Phoenix Bio

研究開発

研究開発

Bezafibrate induces multidrug-resistance P-Glycoprotein 3 expression in cultured human hepatocytes and humanized livers of chimeric mice.

    Shoda J, Okada K, Inada Y, Kusama H, Utsunomiya H, Oda K, Yokoi T, Yoshizato K, Suzuki H.
    Hepatol Res. 2007 Jul;37(7):548-56.

    Humanization of Excretory Pathway in Chimeric Mice with Humanized Liver

      Okumura H, Katoh M, Sawada T, Nakajima M, Soeno Y, Yabuuchi H, Ikeda T, Tateno C, Yoshizato K, Yokoi T.
      Toxicol Sci. 2007 Jun;97(2):533-8. Epub 2007 Mar 6.

      Infection of human hepatocyte chimeric mouse with genetically engineered hepatitis C Virus and its susceptibility to interferon

        Hiraga N, Imamura M, Tsuge M, Noguchi C, Takahashi S, Iwao E, Fujimoto Y, Abe H, Maekawa T, Ochi H, Tateno C, Yoshizato K, Sakai A, Sakai Y, Honda M, Kaneko S, Wakita T, Chayama K.
        FEBS Lett. 2007 May 15;581(10):1983-7. Epub 2007 Apr 20.

        Early Dynamics of Hepatitis B Virus in Chimeric Mice Carrying Human Hepatocytes Monoinfected or Coinfected with Genotype G

          Sugiyama M, Tanaka Y, Sakamoto T, Maruyama I, Shimada T, Takahashi S, Shirai T, Kato H, Nagao M, Miyakawa Y, Mizokami M.
          Hepatology. 2007 Apr;45(4):929-37.

          Evaluation of Cyclophilin Inhibitor in Hepatitis C Virus-Infected Chimeric Mice In Vivo

            Inoue K, Umehara T, Ruegg UT, Yasui F, Watanabe T, Yasuda H, Dumont JM, Scalfaro P, Yoshiba M, Kohara M.
            Hepatology. 2007 Apr;45(4):921-8.

            Humanized mice in translational biomedical research.

              Shultz LD, Ishikawa F, Greiner DL.
              Nat Rev Immunol. 2007 Feb;7(2):118-30.

              Hsp90 inhibitors suppress HCV replication in replicon cells and humanized liver mice

                Nakagawa S, Umehara T, Matsuda C, Kuge S, Sudoh M, Kohara M.
                Biochem Biophys Res Commun. 2007 Feb 23;353(4):882-8. Epub 2006 Dec 22.

                Application of chimeric mice with humanized liver for predictive adme

                  Katoh M, Yokoi T.
                  Drug Metab Rev. 2007;39(1):145-57.

                  In Vivo Induction of Human Cytochrome P450 Enzymes Expressed in Chimeric Mice with Humanized Liver

                    Katoh M, Matsui T, Nakajima M, Tateno C, Soeno Y, Horie T, Iwasaki K, Yoshizato K, Yokoi T.

                    Drug Metab Dispos. 2005 Jun;33(6):754-763.

                    Influence of Hepatitis B Virus Genotypes on the Intra- and Extracellular Expression of Viral DNA and Antigens

                      Sugiyama M, Tanaka Y, Kato T, Orito E, Ito K, Acharya SK, Gish RG, Kramvis A, Shimada T, Izumi N, Kaito M, Miyakawa Y, Mizokami M.

                      Hepatology. 2006 Oct;44(4):915-24.

                      Evaluation of Human CYP1A2 and CYP3A4 mRNA Expression in Hepatocytes from Chimeric Mice with Humanized Liver

                        Yoshitsugu H, Nishimura M, Tateno C, Kataoka M, Takahashi E, Soeno Y, Yoshizato K, Yokoi T, Naito S.

                        Drug Metab Pharmacokinet. 2006;21(6):465-474.

                        Emergence of a Novel Lamivudine-Resistant Hepatitis B Virus Variant with a Substitution Outside the YMDD Motif

                          Yatsuji H, Noguchi C, Hiraga N, Mori N, Tsuge M, Imamura M, Takahashi S, Iwao E, Fujimoto Y, Ochi H, Abe H, Maekawa T, Tateno C, Yoshizato K, Suzuki F, Kumada H, Chayama K.
                          Antimicrob Agents Chemother. 2006 Nov;50(11):3867-74. Epub 2006 Sep 18.

                          Characterization of Humanized Liver from Chimeric Mice Using Coumarin as a Human CYP2A6 and Mouse CYP2A5 Probe

                            Aoki K, Kashiwagura Y, Horie T, Sato H, Tateno C, Ozawa N, Yoshizato K.

                            Drug Metab Pharmacokinet. 2006 ;21(4):277-285.

                            Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse model

                              Umehara T, Sudoh M, Yasui F, Matsuda C, Hayashi Y, Chayama K, Kohara M.

                              Biochem Biophys Res Commun. 2006 Jul 21;346(1):67-73. Epub 2006 May 24.

                              Generation of hybrid hepatocytes by cell fusion from monkey embryoid body cells in the injured mouse liver

                                Okamura, K. Asahina, K. Fujimori, H. Ozeki, R. Shimizu-Saito, K. Tanaka, Y. Teramoto, K. Arii, S. Takase, K. Kataoka, M. Soeno, Y. Tateno, C. Yoshizato, K. Teraoka, H.

                                Histochem Cell Biol. 2006 ;125(3):247-257.

                                Infection of Human Hepatocyte Chimeric Mouse With Genetically Engineered Hepatitis B Virus

                                  Tsuge M, Hiraga N, Takaishi H, Noguchi C, Oga H, Imamura M, Takahashi S, Iwao E, Fujimoto Y, Ochi H, Chayama K, Tateno C, Yoshizato K.

                                  Hepatology. 2005 Nov;42(5):1046-54.

                                   

                                  Induction of Human CYP1A2 and CYP3A4 in Primary Culture of Hepatocytes from Chimeric Mice with Humanized Liver

                                    Nishimura M, Yokoi T, Tateno C, Kataoka M, Takahashi E, Horie T, Yoshizato K, Naito S.

                                    Drug Metab Pharmacokinet. 2005;20(2):121-126.

                                    Evaluation of mRNA expression of human drug-metabolizing enzymes and transporters in chimeric mouse with humanized liver

                                      Nishimura M, Yoshitsugu H, Yokoi T, Tateno C, Kataoka M, Horie T, Yoshizato K, Naito S.

                                      Xenobiotica. 2005 Sep;35(9):877-890.

                                      In vivo induction of human cytochrome P450 3A4 by rifabutin in chimeric mice with humanized liver

                                        Katoh M, Watanabe M, Tabata T, Sato Y, Nakajima M, Nishimura M, Naito S, Tateno C, Iwasaki K, Yoshizato K, Yokoi T.

                                        Xenobiotica. 2005 Sep;35(9):863-875.

                                        Efficient in vivo Xenogeneic retroviral vector-mediated gene transduction into human hepatocytes.

                                          Kentaro Emoto, Chise Tateno, Hiroshi Hino, Hironobu Amano, Yasuhiro Imaoka, Kinji Asahina, Toshimasa Asahara and Katsutoshi Yoshizato

                                          Hum Gene Ther. 2005 Oct; 16: 1168-1174.