Delaney, W. Schmitz, U.

Antiviral Res. 2019 Jun 18:104538. doi: 10.1016/j.antiviral.2019.104538.

An interferon-like small chemical compound CDM-3008 suppresses hepatitis B virus through induction of interferon-stimulated genes

2019/11/28

Furutani, Y. Toguchi, M. Shiozaki-Sato, Y. Qin, X. Y. Ebisui, E. Higuchi, S. Sudoh, M. Suzuki, H. Takahashi, N. Watashi, K. Wakita, T. Kakeya, H. Kojima, S.

PLoS One. 2019 Jun 12;14(6):e0216139. doi: 10.1371/journal.pone.0216139. eCollection 2019.

ICoFF2019 KOBEでのPXBマウス・PXB-cells関連発表のご案内

2019/11/28

2019年12月1日(日)~5日(木)に神戸国際会議場(兵庫県)で開催されますICoFF2019(International Conference on Food Factors)にて、PXBマウス・PXB-cells関連発表があります。