Phoenix Bio

研究開発

研究開発

Interferon alpha treatment stimulates interferon gamma expression in type I NKT cells and enhances their antiviral effect against hepatitis C virus

    Miyaki, E. Hiraga, N. Imamura, M. Uchida, T.  Kan, H.  Tsuge, M. Abe-Chayama, H. Hayes, C. N. Makokha, G. N. Serikawa, M. Aikata, H. Ochi, H. Ishida, Y. Tateno, C. Ohdan, H. Chayama, K.

    PLoS One. 2017 Mar 2;12(3):e0172412.

    Usefulness of humanized cDNA-uPA/SCID mice for the study of hepatitis B virus and hepatitis C virus virology

      Uchida, T. Imamura, M. Kan, H. Hiraga, N. Hayes, C. N. Tsuge, M. Abe-Chayama, H. Aikata, H. Makokha, G. N. Miki, D. Ochi, H. Ishida, Y. Tateno, C. Chayama, K.

      J Gen Virol. 2017 Jan 28. doi: 10.1099/jgv.0.000726.

      Evaluation of the Utility of Chimeric Mice with Humanized Livers for the Characterization and Profiling of the Metabolites of a Selective Inhibitor (YM543) of the Sodium-Glucose Cotransporter 2

        Nakada, N.

        Pharm Res. 2017 Feb 13. doi: 10.1007/s11095-017-2116-4.

        Propagation of Human Hepatocytes in uPA/SCID Mice: Producing Chimeric Mice with Humanized Liver

        Ohshita, H. Tateno, C.

        Methods Mol Biol. 2017;1506:91-100. (Book of Hepatocyte Transplantation)

         

        Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver

          Miyamoto, M. Iwasaki, S.  Chisaki, I. Nakagawa, S. Amano, N. Hirabayashi, H.

          Xenobiotica. 2016 Nov 28:1-54.

          Cyclosporin derivatives inhibit hepatitis B virus entry without interfering with NTCP transporter activity

            Shimura, S. Watashi, K. Fukano, K. Peel, M. Sluder, A. Kawai, F. Iwamoto, M. Tsukuda, S. Takeuchi, J. S. Miyake, T. Sugiyama, M. Ogasawara, Y. Park, S. Y. Tanaka, Y. Kusuhara, H. Mizokami, M. Sureau, C. Wakita, T.

            J Hepatol. 2016 Nov 24. pii: S0168-8278(16)30683-3. doi: 10.1016/j.jhep.2016.11.009.

            A new class of hepatitis B and D virus entry inhibitors, proanthocyanidin and its analogs, that directly act on the viral large surface proteins

              Tsukuda, S. Watashi, K. Hojima, T. Isogawa, M. Iwamoto, M. Omagari, K. Suzuki, R. Aizaki, H. Kojima, S. Sugiyama, M. Saito, A. Tanaka, Y. Mizokami, M. Sureau, C. Wakita, T.

              Hepatology. 2016 Nov 18. doi: 10.1002/hep.28952.

              Lack of exposure in a first-in-man study due to aldehyde oxidase metabolism: Investigated by use of 14C-microdose, humanized mice, monkey pharmacokinetics and in vitro methods

                Jensen, K. G. Jacobsen, A. M. Bundgaard, C. Nilausen, D. O. Thale, Z. Chandrasena, G. Jorgensen, M.

                Drug Metab Dispos. 2016 Oct 13. pii: dmd.116.072793.

                Assessing the Therapeutic Potential of Lab-Made Hepatocytes

                Rezvani, M. Grimm, A. Willenbring, H.

                Hepatology. 2016 Mar 25. doi: 10.1002/hep.28569

                Protease inhibitor resistance remains even after mutant strains become undetectable using deep sequencing

                  Kan, H. Imamura, M. Uchida, T. Hiraga, N. Hayes, C. N. Tsuge, M. Abe, H. Aikata, H. Makokha, G. N. Chowdhury, S. Miki, D. Ochi, H. Ishida, Y. Tateno, C. Chayama, K.

                  J Infect Dis. 2016 Sep 20. pii: jiw437.

                  Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation

                    Tanaka, T. Okuyama-Dobashi, K. Murakami, S. Chen, W. Okamoto, T. Ueda, K. Hosoya, T. Matsuura, Y. Ryo, A. Tanaka, Y. Hagiwara, M. Moriishi, K.

                    Antiviral Res. 2016 Aug 8. pii: S0166-3542(16)30357-6.

                    Hepatitis C virus dynamics and cellular gene expression in uPA-SCID chimeric mice with humanized livers during intravenous silibinin monotherapy

                      DebRoy, S.  Hiraga, N. Imamura, M. Hayes, C. N. Akamatsu, S. Canini, L. Perelson, A. S. Pohl, R. T. Persiani, S. Uprichard, S. L. Tateno, C. Dahari, H. Chayama, K.

                      J Viral Hepat. 2016 Jun 8. doi: 10.1111/jvh.12551.

                      新規核酸アナログ4′-C-cyano-2′-deoxyadenosine, 4′-C-cyano-2′-deoxyguanosineは薬剤耐性B型肝炎ウイルス変異種に対して有効である(短報)

                      林 佐奈衣、高松悠樹、前田賢次、村上周子,尾曲克已、松居剛志、五十川正記、渡邊網正、狩野吉康、向後悟、濱屋裕明、田中靖人

                      肝臓 2016; 57(6):299-301

                      Halogenated hydrocarbon solvent-related cholangiocarcinoma risk: biliary excretion of glutathione conjugates of 1,2-dichloropropane evidenced by untargeted metabolomics analysis

                        Toyoda, Y. Takada, T. Suzuki, H.

                        Sci Rep. 2016 Apr 18;6:24586. doi: 10.1038/srep24586.

                        Antiviral effects of anti-HBs immunoglobulin and vaccine on HBs antigen seroclearance for chronic hepatitis B infection

                          Tsuge, M. Hiraga, N. Uchida, T. Kan, H. Miyaki, E. Masaki, K. Ono, A. Nakahara, T. Abe-Chayama, H. Zhang, Y. Naswa, M. G. Kawaoka, T. Miki, D. Imamura, M. Kawakami, Y. Aikata, H. Ochi, H. Hayes, C. N. Chayama, K.

                          J Gastroenterol. 2016 Mar 4.

                          Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound

                            Kamimura, H. Ito, S.

                            Xenobiotica. 2015 Oct 7:1-13.

                            動物モデルを用いた発癌研究

                            森屋恭爾、三好秀征、小池和彦

                            新ウイルス性肝炎学 2015 page74-78

                            肝炎ウイルスの動物モデルと治療開発

                            茶山一彰、今村道雄

                            新ウイルス性肝炎学 2015 page69-73

                            ヒト肝細胞キメラマウスを用いたin vivoおよびin vitro HBV感染モデル

                            石田雄二、横道博、加国雅和、立野知世

                            新ウイルス性肝炎学 2015 page386-391

                            In Vitro and in Vivo Assessments of Drug-induced Hepatotoxicity and Drug Metabolism in Humans (In Japanese)(ヒトにおける医薬品の肝毒性及び代謝物のin vtro, in vivo予測評価系の構築に関する研究)

                              Sanoh, S.

                              Yakugaku Zasshi. 2015;135(11):1273-9. doi: 10.1248/yakushi.15-00200.